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Applicability of in Vitro Models in Predicting the in Vivo Bioavailability of Lycopene and β-Carotene from differently Processed Soups

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Food and Nutrition Sciences 2012年第4期3卷 477-489页

作者： Marie Alminger Cecilia Svelander Anna Wellner rebeca Martinez-Tomas Lucy Bialek Elvira Larque Francisca Perez-Llamas department of Chemical and Biological Engineering Food ScienceChalmers University of TechnologyGoteborgSweden Physiology department Faculty of BiologyUniversity of MurciaMurciaSpain unilever discover r&d Unilever Food and Health Research InstituteVlaardingenThe Netherlands

Presently, there is no clear consensus on the best approach to estimate carotenoid bioavailability. The best alternative would be to use human studies, but they are labour-intensive and expensive and can only be used to investigate a limited number of samples. Hence, a number of in vitro: models have been developed to study pre-absorptive processes and factors affecting bioavailability. The question is, however, how well the results obtained by the various methods correlate to each other and to the in vivo situation. In the present paper, we have compared in vivo data from two human studies on differently processed soups containing carrots, tomato and broccoli, with results obtained by in vitro characterisation of the same soups. In vitro bioaccessibility was estimated by a static in vitro digestion investigating matrix release and micellarization of carotenoids and by uptake studies in a human intestinal cell line (Caco-2). In vivo data was obtained from clinical studies measuring total plasma carotenoid concentrations in human subjects after 4 weeks daily consumption of the soups. Comparison of the in vitro and in vivo results indicate that the combination of a two-step in vitro digestion and Caco-2 cells seems to be a useful tool for estimation of β-carotene bioaccessibility and screening of factors governing the release of β-carotene from this type of food. For lycopene the in vitro and in vivo results were less consistent, suggesting that reliable prediction of lycopene bioavailability might be more problematic.

关键词： In Vitro digestion Human Uptake Caco-2 Cells β-Carotene Lycopene Carotene Bioavailability

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PET分子量对PET/PC共混体系高压结晶行为的影响

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化学研究与应用 2006年第3期18卷 257-260页

作者：吕军黄锐李良彬四川大学高分子科学与工程学院四川成都610065 Foods research Centre Unilever R&D Vlaardingen

以往高压合成的聚合物伸直链晶体尺寸较小且合成时间过长,不能满足单晶应用的要求。加入10wt%PC于不同分子量的PET中,采用自制高压装置,制备共混体系,用WAXd,SEM,dSC等表征手段,研究了PET/PC共混体系在高压下的结晶行为。研究结果表明:... 详细信息

以往高压合成的聚合物伸直链晶体尺寸较小且合成时间过长,不能满足单晶应用的要求。加入10wt%PC于不同分子量的PET中,采用自制高压装置,制备共混体系,用WAXd,SEM,dSC等表征手段,研究了PET/PC共混体系在高压下的结晶行为。研究结果表明:通过PET/PC体系在高压下化学反应诱导的自组装,不同分子量PET的PET/PC共混体系均在较短的时间内生成了尺寸较大的聚酯伸直链晶体,对应于三斜晶系,其中PET/PC体系最适于大尺寸伸直链晶体的合成,仅需6hr时间即生成PE需200hr方可合成的40μm厚度的伸直链晶体。同时提出了PET1/PC体系中伸直链晶体高温下缺陷自我修复模型。

关键词：聚对苯二甲酸乙二醇酯聚碳酸酯高压结晶伸直链晶体

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Poroelastic Modelling of Gravitational Compaction

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Open Journal of Physical Chemistry（物理化学期刊） 2019年第3期

作者： Pieter Broer van der Weg (Peter) unilever r & d Vlaardingen

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纳米技术在个人和家用护理工业的革新(英文)

纳米技术在个人和家用护理工业的革新(英文)

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2005（第五届）中国日用化学工业研讨会

作者： Michael F.Butler unilever r＆d Colworth SharnbrookBedfordshireMK44 1LQUK

＜正＞In recent years there has been a huge increase in the amount of research devoted to understanding the properties of matter at the nanoscale,which has led to the development of many interesting new materials.

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高新技术中小企业的战略优势与劣势-战略发展分析

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科研管理 2004年第Z1期25卷 120-124页

作者： roland Helm reinhard Meckl Prof.dr.roland Helm Friedrich Schiller University JenaUnilever-Chair for Marketing and Business AdministrationCarl Zeiss Str.3D07743 JenaGermany Prof.dr.reinhard Meckl University of BayreuthChair for International ManagementD-95540 BayreuthGermany

工业国家的中小型高科技企业有很大的创新潜力,同时对所在地区的经济发展起到了积极的作用。由于公司规模大小不一,所以很难有时间从众多的案例中找到具体的管理技巧。本文主要对创新公司的战略等问题的具体内容和方法进行调查研究。

关键词：高技术中小企业创新聚集战略过程创新抑制

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Scientific Validation of the Ethnomedicinal Properties of the Ayurvedic drug Triphala:A review

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Chinese Journal of Integrative Medicine 2012年第12期18卷 946-954页

