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Efficacy of a diabetes Specific Nutritional Supplement (dSNS) on Glycemic response in Prediabetic Adults: A Two-Armed, Open-Labelled randomized Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 612-643页

作者： deepti Khanna Kejal Joshi reddy Hema S. Gopalan Jaladhi Bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek department of r&d Hindustan Unilever Limited Gurugram India Mumbai India Cliantha research Ahmedabad India

It is well known that diabetes Specific Nutritional Supplements (dSNSs) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of dSNSs in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose response (ABGr) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGr of dSNS versus an isocaloric snack, measured by incremental Area under the Curve (iAUC). Test and control received 60 g of dSNS and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. during the 4 weeks intervention phase, the test group received dSNS with lifestyle counselling (dSNS + LC) and was compared with the control receiving lifestyle counselling alone (LC alone). Impact was studied on FBG, HbA1C, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of dSNS was also studied using CGM between two 14-day phases: CGM1 baseline (days 1 - 14) and CGM2 endline (days 28 - 42). dSNS showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by dSNS + LC versus LC alone. No other significant changes were reported between groups. It may be concluded that dSNS may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： diabetes Specific Nutritional Supplement Prediabetes Acute Blood Glucose response Incremental Area under Curve Lifestyle Counselling

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Efficacy of a diabetes Specific Nutrition Supplement on Glycemic, Anthropometric, dietary and Gut Health Markers in Adults with Type 2 diabetes: An rCT

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Food and Nutrition Sciences 2024年第8期15卷 846-867页

作者： deepti Khanna Hema S. Gopalan Kuzhandaivelu Abirami Vasudevan Sudha rajagopal Gayatri Kejal Joshi-reddy Jaladhi Bhatt raman Ganesh Jeevan Karthikeyan Parkavi Vadivel deepika Manoj Pareek ranjit Mohan Anjana Viswanathan Mohan r&d department Hindustan Unilever Limited Gurugram India department of Foods Nutrition & Dietetics Research Madras Diabetes Research Foundation Chennai India department of diabetology Dr. Mohans Diabetes Specialities Centre Chennai India

With increasing incidence of diabetes, use of diabetes specific nutrition supplements (dSNS) is common for better management of the disease. To study effect of 12-week dSNS supplementation on glycemic markers, anthropometry, lipid profile, SCFAs, and gut microbiome in individuals with diabetes. Markers studied were glycemic [Fasting Blood Glucose (FBG), Post Prandial Glucose (PPG), HbA1c, Incremental Area under curve (iAUC), Mean Amplitude of Glycemic Excursions (MAGE), Time in/above range (TIr/TAr)], anthropometry [weight, Body Mass Index (BMI), waist circumference (WC)], lipid profile, diet and gut health [plasma short chain fatty acids (SCFAs)]. N = 210 adults were randomized to receive either dSNS with standard care (dSNS + SC;n = 105) or standard care alone (SC alone;n = 105). After 12 weeks, significant differences between dSNS + SC versus SC alone was observed in FBG [−3 ± 6 vs 14 ± 6 mg/dl;p = 0.03], PPG [−35 ± 9 vs −3 ± 9 mg/dl;p = 0.01], weight [−0.6 ± 0.1 vs 0.2 ± 0.1 kg;p = 0.0001], BMI [−0.3 ± 0.1 vs 0.1 ± 0.1 kg/m2;p = 0.0001] and WC [−0.3 ± 0.2 vs 0.2 ± 0.2 cm;p = 0.01]. HbA1C and low-density lipoprotein (LdL) were significantly reduced in dSNS + SC [−0.2 ± 0.9;p = 0.04 and −5 mg/dl;p = 0.03] respectively with no change in control. Continuous Glucose Monitoring (CGM) reported significant differences between dSNS + SC versus SC alone for mean glucose [−12 ± 65 vs 28 ± 93 mg/dl;p r 180 [−9 ± 42 vs 7 ± 45 mg/dl;p = 0.04], TAr 250 [−3 ± 27 vs 9 ± 38 mg/dl;p = 0.05], iAUC [−192 (1.1) vs −48 (1.1) mg/dl;p = 0.03]. MAGE was significantly reduced for both dSNS + SC (−19 ± 67;p d SC alone (−8 ± 70;p = 0.04), with reduction being more pronounced for dSNS + SC. dSNS + SC reported a decrease in carbohydrate energy % [−9.4 (−11.3, −7.6) %;p d amount [−47.4 (−67.1, −27.7) g;p reased dietary fiber [9.5 (7.2, 11.8) g;p d protein energy % [0.9 (0.5, 1.3) %;p rsus SC alone. dSNS + SC reported signi

