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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

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Translational Neurodegeneration 2019年第1期8卷 433-449页

作者： Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler Institut de Pharmacologie Moléculaire et Cellulaire CNRS-UMR7275team labeled«Fondation pour la Recherche Médicale»et«Laboratoire d’excellence Distalz»Universitéde Nice-Sophia-AntipolisSophia-AntipolisFrance Institut-Myologie ParisFrance

Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse ***,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated *** here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced ***:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by *** pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing *** APP-CTF localization was determined by ***:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/***,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell ***,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor *** combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or *** analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in *** D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient ***,our data proposed t

关键词： Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization Endosomes Lysosomes trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease

BABA-induced pathogen resistance: a multi-omics analysis of the tomato response reveals a hyper-receptive status involving ethylene

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Horticulture Research 2023年第6期10卷 16-29页

作者： Martina Zapletalova Corinne Rancurel Benoit Industri Marc Bardin Kevin Le Brigand Philippe Nicot Virginie Magnone Aurelie Seassau Pascal Barbry David Potesil Zbynek Zdrahal Michel Ponchet Jan Lochman UMR Institut Sophia Agrobiotech INRAE 1355 CNRS 6254UniversitéCôte d’Azur400Route des Chappes06903 Sophia AntipolisFrance Department of Biochemistry Faculty of ScienceMasaryk UniversityKotlarska261137 BrnoCzech Republic Unité407 Pathologie végétale INRAEDomaine Saint-Maurice84143 Montfavet cedexFrance UMR Institut de Pharmacologie Moléculaire et Cellulaire UniversitéCôte d’AzurCNRS 7275660 Route des Lucioles 06560 ValbonneFrance Central European Institute of Technology Masaryk UniversityKamenice 562500 BrnoCzech Republic

Prior exposure to microbial-associated molecular patterns or specific chemical compounds can promote plants into a primed state with stronger defence responses.β-aminobutyric acid(BABA)is an endogenous stress metabolite that induces resistance protecting various plants towards diverse *** this study,by integrating BABA-induced changes in selected metabolites with transcriptome and proteome data,we generated a global map of the molecular processes operating in BABA-induced resistance(BABA-IR)in *** significantly restricts the growth of the pathogens Oidium neolycopersici and Phytophthora parasitica but not Botrytis cinerea.A cluster analysis of the upregulated processes showed that BABA acts mainly as a stress factor in *** main factor distinguishing BABA-IR from other stress conditions was the extensive induction of signaling and perception machinery playing a key role in effective resistance against ***,the signalling processes and immune response activated during BABA-IR in tomato differed from those in Arabidopsis with substantial enrichment of genes associated with jasmonic acid(JA)and ethylene(ET)signalling and no change in Asp *** results revealed key differences between the effect of BABA on tomato and other model plants studied until ***,salicylic acid(SA)is not involved in BABA downstream signalization whereas ET and JA play a crucial role.

关键词： BABA resistance analysis

Increased circulating rather than spinal cytokines accompany chronic pain behaviors in experimental bone cancer and arthritis

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Neuroimmunology and Neuroinflammation 2014年第1期1卷 153-160页

作者： Line Pourtau Amarins Nieske Heeringa Carole Rovère Agnès Aubert Jean-Louis Nahon Sylvain Miraux Jan Pieter Konsman cnrs PsychoNeuroImmunologieNutrition et GénétiqueUMR 522633076 BordeauxFrance Univ.Bordeaux PsyNuGenUMR 522633076 BordeauxFrance cnrs Institut de Pharmacologie Moléculaire et CellulaireUMR 727506560 ValbonneFrance Univ.Nice Sophia Antipolis 06130 NiceFrance cnrs Résonance Magnétique des Systèmes BiologiquesUMR 553633076 BordeauxFrance Univ.Bordeaux RMSBUMR 553633076 BordeauxFrance

Aim:Peripheral cytokines contribute to arthritis and bone cancer pain through sensory nerve ***,increased spinal cytokine and glial filament expression,coined neuroinflammation,has also been proposed to play a part in chronic ***,spinal cord,dorsal root ganglia and circulating cytokines were compared in murine arthritis and bone cancer models in relationship to behavioral signs of ***:Exploratory behaviors were studied after intra-articular complete Freund’s adjuvant or bone intramedullary sarcoma cell *** tissue and blood cytokine expression were determined by real-time polymerase chain reaction(PCR)and multiplex immunoassays,***:PCR analysis did not reveal any hallmark of spinal neuroinflammation in spontaneously-behaving mice with cartilage or bone ***,imposed paw stimulation during joint inflammation increased spinal interleukin-1β(IL-1β)*** paw guarding during rearing was displayed by animals with joint inflammation and bone destruction and was accompanied by increased circulating IL-6 and monocyte chemoattractant protein-1,*** addition,dorsal root ganglia were found to constitutively express receptors for this chemotactic ***:Our findings indicate that spinal neuroinflammation is not a necessary condition for chronic pain and suggest that circulating cytokine action in dorsal root ganglia may contribute to experimental joint inflammation and bone cancer pain.

