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optical Molecular imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity

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Engineering 2015年第3期1卷 309-323页

作者： Kun Wang Chongwei Chi Zhenhua Hu Muhan Liu Hui Hui Wenting Shang Dong Peng Shuang Zhang Jiezuo Ye Haixiao Liu Jie Tian Key laboratory of Molecular imaging Institute of Automation Chinese Academy of Sciences

Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging(CLI), and optical imageguided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment—one of the ultimate goals of precision medicine.

关键词： optical molecular imaging multimodality molecular imaging optical multimodality tomography Cerenkov luminescence imaging intraoperative image-guided surgery

Application of machine learning method in optical molecular imaging: a review

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Science China(Information Sciences) 2020年第1期63卷 5-20页

作者： Yu AN Hui MENG Yuan GAO Tong TONG Chong ZHANG Kun WANG Jie TIAN CAS Key laboratory of Molecular imaging Beijing Key Laboratory of Molecular ImagingThe State Key Laboratory of Management and Control for Complex SystemsInstitute of Automation Chinese Academy of Sciences Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang University University of Chinese Academy of Sciences

optical molecular imaging(OMI) is an imaging technology that uses an optical signal, such as near-infrared light, to detect biological tissue in organisms. Because of its specific and sensitive imaging performance, it is applied in both preclinical research and clinical surgery. However, it requires heavy data analysis and a complex mathematical model of tomographic imaging. In recent years, machine learning(ML)-based artificial intelligence has been used in different fields because of its ability to perform powerful data processing. Its analytical capability for processing complex and large data provides a feasible scheme for the requirement of OMI. In this paper, we review ML-based methods applied in different OMI modalities.

关键词： optical molecular imaging machine learning artificial intelligence

optical Brain imaging： A Powerful Tool for Neuroscience

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Neuroscience Bulletin 2017年第1期33卷 95-102页

作者： Xinpei Zhu Yanfang Xia Xuecen Wang Ke Si Wei Gong Institute of Neuroscience Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology Zhejiang University School of MedicineHangzhou 310058 China State Key laboratory of Modern optical Instrumentation College of Optical Science and Engineering and the Collaborative Innovation Center for Brain Science Zhejiang University Hangzhou 310027 China

As the control center of organisms, the brain remains little understood due to its complexity. Taking advantage of imaging methods, scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods, optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here, we overview several optical imaging techniques in neuroscience of recent years, including brain clearing, the micro-optical sectioning tomography system, and deep tissue imaging.

关键词： Brain imaging Tissue clearing MOSToptical microscopy Deep tissue imaging

Mathematical method in optical molecular imaging

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Science China(Information Sciences) 2015年第3期58卷 4-16页

作者： LENG ChengCai TIAN Jie School of Mathematics and Information Sciences Nanchang Hangkong University Key laboratory of Molecular imaging Institute of Automation Chinese Academy of Sciences

optical molecular imaging is an important technique of studies at molecular level and provides promising tools to non-invasively delineate in vivo physiological and pathological activities at cellular and molecular levels,and it has been widely used for diagnosing,managing diseases,metastasis detection and drug *** a mathematical perspective,this paper mainly focuses on the forward problem and inverse problem in biological tissues based on the radiative transfer equation(RTE).The forward problem is accustomed to describing photon propagation in biological tissues and the inverse problem is used to reconstruct internal source distribution from the signal detected on the external *** also introduce the detailed derivation of the RTE and Robin boundary condition and discretization of the forward problem,along with the reconstruction methods and iterative solution algorithms summarized for the inverse ***,the current and future challenges of optical molecular imaging are *** survey aims to construct a mathematical method,a state-of-the-art framework for optical molecular imaging,from which future research may benefit.

关键词： radiative transfer equation(RTE) regularization method source reconstruction optical molecular imaging mathematical method

Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第6期11卷 417-422页

作者： Li-li CHEN Li JIANG Ya-lun WANG Jun QIAN Sailing HE Centre for optical and Electromagnetic Research State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310058 China Department of Electromagnetic Engineering School of Electrical Engineering Royal Institute of Technology S-100 44 Stockholm Sweden

We report the application of multilayered polyelectrolyte-coated gold nanorods(GNRs) as multifunctional optical contrast agents for cancer cell *** surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic *** unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both "scattering contrast agents" and "Raman contrast agents".In our experiments,the staining of GNRs in cells was further confirmed by dark field microscopy and Raman *** experiment results indicated that GNRs have great potential as multifunctional "optical contrast agents" for future in vivo animal imaging.

