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Individualized therapy for breast cancer:a decade of improvement

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中华乳腺病杂志（电子版） 2015年第4期9卷 223-230页

作者： Louis Wing Cheong Chow Wings Tjing Yung Loo Qing Liu institute for Applied research in Medicine and Health Macao University of Science and Technology organisation for oncology and translational research and unimed medical institute

Breast cancer is the most prevalent female cancer in both the developed and less developed *** to WHO 2013 estimates,there were over 522 000 female breast cancer deaths in2012[1].Breast cancer(1.7 million)was the second commonly diagnosed cancer worldwide after lung cancer(1.8 million),and followed by colorectal cancer(1.4 million)[1].In

关键词：乳腺病临床诊断治疗

Expression of cancer stem cell surface markers after chemotherapeutic drug treatment to reflect breast cancer cell regrowth

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中华乳腺病杂志（电子版） 2014年第1期8卷 28-32页

作者： Qing Liu Wings Tjing Yung Loo Louis Wing Cheong Chow Kelly Wei Yu Rui unimed medical institute and Organizationfor oncology and translational research

Objective To detect the cell viability and the expressions of stem cell surface markers after chemotherapeutic drug *** We observed the cytotoxic effects of three chemotherapeutic agents[epirubicin(Epi),fluorouracil(5-FU)and cyclophosphamide(Cyc)]in three cell lines,and the cell viabilities after removed these chemotherapeutic *** of stem cell surface markers CD44,CD24,CD90,CD14 and aldehyde dehydrogenase1(ALDH1)in breast cancer cells were analyzed by real-time *** post hoc analysis(Tukey’s tests)in conjunction with one-way ANOVA was used for statistical *** The initial cytotoxic efficacy was most *** the treatment of the same therapeutic agents,cell viability was decreased by 64.8%35.14%,32.25%in BT-483 cells,66.4%,22.94%and 45.88%in MDA-MB-231 cells,97.1%,99.5%and 76.4%in MCF *** difference was significant compared with that before treatment(P=0.000).However,the inhibitory effects were diminished after chemotherapeutic agent *** viabilities were increased to 167.9%,212.04%and 188.66%in MDA-MB-231 cells at48 h after *** 72 h after withdrawal,cell viability was increased with a significant difference in three cell lines(all P values=0.000).Expressions of CD44 and ALDH1 were most prevalent for MDA-MB-231,BT-483 and MCF-7 ***1 mRNA level was significant higher in BT-483(HER-2 overexpression cell line)than MDA-MB-231(triple negative cell line)(P=0.012).CD14 mRNA level in MCF-7 cells were significantly lower than that in MDA-MB-231 and BT-483(P=0.003,0.001).BT-483 showed significantly higher level of CD44 than MDA-MB-231 and MCF-7 cell line(P=0.013,0.020),and no significant difference was detected between MDA-MB-231 and MCF-7 breast cancer cells(P=0.955).CD90 mRNA expressions were detected in MDA-MB-231 cells and MCF-7 cells,but not in BT-483 *** Some malignant cells could survive in vitro and begin to proliferate again between cycles of chemotherapy.

关键词：乳腺癌细胞活性治疗方法临床分析

Voltage-gated K^+channels promote BT-474 breast cancer cell migration

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Chinese Journal of Cancer research 2018年第6期30卷 613-622页

作者： Louis WC Chow Ka-Shun Cheng Kar-Lok Wong Yuk-Man Leung State Key Laboratory of Quality research in Chinese Medicines Macao University of Science and TechnologyTaipaMacao 999078China unimed medical institute Hong Kong 999077China organisation for oncology and translational research Hong Kong 999077China Department of Anesthesiology China Medical University HospitalTaiehung 40447TaiwanChina Department of Anesthesiology the Qingdao University Yuhuangding HospitalYantai 264000China Department of Physiology China Medical UniversityTaichung 40402TaiwanChina

Objective: A variety of ion channels have been implicated in breast cancer proliferation and *** K+(Kv) channels not only cause repolarization in excitable cells,but are also involved in multiple cellular functions in non-excitable *** this study we investigated the role of Kv channels in migration of BT474 breast cancer ***: Transwell technique was used to separate migratory cells from non-migratory ones and these two groups of cells were subject to electrophysiological examinations and microfluorimetric measurements for cytosolic *** migration was examined in the absence or presence of Kv channel ***: When compared with non-migratory cells,migratory cells had much higher Kv current densities,but rather unexpectedly,more depolarized membrane potential and reduced *** transcriptasepolymerase chain reaction(RT-PCR) analysis revealed the presence of Kv1.1,Kv1.3,Kv1.5,Kv2.1,Kv3.3,Kv3.4 and Kv4.3 *** migration was markedly inhibited by tetraethylammonium(TEA),a delayed rectifier Kv channel blocker,but not by 4-aminopyridine,an A-type Kv channel ***: Taken together,our results show that increased Kv channel expression played a role in BT474 cell migration,and Kv channels could be considered as biomarkers or potential therapeutic targets for breast cancer *** mechanism(s) by which Kv channels enhanced migration appeared unrelated to membrane hyperpolarization and Cainflux.

