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Evaluation of functional capacity, body composicion and pulmonary function after bariatric surgery

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Health 2013年第8期5卷 47-53页

作者： Flavia Sales Leite Marcela Cangussu Barbalho-Moulim Kadma Karenina Damaceno Soares Fernanda Dultra Dias Fabiana Sobral Peixoto-Souza Dirceu Costa uninove—nove de julho university Sao PauloBrazil UFSCar—Federal university of Sao Carlos Sao CarlosBrazil

Introduction: Obesity has been considered a global epidemic and a serious public health problem closely related to other diseases. Moreover, obese individuals have limitations in physical capacity and pulmonary function. Weight loss induced by bariatric surgery appears to help reverse this situation. However, questions about physical capacity and lung function, and its relationship with body composition remain to be clarified. Objective: To evaluate the physical capacity, body composition and lung function in women undergoing bariatric surgery. Methods: Twenty five women who underwent bariatric surgery between 6 and 24 months ago, and 10 non-obese women were evaluated for exercise capacity by the six minutes walk test (6 MWT), body composition by bio-electrical impedance analysis and lung function by spirometry and measurement of maximal static respiratory pressures. Results: Subjects with BMI 2 were found to have better physical performance, demonstrated by increased 6 MWT distance, not differing from non-obese women. When compared with non-obese women, there were no significant differences in body composition and lung function. Higher BMI was correlated with shorter distances in 6 MWT. Conclusion: 6 to 24 months after surgery, when the weight loss of patients who underwent bariatric surgery reaches levels considered non-obese, it provides improvement in physical performance to a level similar to that of non-obese patients.

关键词： Obesity Bariatric Surgery Exercise Spirometry Muscle Strength

Co-Creation in the Game Industry:A Case Study in a Brazilian developer

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Social Networking 2018年第1期7卷 63-78页

作者： Marcos Vinicius Cardoso Huoston Rodrigues Batista Ernani Marques da Silva Marcos Antonio Gaspar Ivanir Costa Fábio Luís Falchi de Magalhaes Universidade Anhembi Morumbi Sao PauloBrazil Graduate Program in Informatics and Knowledge Management Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

The objective of this work is to understand how the process of co-creation occurs within the creative industry of video games. For this, concepts of the creative industry, co-creation, information and communication technologies (ICTs) and innovation were studied. Since this is an exploratory and qualitative research, a single case study was chosen as a method. The analysis was done in a Brazilian company that develops games for mobile devices. The results show that the consumer (gamer) participates in value creation in the company’s products, mainly in the initial production stages. In the later phases, after the launch and other steps of the life cycle, although there is a relationship with the users, the joint creation of value is little explored by the organization. Also, it was verified that the co-creation process is supported by different information and communication tools, which provide agility to the process.

关键词： Co-Creation Empirical Studies Gaming Communities Information and Communication Technologies Innovation

Case Report: Successful Post-COVID Severe Peripheral Polyneuropathy Treatment Post AZD1222 ChAdOx1 SARS-CoV-2 Vaccination

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Case Reports in Clinical Medicine 2022年第5期11卷 146-151页

作者： Paulo Macio Porto de Melo Rute Alves Pereira e Costa Universidade nove de julho Uninove S&#227 o Paulo Brazil Sociedade Brasileira de Valorizacao das Sociedades Medicas-Sobemed S&#227 o Paulo Brazil

Background: The condition known as polyneuropathy causes peripheral nerve disability, and is characterized by symmetrical distal numbness and paresthesia, often accompanied by pain and weakness. With the advancement of the pandemic in Brazil and in the world, the need for therapies as well as prophylaxis became the main focus in disease control as the viral vector platform vaccine AstraZeneca. Some effects were observed over the period of application. Case Summary: A male patient, 63 years old, previously vaccinated for COVID-19, developed active infection by the virus and in his convalescent period presented intense weakness, with prejudice to his daily activities, including personal hygiene ones. Conclusion: The patient made a complete recovery after combination therapy with testosterone derivates, ivermectin, corticosteroids, and vitamins, besides rehabilitation.

