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Contrast-enhanced fluorescence microscope by LED integrated excitation cubes

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Light(Advanced Manufacturing) 2023年第2期4卷 18-27页

作者： Yuanhua Liu Xiang Zhang Fei Su Zhiyong Guo Dayong Jin uts-sustech joint research centre for biomedical materials and devices Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055China Institute for biomedical materials and devices(IBMD) Faculty of ScienceUniversity of Technology SydneyNSW 2007Australia

Fluorescence microscopy is a powerful tool for scientists to observe the microscopic world,and the fluorescence excitation light source is one of the most critical *** compensate for the short operation lifetime,integrated light sources,and low excitation efficiency of conventional light sources such as mercury,halogen,and xenon lamps,we designed an LED-integrated excitation cube(LEC)with a decentralized structure and high optical power *** a Fresnel lens,the light from the light-emitting diode(LED)was effectively focused within a 15 mm mounting distance to achieve high-efficiency *** can be easily designed in the shape of fluorescence filter cubes for installation in commercial fluorescence ***’optical efficiency is 1–2 orders of magnitude higher than that of mercury lamps;therefore,high-quality fluorescence imaging with spectral coverage from UV to red can be *** replacing conventional fluorescence filter cubes,LEC can be easily installed on any commercial fluorescence microscope.A built-in LEC driver can identify the types of LEDs in different spectral bands to adopt the optimal operating current and frequency of ***,high-contrast images can be achieved in pulse mode by time-gated imaging of long-lifetime luminescence.

关键词： LED-integrated excitation cube Filter cube Time-gated imaging Fluorescence microscopy

Deep learning enhanced NIR-Ⅱ volumetric imaging of whole mice vasculature

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Opto-Electronic Advances 2023年第4期6卷 6-14页

作者： Sitong Wu Zhichao Yang Chenguang Ma Xun Zhang Chao Mi Jiajia Zhou Zhiyong Guo Dayong Jin uts-sustech joint research centre for biomedical materials&devices Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen 518055China Institute for biomedical materials&devices Faculty of ScienceUniversity of Technology SydneyUltimoNew South Wales 2007Australia Guangdong Provincial Key Laboratory of Advanced biomaterials Southern University of Science and TechnologyShenzhen 518055China

Fluorescence imaging through the second near-infrared window(NIR-Ⅱ,1000–1700 nm) allows in-depth ***, current imaging systems use wide-field illumination and can only provide low-contrast 2D information, without depth resolution. Here, we systematically apply a light-sheet illumination, a time-gated detection, and a deep-learning algorithm to yield high-contrast high-resolution volumetric images. To achieve a large Fo V(field of view) and minimize the scattering effect, we generate a light sheet as thin as 100.5 μm with a Rayleigh length of 8 mm to yield an axial resolution of 220 μm. To further suppress the background, we time-gate to only detect long lifetime luminescence achieving a high contrast of up to 0.45 Icontrast. To enhance the resolution, we develop an algorithm based on profile protrusions detection and a deep neural network and distinguish vasculature from a low-contrast area of 0.07 Icontrast to resolve the 100μm small vessels. The system can rapidly scan a volume of view of 75 × 55 × 20 mm3and collect 750 images within 6mins. By adding a scattering-based modality to acquire the 3D surface profile of the mice skin, we reveal the whole volumetric vasculature network with clear depth resolution within more than 1 mm from the skin. High-contrast large-scale 3D animal imaging helps us expand a new dimension in NIR-Ⅱ imaging.