关键词： Breast cancer Kv channels migration biomarkers

Adjuvant therapy for hormone receptor-positive breast cancer: Perspective from a survey on breast cancer physicians' acceptance of practice-changing data

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Chinese Journal of Cancer research 2023年第2期35卷 191-196页

作者： Asian institute of Clinical oncology(AICO)Expert Panel Louis W.C.Chow 不详 organisation for oncology and translational research Unit 160416/FStrand 5050 Bonham StrandSheung WanHong Kong SARChina

A cross-sectional online survey was conducted.A high proportion of the Chinese breast cancer(BC)physician respondents(n=77)would prescribe extended adjuvant endocrine therapy(AET)with aromatase inhibitors(AI)beyond 5 years for postmenopausal females with BC,especially those with higher *** with≥15 years of clinical experience were more likely to prescribe a longer duration of AET for low-risk *** of the respondents considered intermittent letrozole as an acceptable *** respondents would prescribe adjuvant chemotherapy to genomic high-intermediate risk[Oncotype DX recurrence score(RS)21-25]females aged≤50 years regardless of the clinical risk classification.

关键词： Breast neoplasms surveys and questionnaires chemotherapy adjuvant practice patterns physicians

Effect of Tai Chi Chuan on serotonin and cortisol for monitoring stress and quality of life in post-treatment breast cancer patients

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中华乳腺病杂志（电子版） 2014年第4期8卷 34-40页

作者： William Wai Nam Tsang Wings Tjing Yung Loo Louis Wing Cheong Chow Elizabeth Lam Yan Ng Adrian Yun San Yip Jianping Chen Department of Rehabilitation Sciences Hong Kong Polytechnic University unimed medical institute and organisation for oncology and translational research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective Immediate physical exercise has been recommended for patients in the recovery phase to improve survival and quality of life(QOL)and reduce recurrence of *** new NCCN Guidelines for Survivorship also highlighted the role of exercise in post-cancer health,encouraging patients to perform light physical activity following *** aim of our study is to effect of Tai Chi Chuan(TCC)on serotonin and cortisol for monitoring stress and QOL in post-treatment breast cancer *** Totally85 post-treatment breast cancer patients were enrolled in this study to observe the effects of practicing TCC on recovery,as well as stress and happiness which are indicators of QOL of in *** blood was drawn from study subjects to analyze the levels of serotonin,cortisol and high sensitive C-reactive protein(HSCRP)at baseline,and at 3,6 and 12 months of TCC *** was drawn from healthy subjects only at baseline.A QOL questionnaire was administered to study subjects at three time points throughout the study,and once for healthy *** data were processed by analysis of variance of repeated *** At 3,6 and 12 months time points following regular TCC exercise,WBC,RBC,hemoglobin in blood samples showed a statistically significant difference(F=161.55,172.14,289.73;all P=0.00);the level of serotonin(biomarker for well-being),cortisol(indicator of stress)and HS-CRP(biomarker for inflammation)showed a statistical improvement(F=307.46,182.85,102.23;all P=0.00).After 3,6 and 12 months of regular TCC exercise,according to the results of QOL questionnaire,the indicators including quality of sleep,perceived hunger,fatigue,contentment,stress and social interaction presented a significant difference(F=312.98,222.64,543.90,46.05,28.10,78.92,all P<0.05),while there was no statistical difference in life dissatisfaction(F=56.61,P=0.166)Conclusions TCC physical activity for post-treatment breast cancer patients improved QOL and overall

关键词：乳腺病患者临床分析治疗方法

Aberrant methylation of Glutathione S-transferase P1 and E-cadherin in invasive ductal breast carcinoma and fibroadenoma

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中华乳腺病杂志（电子版） 2010年第5期4卷 14-19页

作者： Wings Tjing Yung Loo Mary Ngan Bing Cheung Louis Wing Cheong Chow unimed medical institute organisation for oncology and translational research Hong Kong School of Chinese Medicine The University of Hong Kong Clinical Trial Centre Li Ka Shing Faculty of MedicineThe University of Hong Kong

