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Renal function after laparoscopic cholecystectomy and analgesia with tramadol and dipyrone or ketorolac

Health 2013年第11期5卷 35-41页

作者： Tiago Pechutti Medeiros Pedro Thadeu Galvao Vianna Leopoldo Muniz da Silva Lidia Raquel de Carvalho Gilberto Elias Wady Leandro Gobbo Braz Yara Marcondes Machado Castiglia Graduate Program in Anesthesiology Botucatu Medical SchoolUNESP-Universidade Estadual PaulistaBotucatuBrazil Department of Anesthesiology Botucatu Medical SchoolUNESP-Universidade Estadual PaulistaBotucatuBrazil Sao Luiz Hospital Sao PauloBrazil Department of Biostatics Institute of BiosciencesUNESP-Universidade Estadual PaulistaBotucatuBrazil Mercy Hospital Sao CarlosBrazil

Background: Laparoscopic cholecystectomy (LC) reduces surgical trauma and hospital stay, but requires effective and safe postoperative analgesia. This prospective and double-blind study investigated the effects of analgesia with tramadol combined with either dipyrone or ketorolac on the postoperative renal function of patients submitted to LC. Methods: Pre-and post-operatively (PO), estimated glomerular filtration rates (GFR), obtained by two formulas dependent on blood Cr and one on blood cystatin C values, and tubular enzymuria—alkaline phosphatase (AP), γ-glutamiltransferase (γ-GT)— were determined in well hydrated patients who underwent LC and analgesia with tramadol combined with either dipyrone (Dipyrone, n = 63) or ketorolac (Ketorolac, n = 63). Upon discharge from the post-anesthetic care unit (PACU), pain (through Verbal Numerical Scale—VNS) and need for rescue analgesia with morphine were evaluated. Results: There was hemodilution PO, which made GFR profile analysis more difficult—those dependent on Cr increased and statistically correlated, but those dependent on cystatin C did not change. There was a significant PO increase in AP in the Dipyrone and Ketorolac groups, and in the product of the both enzymes in the Ketorolac group. Upon PACU discharge, the Dipyrone group showed signifi cantly higher VNS scores than the Ketorolac group. All patients received morphine PO, and the total dose needed for pain control differed between groups, but without statistical significance. Conclusions: The association of tramadol with dipyrone or ketorolac in well hydrated patients submitted to LC had similar analgesic effectiveness in the PACU. Postoperatively, the effect on GFR may have been masked by hemodilution, and enzymuria was discreetly enhanced when ketorolac was used.

关键词： Kidney Function Tests Pneumoperitoneum Biological Markers Cystatin C Ketorolac Analgesia

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A Study of Laser Effectiveness in Injured Tissues Regeneration

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Journal of Biosciences and Medicines 2021年第3期9卷 55-63页

作者： Marcus Vinicius de Mello Pinto Aline Ronis Sampaio Miriam Viviane Baron Carolina Macedo Alves Moreira Carolina Gonçalves Pinheiro Michele Paula dos Santos Andres Felipe Mantilla Santamaria Cristine Brandenburg Nathália Ken Pereira Iketani Mara Alessandra Porto dos Reis Oliveira Alexandre Sancho Felice Picariello Esteban Fortuny Juliano Tibola Nilton Petrone Vilardi Junior Celulare institute Petrópolis Rio de Janeiro Brazil School of Medicine Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Brazil Dr. Daniel Thomaz Clinic Uberlandia Minas Gerais Brazil Faculty of Medicine of ABC (FMABC) Santo André Brazil Vale do Salgado Faculty (FVS) Ceará Brazil School of Medicine Industrial University of Santander (UIS) Bucaramanga Colombia Federal University of Ceará (UFC) Fortaleza Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Clínica Instituto de Cirurgia Plástica Vênus Barreiras Bahia Brazil Unigranrio Rio de Janeiro Brazil da Universita Federico II di Napoli Italia e Pesquisador do Internacional Research Group Rio Grande do Norte Brazil Universidad Finis Terrae Santiago Chile UDESC Florianopolis SC Brazil Fluminense Football Club Rio de Janeiro RJ Brazil