关键词： COVID-19 Vaccines Case Report Corticosteroids Testosterone Ivermectin

Neuroplasticity in Spinal Trauma: A Current Narrative Review of Treatments

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World Journal of Neuroscience 2021年第2期11卷 91-107页

作者： Vinicius Benatti Freire Lucas Cressoni de Souza Mario Henrique de Lima Martinelli Leonardo Moysés Sacchi Thales Andolfo de Souza Antonio Eduardo Damin Medical Students of the nove de julho university (Campus Vergueiro) S&#227o Paulo Brazil department of Neurology of the nove de julho university Medical School Neurologist and Professor of Neurology at Nove de Julho University Medical School S&#227o Paulo Brazil

Neuroplasticity is a condition that is present from birth, being found in the central and peripheral nervous system, in both physiological and pathological terms. Based on the findings, therapeutic and non-therapeutic attempts were tested on spinal cord trauma to recover locomotor function below the level of the injury. The work defined and showed other forms of the term neuroplasticity, talk about some pathological and non-pathological conditions, and, finally, show neuroplasticity and some of its treatments in the spinal cord injury process. A narrative literature review from 2000 to 2020 of the PubMed platform was conducted and analysis of two books for the elaboration of this work. Animal/human studies were included that addressed pathologies, forms of treatment for spinal trauma, and qualis from B1 to A1. Pre-2000 articles, which addressed neuroplasticity only to understand the molecular mechanisms and articles that were not in English, were excluded. As a result, the main molecules and structures that inhibit neuroplasticity were found, and, based on their knowledge, forms of treatments were developed to inhibit these molecules and structures to assist in neuroplasticity and assist in possible functional recovery. It can be concluded that the physiological barriers are already being overcome by the most recent forms of treatment and that soon new studies may propose a form of treatment that is protocoled for all patients.

关键词： Neuroplasticity Spinal Cord Injury Regeneration Nanomaterials Stem Cell Pharmacology

Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P des(TGL)(TT vs XA; P degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

Assessment of the Effects of Manual Chest Compression Technique on Atelectasis in Infants: A Randomized Clinical Trial

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International Journal of Clinical Medicine 2014年第9期5卷 507-513页

作者： Natania Florentino Diniz1] Evelim Leal de Freitas Dantas Gomes1] Cristiane Aparecida Moran1] Silvana Alves Pereira1] Livia Maria de Andrade Martins1] Luciana Carnevalli Pereira1] Universidade nove de julho(uninove) Sao PauloBrazil 2Universidade Federal do Rio Grande do Norte(UFRN/FACISA)Santa CruzBrazil

Objectives: To evaluate the effect of manual chest compression (MCC) in the variables of oxygenation, hemodynamic and respiratory effeteness in infants suffering from respiratory diseases with atelectasis. Methods: Controlled clinical trial, in which 38 infants were evaluated,19 ineach study group (group A: atelectasis and group B: control). Data were measured before, immediately after and 10 minutes after the end of the technique’s application. Results: The average age was of 5.05 months. There was an increase of RR in group A immediately after the application of the technique and signs of respiratory distress with a decrease in the oxygen saturation. Conclusion: There was a reduction in SpO2, an increase of RR and a worsening of clinical signs of respiratory distress. Given this, one may consider that there is a controversy about the benefits, mechanism of action, physiological and therapeutic effects of MCC when applied to infants.

关键词： Pulmonary Atelectasis Physiotherapy Modality Respiratory Therapy Infant Infant Care Clinical Trials

Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

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Cancer Drug Resistance 2023年第1期6卷 116-137页