Objective To investigate the hypermethylation status of glutathione transferase P1(GSTP1)and E-cadherin(ECAD),TSGs(tumor suppressor genes)in our breast cancer samples and explore their correlation with clinicopathological features of corresponding cancer *** One hundred and thirty-six IDC(invasive ductal carcinoma)patients were recruited for analysis and 16 fibroadenoma patients acted as *** extraction and methylation-specific PCR(MSP)were subsequently performed preceded by pathological *** The percentage of hypermethylated GSTP1 in carcinoma and fibroadenoma groups was 34.92% and 15.79% respectively and the percentage of hypermethylated ECAD in carcinomas and fibroadenomas was 18.00% and 0.00% *** had the highest percentage of c-erbB2 overexpression being 54.55% among the clinicopathological *** Hypermethylation patterns are frequent in IDC and seem to relate to c-erbB2 overexpression,and such epigenetic change should not be neglected in *** methylation status in cancer patients can be determined at early stage and it may be a reference for better treatment planning.

关键词：乳腺癌临床治疗疗效

Methods of early detection:would clinical breast examination and breast ultrasonography be a good alternative to mammography?

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中华乳腺病杂志（电子版） 2011年第6期5卷 1-9页

作者： Adrian YS Yip Louis WC Chow Wings TY Loo Eleanor YY Ong Wincy Chan organisation for oncology and translational research Hong Kong Clinical Trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Comprehensive Centre for Breast Diseases UNIMED Medical InstituteHong Kong

Breast cancer is one of the leading causes of cancer deaths among women[1].In the past 40 years,breast cancer incidence has doubled or even tripled in developed countries such as South Korea and Japan; whereas it is a... 详细信息

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Immunotherapeutic approach on triple negative breast cancer: recent progress and predictors of response

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中华乳腺病杂志（电子版） 2022年第4期16卷 199-203页

作者： Louis Wing-Cheong Chow Erich Ferdiansyah Lie unimed medical institute Hong KongChina organisation for oncology and translational research Hong KongChina

Clinical trials utilizing the immune checkpoint inhibitors,particularly the IMpassion and KEYNOTE trials,have made it possible to understand how the immune checkpoint inhibitors can be used to treat patients with triple negative breast cancer(TNBC).Patient stratification based on simply PD-L1 positivity has now been shown to be insufficient and inaccurate as a predictor of response to the immune checkpoint inhibitors,and the role of the tumor microenvironment has become more *** article serves as a brief overview of the latest progress on the clinical trials as well as the potential predictors of response to immune checkpoint blockade.

关键词： Triple negative breast cancer Immunotherapy Microenvironment

Application of single and combination therapy of clarithromycin and tamoxifen to suppress breast cancer cell proliferation and metabolism

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中华乳腺病杂志（电子版） 2012年第1期6卷 26-31页

作者： Wings T.Y.Loo Louis W.C.Chow Adrian Y.S Yip Mary N.B.Cheung unimed medical institute Organization for oncology and translational research Hong Kong Organization for oncology and translational research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong Clinical Trial Center Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective This study compares the anti-tumor effects of single and combination use of clarithromycin and tamoxifen on estrogen receptor (ER) positive breast cancer cell lines,BT-483 and MCF-7 as well as triple negative cell line,MBA-MD-231,which acts as a negative *** effect of solid breast tumor inhibition by clarithromycin is also *** BT-483,MCF-7 and MBA-MD-231 were cultured in 6-well plates in a 37 ℃ humidified incubator without CO2 for 24 h prior to the addition of the test *** test groups were clarithromycin (Group 1),tamoxifen (Group 2),clarithromycin and tamoxifen (Group 3),and control (Group 4).Group 3 was prepared in 1 to 1 ratio at a concentration of 1.5 mmol/L clarithromycin and 25 μmol/L *** the other hand,1 mm3 solid breast tumors were submerged into various groups as above for 24 *** the harvest day,the proliferation of cancer cells and solid breast tumor samples were measured by WST-1 proliferation reagent while ATP bioluminescence assay was employed to measure the metabolic rate of the three cell *** The proliferation of BT-483 and MCF-7 was suppressed most by combination use of clarithromycin and tamoxifen with statistical *** two drugs did not have an inhibitory effect on the hormonal negative cancer *** solid breast tumor samples,all the test groups showed reduced metabolic rate as compared with the control group (P<0.05).Conclusion Combination use of tamoxifen and clarithromycin are effective in suppressing cell proliferation and metabolism rate of breast cancer cells while single use of clarithromycin effectively inhibits the proliferation of solid breast tumor.

关键词：摘要编辑部编辑工作读者