关键词： NIR-Ⅱfluorescence time-gated light sheet illumination deep learning vessel enhancement 3D imaging

Viral inactivation by light

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eLight 2022年第1期2卷 237-254页

作者： Mohammad Sadraeian Le Zhang Farzaneh Aavani Esmaeil Biazar Dayong Jin Present Address:Institute for biomedical materials and devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia Department of Oral and Maxillofacial Surgery Division of Regenerative Orofacial MedicineUniversity Hospital Hamburg-Eppendorf20251 HamburgGermany Department of biomedical Engineering Islamic Azad UniversityTonekabon BranchTonekabonIran uts‑sustech joint research centre for biomedical materials&devices Department of Biomedical EngineeringCollege of EngineeringSouthern University of Science and TechnologyShenzhenGuangdongChina

Nowadays,viral infections are one of the greatest challenges for medical sciences and human *** antiviral compounds and chemical inactivation remain inadequate,physical approaches based on irradiation provide new potentials for prevention and treatment of viral infections,without the risk of drug resistance and other unwanted side *** across the electromagnetic spectrum can inactivate the virions using ionizing and non-ionizing *** review highlights the anti-viral utility of radiant methods from the aspects of ionizing radiation,including high energy ultraviolet,gamma ray,X-ray,and neutron,and non-ionizing photo-inactivation,including lasers and blue light.

关键词： Antiviral therapy Enveloped virus Photo-inactivation Ionizing radiation Nuclear radiations

Two-photon MINFLUX with doubled localization precision

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eLight 2022年第1期2卷 58-67页

作者： Kun Zhao Xinzhu Xu Wei Ren Dayong Jin Peng Xi Department of biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China Wallace H.Coulter Department of biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332 GeorgiaUSA uts‑sustech joint research centre for biomedical materials&devices Department of Biomedical EngineeringCollege of EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055China National biomedical Imaging Center Peking UniversityBeijing 100871China

Achieving localization with molecular precision has been of great interest for extending fluorescence microscopy to *** pioneers this transition through point spread function(PSF)engineering,yet its performance is primarily limited by the signal-to-background *** we demonstrate theoretically that two-photon MINFLUX(2p-MINFLUX)could double its localization precision through PSF engineering by nonlinear ***ér-Rao Bound(CRB)is studied as the maximum localization precision,and CRB of two-photon MINFLUX is halved compared to single-photon MINFLUX(1p-MINFLUX)in all three ***,in order to achieve same localization precision with 1p-MINFLUX,2p-MINFLUX requires only 1/4 of fluorescence *** simultaneous two-photon excitation of multiple fluorophore species,2p-MINFLUX may have the potential for registration-free nanoscopy and multicolor tracking.

关键词： Super-resolution microscopy Single-molecule localization MINFLUX Two-photon microscopy

Polarization modulation with optical lock-in detection reveals universal fluorescence anisotropy of subcellular structures in live cells

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Light(Science & Applications) 2022年第1期11卷 50-62页

作者： Meiling Guan Miaoyan Wang Karl Zhanghao Xu Zhang Meiqi Li Wenhui Liu Jing Niu Xusan Yang Long Chen Zhenli Jing Micheal Q.Zhang Dayong Jin Peng Xi Juntao Gao Department of biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China uts-sustech joint research centre for biomedical materials&devices Department of Biomedical EngineeringCollege of EngineeringSouthern University of Science and TechnologyShenzhenGuangdongChina MOE Key Laboratory of bioinformatics Bioinformatics DivisionCenter for Synthetic&Systems BiologyBNRistBeijingChina Center for Synthetic&Systems biology Department of AutomationTsinghua UniversityBeijing 100084China Beijing Institute of Collaborative Innovation Beijing 100094China Department of biological Sciences and Center for System biology The University of Texas at DallasRichardson 75080USA School of medical Sciences Tsinghua UniversityBeijing 100084China Institute for biomedical materials and devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia National biomedical Imaging Center Peking UniversityBeijing 100871China