This study aimed to understand the use of low level laser in the regeneration of injured tissues. Also to design our own opinion on the subject, as chemists. Laser is nothing more than a light with very special characteristics that grant it therapeutic properties. We can observe the existence of three different types of laser, being one of them the therapeutic laser, which is used in substitution for medications or along with them. Another type of laser is the surgical one and, in addition to these, there is a diagnostic type. A great advantage is that, instead of taking the medicine, the patient’s own body can be activated by the laser to produce certain substances that can often replace the drugs. This is a literature review emphasizing the use of low level laser. Thus, the reflections from this study can contribute to the amplification of the production of knowledge that aims at the resignification of the use of laser in therapy. Greater attention was given to two types of laser radiation: He-Ne and As-Ga, both presenting a high therapeutic potential in superficial and deep injures. However, the He-Ne laser excels in superficial lesions, whereas the As-Ga laser does so in deep injures, such as articular, muscular, etc.

关键词： Laser Injury Regeneration

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Ovarian teratoma related anti-N-methyl-D-aspartate receptor encephalitis:A case series and review of the literature

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World Journal of Clinical Cases 2022年第16期10卷 5196-5207页

作者： Shan-Ji Li Min-Hua Yu Jie Cheng Wen-Xin Bai Wen Di Department of Obstetrics and Gynecology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Center for Reproductive Medicine Shanghai Jiao Tong UniversityShanghai 200135China Department of Medicine Shanghai Jiao Tong UniversityShanghai 200025China Department of Obstetrics and Gynecology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory of Gynecologic Oncology Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China

BACKGROUND Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis is a rare but important complication of ovarian *** July 2012 and December 2019,six patients with ovarian teratoma-associated anti-NMDAR encephalitis were enrolled in our hospital and their clinical characteristics,treatment,and follow-up were *** also conducted a systematic literature review of ovarian teratoma related anti-NMDAR encephalitis reports between January 2014 and December *** To better understand anti-NMDAR encephalitis through literature review and patients enrolled in our *** The six patients enrolled in the study were those diagnosed with anti-NMDAR *** history,clinical manifestations,and medications were recorded and optimum treatment provided in addition to maintaining a record of the *** addition,we also extensively surveyed the literature and provide summarized data from 155 published cases of anti-NMDAR encephalitis from 130 case *** and Scopus were the sources of these publications and the time period covered was 6 years ranging from January 2014 through December *** The six patients enrolled for this study presented with typical symptoms resulting in a diagnosis of ovarian teratoma induced anti-NMDAR *** interventions led to a positive outcome in all the patients,with five of six patients reporting full recovery and the sixth patient recovering with a few *** death was *** literature survey comprising of 155 patients cases across 130 case reports of anti-NMDAR encephalitis clearly indicated an upward trend in the reports/diagnosis in China,particularly in the surveyed time from 2014 through *** majority of patients(150/155)underwent surgical intervention resulting in positive *** treatment intervention was mentioned for one case while the four patients who were not surgically operated succumbed to the *** Suspected anti-NMDAR encepha

关键词： Ovarian teratoma Anti-N-methyl-D-aspartate receptor encephalitis Immunotherapy Surgery

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Role of orthoptics and scoring system for orbital floor blowout fracture:surgical or conservative treatment

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1928-1934页

作者： Juraj Timkovic Jiri Stransky Katerina Janurova Petr Handlos Jan Stembirek Clinic of Ophthalmology University Hospital Ostrava17.Listopadu 1790/5Ostrava 70852Czech Republic Department of Craniofacial Surgery Faculty of MedicineOstrava UniversitySyllabova 19Ostrava 70300Czech Republic Clinic of Oral and Maxillofacial Surgery University Hospital Ostrava17.Listopadu 1790/5Ostrava 70852Czech Republic IT4Innovations VSB-Technical University of OstravaStudentská6231Ostrava 70833Czech Republic Department of Forensic Medicine University Hospital Ostrava17.Listopadu 1790/5Ostrava 70852Czech Republic Laboratory of Molecular Morphogenesis Institute of Animal Physiology and Genetics CASVeveří97Brno 60200Czech Republic

