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LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第16期16卷 2046-2054页

作者： Huang, Guo-Liang Li, Bin-Kui Zhang, Mei-Yin Zhang, Hui-Zhong Wei, Rong-Rong Yuan, Yun-Fei Shi, Ming Chen, Xiao-Qian Huang, Long Li, An-Hua Huang, Bi-Jun Li, Hong-Hua Wang, Hui-Yun Sun Yat Sen Univ Ctr Canc State Key Lab Oncol S China Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc Dept Hepatobiliary Oncol Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc Dept Pathology Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Ctr Canc Dept Ultrasound & Electrocardiogram Guangzhou 510060 Guangdong Peoples R China umdnj Robert Wood Johnson Med Sch Canc Inst New Jersey Dept Microbiol Mol Genet & Immunol Piscataway NJ 08854 USA

AIM:To investigate genes around the locus D4S2964 affected by loss of heterozygosity(LOH) and their clinical ***:Four hundred and forty single nucleotide polymorphisms(SNPs) located at 49 genes around D4S2964 were selected from the National Center for Biotechnology Information website for the SNPs microarray *** of SNPs markers in 112 cases of hepatocellular carcinoma(HCC) tissues and paired adjacent liver tissues were investigated by the SNPs *** correlation between allelic losses with clinicopathological features and overall survival was ***:A f ine map of LOH of SNPs in genes around D4S2964 was *** average frequency of LOH in genes was 0.39.A correlation between cirrhosis and the FAL index(fractional allelic loss) was found(P = 0.0202).Larger tumor size was found to be signif icantly associated with LOH in genes ADP-ribosyltransferase 3(ART3),nucleoporin 54 kDa(NUP54),scavenger receptor class B,member 2(SCARB2) and coiled-coil domain containing 158(CCDC158)(P = 0.043,P = 0.019,P = 0.001,P = 0.037,respectively).Kaplan-Meier analysis showed that patients with LOH in ARD1 homolog B(ARD1B) and septin 11(SEPT11) had a significantly lower survival rate than those with retention(P = 0.021 and P = 0.004,respectively).A Cox regression model suggested that LOH in ARD1B and SEPT11,respectively,were predictors of the overall survival in HCC(P = 0.006 and P = 0.026,respectively).CONCLUSION:LOH in genes around D4S2964 may play an important role in HCC development and *** in ARD1B and SEPT11 could serve as novel prognostic predictors in HCC patients.

关键词： ARD1 homolog B Hepatocellular carcinoma Loss of heterozygosity Septin 11 Single nucleotide polymorphism

一种小鼠新α干扰素亚型基因的发现、序列测定与表达

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中国科学（C辑） 1997年第3期27卷 216-221页

作者：王焱周鸣南王征宇蔡菊娥孙兰英刘新垣 B.L.Daugherty S.Pestka 中国科学院上海生物化学研究所上海200031 Dept.of Mol.Gen.&Micro.umdnj-robert wood johnson med.sch.

用引物测序法从小鼠cDNA库的克隆中发现一种小鼠新型α干扰素(简称mIFN-αB),其结果与已知基因库中所有的小鼠α干扰素不同.以后对其编码区及5’和3’端非翻译区的核苷酸序列共1.2kb进行了全顺序测定.结果申请加入了基因库.将此α干扰... 详细信息

用引物测序法从小鼠cDNA库的克隆中发现一种小鼠新型α干扰素(简称mIFN-αB),其结果与已知基因库中所有的小鼠α干扰素不同.以后对其编码区及5’和3’端非翻译区的核苷酸序列共1.2kb进行了全顺序测定.结果申请加入了基因库.将此α干扰素基因装入表达载体中,在大肠杆菌中得到了很好的表达.

关键词：鼠 α干扰原核表达亚型基因序列测定

Characterizing the Impact of Caffeine on Heart Arrhythmias

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Open Journal of Preventive med.cine 2023年第11期13卷 285-295页

作者： Siddhant Malani Gaurav Pathak Hill Spring International sch.ol Mumbai India Department of Dermatology Robert Wood Johnson School of Medicine Somerset New Jersey USA

Caffeine is one of the most commonly consumed.stimulants and is found in many items like coffee and energy drinks. Heart arrhythmias are irregular heart rhythms, which can occur when the electrical signals that control the heart’s rhythm are not functioning properly. Due to the stimulant properties of caffeine, it is theorized that caffeine consumption may cause tachycardias-like ventricular arrhythmias. This review article describes the relationship between caffeine intake and heart arrhythmias using a comprehensive Pub-med.search. A comprehensive search was conducted using the search terms “caffeine arrhythmia” which was conducted and a total of 26 search results were obtained. The majority of clinical studies suggest that there are no strong associations between caffeine consumption and arrhythmias. There is little evidence suggesting a direct relationship between caffeine and ventricular arrhythmias (relative Risk 1.00, 95% CI 0.94 - 1.06;13.5%, p = 0.32). Conversely, caffeine consumption has an inverse relationship with the risk of atrial fibrillation (p for overall trend = 0.015;p for nonlinearity = 0.27). Caffeine related deaths are uncommon, but certain groups such as infants, psychiatric patients, and athletes may have an increased risk of arrhythmias following caffeine consumption. Overall, caffeine consumption is not strongly linked to heart arrhythmias and limited studies suggest it may reduce the risk of arrhythmias. Although there is not a strong relationship between caffeine intake and heart arrhythmias, it does cause other cardiovascular problems including high blood pressure and hence should be consumed.responsibly (40 - 180 mg/day).

