检索结果-南通市图书馆

Efficacy of a diabetes Specific Nutritional Supplement (dSNS) on Glycemic response in Prediabetic Adults: A Two-Armed, Open-Labelled randomized Controlled Study

引用

Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： deepti Khanna Kejal Joshi reddy Hema S. Gopalan Jaladhi Bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek department of r&d Hindustan Unilever Limited Gurugram India Mumbai India Cliantha research Ahmedabad India

It is well known that diabetes Specific Nutritional Supplements (dSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of dSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose response (ABGr) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGr of dSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of dSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. during the 4 weeks intervention phase, the test group received dSNS with lifestyle counselling (dSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of dSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). dSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by dSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that dSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose response Incremental Area under Curve Lifestyle Counselling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glycemic Indices of Multiple Oral Nutritional Supplements: A randomized Cross-Over Study in Indian Adults

引用

Food and Nutrition Sciences 2023年第10期14卷 941-962页

作者： deepti Khanna Jaladhi Bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek divya Agrawal Hindustan unilever Limited R&D Department Gurugram India Independent Biostatistician & researcher Mumbai India Cliantha research Ahmedabad India

Background: A randomized cross-over study was conducted to assess the glycemic index (GI) of seven Oral Nutritional Supplements (ONSs). These ONSs are designed to support the nutritional requirements of different age-groups, physiological states, or health conditions among Indian adults. Methods: The study had two phases viz., phase1 (n = 18) studied two ONSs: A1 and B1 and phase 2 (n = 20) studied five ONSs: A2, B2, C2, d2 & E2. The subjects were healthy, non-diabetic adults, aged between 20 - 44 years with a mean Body Mass Index of 21.2 ± 1.52 kg/m2 (Phase 1) and 21.0 ± 1.45 kg/m2 (Phase 2). All these ONSs were compared with reference drinks (glucose). The carbohydrates in one serving of each ONS were matched to carbohydrates from 25 grams of glucose following ISO 2010 guidelines. Capillary blood was assessed for blood glucose response at baseline, 15, 30, 45, 60, 90 and 120 minutes. GI was calculated as the incremental area under the curve (iAUC) for the test drinks and expressed as a percentage of the average iAUC from glucose. results: Phase 1 indicated that the high fiber diabetes-specific nutrition supplement A1 with higher protein (23% energy), higher fat (25% energy) and reduced carbohydrates (40% energy) had a significantly (p = 0.002) lower GI [34 (±6)] as compared to B1 [63 (±7)] (protein 19%, fat 7% and carbohydrates 60% energy) even with similar amount (22%) and type of fiber. Phase 2 reported that all test products [A2 (32 ± 5), B2 (37 ± 4), C2 (31 ± 5), d2 (31 ± 5) and E2 (55 ± 4)] had a low GI. As compared to phase 1, ONSs in phase 2 had lower fiber content (1.6% - 4.6% energy). Conclusion: The glycemic index of oral nutrition supplements is influenced not only by their fiber content, but also by the overall macronutrient composition including protein (≥17% energy), fat (≥10% - 27% energy) and carbohydrates (40% - 57.5% energy).

关键词： Glycemic Index Oral Nutritional Supplements Incremental Area under the Curve diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Poroelastic Modelling of Gravitational Compaction

引用

Open Journal of Physical Chemistry 2019年第3期9卷 126-169页

作者： Pieter Broer van der Weg unilever r & d Vlaardingen The Netherlands

A dynamic in-silico model captures the kinetics of 1-d gravity driven instabilities, in gravity or centrifuge, of fluid-infiltrated poroelastic media in a partial differential equation (pde). The pde yields the porosity profile over height and time for the given initial and boundary conditions, during slow compaction in counter-current fluid drainage. Processes captured are amongst others sedimentation, creaming and subsidence. The most important limiting prerequisite is that the incompressible dispersed medium is sufficiently structured and/or concentrated that it compacts during slow drainage, without segregation in sizes or in components. For unilever, modeling of gravitational instability of products is important to quantify or extrapolate long time behavior during shelf life or use centrifuge data to quickly predict long term shelf performance of products.