AIM:To assess the role of orthoptics in referring patients with orbital floor blowout fracture(OFBF)for conservative or surgical treatment and based on the results,to propose a scoring system for such decision ***:A retrospective analysis of 69 patients with OFBF was performed(35 treated conservatively,34 surgically).The role of orthoptics in referring to surgery or conservative treatment was retrospectively evaluated,the factors with the highest significance for decision making were identified,and a scoring system proposed using Logistic ***:According to defined criteria,the treatment was unsuccessful in 2(6%)surgically treated and only in one(3%)conservatively treated *** proposed scoring system includes the defect size and several values resulting from the orthoptic examination,the elevation of the eyebulb measured on Lancaster screen being the most ***:The study demonstrates the benefits of orthoptic examination when making decisions on conservative or surgical treatment and for diagnosing ocular motility disorder(with or without binocular diplopia)in OFBF *** proposed scoring system could,following verification in a prospective study,become a valuable adjunctive tool.

关键词： orbital floor blowout fracture scoring system orthoptics ocular motility diplopia conservative treatment surgical treatment

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RNA binding protein-based risk score model for prognosis prediction of patients with hepatocellular carcinoma

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Chinese Medical Journal 2022年第23期135卷 2890-2892页

作者： Shengjun Xu Ning Ding Sheng Zheng Jun Chen Yafeng Wan Sunbin Ling Xiao Xu Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China institute of Organ Transplantation Zhejiang UniversityHangzhouZhejiang 310003China

To the Editor:Liver cancer is estimated to be the sixth most lethal tumor,representing approximately 5.0%of all cancer-related deaths.[1]Mainly due to the high rate of infection with hepatitis B virus,liver cancer remains a serious health concern in China,severely limiting the extension of human life *** China,the number of new cases and deaths from liver cancer is projected to exceed 400,000 in 2022.[2]Hepatocellular carcinoma(HCC)is the major histological type of liver cancer and is a complex and highly heterogeneous *** to the lack of early symptoms,patients with HCC are usually diagnosed at an advanced stage,thus losing the opportunity for surgical resection or liver *** recurrence and metastasis are major bafflements that limit the efficiency of surgical *** is urgent to explore the molecular mechanism of HCC to develop effective methods for early diagnosis and identify patients at high risk of tumor recurrence and metastasis.

关键词： patients diagnosis prediction

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Expert consensus on elderly patients with hip fracture under epidemic of novel coronavirus pneumonia

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中华创伤杂志 2020年第2期36卷 104-110页

作者： Liu Guohui Liu Ximing Tong Xiaoling Wang Dongliang Chen Yanxi Cao Liehu Liu Guodong Liu Jing Hu Yan Huang Biaotong Shi Zhongmin Zhang Dianying Hou Zhiyong Liu Hongjian Tong Peijian Song Shaojun Yang Lei Wang Yong Zhang Lei Luo Tao Wang Meitang Zhang Peng Zhang Yong Lin Haodong Yu Baoqing Mi Bobin Zhang Yingze Su Jiacan Department of Orthopedics Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430000 China Central Theater General Hospital of PLA Outpatient Department Hankou Hospital Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 Zhongshan Hospital Affiliated to Fudan University Shanghai 200032 Department of Traumatic Orthopedics Changhai Hospital Affiliated to Naval Medical University Shanghai 200433 Department of Orthopedics Luodian Hospital Baoshan District Shanghai 201908 Medical Center of Trauma and War Injuries Daping Hospital army Military Medical University Chongqing 400042 institute of Translational Medicine Shanghai University Shanghai 200444 Sixth People''s Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233 Peking University People''s Hospital Beijing 100035 Trauma Emergency Center Third Affiliated Hospital of Hebei Medical University Shijiazhuang 075061 First Affiliated Hospital of Zhengzhou University Wenzhou 450018 Zhejiang Provincial Hospital of Traditional Chinese Medicine Hangzhou 310003 Department of Emergency Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325027 Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Wenzhou 325001 Putuo District Central Hospital Affiliated to Shanghai University of Chinese Medicine Shanghai 200062 Shanghai Public Health Clinical Center Shanghai 200083 Changhai Hospital Naval Medical University Shandong Provincial Hospital Jinan 250021 Tangdu Hospital Air Force Medical University Xi''an 710038 First Affiliated Hospital of Shanghai Jiaotong University Shanghai 200080 Pudong Hospital Fudan University Shanghai 201399