The orientation of fluorophores can reveal crucial information about the structure and dynamics of their associated subcellular *** significant progress in super-resolution,fluorescence polarization microscopy remains limited to unique samples with relatively strong polarization modulation and not applicable to the weak polarization signals in samples due to the excessive background *** we apply optical lock-in detection to amplify the weak polarization modulation with *** novel technique,termed optical lock-in detection super-resolution dipole orientation mapping(OLID-SDOM),could achieve a maximum of 100 frames per second and rapid extraction of 2D orientation,and distinguish distance up to 50 nm,making it suitable for monitoring structural dynamics concerning orientation changes in ***-SDOM was employed to explore the universal anisotropy of a large variety of GFP-tagged subcellular organelles,including mitochondria,lysosome,Golgi,endosome,*** found that OUF(Orientation Uniformity Factor)of OLID-SDOM can be specific for different subcellular organelles,indicating that the anisotropy was related to the function of the organelles,and OUF can potentially be an indicator to distinguish normal and abnormal cells(even cancer cells).Furthermore,dual-color super-resolution OLID-SDOM imaging of lysosomes and actins demonstrates its potential in studying dynamic molecular *** subtle anisotropy changes of expanding and shrinking dendritic spines in live neurons were observed with real-time *** previously unobservable fluorescence anisotropy in various samples and indicating their underlying dynamic molecular structural changes,OLID-SDOM expands the toolkit for live cell research.

关键词： anisotropy Polarization concerning

PY-IT,an Excellent Polymer Acceptor

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Chinese Journal of Chemistry 2023年第24期41卷 3714-3728页

作者： Qingqing Bai Qiming Liang Qian Liu Bin Liu Xugang Guo Li Niu Huiliang Sun Center for Advanced Analytical Science Guangzhou Key Laboratory of Sensing Materials and DevicesGuangdong Engineering Technology Research Center for Photoelectric Sensing Materials and DevicesSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhouGuangdong510006 China Department of materials Science and Engineering Southern University of Science and Technology (SUSTech)ShenzhenGuangdong518055 China

All-polymer solar cells(all-PSCs)have attracted considerable attention due to their inherent advantages over other types of organic solar cells,including superior optical and thermal stability,as well as exceptional mechanical ***,all-PSCs have experienced remarkable advancements in device performance thanks to the invention of polymerized small-molecule acceptors(PSMAs)since *** these PSMAs,PY-IT has garnered immense interest from the scientific community due to its exceptional performance in *** this review,we presented the design principles of PY-IT and discussed the various strategies employed in device engineering for PY-IT-based *** strategies include additive and interface engineering,layer-by-layer processing methods,meniscus-assisted coating methods,and ternary ***,this review highlighted several novel polymeric donor materials that are paired with PY-IT to achieve efficient ***,we summarized the inspiring strategies for further advancing all-PSCs based on *** strategies aim to enhance the overall performance and stability of all-PSCs by exploring new materials,optimizing device architectures,and improving fabrication *** leveraging these approaches,we anticipate significant progress in the development of all-PSCs and their potential as a viable renewable energy source.

关键词： PY-IT Polymer acceptors Device engineering Organic solar cells Synthesis design

Over 16% efficiency all-polymer solar cells by sequential deposition

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Science China Chemistry 2022年第6期65卷 1157-1163页

作者： Bangbang Li Xuanyu Zhang Ziang Wu Jie Yang Bin Liu Qiaogan Liao Junwei Wang Kui Feng Rui Chen Han Young Woo Fei Ye Li Niu Xugang Guo Huiliang Sun Department of materials Science and Engineering Southern University of Science and Technology(SUSTech)Shenzhen518055China Center for Advanced Analytical Science School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou510006China Department of Electrical and Electronic Engineering Southern University of Science and Technology(SUSTech)Shenzhen518055China Department of Chemistry Korea UniversitySeoul136-713Republic of Korea Guangdong Provincial Key Laboratory of Functional Oxide materials and devices SUSTechShenzhen518055China