关键词： Gold nanorods Polyelectrolyte Scattering Raman Cancer cell imaging

In-vivo retinal imaging by optical coherence tomography using an RSOD-based phase modulator

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第4期10卷 607-612页

作者： Ling WANG Zhi-hua DING Guo-hua SHI Yu-dong ZHANG State Key laboratory of Modern optical Instrumentation Zhejiang University Hangzhou 310027 China Institute of Optics and Electronies Chinese Academy of Sciences Chengdu 610209 China

Fourier-domain rapid scanning optical delay line (RSOD) was introduced for phase modulation and depth scanning in a time-domain optical coherence tomography (TD-OCT) system. Investigation of parameter optimization of RSOD was conducted. Experiments for RSOD characterization at different parameters of the groove pitch, focal length, galvomirror size, etc. were performed. By implementing the optimized RSOD in our established TD-OCT system with a broadband light source centered at 840 nm with 50 nm bandwidth, in vivo retina imaging of a rabbit was presented, demonstrating the feasibility of high-quality TD-OCT imaging using an RSOD-based phase modulator.

关键词： optical coherence tomography (OCT) Phase modulation Retina imaging

Piecewise spectrally band-pass for compressive coded aperture spectral imaging

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Chinese Physics B 2015年第8期24卷 248-253页

作者：钱路路吕群波黄旻相里斌 Key laboratory of Computational optical imaging Technology Academy of Opto-electronics Chinese Academy of Sciences

Coded aperture snapshot spectral imaging(CASSI) has been discussed in recent years. It has the remarkable advantages of high optical throughput, snapshot imaging, etc. The entire spatial-spectral data-cube can be reconstructed with just a single two-dimensional(2D) compressive sensing measurement. On the other hand, for less spectrally sparse scenes,the insufficiency of sparse sampling and aliasing in spatial-spectral images reduce the accuracy of reconstructed threedimensional(3D) spectral cube. To solve this problem, this paper extends the improved CASSI. A band-pass filter array is mounted on the coded mask, and then the first image plane is divided into some continuous spectral sub-band areas. The entire 3D spectral cube could be captured by the relative movement between the object and the instrument. The principle analysis and imaging simulation are presented. Compared with peak signal-to-noise ratio(PSNR) and the information entropy of the reconstructed images at different numbers of spectral sub-band areas, the reconstructed 3D spectral cube reveals an observable improvement in the reconstruction fidelity, with an increase in the number of the sub-bands and a simultaneous decrease in the number of spectral channels of each sub-band.

关键词： coded aperture spectral imaging compressive sensing information reconstruction

Near-Field optical Transfer Function for Far-Field Super-Resolution imaging

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Chinese Physics Letters 2009年第1期26卷 132-135页

作者：张志友杜惊雷郭永康牛晓云李敏罗先刚杜春雷 Department of Physics Sichuan University Chengdu 610064 State Key laboratory of optical Technologies for Microfabrication Institute of Optics and Electronics Chinese Academy of Sciences Chengdu 610209

The far-field superlens based on surface plasmon polaritons （SPP） has shown great application potential, but it is difficult and time-consuming to reconstruct the far-field image. We derive a near-field optical transfer function （NOTF） of a silver slab and analyse its validity so that accurate information of nano-seale object in the near-field can be computed rapidly. The NOTF is helpful not only for analysing the super-resolution imaging process in far-field, but also for providing a track to describe the transmission of optical information from near-field to far-field by using the optical transfer functions theorv only.

关键词： field emission molybdenum dioxide enhancement factor

High-resolution polarization-sensitive optical coherence tomography and optical coherence tomography angiography for zebrafish skin imaging

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Journal of Innovative optical Health Sciences 2021年第6期4卷 131-144页

作者： Di Yang Zhuoqun Yuan Zihan Yang Muyun Hu Yanmei Liang Institute of Modern Optics Nankai University Tianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350P.R.China

Zebrafish is an important animal model,which is used to study development,pathology,and genetic *** zebrafish skin model is widely used in cutaneous research,and angiogenesis is critical for cutaneous wound ***,limited by the penetration depth,the available optical methods are difficult to describe the internal skin structure and the connection of blood vessels between the skin and subcutaneous *** a homemade high-resolution polarization-sensitive optical coherence tomography(PS-OCT)system,we imaged the polarization contrast of zebrafish skin and the zebrafish skin vasculature with optical coherence tomography angiography(OCTA).Based on these OCT images,the spatial distribution of the zebrafish skin vasculature was ***,we monitored the healing process of zebrafish cutaneous *** think the high-resolution PS-OCT system will be a promising tool in studying cutaneous models of zebrafish.

关键词： Polarization-sensitive optical coherence tomography optical coherence tomography angiography zebrafish skin vasculature