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World Journal of Gastroenterology 2021年第33期27卷 5460-5473页

作者： Pankaj Garg Baljit Kaur Vipul D Yagnik Sushil Dawka Geetha R Menon Department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia Department of Colorectal Surgery Indus International HospitalMohali 140201PunjabIndia Department of Radiology SSRD Magnetic Resonance Imaging InstituteChandigarh 160011ChandigarhIndia Department of surgical Gastroenterology Nishtha Surgical Hospital and Research CenterPatan 384265GujaratIndia Department of Surgery SSR Medical CollegeBelle RiveMauritius Department of Statistics Indian Council of Medical ResearchNew Delhi 110029New DelhiIndia

Magnetic resonance imaging(MRI)is considered the gold standard for the evaluation of anal *** is sufficient literature available outlining the interpretation of fistula MRI before performing ***,the interpretation of MRI becomes quite challenging in the postoperative period after the surgery of fistula has been ***,there are scarce data and no set guidelines regarding analysis of fistula MRI in the postoperative *** this article,we discuss the challenges faced while interpreting the postoperative MRI,the timing of the postoperative MRI,the utility of MRI in the postoperative period for the management of anal fistulas,the importance of the active involvement and experience of the treating clinician in interpreting MRI scans,and the latest advancements in the field.

关键词： Anal fistula Magnetic resonance imaging Postoperative Hyperintensity Internal opening

Robust single machine scheduling problem with uncertain job due dates for industrial mass production

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Journal of Systems Engineering and Electronics 2020年第2期31卷 350-358页

作者： YUE Fan SONG Shiji JIA Peng WU Guangping ZHAO Han Department of Automation Tsinghua UniversityBeijing 100084China research institute of Systems Engineering Beijing 100072China Jiuquan Satellite Launch Centre Jiuquan 735000China Department of Basic Science Army Logistics AcademyChongqing 401311China

The single machine scheduling problem which involves uncertain job due dates is one of the most important issues in the real make-to-order environment. To deal with the uncertainty, this paper establishes a robust optimization model by minimizing the maximum tardiness in the worst case scenario over all jobs. Unlike the traditional stochastic programming model which requires exact distributions, our model only needs the information of due date intervals. The worst case scenario for a given sequence that belongs to a set containing only n scenarios is proved, where n is the number of jobs. Then, the model is simplified and reformulated as an equivalent mixed 0-1 integer linear programming(MILP) problem. To solve the MILP problems efficiently, a heuristic approach is proposed based on a robust dominance rule. The experimental results show that the proposed method has the advantages of robustness and high calculating efficiency, and it is feasible for large-scale problems.

关键词： robust optimization single machine scheduling maximum tardiness uncertain due date

Toward broad optimal output bandwidth dielectric elastomer actuators

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Science China(Technological Sciences) 2022年第5期65卷 1137-1148页

作者： CAO ChongJing CHEN LiJin LI Bo CHEN GuiMin NIE ZeDong WANG Lei GAO Xing research Centre for Medical Robotics and Minimally Invasive surgical Devices Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen518055China Shaanxi Key Laboratory of Intelligent Robots School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an710049China

Dielectric elastomer actuators(DEAs)are one of the most promising soft actuation technologies owing to their relatively high power density and electromechanical efficiency enabled by a resonant actuation ***,existing DEA designs suffer from a very narrow optimal output bandwidth close to resonance and poor output control capability due to their fixed geometrical *** condition greatly limits their applications in programmable actuation and broad-bandwidth ***,this work developed a novel resonance tunable DEA(RTDEA)design for broad-optimal-output actuation bandwidths that is enabled by an integration of a stiffness and voltage control *** design features a broad resonant frequency adjustment from 84 to 126 Hz and independent tunings of its resonant amplitude and *** studies were conducted to illustrate the fundamental principles behind the resonance tuning strategy,and optimization was performed to maximize the tuning ***,a resonance tuning control strategy is proposed to achieve accurate adjustments of the RTDEA’s resonance based on the stiffness and voltage control *** resonance tunable soft actuators are envisioned to greatly expand DEAs’applications in,for instance,soft robotic locomotion,human–robot communication,and active vibrational control with demands of broad actuation bandwidths and high output performance.