关键词： itis bone cancer CCL2 cytokines dorsal root ganglia pain spinal cord

基于有限温相对论Hartree-Fock-Bogoliubov理论的对相变研究

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中国科学：物理学、力学、天文学 2016年第1期46卷 94-105页

作者：龙文辉杨申李佳杰兰州大学核科学与技术学院兰州730000 中国科学院近代物理研究所兰州730000 巴黎南大学 IN2P3-CNRS核物理研究所法国Orsay F-91406 里昂大学 IN2P3-CNRS核物理研究所法国Villeurbanne F-69622

本文介绍了有限温相对论Hartree-Fock-Bogoliubov(FT-RHFB)理论,其中积分微分的FT-RHFB方程采用能合理描述连续态渐近行为的Dirac Woods-Saxon(DWS)基来自洽求解.考虑两种对相互作用即有限程的Gogny对力与零程的Delta对力,系统计算了稳... 详细信息

本文介绍了有限温相对论Hartree-Fock-Bogoliubov(FT-RHFB)理论,其中积分微分的FT-RHFB方程采用能合理描述连续态渐近行为的Dirac Woods-Saxon(DWS)基来自洽求解.考虑两种对相互作用即有限程的Gogny对力与零程的Delta对力,系统计算了稳定核以及弱束缚核并分析讨论了它们的对相变特征.研究结果表明,采用有限程Gogny对力的计算预言对关联消失的临界温度Tc与零温时平均对能隙?(0)之间的关系为Tc=0.60?(0),而采用零程Delta对力该关系则被预言为Tc=0.57?(0).同时,研究发现了两种分别源于子壳结构和连续态耦合的对保持现象.对于选定原子核的热响应分析研究表明,对关联对比热曲线的s-形状有贡献,并显著消除了模型之间的差别;对于稳定核,这种差别主要根源于核物质有效质量.

关键词：对相变热原子核 RHFB理论临界温度

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空气中激光等离子体通道诊断方法比较研究

中国科学（G辑） 2006年第1期36卷 38-45页

作者：郝作强张杰俞进郑志远远晓辉张喆李玉同王兆华令维军魏志义中国科学院物理研究所光物理实验室 Laboratoire de Spectrométrie Ionique et Moléculaire UMR CNRS 5579Université Claude Bernard-Lyon 143Bd.du 11 Novembre 1918F-69622 Villeurbanne CedexFrance

使用3种诊断方法(通道横截面成像法、电阻率测量法和声学测量法)对超强飞秒激光脉冲在空气中形成的长等离子体通道进行了测量.研究发现,通道横截面成像法利用了通道内细丝具有较大的激光强度这个性质,是研究通道内细丝分布以及细丝演化... 详细信息

使用3种诊断方法(通道横截面成像法、电阻率测量法和声学测量法)对超强飞秒激光脉冲在空气中形成的长等离子体通道进行了测量.研究发现,通道横截面成像法利用了通道内细丝具有较大的激光强度这个性质,是研究通道内细丝分布以及细丝演化等最精确的方法;电阻率测量利用了通道的导电特性,其误差较大,适合对通道进行粗略估计;声学测量方法通过测量通道辐射出来的声波,间接反映了通道内的激光强度和电子密度演化是3种方法中最快速,最易于操作的方法.等离子体通道诊断方法的比较研究对于人们深入研究通道各个方面的性质,以及正确选择不同的实验手段都有重要意义.

关键词：等离子体通道细丝横截面成像电阻率测量声学测量

神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐

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国际脑血管病杂志 2019年第2期27卷 84-97页

作者： Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti Pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) Department of Medic al-Surgical Intensive Care Medicine Faculty of Biology and Medicine Centre Hospitalier Universitaire VauDOIs (CHUV) Lhiversity of Lausanne Rue du Bugnon 46 B4 08.623 1011 Lausanne Switzerland Department of Intensive Care Medicine St James's Lhiversity Hospital James's St Ushers P.O. Box 580 Dublin & Ireland Service de Reanimation Medic o-chirurgic ale Hopital Pasteur 2 UniversiteCote d'Azur CHU de Nice 06000 Nice France unite cnrs 7275 Sophia-Antipolis France Department of Intensive Care Erasme Hospital University Libre de Bruxelles Brussels Belgium Neurosciences Critical Care Departments of Anesthesiology and Critical Care Medicine Neurology and Neurosurgery Johns Hopkins Lhiversity Baltimore MD USA Department of Neurology University of California San Francisco San Francisco CA LKA Service de Reanimation Polyvalente Hopital Pasteur 2 CHU de Nice 30 Voie Romaine CS 51069 06001 Nice Cedex 1 France Division of Anaesthesia University of Cambridge Addenbrooke's Ffospital Box 93 Hfills Road Cambridge Cambridgeshire CB2 2QQ UK Department of Intensive Care 4131 Copenhagen University Hospital- Rigshospitalet Copenhagen Denmark Department of Neuroanesthesia and Neurocritic al Care The National Ffospital for Neurosurgery and Neurology Lhiversity College London Hospitals London UK Anesthesia and Intensive Care Operative th it S. Martino Hospital Belluno Italy Hospital Nacional Professor Alejandro Posadas Buenos Aires Argentina Department of Neurosciences IRCCS-Istituto di Ricerche Farmacotogiche Mario Negri Milan Italy School of Medicine and Surgery University of Milan-Bicocca Milan Italy Neurointensive Care San Gerardo Hospital ASST-Monza 20900 Monza Italy 南方医科大学南方医院神经内科广州510515 Neurological Intensive Care Lhit Department of Neurology Medical University of Innsbruck Innsbruck Austria Department of Intensive Care Medicine University Hospitals Leuven Louvain Belgium Neuroscience Intensive Care Unit Department of Anesthesia and C

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会... 详细信息

目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。

关键词：循证医学指南液体治疗创伤性脑损伤蛛网膜下腔出血脑出血卒中甘露醇高渗神经重症监护