Increased circulating rather than spinal cytokines accompany chronic pain behaviors in experimental bone cancer and arthritis

作     者：Line Pourtau Amarins Nieske Heeringa Carole Rovère Agnès Aubert Jean-Louis Nahon Sylvain Miraux Jan Pieter Konsman 

作者机构：CNRSPsychoNeuroImmunologieNutrition et GénétiqueUMR 522633076 BordeauxFrance Univ.BordeauxPsyNuGenUMR 522633076 BordeauxFrance CNRSInstitut de Pharmacologie Moléculaire et CellulaireUMR 727506560 ValbonneFrance Univ.Nice Sophia Antipolis06130 NiceFrance CNRSRésonance Magnétique des Systèmes BiologiquesUMR 553633076 BordeauxFrance Univ.BordeauxRMSBUMR 553633076 BordeauxFrance 

出 版 物：《Neuroimmunology and Neuroinflammation》 (神经免疫与神经炎症（英文版）)

年 卷 期：2014年第1卷第1期

页      面：153-160页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：itis bone cancer CCL2 cytokines dorsal root ganglia pain spinal cord 

摘      要：Aim:Peripheral cytokines contribute to arthritis and bone cancer pain through sensory nerve ***,increased spinal cytokine and glial filament expression,coined neuroinflammation,has also been proposed to play a part in chronic ***,spinal cord,dorsal root ganglia and circulating cytokines were compared in murine arthritis and bone cancer models in relationship to behavioral signs of ***:Exploratory behaviors were studied after intra-articular complete Freund’s adjuvant or bone intramedullary sarcoma cell *** tissue and blood cytokine expression were determined by real-time polymerase chain reaction(PCR)and multiplex immunoassays,***:PCR analysis did not reveal any hallmark of spinal neuroinflammation in spontaneously-behaving mice with cartilage or bone ***,imposed paw stimulation during joint inflammation increased spinal interleukin-1β(IL-1β)*** paw guarding during rearing was displayed by animals with joint inflammation and bone destruction and was accompanied by increased circulating IL-6 and monocyte chemoattractant protein-1,*** addition,dorsal root ganglia were found to constitutively express receptors for this chemotactic ***:Our findings indicate that spinal neuroinflammation is not a necessary condition for chronic pain and suggest that circulating cytokine action in dorsal root ganglia may contribute to experimental joint inflammation and bone cancer pain.