关键词： dielectric elastomer actuators soft robotics soft actuators resonance tuning resonant actuation

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Effective forecast of Northeast Pacific sea surface temperature based on a complementary ensemble empirical mode decomposition–support vector machine method

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Atmospheric and Oceanic Science Letters 2017年第3期10卷 261-267页

作者： LI Qi-Jie ZHAO Ying LIAO Hong-Lin LI Jia-Kang institute of Sciences University of Science and Technology of the Chinese People's Liberation Army

The sea surface temperature （SST） has substantial impacts on the climate; however, due to its highly nonlinear nature, evidently non-periodic and strongly stochastic properties, it is rather difficult to predict SST. Here, the authors combine the complementary ensemble empirical mode decomposition （CEEMD） and support vector machine （SVM） methods to predict SST. Extensive tests from several different aspects are presented to validate the effectiveness of the CEEMD-SVM method. The results suggest that the new method works well in forecasting Northeast Pacific SST at a 12-month lead time, with an average absolute error of approximately 0.3℃ and a correlation coefficient of 0.85. Moreover, no spring predictability barrier is observed in our experiments.

关键词： Sea surface temperature complementary ensemble empirical mode decomposition support vector machine prediction

Tunable electron and phonon properties of folded single-layer molybdenum disulfide

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Nano research 2018年第3期11卷 1541-1553页

作者： Jie Peng Peter W. Chung Madan Dubey Raju R. Namburu Department of Mechanical Engineering University of Maryland College Park MD 20742 USA Sensors & Electron Devices Directorate U.S. Army Research Laboratory Adelphi MD 20783 USA Computational & Information Sciences Directorate U.S. Army Research Laboratory Aberdeen Proving Ground MD 21005 USA

A unique feature of transition metal dichalcogenides is their single-layer form, which enables folding. Although folding has been found to significantly affect the photoluminescence spectrum and some in-plane properties, only limited insight has been gained on how to modulate those properties. In this report, we examine the structure of folds of a single sheet of MoS2 and the dependence of the ground-s tate electronic and phonon transport properties on the wrapping length. As the folded structure is effectively a bilayer that terminates in a loop, the wrapping length modulates the relative size of the bilayer region to the closed loop along the edge. A combination of computational methods, including approaches based on variational mechanics, classical potentials, and density functional theory, are employed. Highly accurate calculations of the reference folded structure are first carried out to show that the folded structure is largely insensitive to the wrapping length. The folded structures are subsequently used to estimate the electronic band gap, which is found to vary significantly as a function of the wrapping length, and converges from below to the limit value corresponding to an infinite bilayer. The gap values range from 0.43 to 1.09 eV, with a crossover to an indirect gap, which suggests that the transitions must be lattice-assisted, similar to the transitions in the bilayer and bulk forms. However, the phonons, while affected by the formation of the folded structure, are insensitive to the wrapping length. In fact, the overall thermal transport behavior along the folding axis is unchanged. The possibility of modulating the gap value while keeping the thermal properties unchanged opens up new exciting avenues for further applications of this emerging material.

关键词： molybdenum disulfide folded structure electronic band structure thermal conductivity phonon

An intelligent algorithm for coherent sound source localization based on a strong tracking filter

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Chinese Journal of Aeronautics 2019年第8期32卷 1895-1902页

作者： Jianchao JI Liang WANG Mingxin WANG Song FU School of Aerospace Engineering Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering Army Aviation InstituteBeijing 101123China

Background noise is inevitable when sensor arrays are used for aeroacoustic measurements in wind tunnels. The direct removal of background noise, however, would affect the measurement accuracy. In particular, the existing array signal processing algorithms are either invalid or inefficient for removing the noise that is coherent with the signal of interest. In this paper, an intelligent algorithm is developed to localize the coherent sound sources and background noise in real time by iteratively checking the collected data from the array. The proposed method can automatically adjust the suboptimal fading factor to extract useful information as much as possible in residual sequence. This algorithm is tested in simulations and then demonstrated in an *** to the two existing methods, the results indicate that the new method has a good phase-shift tracking ability and rapid estimation-error convergence speed, and can achieve an acceptable performance even for low-cost acoustic sensors. Overall, the proposed method should assist array beamforming and hence benefit aeroacoustic measurement.

关键词： Aeroacoustics Beamforming Coherence Sensor arrays Signal processing

Optimal Design of High-Speed Partial Flow Pumps using Orthogonal Tests and Numerical Simulations

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1203-1218页

作者： Jiaqiong Wang Tao Yang Chen Hu Yu Zhang Ling Zhou National research Center of Pumps Jiangsu UniversityZhenjiangChina Wenling Fluid Machinery Technology institute of Jiangsu University WenlingChina National Engineering research Center for Disaster and Emergency Rescue Equipment Army Logistics AcademyChongqingChina

To investigate the influence of structural parameters on the performances and internal flow characteristics of partial flow pumps at a low specific speed of 10000 rpm,special attention was paid to the first and second stage impeller guide ***,the impeller blade outlet width,impeller inlet diameter,blade inclination angle,and number of blades were considered for orthogonal ***,nine groups of design solutions were formed,and then used as a basis for the execution of numerical simulations(CFD)aimed at obtaining the efficiency values and heads for each design solution *** influence of impeller geometric parameters on the efficiency and head was explored,and the“weight”of each factor was obtained via a range *** structural parameters were finally chosen on the basis of the numerical simulation results,and the performances of the optimized model were verified accordingly(yet by means of CFD).Evidence is provided that the increase in the efficiency and head of the optimized model was 12.11%and 23.5 m,respectively,compared with those of the original model.