作者： Manjeshwar Shrinath Baliga Sharake Meera Benson Mathai Manoj Ponadka rai Vikas Pawar Princy Louis Palatty department of research and development Father Muller Medical CollegeKankanadyMangaloreKarnataka(575002)India Sanjeevini Ayurvedic Chikitsalaya MallikatteMangaloreKarnataka(575003)India department of Pharmacology St.John's Pharmacy CollegeVijayanagar Ⅱ StageBangaloreKarnataka(560040)India unilever r&d No.64Main RoadWhitefieldBangaloreKarnataka(560066)India department of Pharmacology Father Muller Medical CollegeKankanadyMangaloreKarnataka(575002)India

Triphala, a herbal formula composed of the three fruits of Terminalia chebula retz. （Haritaki, Family： Combretaceae）, Terminalia bellirica roxb. （Bibhitaki, Family： Combretaceae） and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. （Amalaki or the Indian gooseberry, Family： Euphorbiaceae） is considered to be a universal panacea in the traditional Indian system of medicine the Ayurveda. It has been described in the Ayurveda text as a ＂Ftasayana＂ and to rejuvenat the debilitated organs. Ayurvedic physicians use Triphala for many ailments but most importantly to treat various gastrointestinal disorders. Scientific studies carried out in the past two decades have validated many of the ethnomedicinal claims and researches have shown Triphala to possess free radical scavenging, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antimutagenic, wound healing, anticariogenic, antistress, adaptogenic, hypoglycaemic, anticancer, chemoprotective, radioprotective and chemopreventive effects. Clinical studies have also shown that Triphala was found to have good laxative property, to improve appetite and reduce gastric hyperacidity. Studies have also shown that Triphala was effective in preventing dental caries and that this effect was equal to that of chlorhexidine. The current review addresses the validated pharmacological properties of Triphala and also emphasizes on aspects that need further investigation for its future clinic application.

关键词： Ayurveda rasayana Triphala Terminalia chebula Terminalia bellerica and Phyllanthus emblicaand Emblica officina/is

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NOVEL LINEAr TUBULAr BrUSHLESS PErMANENT MAGNET MOTOr

NOVEL LINEAR TUBULAR BRUSHLESS PERMANENT MAGNET MOTOR

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2002年全国直线电机学术年会

作者： Z.Q.Zhu P.J.Hor d.Howe J.rees-Jones University of Sheffield.UK University of Sheffield.UK University of Sheffield.UK unilever research Port Sunlight Laboratory.UK

＜正＞ INTrOdUCTIONThere is an increasing requirement for controlled linear motion over short and long strokes, in the factory automation and packaging industries, for example. Linear brushless PM motors could offer significant advantages over conventional actuation technologies, such as motor driven cams and linkages and pneumatic/hydraulic rams . in terms of efficiency, operating bandwidth, speed and thrust control, stroke and positional accuracy, and indeed over other linear motor technologies, such as induction and switched reluctance motors.

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Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage

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Journal of Molecular Cell Biology 2021年第11期13卷 822-833页

作者： Chengming Zhang Hong Zhang Jing Ge Tingyan Mi Xiao Cui Fengjuan Tu Xuelan Gu Tao Zeng Luonan Chen State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China unilever research&development Centre Shanghai Shanghai 200335China Bio-Med Big data Center Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Guangdong Institute of Intelligence Science and Technology Zhuhai 519031China

Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin ***,skin response process to ultraviolet B(UVB)irradiation is a nonlinear dynamic process,with unknown underlying molecular mechanism of critical ***,the landscape dynamic network biomarker(ldNB)analysis of time series transcriptome data on 3d skin model was conducted to reveal the complicated process of skin response to UV irradiation at both molecular and network *** advanced l-dNB analysis approach showed that:(i)there was a tipping point before critical transition state during pigmentation process,validated by 3d skin model;(ii)13 core dNB genes were identified to detect the tipping point as a network biomarker,supported by computational assessment;(iii)core dNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening,validated by independent human skin ***,this study provides new insights for skin response to repetitive UVB irradiation,including dynamic pathway pattern,biphasic response,and dNBs for skin lightening change,and enables us to further understand the skin resilience process after external stress.

关键词： single-sample network tipping point UVB irradiation living skin equivalent model time series data skin lightening

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联合降胆固醇饮食与洛伐他汀对血脂和C-反应蛋白的影响

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美国医学会杂志（中文版） 2004年第5期23卷 233-239页