关键词： Poroelastic Compaction Consolidation Gravity Centrifuge Sedimentation Creaming Subsidence Emulsion dispersion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Structures of Two New Monoprotonated Products of 1,4,7 trimethyl-1,4,7-triazacyclononane: （Me3〔9〕aneN3H）(SO3CF3) and （Me3〔9〕aneN3H）I

引用

Chinese Journal of Structural Chemistry 2000年第1期19卷 48-52页

作者： dENG dao Lia * ZHANG Yan Hui a dAI Cong Yun a ZENG Hong a YAN Zhi Qing a YE Chang Qing a ronald Ha\|Ge ba (unilever research SIOC, 354 Fenglin road, Shanghai 200032. China) b (unilever research Laboratorium, Olivier van Noor unilever research SIOC 上海 2 0 0 0 32 unilever research Laboratorium 荷兰 Vlaardinge

Two new monoprotonated products of macrocyclic polyamine 1,4,7 trimethyl 1,4,7 triazacyclononane(Me 3〔9〕aneN 3), (Me 3〔9〕aneN 3H)(SO 3CF 3) 1 (C 10 H 22 N 3O 3SF 3, M r =321.36) and (Me 3〔9〕aneN 3H)I 2 (C 9H 22 N 3I, M r =299.20) were obtained by the reactions of Me 3〔9〕aneN 3 and yttrium triflate or ytterbium diiodide as the unexpected products. The crystal structures of compounds 1 and 2 have been determined. Crystal 1 is orthorhombic, space group P2 12 12 1(#19), a =12.609(3), b=13.531(1), c=9.225(3) , V=1573.9(7)  3, Z=4, d c= 1.356 g/cm 3, μ =2.47 cm -1 , F (000)=680 and r=0.052, r w =0.052 for 807 unique reflections with I>2σ(I) . Crystal 2 belongs to the orthorhombic system with space group P2 12 12 1(#19), a=11.417(2), b=13.099(3), c=8.762(2) , V=1310.5(4)  3, Z=4, d c =1\^516 g/cm 3, μ =24.14 cm -1 , F (000)=600 and r=0.035, r w =0.042 for 1427 unique reflections with I>3σ(I) . The two structures contain the same cyclic framework in which the acid proton is bonded to an amine nitrogen. This proton exhibits strong intramolecular hydrogen bonds with the other two nitrogen atoms. The methyl groups are directed away from the ring cavity. The bond distance between acid proton and an amine nitrogen in compound 2 is extremely short. The bond angles for 1 and 2 also exhibit obvious diversity inside of triazacyclononae.

关键词： formation crystal structure protonation triazacyclononane

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

reduction of Environmental Impact of drum Machine Washing

引用

Journal of Applied Mathematics and Physics 2020年第1期8卷 132-157页

作者： Pieter Broer van der Weg (Peter) retired VU Amsterdam Shell R & D Rijswijk Stork DI Boxmeer Unilever R & D Vlaardingen Vlaardingen The Netherlands

An improvement of efficiency of the horizontally rotating drum washing machine is possible by using a more open type of drum, essentially without suds in the annulus, by using a pump to wet the clothes during rotation and fall. Modelling and simulation are used to quantify these claims and further optimize the design of the horizontal washing machine. The flow of suds inside the deforming clothes at impact with the drum is calculated. The wash performance is shown to be largely proportional to the open perforation area in the drum. The traditional design uses 1/8 of drum area for the perforation holes. A significant reduction of water, detergent, electrical energy, and wash time, with parity in wash performance, provides a step towards a cleaner and more sustainable future.

关键词： drum Wash Machine design Efficiency Poroelastics darcy Simulation Modelling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bacterial adhesion and biofilms on surfaces

引用

Progress in Natural Science:Materials International 2008年第9期18卷 1049-1056页

作者： Trevor roger Garrett Manmohan Bhakoo department of Chemical Engineering School of Engineering The University of Birmingham Edgbaston Birmingham B15 2TT UK unilever r&d Port Sunlight Quarry Road East Bebington Merseyside CH63 3JW UK

Bacterial adhesion has become a significant problem in industry and in the domicile, and much research has been done for deeper understanding of the processes involved. A generic biological model of bacterial adhesion and population growth called the bacterial biofilm growth cycle, has been described and modified many times. The biofilm growth cycle encompasses bacterial adhesion at all levels, starting with the initial physical attraction of bacteria to a substrate, and ending with the eventual liberation of cell clusters from the biofilm matrix. When describing bacterial adhesion one is simply describing one or more stages of biofilm development, neglecting the fact that the population may not reach maturity. This article provides an overview of bacterial adhesion, cites examples of how bac- terial adhesion afiects industry and summarises methods and instrumentation used to improve our understanding of the adhesive prop- erties of bacteria.

