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Applicability of in Vitro Models in Predicting the in Vivo Bioavailability of Lycopene and β-Carotene from Differently Processed Soups

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Food and Nutrition Sciences 2012年第4期3卷 477-489页

作者： Marie Alminger Cecilia Svelander Anna Wellner Rebeca Martinez-Tomas Lucy Bialek Elvira Larque Francisca Perez-Llamas Department of Chemical and Biological Engineering Food ScienceChalmers University of TechnologyGoteborgSweden Physiology Department Faculty of BiologyUniversity of MurciaMurciaSpain unilever Discover R&D Unilever Food and Health Research InstituteVlaardingenThe Netherlands

Presently, there is no clear consensus on the best approach to estimate carotenoid bioavailability. The best alternative would be to use human studies, but they are labour-intensive and expensive and can only be used to investigate a limited number of samples. Hence, a number of in vitro: models have been developed to study pre-absorptive processes and factors affecting bioavailability. The question is, however, how well the results obtained by the various methods correlate to each other and to the in vivo situation. In the present paper, we have compared in vivo data from two human studies on differently processed soups containing carrots, tomato and broccoli, with results obtained by in vitro characterisation of the same soups. In vitro bioaccessibility was estimated by a static in vitro digestion investigating matrix release and micellarization of carotenoids and by uptake studies in a human intestinal cell line (Caco-2). In vivo data was obtained from clinical studies measuring total plasma carotenoid concentrations in human subjects after 4 weeks daily consumption of the soups. Comparison of the in vitro and in vivo results indicate that the combination of a two-step in vitro digestion and Caco-2 cells seems to be a useful tool for estimation of β-carotene bioaccessibility and screening of factors governing the release of β-carotene from this type of food. For lycopene the in vitro and in vivo results were less consistent, suggesting that reliable prediction of lycopene bioavailability might be more problematic.

关键词： In Vitro Digestion Human Uptake Caco-2 Cells β-Carotene Lycopene Carotene Bioavailability

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Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage

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Journal of Molecular Cell Biology 2021年第11期13卷 822-833页

作者： Chengming Zhang Hong Zhang Jing Ge Tingyan Mi Xiao Cui Fengjuan Tu Xuelan Gu Tao Zeng Luonan Chen State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China unilever Research&Development Centre Shanghai Shanghai 200335China Bio-Med Big Data Center Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Systems health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Guangdong institute of Intelligence Science and Technology Zhuhai 519031China

Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin ***,skin response process to ultraviolet B(UVB)irradiation is a nonlinear dynamic process,with unknown underlying molecular mechanism of critical ***,the landscape dynamic network biomarker(lDNB)analysis of time series transcriptome data on 3D skin model was conducted to reveal the complicated process of skin response to UV irradiation at both molecular and network *** advanced l-DNB analysis approach showed that:(i)there was a tipping point before critical transition state during pigmentation process,validated by 3D skin model;(ii)13 core DNB genes were identified to detect the tipping point as a network biomarker,supported by computational assessment;(iii)core DNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening,validated by independent human skin ***,this study provides new insights for skin response to repetitive UVB irradiation,including dynamic pathway pattern,biphasic response,and DNBs for skin lightening change,and enables us to further understand the skin resilience process after external stress.

关键词： single-sample network tipping point UVB irradiation living skin equivalent model time series data skin lightening

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Concepts, processing, and recent developments in encapsulating essential oils

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Chinese Journal of Chemical Engineering 2021年第2期34卷 255-271页

作者： Qirui Tian Weiqing Zhou Qiong Cai Guanghui Ma Guoping Lian Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUK State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences School of Chemical SciencesBeijing 100049China unilever Research Colworth Colworth ParkSharnbrookBedfordshire MK441LQUK

By the virtue of their olfactory,physicochemical,and biological characteristics,essential oils(EOs)have drawn wide attention as additives in daily chemicals like perfume or personal care ***,they are physicochemically unstable and susceptible to degradation or *** offers a feasible strategy to stabilize and prolong release of *** review summarizes the recognized benefits and functional properties of various preparation and characterization methods,wherein innovative fabrication strategies and their formation mechanisms are especially *** in combining detecting/measuring technologies with kinetic modelling are discussed,to give an integral approach of controlling the dynamic release of encapsulated ***,new development trends of EOs capsules are also highlighted.

关键词： Essential oils Encapsulation Sustained release

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Mitochondrial toxicity and new China goals for TT21C/Adverse Outcome Pathways

Mitochondrial toxicity and new China goals for TT21C/Adverse...