作者：倪永斌胡大一 Clinical Nutrition and risk Factor Modification Center Department of Medicine Division of Endocrinology and Metabolism StMichael′s Hospital and Departments of Nutritional SciencesStMichael′s HospitalMedicine Faculty of Medicine University of Toronto TorontoOntario the Almond Board of California Modesto unilever Health Institute Unilever Research and Development Vlaardingen the Netherlands Clinical Nutrition and risk Factor Modification Center Department of Medicine Division of Endocrinology and Metabolism StMichael′s Hospital and Departments of Nutritional SciencesStMichael′s Hospital and Departments of Nutritional SciencesStMichael Clinical Nutrition and risk Factor Modification Center Department of Medicine Division of Endocrinology and MetabolismStMichael′s Hospital and Departments of Nutritional Sciences StMichael′s Hospital Medicine department of Medicine Division of Endocrinology and MetabolismStMichael′s HospitalMedicineLaboratory Medicine and Pathobiology Clinical Nutrition and risk Factor Modification Center StMichael′s Hospital and Departments of Nutritional Sciences StMichael′s Hospital and Departments of Nutritional Sciences Clinical Nutrition and risk Factor Modification Center StMichael′s Hospital and Departments of Nutritional Sciences

背景：为增强饮食治疗降低胆固醇的效果，国家胆固醇教育计划(National Cholesterol Education Program，NCEP)成人治疗小组(Adult Treatment Panel，ATP)III强调食用低饱和脂肪以及植物固醇和粘胶纤维食物，而美国心脏病协会(American ... 详细信息

背景：为增强饮食治疗降低胆固醇的效果，国家胆固醇教育计划(National Cholesterol Education Program，NCEP)成人治疗小组(Adult Treatment Panel，ATP)III强调食用低饱和脂肪以及植物固醇和粘胶纤维食物，而美国心脏病协会(American Heart Association，AHA)则支持食用大豆蛋白和坚果。目的：确定食用含有这些推荐食物所有成分的食物是否可以取得类似于3-羟-3-甲戊二酰辅酶A还原酶抑制剂(他汀类)的降低胆固醇的效果。设计：于2002年10月至12月间进行的随机对照试验。地点和参试者：从一家加拿大医院的营养研究中心和社区入选46例成年高脂血症患者(25例男性和21例已绝经女性)，平均年龄(SE)59岁(1岁)，体重指数27．6（0．5)。干预：参与者随机分配至以下三种干预门诊治疗1个月：极低饱和脂肪饮食，以碾碎的全麦谷类食品和低脂奶制品为基础(n=16；对照组)；极低饱和脂肪饮食加洛伐他汀20mg/d(n=14，他汀组)；富含植物固醇(1．0g／1000kcal)、大豆蛋白(21．4g／1000kcal)、粘胶纤维(9．8g／1000kcal)和杏仁(14g／1000kcal)的饮食(联合饮食组)。主要观察指标：血脂和C-反应蛋白水平，来自空腹血样；血压；体重；在0周、2周和4周时分别测量这些指标，并在三组间比较。结果：对照组、他汀组和联合饮食组低密度脂蛋白胆固醇分别平均(SE)下降8．0％(2．1％)(P=0．002)、30．9％(3．6％)(P<0．001)和28．6％(8．6％)(P<0．001)。C-反应蛋白分别下降10．0％(8．6％)(P=0．27)、33．3％(8．3％)(P=0．002)和28．2％(10．8％)(P=0．02)。他汀组和联合饮食组降低程度明显大于对照组。他汀治疗和联合饮食治疗的效果无显著差异。结论：研究显示，在同一饮食方案中，降胆固醇成分的多样化增加了饮食治疗高胆固醇血症的效果。

关键词：饮食治疗联合他汀 C-反应蛋白饱和脂肪对照组血脂粘胶纤维增强还原酶抑制剂

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抗生素耐药性环境中产生和转移的人类健康风险评估(HHrA)

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环境与职业医学 2014年第2期31卷 151-157页

作者： Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors rita Finley William H.Gaze Thomas Heberer John r.Lawrence d.G.Joakim Larsson Scott A.McEwen James J.ryan Jens Schnfeld Peter Silley Jason r.Snape Christel Van den Eede Edward Topp 王晓宇张伊人操仪 U.S.Environmental Protection Agency Office of Research and Development unilever-Safety and Environmental Assurance Centre department of Biological and Environmental Sciences Gothenburg University Veterinary Medicines directorate department of Plant and Environmental Sciences University of Copenhagen The Canberra Hospital and Canberra Clinical School Australian National University ECT Oekotoxikologie GmbH Fl?rsheim/Main Public Health Agency of Canada European Centre for Environment and Human Health Exeter University Medical School Knowledge Spa Royal Cornwall Hospital Federal Office of Consumer Protection and Food Safety Department 3: Veterinary Drugs Environment Canada Saskatoon Institute for Biomedicine The Sahlgrenska Academy University of Gothenburg department of Population Medicine University of Guelph Environment Health and Safety GlaxoSmithKline Umweltbundesamt Federal Environment Agency MB Consult Limited Southampton University of Bradford Brixham Environmental Laboratory Pfizer Animal Health VMrd Agriculture and Agri-Food Canada London Ontario Canada

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHrA)的研究需求,这项评估注重环境在抗生素耐药性... 详细信息

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHrA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生"热点区域"的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ArB)产生;b)在相关的环境组成部分的"热点区域"中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ArB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ArB的HHrA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHrA,并使风险管理者了解环境抗生素耐药性。

关键词：抗生素耐药性健康风险评估环境评估人类健康基因转移剂量反应决策分析方法耐药性细菌

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