关键词： Adhesion Bacteria Biofilm Cleaning Micromanipulation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Perceptual and Sensory-Functional Consequences of Skin Care Products

引用

Journal of Cosmetics, dermatological Sciences and Applications 2013年第1期3卷 66-78页

作者： Steve Guest Francis McGlone Andrew Hopkinson Zachary A. Schendel Kevin Blot Greg Essick regional Center for Neurosensory disorders School of Dentistry University of North Carolina at Chapel Hill Chapel Hill USA School of Natural Sciences and Psychology Liverpool John Moores University Liverpool UK unilever r & d Port Sunlight UK 4unilever r & d Trumbull USA. unilever r & d Trumbull USA.

Skin care products are often designed to provide tangible, physical benefits to skin health. Alleviation of dry skin and minimization of the signs of aging and post-injury scarring are important benefits targeted by many products on the market. Equally important to these benefits are favorable, desirable sensory attributes, without which products are unlikely to be used and repurchased. Other products are designed primarily to deliver sensory—or sensual—benefits (e.g., many cosmetic creams). This review considers the tactile sensory experience delivered by skin care products by examining: 1) their instrumentally-measured rheology and tribology;2) their influence on the skin’s mechanics (e.g., compliance);3) their implications for changing sensory function (e.g., tactile sensitivity);and 4) the possibility that skin care products alter their own perception. Products that contain chemosensates (e.g., capsaicin, menthol) or pharmaceutical actives are not considered here. Although numerous perceptual-physical links have been reported, formulation rules by which products can be designed for optimal skinfeels are currently unavailable from the existing literature. This is because of inconsistencies among studies in the perceptual attributes investigated, the physical characterizations chosen to describe the products, and analysis methods employed. To provide a robust method for designing products with beneficial and desirable skinfeels, we propose the use of 1) a consistent lexicon that fully describes the perceptual experience of any product investigated, 2) a means of recording the mechanical events at the fingertip skin that occur when a skin care product is manually applied to the body. This approach contrasts with previous instrumental (in vitro) methods that may not generalize well to product-treated human skin (in vivo). Ongoing studies that record mechanical events at the skin surface show promise in identifying realistic models of the perception of skin care prod

关键词： review rheology Tribology Perception Sensory Function Tactile

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxicity testing in the 21st century:taking a pathway-led approach

Toxicity testing in the 21st century:taking a pathway-led ap...

引用

中国毒理学会第六届全国毒理学大会

作者： Paul L CArMICHAEL unilever r&d Safety & Environmental Assurance Centre

In 2007,the US National research Council’s publication ’Toxicity Testing in the Twenty-First Century(7721 C):A Vision and a Strategy’(Krewski et al 2010) outlined an approach to safety assessment that ’could transform toxicity testing from a system based on whole-animal testing to one founded primarily on in vitro methods that evaluate changes in biologic processes using cells,cell lines,or cellular components, preferably of human origin’.At the core of this vision is an understanding of key biological pathways(termed ’toxicity pathways’ in the original report)which,if sufficiently perturbed by a chemical,would result in an adverse outcome for the exposed human/*** recently, this concept of pathways-based approaches to risk assessment has been built upon by the description of ’Adverse Outcome Pathways’ (AOPs).Each AOP begins with a Molecular Initiating Event(MIE) in which the chemical interacts with a biological target leading to a sequence of events across different levels of biological organisation (Ankley et al,2010).The OECd has begun to formalize the use of this framework based on AOPs to capture and peer review the mechanistic understanding of specific toxic effects for the evaluation of non-animal methods(OECd, 2011).Our goal has been to take the above strategy and vision from the conceptual,to the practical;developing the necessary steps to use the TT21C/AOP foresight as the basis for the safety assessment of new ingredients in consumer products,without animal ***,members of a work-team in the Transatlantic Think Tank of Toxicology(t) produced a workflow on how to implement TT21C for a given ingredient (Blaauboer et al ATLA in preparation).The workflow begins with the chemical of concern and some initial assessment of the route of,and the extent of ***,the toxicity pathways of relevance must be identified for that particular *** will require a combination of both in vitro high-throughput screening(HTS) for pathwa