With the spread of novel coronavirus pneumonia (NCP) in December 2019, the management and rehabilitation of elderly patients with hip fractures and protection of medical staff face new challenges, and need to be adjusted appropriately under this very circumstances. Hip fractures in the elderly account for more than half of osteoporotic fractures. Expert group formulate this consensus so as to make better decision against this epidemic and protect patients'' families and medical staff. This consensus elaborates not only epidemic condition of NCP, but also general principles of medical admission, treatment and protection for both medical staff and patients, in order to provide some reference and promote the standardization of clinical diagnosis and treatment of elderly patients with hip fractures under the condition of NCP.

关键词： Aged Hip fractures Coronavirus infections Pneumonia Expert consensus

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CRISPR/Cas9-mediated mutation of asparagine-linked glycosylation 13 transcript variant 1 causes epilepsy in mice

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Journal of Bio-X research 2020年第1期3卷 6-12页

作者： Yu Baoli Zhu Geng Li Shangang Chen Xuejin Fang Qian Zhang Yan Liu Yixun Li Shengtian Wu Ji Renji Hospital Shanghai Jiaotong University School of Medicine Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Bio-X InstitutesShanghai Jiao Tong UniversityShanghai Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education Ningxia Medical UniversityYinchuanNingxia Hui Autonomous Region Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education) Bio-X InstitutesShanghai Jiao Tong University Department of Biomedical Engineering School of Medical InstrumentShanghai University of Medicine&Health Sciences Department of Laboratory Animal Sciences Shanghai Jiao Tong University School of MedicineShanghai institute of Biophysics Chinese Academy of Sciences State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina

Objective:The asparagine-linked glycosylation 13 homolog(Alg13)has been identified as causative for congenital disorders of glycosylation type I with *** aim of this study was to determine whether mice carrying a mutated version of Alg13 could be used as a model for epileptic encephalopathies or congenital disorders of glycosylation type ***:A model of epileptic encephalopathy was established in C57BL/6 mice by introducing mutations in Alg13 via the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9)*** surgical procedures were approved by the Institutional Animal Care and use Committee of Shanghai Jiao Tong University(A2016084)on October 8,***:Mice with 3 different mutations,Alg13^(-54nt),Alg13^(-5nt)and Alg13^(-4nt),all of which are located in Alg13 transcript variant 1,were *** Alg13^(-5nt)mice exhibited spontaneous seizures similar to patients with Alg13 mutations,suggesting that they could be used as a model for *** blot analysis demonstrated that Alg13^(-5nt)mice had lower levels of Alg13 expression than wild-type *** observations showed that two of the 17 Alg13^(-5nt)mice had stage 5 seizures involving jumping and falling,while 12 had stage 3 seizures with head ***:The Alg13 mouse model provides an outstanding tool for studying epileptic encephalopathies and investigating different aspects of defects in glycosylation or other post-translational modification that cannot be assessed in patients or cell culture systems.

关键词： Alg13 CRISPR/Cas9 epilepsy mouse mutant

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Clinical application and management of temporary mechanical circulatory support:A clinical consensus