关键词： High-speed partial flow pump orthogonal test optimal design numerical calculation

Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu Zhuolei Han Xin Jin Jusung An Jaewon Kim Wenting Chen Jong Seung Kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China institute of Burn research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury

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Cell research 2004年第6期14卷 450-459页

作者： Juliann G.KIANG Department of Cellular Injury Walter Reed army institute of research Silver Spring MD 20910-7500 usA. Departments of Medicine and of Pharmacology Uniformed Services University of The Health Sciences Bethesda MD 20814-4799

Inducible heat shock protein 70 kD (HSP-70i) has been shown to protect cells, tissues, and organs from harmful assaults in in vivo and in vitro experimental models. Hemorrhagic shock followed by resuscitation is the principal cause of death among trauma patients and soldiers in the battlefield. Although the underlying mechanisms are still not fully understood, it has been shown that nitric oxide (NO) overproduction and inducible nitric oxide synthase (iNOS) over expression play important roles in producing injury caused by hemorrhagic shock including increases in polymorpho nuclear neutrophils (PMN) infiltration to injured tissues and leukotriene B4 (LTB4) generation. Moreover, transcription factors responsible for iNOS expression are also altered by hemorrhage and resuscitation. It has been evident that either up-regulation of HSP-70i or down-regulation of iNOS can limit tissue injury caused by ischemia/reperfusion or hemorrhage/resuscitation. In our laboratory, geldanamycin, a member of ansamycin famil

关键词： inducible HSP-70 iNOS eNOS hemorrhage caspase-3 ATP KLF6 resuscitation

Radix Sanguisorbae Improves Intestinal Barrier in Septic Rats via HIF-1α/HO-1/Fe^(2+)Axis

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Chinese Journal of Integrative Medicine 2024年第12期30卷 1101-1112页

作者： LIU Yi-yan BAO Dai-qin ZHANG Zi-sen ZHU Yu LIU Liang-ming LI Tao State Key Laboratory of Trauma Burns and Combined InjuriesDepartment of War Wound Shock and TransfusionInstitute of Surgery ResearchChongqing 400042China Department of Anesthesiology Army Medical Center of PLAChongqing 400042China

Objective:To investigate whether Radix Sanguisorbae(RS,Diyu)could restore intestinal barrier function following sepsis using a cecal ligation and puncture(CLP)-induced septic rat model and lipopolysaccharide(LPS)-challenged IEC-6 cell model,***:Totally 224 rats were divided into4 groups including a control,sham,CLP and RS group according to a random number *** rats in the control group were administrated with Ringer's lactate solution(30 mL/kg)with additional dopamine[10μg/(kg·min)]and given intramuscular injections of cefuroxime sodium(10 mg/kg)12 h following *** rats in the RS group were administrated with RS(10 mg/kg)through tail vein 1 h before CLP and treated with RS(10 mg/kg)12 h following *** rats in the sham group were only performed abdominal surgery without *** rats in the CLP group were performed with CLP without any *** other steps were same as control *** effects of RS on intestinal barrier function,mesenteric microvessels barrier function,multi-organ function indicators,inflammatory response and 72 h survival window following sepsis were *** vitro,the effects of RS on LPS-challenged IEC-6 cell viability,the expressions of zona occludens-1(ZO-1)and ferroptosis index were evaluated by cell counting kit-8,immunofluorescence and Western blot *** tools were applied to investigate the pharmacological network of RS in sepsis to predict the active compounds and potential protein targets and ***:The sepsis caused severe intestinal barrier dysfunction,multi-organ injury,lipid peroxidation accumulation,and ferroptosis in *** treatment significantly prolonged the survival time to 56 h and increased 72-h survival rate to 7/16(43.75%).RS also improved intestinal barrier function and relieved intestinal ***,RS significantly decreased lipid peroxidation and inhibited ferroptosis(P<0.05 or P<0.01).Administration of RS significantly worked better than Ringer'

关键词： Radix Sanguisorbae sepsis ferroptosis intestinal barrier function network pharmacology Chinesemedicine