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Applicability of in Vitro Models in Predicting the in Vivo Bioavailability of Lycopene and β-Carotene from differently Processed Soups

引用

Food and Nutrition Sciences 2012年第4期3卷 477-489页

作者： Marie Alminger Cecilia Svelander Anna Wellner rebeca Martinez-Tomas Lucy Bialek Elvira Larque Francisca Perez-Llamas department of Chemical and Biological Engineering Food ScienceChalmers University of TechnologyGoteborgSweden Physiology department Faculty of BiologyUniversity of MurciaMurciaSpain unilever discover r&d Unilever Food and Health Research InstituteVlaardingenThe Netherlands

Presently, there is no clear consensus on the best approach to estimate carotenoid bioavailability. The best alternative would be to use human studies, but they are labour-intensive and expensive and can only be used to investigate a limited number of samples. Hence, a number of in vitro: models have been developed to study pre-absorptive processes and factors affecting bioavailability. The question is, however, how well the results obtained by the various methods correlate to each other and to the in vivo situation. In the present paper, we have compared in vivo data from two human studies on differently processed soups containing carrots, tomato and broccoli, with results obtained by in vitro characterisation of the same soups. In vitro bioaccessibility was estimated by a static in vitro digestion investigating matrix release and micellarization of carotenoids and by uptake studies in a human intestinal cell line (Caco-2). In vivo data was obtained from clinical studies measuring total plasma carotenoid concentrations in human subjects after 4 weeks daily consumption of the soups. Comparison of the in vitro and in vivo results indicate that the combination of a two-step in vitro digestion and Caco-2 cells seems to be a useful tool for estimation of β-carotene bioaccessibility and screening of factors governing the release of β-carotene from this type of food. For lycopene the in vitro and in vivo results were less consistent, suggesting that reliable prediction of lycopene bioavailability might be more problematic.

关键词： In Vitro digestion Human Uptake Caco-2 Cells β-Carotene Lycopene Carotene Bioavailability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Scientific Validation of the Ethnomedicinal Properties of the Ayurvedic drug Triphala:A review

引用

Chinese Journal of Integrative Medicine 2012年第12期18卷 946-954页

作者： Manjeshwar Shrinath Baliga Sharake Meera Benson Mathai Manoj Ponadka rai Vikas Pawar Princy Louis Palatty department of research and development Father Muller Medical CollegeKankanadyMangaloreKarnataka(575002)India Sanjeevini Ayurvedic Chikitsalaya MallikatteMangaloreKarnataka(575003)India department of Pharmacology St.John's Pharmacy CollegeVijayanagar Ⅱ StageBangaloreKarnataka(560040)India unilever r&d No.64Main RoadWhitefieldBangaloreKarnataka(560066)India department of Pharmacology Father Muller Medical CollegeKankanadyMangaloreKarnataka(575002)India

Triphala, a herbal formula composed of the three fruits of Terminalia chebula retz. （Haritaki, Family： Combretaceae）, Terminalia bellirica roxb. （Bibhitaki, Family： Combretaceae） and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. （Amalaki or the Indian gooseberry, Family： Euphorbiaceae） is considered to be a universal panacea in the traditional Indian system of medicine the Ayurveda. It has been described in the Ayurveda text as a ＂Ftasayana＂ and to rejuvenat the debilitated organs. Ayurvedic physicians use Triphala for many ailments but most importantly to treat various gastrointestinal disorders. Scientific studies carried out in the past two decades have validated many of the ethnomedicinal claims and researches have shown Triphala to possess free radical scavenging, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antimutagenic, wound healing, anticariogenic, antistress, adaptogenic, hypoglycaemic, anticancer, chemoprotective, radioprotective and chemopreventive effects. Clinical studies have also shown that Triphala was found to have good laxative property, to improve appetite and reduce gastric hyperacidity. Studies have also shown that Triphala was effective in preventing dental caries and that this effect was equal to that of chlorhexidine. The current review addresses the validated pharmacological properties of Triphala and also emphasizes on aspects that need further investigation for its future clinic application.

关键词： Ayurveda rasayana Triphala Terminalia chebula Terminalia bellerica and Phyllanthus emblicaand Emblica officina/is

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：