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中国毒理学会第六届全国毒理学大会

作者： PENG Shuang-qing GUO Jia-bin YUAN Hai-tao ZHANG Ting-fen HOU Ming-yue ZHAO Jun LI Jin Paul CARMICHAEL Evaluation and Research Centre for Toxicology Institute of Disease Control and PreventionAcademy of Military Medical Sciences unilever Safety and Environmental Assurance Centre

＜正＞Mitochondria are major sources of cellular energy and reactive oxygen species （ROS）,playing fundamental roles in regulation of cell survival and death under pathological conditions. Numerous chemicals have shown to significantly induce mitochondrial toxicity in targeted organ such as liver and *** identification of mitochondrial toxicity for chemicals is important for avoiding hazard exposure in human or environment. However,due to the complexity of mitochondrial toxicity which may involve multiple mechanisms,the assessment of mitochondrial toxicity based on animal test is unsatisfactory. The release of Toxicity Testing in the Twenty-First Century:Vision and A Strategy by the US National Research Council brings new perspectives to the strategy and methods on the assessment of chemical-induced mitochondrial *** development of toxicity testing of mitochondrial toxicity is also transforming expensive and lengthy traditional in vivo animal tests to in vitro high-throughput alternative methods with quantitative parameters analysis and mechanistic exploration. Recently,many in vitro alternative methods have been established for accessing chemical-induced mitochondrial toxicity,such as high content screening,mechanism-based toxicity testing（eg, mitochondrial membrane potential,ATP production, oxygen consumption rate,oxidative phosphorylation, and mitochondrial superoxide generation）. In particular,adverse outcome pathway （AOP）for mitochondrial toxicity is highlighted to get a better mechanistic understanding and in vitro to in vivo *** AOP integrates from chemical characterization to molecular initiating event（MIE）and population response.A significant effort has been made by Chinese scientists to establish and develop Chinese TT21C/*** on previous studies in toxicological alternatives,many new projects have been carried out using TT21C strategies to access toxicitv of various chemicals.

关键词： mitochondrial toxicity toxicity testing risk assessment

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Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese

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Journal of Genetics and Genomics 2009年第7期36卷 417-423页

作者： Yabing Wang Di Zhang Yun Liu Yifeng Yang Teng Zhao Jie Xu Sheng Li Zuofeng Zhang Guoyin Feng Lin He He Xu institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Bio-X Center Shanghai Jiao Tong University Shanghai 200030 China Department ofEpidemiology UCLA School of Public Health Los Angeles California 90095-1772 USA institutes of Biomedical Sciences Fudan University Shanghai 200032 China

Single-nucleotide polymorphisms （SNPs） of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus （T2DM）, but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs ofADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects, rs 16861194 （-11426 A〉G） in the putative promoter of ADIPOQ was associated with T2DM （P = 0.007; OR = 1.29, 95% CI 1.08-1.55）. None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs 16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population.

关键词： adiponectin ADIPOQ ADIPORs SNP diabetes

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抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)

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环境与职业医学 2014年第2期31卷 151-157页

作者： Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇张伊人操仪 U.S.Environmental Protection Agency Office of Research and Development unilever-Safety and Environmental Assurance Centre Department of Biological and Environmental Sciences Gothenburg University Veterinary Medicines Directorate Department of Plant and Environmental Sciences University of Copenhagen The Canberra Hospital and Canberra Clinical School Australian National University ECT Oekotoxikologie GmbH Fl?rsheim/Main Public health Agency of Canada European Centre for Environment and Human health Exeter University Medical School Knowledge Spa Royal Cornwall Hospital Federal Office of Consumer Protection and Food Safety Department 3: Veterinary Drugs Environment Canada Saskatoon institute for Biomedicine The Sahlgrenska Academy University of Gothenburg Department of Population Medicine University of Guelph Environment Health and Safety GlaxoSmithKline Umweltbundesamt Federal Environment Agency MB Consult Limited Southampton University of Bradford Brixham Environmental Laboratory Pfizer Animal health VMRD Agriculture and Agri-Food Canada London Ontario Canada

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性... 详细信息

[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生"热点区域"的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的"热点区域"中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。

关键词：抗生素耐药性健康风险评估环境评估人类健康基因转移剂量反应决策分析方法耐药性细菌

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Correction to‘Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage’

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Journal of Molecular Cell Biology 2022年第3期14卷 65-65页

作者： Chengming Zhang Hong Zhang Jing Ge Tingyan Mi Xiao Cui Fengjuan Tu Xuelan Gu Tao Zeng Luonan Chen State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Chinese Academy of SciencesBeĳing 100049China unilever Research&Development Centre Shanghai Shanghai 200335China Bio-Med Big Data Center Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Systems health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Guangdong institute of Intelligence Science and Technology Zhuhai 519031China