关键词： diabetes Specific Nutrition Supplement Standard of Care diabetes Glycemic Markers HbA1C

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Effect of Particle Phase Volume, Shape and Liquid Phase Concentrations on rheological Properties of Large Particulate-Liquid Model Food Systems by Using Ball Measuring System

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Journal of Chemistry and Chemical Engineering 2013年第7期7卷 643-652页

作者： Chlharu Inoue Peter Versluis Pablo Coronel Johanna Maria Martina Elberse unilever r&d vlaardingen Vlaardingen 3133AT The Netherlands

rheological properties of large particulate-liquid model food systems were studied by using the BMS （ball measuring system）. The model food systems were composed of alginate gel particles （-10mm） and a gelatinised starch solution with 1% w/w sodium chloride as a liquid phase. The effects of particle phase volume （Ф, 0-0.60）, particle shapes （cube, sphere, rod and disc） and starch concentrations （3% and 5% w/w starch） were investigated. The power law model was successfully applied to characterize the flow properties of each system and the consistency K and power law index n were obtained. The K increased and n decreased with increasing # for samples at all particle shapes at 3% w/w starch in the liquid phase. The particle effect on the viscosity is further analysed by means of the Krieger-dougherty model and the maximum packing fraction #,, and the intrinsic viscosity [η] were obtained in each system. The Фm, depended on the particle shape, as expected. The [7] value depended on particle shape and was largely in the order of 4.04 （cube）, 3.28 （disc）, 2.56 （sphere） and 2.32 （rod） at 3% w/w starch. The [η] also depended on starch concentration and was 1.1 at 5%,6 w/w starch in the liquid phase with spherical particles. The present results show successful application of BMS to study the rheological properties of large particulate liquid food systems at relatively small scale experiment （-0.5 L） and also that existing models for suspension rheology are applicable for such food systems to a great extend.

关键词： Large particulate-liquid model food flow property ball measuring system power law model krieger-dougherty model.

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Poroelastic Modelling of Gravitational Compaction

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Open Journal of Physical Chemistry 2019年第3期9卷 126-169页

作者： Pieter Broer van der Weg unilever r & d Vlaardingen The Netherlands

A dynamic in-silico model captures the kinetics of 1-d gravity driven instabilities, in gravity or centrifuge, of fluid-infiltrated poroelastic media in a partial differential equation (pde). The pde yields the porosity profile over height and time for the given initial and boundary conditions, during slow compaction in counter-current fluid drainage. Processes captured are amongst others sedimentation, creaming and subsidence. The most important limiting prerequisite is that the incompressible dispersed medium is sufficiently structured and/or concentrated that it compacts during slow drainage, without segregation in sizes or in components. For unilever, modeling of gravitational instability of products is important to quantify or extrapolate long time behavior during shelf life or use centrifuge data to quickly predict long term shelf performance of products.

关键词： Poroelastic Compaction Consolidation Gravity Centrifuge Sedimentation Creaming Subsidence Emulsion dispersion

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reduction of Environmental Impact of drum Machine Washing

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Journal of Applied Mathematics and Physics 2020年第1期8卷 132-157页

作者： Pieter Broer van der Weg (Peter) retired VU Amsterdam Shell R & D Rijswijk Stork DI Boxmeer Unilever R & D Vlaardingen Vlaardingen The Netherlands

An improvement of efficiency of the horizontally rotating drum washing machine is possible by using a more open type of drum, essentially without suds in the annulus, by using a pump to wet the clothes during rotation and fall. Modelling and simulation are used to quantify these claims and further optimize the design of the horizontal washing machine. The flow of suds inside the deforming clothes at impact with the drum is calculated. The wash performance is shown to be largely proportional to the open perforation area in the drum. The traditional design uses 1/8 of drum area for the perforation holes. A significant reduction of water, detergent, electrical energy, and wash time, with parity in wash performance, provides a step towards a cleaner and more sustainable future.

