Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging

作     者：Li-li CHEN Li JIANG Ya-lun WANG Jun QIAN Sailing HE 

作者机构：Centre for Optical and Electromagnetic Research State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310058 China Department of Electromagnetic Engineering School of Electrical Engineering Royal Institute of Technology S-100 44 Stockholm Sweden 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2010年第11卷第6期

页      面：417-422页

核心收录：

学科分类：080901[工学-物理电子学] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 071009[理学-细胞生物学] 09[农学] 090102[农学-作物遗传育种] 0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 0901[农学-作物学] 0803[工学-光学工程] 

基　　金：supported by the Swedish Foundation for Strategic Research (SSF) and the US Air Force Office of Scientific Research (Asia Office) 

主　　题：Gold nanorods Polyelectrolyte Scattering Raman Cancer cell imaging 

摘      要：We report the application of multilayered polyelectrolyte-coated gold nanorods(GNRs) as multifunctional optical contrast agents for cancer cell *** surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic *** unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both scattering contrast agents and Raman contrast agents.In our experiments,the staining of GNRs in cells was further confirmed by dark field microscopy and Raman *** experiment results indicated that GNRs have great potential as multifunctional optical contrast agents for future in vivo animal imaging.