In the originally published version of this article(p.822),there was an error in the second affiliation of author Chengming *** erroneous affiliation was given as‘University of the Chinese Academy of Sciences’.This ... 详细信息

关键词： programming damage network

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减少向环境中释放抗生素和抗生素耐药基因的管理措施

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环境与职业医学 2014年第1期31卷 72-77页

作者： Amy Pruden D.G.Joakim Larsson Alejandro Amézquita Peter Collignon Kristian K.Brandt David W.Graham James M.Lazorchak Satoru Suzuki Peter Silley Jason R.Snape Edward Topp Tong Zhang Yong-Guan Zhu 何蓉汪源张伊人金泰廙 Department of Civil and Environmental Engineering Virginia TechBlacksburgVirginiaUSA institute for Biomedicine The Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden unilever-Safety & Environmental Assurance Centre SharnbrookUnited Kingdom Australian National University CanberraAustralia Canberra Hospital CanberraAustralia Department of Plant and Environmental Sciences University of CopenhagenFrederiksbergDenmark School of Civil Engineering and Geosciences Newcastle UniversityNewcastle upon TyneUnited Kingdom Office of Research and Development U.S. Environmental Protection AgencyCincinnatiOhioUSA Center for Marine Environmental Studies Ehime UniversityMatsuyamaEhimeJapan MB Consult Limited SouthamptonUnited Kingdom University of Bradford BradfordUnited Kingdom AstraZeneca Brixham Environmental LaboratoryBrixhamUnited Kingdom Agriculture and Agri-Food Canada LondonOntarioCanada Department of Civil Engineering University of Hong Kong Key Laboratory of Urban Environment and health Institute of Urban EnvironmentChinese Academy of Sciences

[背景]全球越来越关注污染土壤、水环境对抗生素耐药性产生和蔓延的作用。[目的]本研究的目的是确定那些可以减少抗生素和抗生素耐药性经环境途径传播影响因素的管理措施,以最终达到延长抗生素使用寿命的目标。此外还研究了实施这些措... 详细信息

[背景]全球越来越关注污染土壤、水环境对抗生素耐药性产生和蔓延的作用。[目的]本研究的目的是确定那些可以减少抗生素和抗生素耐药性经环境途径传播影响因素的管理措施,以最终达到延长抗生素使用寿命的目标。此外还研究了实施这些措施的激励和阻碍因素。[方法]着重研究有关农业源头限制,生活、医院和工业废水处理,以及水产养殖三方面的管理措施。[讨论]我们确定了若干措施,如养份管理、径流控制和基础设施升级。凡适当处,可提供世界不同地区的典型实例。研究还强调了监测和验证管理策略有效性的重要性。最后,介绍了一则瑞典的案例研究,展示了通过沟通来发动利益相关方参与和促进行动的重要作用。[结论]在许多情况下,可以花费很少或根本不花费成本来减少抗生素和抗生素耐药性细菌的环境释放。一些管理措施与现有的政策和目标协同作用。预期的效益是延长现有和未来的抗生素使用寿命。虽然往往难以量化所降低的风险,但是全球抗生素耐药性相关发病率和死亡率加速增长,这一情况的严重程度强烈表明采取行动的必要性。

关键词：农业抗生素制造抗生素耐药性水产养殖畜牧粪便管理政策废水处理

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Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial

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四川生理科学杂志 2021年第10期43卷 1819-1819页

作者： Arabella S V Stuart Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK Oxford University Hospitals NHS Foundation Trust Oxford UK Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK Statistics Modelling and Economics Department UK Health Security Agency London UK Immunisation and Countermeasures Division National Infection Service UK Health Security Agency London UK Public health Scotland Glasgow Scotland UK UK health Security Agency Porton Down Salisbury UK Liverpool School of Tropical Medicine Liverpool UK Department of Infection Immunity and Cardiovascular Disease University of Sheffield Sheffield UK Department of Infection and Tropical Medicine Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK Translational and Clinical Research institute Newcastle University Newcastle UK NIHR Southampton Clinical Research Facility and Biomedical Research Centre University Hospital Southampton NHS Foundation Trust Southampton UK Faculty of Medicine and institute for Life Sciences University of Southampton Southampton UK School of Population health Sciences and School of Cellular and Molecular Medicine University of Bristol Bristol UK Department of Infection and NIHR BRC Guy's and St Thomas' NHS Foundation Trust London UK MRC Clinical Trials Unit University College London London UK NIHR/Wellcome Trust Clinical Research Facility University Hospitals Birmingham NHS Foundation Trust Birmingham UK institute of Microbiology and Infection University of Birmingham Birmingham UK The Vaccine institute St George's University of London London UK Oxford Vaccine Group Department of Paediatrics University of Oxford Oxford UK Chinese Academy of Medical Science Oxford Institute University of Oxford Oxford UK North Bristol NHS Trust Bristol UK NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre University College London Ho

Background:Given the importance of flexible use of different COVID-19 vaccines within the same schedule to facilitate rapid deployment,we studied mixed priming schedules incorporating an adenoviral-vectored vaccine(ChAdOx1 nCoV-19[ChAd],AstraZeneca),two mRNA vaccines(BNT162b2[BNT],Pfizer-BioNTech,and mRNA-1273[m1273],Moderna)and a nanoparticle vaccine containing SARS-CoV-2 spike glycoprotein and Matrix-M adjuvant(NVX-CoV2373[NVX],Novavax).