关键词： drum Wash Machine design Efficiency Poroelastics darcy Simulation Modelling

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Applicability of in Vitro Models in Predicting the in Vivo Bioavailability of Lycopene and β-Carotene from differently Processed Soups

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Food and Nutrition Sciences 2012年第4期3卷 477-489页

作者： Marie Alminger Cecilia Svelander Anna Wellner rebeca Martinez-Tomas Lucy Bialek Elvira Larque Francisca Perez-Llamas department of Chemical and Biological Engineering Food ScienceChalmers University of TechnologyGoteborgSweden Physiology department Faculty of BiologyUniversity of MurciaMurciaSpain unilever discover r&d Unilever Food and Health Research InstituteVlaardingenThe Netherlands

Presently, there is no clear consensus on the best approach to estimate carotenoid bioavailability. The best alternative would be to use human studies, but they are labour-intensive and expensive and can only be used to investigate a limited number of samples. Hence, a number of in vitro: models have been developed to study pre-absorptive processes and factors affecting bioavailability. The question is, however, how well the results obtained by the various methods correlate to each other and to the in vivo situation. In the present paper, we have compared in vivo data from two human studies on differently processed soups containing carrots, tomato and broccoli, with results obtained by in vitro characterisation of the same soups. In vitro bioaccessibility was estimated by a static in vitro digestion investigating matrix release and micellarization of carotenoids and by uptake studies in a human intestinal cell line (Caco-2). In vivo data was obtained from clinical studies measuring total plasma carotenoid concentrations in human subjects after 4 weeks daily consumption of the soups. Comparison of the in vitro and in vivo results indicate that the combination of a two-step in vitro digestion and Caco-2 cells seems to be a useful tool for estimation of β-carotene bioaccessibility and screening of factors governing the release of β-carotene from this type of food. For lycopene the in vitro and in vivo results were less consistent, suggesting that reliable prediction of lycopene bioavailability might be more problematic.

关键词： In Vitro digestion Human Uptake Caco-2 Cells β-Carotene Lycopene Carotene Bioavailability

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Bacterial adhesion and biofilms on surfaces

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Progress in Natural Science:Materials International 2008年第9期18卷 1049-1056页

作者： Trevor roger Garrett Manmohan Bhakoo department of Chemical Engineering School of Engineering The University of Birmingham Edgbaston Birmingham B15 2TT UK unilever r&d Port Sunlight Quarry Road East Bebington Merseyside CH63 3JW UK

Bacterial adhesion has become a significant problem in industry and in the domicile, and much research has been done for deeper understanding of the processes involved. A generic biological model of bacterial adhesion and population growth called the bacterial biofilm growth cycle, has been described and modified many times. The biofilm growth cycle encompasses bacterial adhesion at all levels, starting with the initial physical attraction of bacteria to a substrate, and ending with the eventual liberation of cell clusters from the biofilm matrix. When describing bacterial adhesion one is simply describing one or more stages of biofilm development, neglecting the fact that the population may not reach maturity. This article provides an overview of bacterial adhesion, cites examples of how bac- terial adhesion afiects industry and summarises methods and instrumentation used to improve our understanding of the adhesive prop- erties of bacteria.

关键词： Adhesion Bacteria Biofilm Cleaning Micromanipulation

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Toxicity testing in the 21st century:taking a pathway-led approach

Toxicity testing in the 21st century:taking a pathway-led ap...

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中国毒理学会第六届全国毒理学大会

作者： Paul L CArMICHAEL unilever r&d Safety & Environmental Assurance Centre

In 2007,the US National research Council’s publication ’Toxicity Testing in the Twenty-First Century(7721 C):A Vision and a Strategy’(Krewski et al 2010) outlined an approach to safety assessment that ’could transform toxicity testing from a system based on whole-animal testing to one founded primarily on in vitro methods that evaluate changes in biologic processes using cells,cell lines,or cellular components, preferably of human origin’.At the core of this vision is an understanding of key biological pathways(termed ’toxicity pathways’ in the original report)which,if sufficiently perturbed by a chemical,would result in an adverse outcome for the exposed human/*** recently, this concept of pathways-based approaches to risk assessment has been built upon by the description of ’Adverse Outcome Pathways’ (AOPs).Each AOP begins with a Molecular Initiating Event(MIE) in which the chemical interacts with a biological target leading to a sequence of events across different levels of biological organisation (Ankley et al,2010).The OECd has begun to formalize the use of this framework based on AOPs to capture and peer review the mechanistic understanding of specific toxic effects for the evaluation of non-animal methods(OECd, 2011).Our goal has been to take the above strategy and vision from the conceptual,to the practical;developing the necessary steps to use the TT21C/AOP foresight as the basis for the safety assessment of new ingredients in consumer products,without animal ***,members of a work-team in the Transatlantic Think Tank of Toxicology(t) produced a workflow on how to implement TT21C for a given ingredient (Blaauboer et al ATLA in preparation).The workflow begins with the chemical of concern and some initial assessment of the route of,and the extent of ***,the toxicity pathways of relevance must be identified for that particular *** will require a combination of both in vitro high-throughput screening(HTS) for pathwa