All-polymer solar cells(all-PSCs) have received extensive attention due to their excellent mechanical robustness and performance stability. However, the power conversion efficiency(PCE) of all-PSCs still lags behind those of organic solar cells(OSCs)based on non-fullerene small molecule acceptors. Herein, we report highly efficient all-PSCs via sequential deposition(SD) with donor and acceptor layers coated sequentially to optimize the film microstructure. Compared with the bulk heterojunction(BHJ)all-PSCs, an optimized morphology with vertical component distribution was achieved for the SD-processed all-PSCs due to the synergistic effect of swelling of polymer films and using additive. Such strategy involves using chlorobenzene as the first layer processing-solvent for polymer donor, chloroform as the second processing-solvent for polymer acceptor with trace 1-chloronaphthalene, efficiently promoting exciton dissociation and charge extraction and reducing trap-assisted ***, over 16% all-PSCs fabricated via SD method was realized for the first time, which is much higher than that(15.2%) of its BHJ counterpart and also among the highest PCEs in all-PSCs. We have further demonstrated the generality of this approach in various all-polymer systems. This work indicates that the SD method can yield excellent all-PSCs and provides a facile approach to fabricating high-performance all-PSCs.

关键词： all-polymer solar cells polymer acceptors planar heterojunction sequential deposition

A dC/dV Measurement for Quantum-Dot Light-Emitting Diodes

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Chinese Physics Letters 2022年第12期39卷 94-98页

作者： Jingrui Ma Haodong Tang Xiangwei Qu Guohong Xiang Siqi Jia Pai Liu Kai Wang Xiao Wei Sun Key Laboratory of Energy Conversion and Storage Technologies(sustech)of Ministry of Education Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and DevicesSUSTech-Huawei Joint Lab for Photonics Industryand Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China Institute of Nanoscience and Applications Southern University of Science and TechnologyShenzhen 518055China Shenzhen Planck Innovation Technologies Co.Ltd. Shenzhen 518173China

We present dC/dV analysis based on the capacitance-voltage(C–V)measurement of quantum-dot lightemitting diodes(QLEDs),and find that some key device operating parameters(electrical and optical turn-on voltage,peak capacitance,maximum efficiency)can be directly related to the turning points and maximum/minimum of the dC/dV(versus voltage)*** the dC/dV study,the behaviors such as low turn-on voltage,simultaneous electrical and optical turn-on process,and carrier accumulation during the device aging can be well ***,we perform the C–V and dC/dV measurement of aged devices,and confirm that our dC/dV analysis is correct for ***,our dC/dV analysis method can be applied universally for QLED *** provides an in-depth understanding of carrier dynamics in QLEDs through simple C–V measurement.

关键词： measurement capacitance Quantum

Silver nanowires for anti-counterfeiting

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Journal of Materiomics 2020年第1期6卷 152-157页

作者： Yan Wang Ningning Bai Junlong Yang Zhiguang Liu Gang Li Minkun Cai Lingyu Zhao Yuan Zhang Jianming Zhang Chunhua Li Yunlong Zhou Chuan Fei Guo School of materials Science and Engineering Harbin Institute of TechnologyHarbin150001China Department of materials Science&Engineering Centers for Mechanical Engineering Research and Education at MIT and SUSTechSouthern University of Science and TechnologyShenzhen518055China c Engineering research Center of Clinical Functional materials and Diagnosis&Treatment devices of Zhejiang Province Wenzhou Institute of Biomaterials and EngineeringUniversity of Chinese Academy of SciencesWenzhou325000China

Silver nanowire(AgNW)films have been widely used as flexible transparent electrodes due to the high electrical conductance and high transmittance in the visible *** infrared(IR)properties of AgNW films,however,are seldom ***,we show that ultrathin AgNWs present high transmittance in the visible range(~95%)and high reflectance(60-70%)in the IR range of 8e14 *** a significant difference makes AgNW films invisible to naked eyes but visible under an IR camera,being an ideal selection for anti-counterfeit technologies,while no excitation is *** have demonstrated that AgNW films can be spray-coated on either flat or microstructured surfaces with high conformability and high scratch-resistance,and thus these anti-counterfeiting materials can be applied to a variety of *** AgNW-based anti-counterfeiting may be helpful for combating counterfeiting crimes in the fields of medicines,artwork,banknotes,brand luxuries,industrial parts,and so on.

关键词： Silver nanowires Anti-counterfeiting Infrared light Excitation-free Conformability