关键词： Pfizer schedule COV

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联合降胆固醇饮食与洛伐他汀对血脂和C-反应蛋白的影响

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美国医学会杂志（中文版） 2004年第5期23卷 233-239页

作者：倪永斌胡大一 Clinical Nutrition and Risk Factor Modification Center Department of Medicine Division of Endocrinology and Metabolism StMichael′s Hospital and Departments of Nutritional SciencesStMichael′s HospitalMedicine Faculty of Medicine University of Toronto TorontoOntario the Almond Board of California Modesto unilever health institute Unilever Research and Development Vlaardingen the Netherlands Clinical Nutrition and Risk Factor Modification Center Department of Medicine Division of Endocrinology and Metabolism StMichael′s Hospital and Departments of Nutritional SciencesStMichael′s Hospital and Departments of Nutritional SciencesStMichael Clinical Nutrition and Risk Factor Modification Center Department of Medicine Division of Endocrinology and MetabolismStMichael′s Hospital and Departments of Nutritional Sciences StMichael′s Hospital Medicine Department of Medicine Division of Endocrinology and MetabolismStMichael′s HospitalMedicineLaboratory Medicine and Pathobiology Clinical Nutrition and Risk Factor Modification Center StMichael′s Hospital and Departments of Nutritional Sciences StMichael′s Hospital and Departments of Nutritional Sciences Clinical Nutrition and Risk Factor Modification Center StMichael′s Hospital and Departments of Nutritional Sciences

背景：为增强饮食治疗降低胆固醇的效果，国家胆固醇教育计划(National Cholesterol Education Program，NCEP)成人治疗小组(Adult Treatment Panel，ATP)III强调食用低饱和脂肪以及植物固醇和粘胶纤维食物，而美国心脏病协会(American ... 详细信息

背景：为增强饮食治疗降低胆固醇的效果，国家胆固醇教育计划(National Cholesterol Education Program，NCEP)成人治疗小组(Adult Treatment Panel，ATP)III强调食用低饱和脂肪以及植物固醇和粘胶纤维食物，而美国心脏病协会(American Heart Association，AHA)则支持食用大豆蛋白和坚果。目的：确定食用含有这些推荐食物所有成分的食物是否可以取得类似于3-羟-3-甲戊二酰辅酶A还原酶抑制剂(他汀类)的降低胆固醇的效果。设计：于2002年10月至12月间进行的随机对照试验。地点和参试者：从一家加拿大医院的营养研究中心和社区入选46例成年高脂血症患者(25例男性和21例已绝经女性)，平均年龄(SE)59岁(1岁)，体重指数27．6（0．5)。干预：参与者随机分配至以下三种干预门诊治疗1个月：极低饱和脂肪饮食，以碾碎的全麦谷类食品和低脂奶制品为基础(n=16；对照组)；极低饱和脂肪饮食加洛伐他汀20mg/d(n=14，他汀组)；富含植物固醇(1．0g／1000kcal)、大豆蛋白(21．4g／1000kcal)、粘胶纤维(9．8g／1000kcal)和杏仁(14g／1000kcal)的饮食(联合饮食组)。主要观察指标：血脂和C-反应蛋白水平，来自空腹血样；血压；体重；在0周、2周和4周时分别测量这些指标，并在三组间比较。结果：对照组、他汀组和联合饮食组低密度脂蛋白胆固醇分别平均(SE)下降8．0％(2．1％)(P=0．002)、30．9％(3．6％)(P<0．001)和28．6％(8．6％)(P<0．001)。C-反应蛋白分别下降10．0％(8．6％)(P=0．27)、33．3％(8．3％)(P=0．002)和28．2％(10．8％)(P=0．02)。他汀组和联合饮食组降低程度明显大于对照组。他汀治疗和联合饮食治疗的效果无显著差异。结论：研究显示，在同一饮食方案中，降胆固醇成分的多样化增加了饮食治疗高胆固醇血症的效果。

关键词：饮食治疗联合他汀 C-反应蛋白饱和脂肪对照组血脂粘胶纤维增强还原酶抑制剂

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