关键词： Caffeine Arrhythmias Atrial Fibrillation

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经腹胎儿脉冲血氧测定法:近红外线分光镜

世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 15-15页

作者： Vintzileos A.M. Nioka S. Lake M. 高雪莲 Department of Obstetrics Gynecology and Reproductive Sciences UMDNJ- Robert Wood Johnson Med. Sch. New Brunswick NJ United States Dr.

The purpose of this study was to determine the feasibility of noninvasive fetal pulse oximetry in the human fetus with transabdominal continuous- wave near- infrared spectroscopy. The instrument has 3 wavelength light- emitting diodes (735, 805, and 850 nm) as light sources and a photomultiplier tube as a detector. This instrument was used in 6 pregnant women (>36 weeks of gestation). First, a fetal heart rate was obtained with a fetal heart rate monitor. Then, the depth of fetal tissue (head) from the maternal abdomen was determined by ultrasound examination; the distance between the optodes (light source and the detector) was set to be approximately twice the depth of the fetus (7- 11 cm). The data analysis was based on the modified Beer- Lambert law and the use of optical densities at 735 and 850 nm to obtain the concentration changes of the oxyhemoglobin and deoxyhemoglobin. The saturation was expressed as the percent of oxygen saturation equal to 100× oxyhemoglobin/ (oxyhemoglobin + deoxyhemoglo- bin). We recorded the spectroscopy data and the fetal heart rate for approximately 3 to 10 minutes in each patient. The mean oxygen saturation values of each of the 6 individual fetuses ranged from 50% to 74% (overall mean saturation, 61% ± 14.8% [SD]). This preliminary data indicate that transabdominal fetal pulse oximetry is feasible for human patient application. The measured values were similar to those that are obtained with transvaginal pulse oximetry. Future studies should correlate transabdominally obtained measurements with those measurements that are obtained by transvaginal fetal pulse oximetry.

关键词：近红外线胎儿组织氧合血红蛋白脱氧血红蛋白胎心率胎心监护仪组织厚度发光二极管持续性数据分析

胎盘早剥的危险因素:早产胎膜早破、子宫内感染和羊水过少

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 38-38页

作者： Ananth C.V. Oyelese Y. Srinivas N. 刘亦恒 Dr.Dept. Obstet. Gynecol./Repro. Sci. UMDNJ-Robert Wood Johnson Med. Sch. 125 Paterson Street New Brunswick NJ United States

OBJECTIVE: To examine whether preterm premature rupture of membranes (PROM), intrauterine infection, and oligohydramnios are risk factors for placental abruption. METHODS: Data for this retrospective cohort study were derived from the 1988 National Maternal and Infant Health Survey (N=11,777). Association between abruption and these clinical risk factors was expressed as relative risk (RR) and 95%confidence interval (CI), with multivariate adjustment for potential confounders. RESULTS: The overall incidence of abruption was 0.87%. The risk of abruption was 3.58-fold higher (95%CI 1.74-7.39)among women with preterm PROM (2.29%) compared with women with intact membranes (0.86%). The rates of abruption among women with and without intrauterine infection were 4.81%and 0.83%, respectively (RR 9.71, 95%CI 3.23-29.17). However, oligohydramnios was not associated with abruption (1.46%compared with 0.87%; RR 2.09, 95%CI 0.92-5.31). Compared with women with intact membranes, the RR for abruption among preterm PROM and whose membranes were ruptured for 24-47 hours and 48 hours or more before delivery, respectively, were 2.37 (95%CI 0.99-9.09), and 9.87 (95%CI 3.57-27.82). When preterm PROM was accompanied by intrauterine infections, the RR for abruption was 9.03 (95%CI 2.80-29.15) compared with women with intact membranes and no infections. Similarly, preterm PROM accompanied by oligohydramnios conferred over a 7.17-fold risk (95%CI 1.35-38.10) for abruption compared with women with neither of these 2 conditions. CONCLUSION: Women presenting with preterm PROM are at increased risk of developing abruption, with the risk being higher either in the presence of intrauterine infections or oligohydramnios. Physicians managing patients with preterm PROM should be aware that these patients are at increased risk of developing abruption after 24 hours following preterm PROM.