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Chinese Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huishan Wang Yingbin Xiao Xianqiang Wang Jinsong Huang Yang Yan Pramod Bonde Neel Sodha Pavan Atluri Juan Pablo Maureira AndréVincentelli Masanobu Yanase Yixuan Wang Haitao Zhang Xiaotong Hou Yoshijuki Takami Pascal Leprince Thierry Folliguet Frank W Sellke Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs Department of Cardiovascular Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovascular Surgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovascular Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac Surgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic Surgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovascular Surgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovascular Surgery and Transplantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovascular Surgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult surgical Intensive Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intensive Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory support(tMCS)plays a pivotal role in managing severe or refractory cardiogenic shock(CS),furnishing essential hemodynamic support,and sustaining organ perfusion from hours to weeks,or to even *** the past decade,the utilization of tMCS has witnessed a signicant increase in American and European *** in Asia,the newly developed concepts and devices constituting tMCS have also made rapid ***,the absence of a consensus or standardized guidelines,especially for the Asian population considering inherited polymorphism,is *** address this knowledge gap,eight associations/societies and experts in thiseld came up with the present consensus after repeated discussions,more specically for the Asian *** comprehensively elucidates the commonly employed tMCS devices,criteria for patient selection,indications and contraindications,clinical management,and the optimal timing for implantation and *** goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical ***-length version of the consensus can be seen in Supplementary File,http://***/CM9/B883.

关键词： application statement discussions

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Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 739-758页

作者： Zhengtao Liu Wenchao Wang Li Zhuang Jingfeng Liu Shuping Que Dan Zhu Linfang Dong Jian Yu Lin Zhou Shusen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina NHC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Organ Transplantation of Zhejiang Province First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College HangzhouChina Science for Life Laboratory KTH-Royal Institute of TechnologySE-17121StockholmSweden Dingxiang Clinics HangzhouChina

Background:Liver transplantation(LT)is one of the most effective surgical treatment for patients with end-stage liver *** is a contributor for inferior graft *** its impact and safety on transplantation was less assessed in Chinese ***:Graft steatosis and related information involved in recipients,donors and surgical procedures were retrospectively collected from 239 ***:Donor macrosteatosis(MaS)caused about 2.14 and 2.80 folds of increment on patient and graft ***-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10%(Pused by MaS grafts was observed in patients with severer ischemia reperfusion ***:Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese *** study is worthy to validate these results and investigate inner mechanism under the phenomenon.

关键词： Steatosis prognosis liver transplantation(LT) dose-response analysis

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Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis:A randomized,activecontrol,multicenter clinical trial

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World Journal of Stem Cells 2023年第12期15卷 1063-1076页

作者： Cong-Zi Wu Zhen-Yu Shi Zhen Wu Wen-Jun Lin Wei-Bo Chen Xue-Wen Jia Si-Cheng Xiang Hui-Hui Xu Qin-Wen Ge Kai-Ao Zou Xu Wang Jia-Li Chen Ping-Er Wang Wen-Hua Yuan Hong-Ting Jin Pei-Jian Tong institute of Orthopaedics and Traumatology of Zhejiang Province The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina epartment of Orthopedic Surgery The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Orthopaedic Surgery Tongde Hospital of Zhejiang ProvinceHangzhou 310012China Department of Orthopaedic Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325015Zhejiang ProvinceChina Department of Orthopaedic Surgery Ruian Hospital of Traditional Chinese MedicineWenzhou 325299Zhejiang ProvinceChina Department of Orthopaedics Ningbo First HospitalNingbo 315010Zhejiang ProvinceChina The First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Osteoarthritis(OA)is the most prevalent form of degenerative whole-joint *** the final option of knee replacement,arthroscopic surgery was the most widely used joint-preserving surgical *** regenerative therapies,such as those involving platelet-rich plasma,mesenchymal stem cells,and microfragmented adipose tissue(MFAT),have been pushed to the forefront of treatment to prevent the progression of ***,MFAT has been successfully applied to treat different types of orthopedic *** To assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA(KOA).METHODS A randomized,multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang,***,302 patients diagnosed with KOA(Kellgren-Lawrence grades 2-3)were randomized to the MFAT group(n=151,were administered MFAT following arthroscopic surgery),or the control group(n=151,were administered hyaluronic acid following arthroscopic surgery).The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,the visual analog scale(VAS)score,the Lequesne index score,the Whole-Organ Magnetic Resonance Imaging Score(WORMS),and safety over a 24-mo period from *** The changes in the WOMAC score(including the three subscale scores),VAS pain score,and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups,as well as when comparing values at the posttreatment visit and those at baseline(Pus adverse events

关键词： Osteoarthritis Microfragmented adipose tissue Lipogems Arthroscopic surgery Knee

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