作者： Juliana Mota Siqueira Daniele Heguedusch Camila Oliveira Rodini Fabio Daumas Nunes Maria Fernanda Setúbal destro Rodrigues department of Stomatology Discipline of Oral and Maxillofacial PathologySchool of DentistryUniversity of São PauloSao Paulo 05508-000Brazil department of Biological Sciences Bauru School of DentistryUniversity of Sao PauloSão Paulo 17012-230Brazil Biophotonics Applied to Health Sciences Nove de Julho UniversityUNINOVESao Paulo 01504-001Brazil

despite scientific advances in the Oncology field,cancer remains a leading cause of death *** and cellular heterogeneity of head and neck squamous cell carcinoma(HNSCC)is a significant contributor to the unpredictability of the clinical response and failure in cancer *** stem cells(CSCs)are recognized as a subpopulation of tumor cells that can drive and maintain tumorigenesis and metastasis,leading to poor prognosis in different types of *** exhibit a high level of plasticity,quickly adapting to the tumor microenvironment changes,and are intrinsically resistant to current chemo and *** mechanisms of CSC-mediated therapy resistance are not fully ***,they include different strategies used by CSCs to overcome challenges imposed by treatment,such as activation of DNA repair system,anti-apoptotic mechanisms,acquisition of quiescent state and Epithelial-mesenchymal transition,increased drug efflux capacity,hypoxic environment,protection by the CSC niche,overexpression of stemness related genes,and immune *** elimination of CSCs seems to be the main target for achieving tumor control and improving overall survival for cancer *** review will focus on the multi-factorial mechanisms by which CSCs are resistant to radiotherapy and chemotherapy in HNSCC,supporting the use of possible strategies to overcome therapy failure.

关键词： Head and neck squamous cell carcinoma cancer stem cell chemotherapy radiotherapy therapy resistance

“If We Only Knew How You Feel”—A Comparative Study of Automated vs. Manual Classification of Opinions of Customers on Digital Media

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Social Networking 2019年第1期8卷 74-83页

作者： Huoston Rodrigues Batista José Carmino Gomes Junior Marcelo Drudi Miranda Andréa Martiniano Renato José Sassi Marcos Antonio Gaspar Postgraduate Program in Informatics and Knowledge Management Nove de Julho University Sao Paulo SP Brazil

The Web development has drastically changed the human interaction and communication, leading to an exponential growth of data generated by users in various digital media. This mass of data provides opportunities for understanding people’s opinions about products, services, processes, events, political movements, and organizational strategies. In this context, it becomes important for companies to be able to assess customer satisfaction about their products or services. One of the ways to evaluate customer sentiment is the use of Sentiment Analysis, also known as Opinion Mining. This research aims to compare the efficiency of an automatic classifier based on dictionary with the classification by human jurors in a set of comments made by customers in Portuguese language. The data consist of opinions of service users of one of the largest Brazilian online employment agencies. The performance evaluation of the classification models was done using Kappa index and a Confusion Matrix. As the main finding, it is noteworthy that the agreement between the classifier and the human jurors came to moderate, with better performance for the dictionary-based classifier. This result was considered satisfactory, considering that the Sentiment Analysis in Portuguese language is a complex task and demands more research and development.

关键词： Sentiment Analysis Opinion Mining Social Media

Dynamic Routing Combined to Forecast the Behavior of Traffic in the City of Sao Paulo Using Neuro Fuzzy Network

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Computer Technology and Application 2011年第1期2卷 36-41页

作者： Ricardo Pinto Ferreira Carlos de Oliveira Affonso Renato Jose Sassi Industrial Engineering Post Graduation Program Nove de Julho University Sao Paulo 05001-100 Brazil

The challenge of keeping and getting new customers drives the development of new practices to meet the consumption needs of increasingly tends to micro-segmentation of product and consumer market. The new consumption habits of brazilians brought new prospects for market. The objective of this paper is to develop of a dynamic vehicle routing system supported by the behavior of urban traffic in the city ofSao Paulo using Neuro Fuzzy Network. The methodology of this paper consists in the capture of relevant events that interfere with the flow of traffic of the city of Sao Paulo and implementation of a Fuzzy Neural Network trained with these events in order to foresee the traffic behavior. The system offers three labels of hierarchical routing, thus is possible to consider not only the basic factors of routing, but too external factors that directly influence on the flow of traffic and the disruption which may be avoided in large cities, through alternative routes （dynamic vehicle routing）. Predicting the behavior of traffic represents the strategic level routing, dynamic vehicle routing is the tactical level, and routing algorithms to the operational level. This paper will not be discussed the operational level.

关键词： Traffic behavior dynamic vehicle routing neuro fuzzy network fuzzy logic.