关键词：胎盘早剥早产胎膜早破羊水过少子宫内感染胎膜破裂婴儿健康多变量校正混杂因素队列分析样地

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Correspondence

Chinese med.cal Journal 1979年第8期

作者： David E.Rogers President The Robert Wood Johnson Foundation PrincetonNJ 08540 USA

To the Editor:During the months of Octoberand November, 1978,I had the privilege of visit-ing the People’s Republic of China with a groupof American health *** impres-sions gained from tha’t trip,coupled with somerecent conversations with members of a Chinesedelegation of the Preparatory Committee of themed.cal Center in Peking who recently visitedthe United States,prompts this letter.I and my colleagues,as with previous med.ical visitors to China,were much impressed withChina’s considerable achievements in deliveringgeneral med.cal care to its *** suggests that you have made monu-mental strides in the control of major infectiousdiseases,in improving nutrition,and in decreas-ing infant mortality and birth *** impressive to those of us working onsimilar problems in the United States,is China’sapparent success in bringing basic health servic-es to rural areas and lower income urban *** cost primary care services ap-pear to be available 6 days a week and often onevenings and holidays,in factories,sch.ols,daycare centers,government office buildings,andisolated rural villages.

关键词：

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前置血管的产前诊断对妊娠结局的影响

世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 33-33页

作者： Oyelese Y. Catanzarite V. Prefumo F. 侯巍 Dr.Division of Maternal-Fetal med.cine Dept. Obstet. Gynecol./Repro. Sci. UMDNJ-Robert Wood Johnson Med. Sch. 125 Paterson Street New Brunswick NJ 08901 United States

OBJECTIVE: To evaluate outcomes and predictors of neonatal survival in pregnancies complicated by vasa previa and to compare outcomes in prenatally diagnosed cases of vasa previa with those not diagnosed prenatally. METHODS: We performed.a multicenter study of 155 pregnancies complicated by vasa previa. Cases were obtained from the Vasa Previa Foundation and 6 large hospitals. Comparisons were made between groups based on prenatal diagnosis status and neonatal survival. RESULTS: The overall perinatal mortality was 36%(55 of 155). In 61 cases (39%), vasa previa was diagnosed prenatally; 59 of 61 (97%) infants from these pregnancies survived compared with 41 of 94 (44%) in cases not diagnosed prenatally (P med.an 1and 5-minute Apgar scores in cases diagnosed prenatally were 8 and 9, respectively, compared with 1 and 4 among survivors in cases not diagnosed prenaially (P < .001). More than half (24 of 41) of surviving neonates born to women without prenatal diagnosis required blood transfusions compared with 2 of 59 diagnosed prenatally (P < .001). Multivariable logistic regression analysis showed that the only significant predictors of neonatal survival were prenatal diagnosis (P <.001) and gestational age at delivery (P = .01). CONCLUSIONS: Good outcomes with vasa previa depend primarily on prenatal diagnosis and cesarean delivery at 35 weeks of gestation or earlier should rapture of membranes, labor, or significant Heeding occur.

关键词：产前诊断妊娠结局存活情况

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乳房过早发育患者活化的GNAS1基因突变

世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 41-42页

作者： Román R. johnson M.C. Codner E. F.Cassorla 郭战宏 Inst.of Maternal and Child ResearchS.Borja Arriarán Clin.Hosp. Sch.of Med.University of ChileSantiagoChile

目的:为了确认在有乳房发育过大和(或)至少持续1年的慢性波动性的乳房过早发育而无其他性早熟体征、骨骼发育异常或McCune-Albright综合征典型皮肤损害的女童的GNAS1基因突变。研究设计:笔者对前述23位女孩的白细胞DNA,应用等位基因特... 详细信息

目的:为了确认在有乳房发育过大和(或)至少持续1年的慢性波动性的乳房过早发育而无其他性早熟体征、骨骼发育异常或McCune-Albright综合征典型皮肤损害的女童的GNAS1基因突变。研究设计:笔者对前述23位女孩的白细胞DNA,应用等位基因特异性的聚合酶链反应和酶切技术研究了其GNAS1基因的突变。结果:14例女童有波动性乳房发育,9例女童为乳房发育过大。分子学研究表明6例女童在密码子201的精氨酸由组氨酸代替[R201H(+)]。3例R201H(+)女童在平均实足年龄为10.8岁时出现月经初潮,9例R201H (-)女童在平均年龄为11岁时出现月经初潮。结论:在一些有慢性波动性乳房过早发育和(或)乳房发育过大而无其他McCune-Albright综合征典型体征的女童可观察到GNAS1基因的活化突变。

关键词：乳房过早发育 GNAS1 基因突变月经初潮等位基因特异性聚合酶链反应典型体波动性性早熟分子学

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arsch.ll, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed.Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA med.Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England med.Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院