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PET分子量对PET/PC共混体系高压结晶行为的影响

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化学研究与应用 2006年第3期18卷 257-260页

作者：吕军黄锐李良彬四川大学高分子科学与工程学院四川成都610065 Foods research Centre Unilever R&D Vlaardingen

以往高压合成的聚合物伸直链晶体尺寸较小且合成时间过长,不能满足单晶应用的要求。加入10wt%PC于不同分子量的PET中,采用自制高压装置,制备共混体系,用WAXd,SEM,dSC等表征手段,研究了PET/PC共混体系在高压下的结晶行为。研究结果表明:... 详细信息

以往高压合成的聚合物伸直链晶体尺寸较小且合成时间过长,不能满足单晶应用的要求。加入10wt%PC于不同分子量的PET中,采用自制高压装置,制备共混体系,用WAXd,SEM,dSC等表征手段,研究了PET/PC共混体系在高压下的结晶行为。研究结果表明:通过PET/PC体系在高压下化学反应诱导的自组装,不同分子量PET的PET/PC共混体系均在较短的时间内生成了尺寸较大的聚酯伸直链晶体,对应于三斜晶系,其中PET/PC体系最适于大尺寸伸直链晶体的合成,仅需6hr时间即生成PE需200hr方可合成的40μm厚度的伸直链晶体。同时提出了PET1/PC体系中伸直链晶体高温下缺陷自我修复模型。

关键词：聚对苯二甲酸乙二醇酯聚碳酸酯高压结晶伸直链晶体

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Glycemic Indices of Multiple Oral Nutritional Supplements: A randomized Cross-Over Study in Indian Adults

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Food and Nutrition Sciences 2023年第10期14卷 941-962页

作者： deepti Khanna Jaladhi Bhatt Jayanti Gupta Simran Sethi Parth Joshi Manoj Pareek divya Agrawal Hindustan unilever Limited R&D Department Gurugram India Independent Biostatistician & researcher Mumbai India Cliantha research Ahmedabad India

Background: A randomized cross-over study was conducted to assess the glycemic index (GI) of seven Oral Nutritional Supplements (ONSs). These ONSs are designed to support the nutritional requirements of different age-groups, physiological states, or health conditions among Indian adults. Methods: The study had two phases viz., phase1 (n = 18) studied two ONSs: A1 and B1 and phase 2 (n = 20) studied five ONSs: A2, B2, C2, d2 & E2. The subjects were healthy, non-diabetic adults, aged between 20 - 44 years with a mean Body Mass Index of 21.2 ± 1.52 kg/m2 (Phase 1) and 21.0 ± 1.45 kg/m2 (Phase 2). All these ONSs were compared with reference drinks (glucose). The carbohydrates in one serving of each ONS were matched to carbohydrates from 25 grams of glucose following ISO 2010 guidelines. Capillary blood was assessed for blood glucose response at baseline, 15, 30, 45, 60, 90 and 120 minutes. GI was calculated as the incremental area under the curve (iAUC) for the test drinks and expressed as a percentage of the average iAUC from glucose. results: Phase 1 indicated that the high fiber diabetes-specific nutrition supplement A1 with higher protein (23% energy), higher fat (25% energy) and reduced carbohydrates (40% energy) had a significantly (p = 0.002) lower GI [34 (±6)] as compared to B1 [63 (±7)] (protein 19%, fat 7% and carbohydrates 60% energy) even with similar amount (22%) and type of fiber. Phase 2 reported that all test products [A2 (32 ± 5), B2 (37 ± 4), C2 (31 ± 5), d2 (31 ± 5) and E2 (55 ± 4)] had a low GI. As compared to phase 1, ONSs in phase 2 had lower fiber content (1.6% - 4.6% energy). Conclusion: The glycemic index of oral nutrition supplements is influenced not only by their fiber content, but also by the overall macronutrient composition including protein (≥17% energy), fat (≥10% - 27% energy) and carbohydrates (40% - 57.5% energy).

关键词： Glycemic Index Oral Nutritional Supplements Incremental Area under the Curve diabetes

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