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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： JoséM.Izquierdo Centro de Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Glial regenerative response in the imaginal discs of Drosophila melanogaster

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Neural Regeneration Research 2023年第1期18卷 109-110页

作者： Sergio B.Velarde Antonio Baonza Centro de Biología Molecular“Severo Ochoa” CSIC/UAMMadridSpain

Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional *** response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior(Gallo and Deneen,2014;Kato et al.,2018).This glial regenerative response is associated with the repairing function of these cells and is found across species,suggesting that it may reflect a common underlying genetic mechanism(Kato et al.,2018).

关键词： damage migrate

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-uam) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Probabilistic Constructions of B_2[g] Sequences

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1309-1314页

作者： Javier CILLERUELO Instituto de Ciencias Matermáticas(CSIC-uam-UCM) Department of Mathematics Universidad Autónoma de Madrid

We use the probabilistic method to prove that for any positive integer g there exists an infinite B2[g] sequence A = {ak} such that ak ≤ k^2＋1/g（log k）^1/g＋0（1） as k→∞. The exponent 2＋1/g improves the previo... 详细信息

关键词： Sidon sets B2 [g] sequences probabilistic method

Selecting the best:Interspecific and age-related diet differences among sympatric steppe passerines

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Avian Research 2023年第4期14卷 611-622页

作者： Julia Zurdo Paula Gomez-Lopez Adrian Barrero Daniel Bustillo-de la Rosa Julia Gomez-Catasús Margarita Reverter Cristian Perez-Granados Manuel B.Morales Juan Traba Terrestrial Ecology Group Department of EcologyUniversidad Autonoma de Madrid(TEG-UAM)MadridSpain Centro de Investigacion en Biodiversidady Cambio Global Universidad Autonoma de Madrid(CIBC-UAM)MadridSpain Ecology Department/IMEM“Ramon Margalef” Universidad de AlicanteAlicanteSpain

Parental food provisioning is crucial for the growth and survival of *** rate depends on food quality and food supplied to offspring may differ from what adults use for their *** the case of steppe passerine birds,detailed characterization on nestling dietary composition,as well as prey choice and resource partitioning among species,is a pending *** differences between nestlings and adults remain also largely *** using faecal DNA metabarcoding,we described the diet of nestlings and adults of five shrub-steppe passerine species over the 2017–2019 breeding seasons in central *** also monitored arthropod availability in the field to assess dietary *** expected interspecific dietary differences to limit competition for food resources among sympatric species,as well as parental selection of high quality prey for *** also predicted age-related differences,with nestlings being fed nutrient-rich prey more frequently than *** main arthropod orders provisioned to nestlings were Orthoptera,Julida,Araneae and *** of the different species showed high interspecific diet overlap,indicating both a coincidence in growth needs among bird species and no or little limitation of the most profitable resources during the breeding *** of all species showed higher diet richness than nestlings,and age-related differences in prey composition were mainly driven by the selection of the most easily digestible,larger protein-and calcium-rich prey for nestlings,which may favour their rapid growth,and avoiding highly sclerotized and less nutritional prey such as *** study sheds light on the basic ecology and conservation of these declining steppe birds,indicating that interspecific competition may not be a major factor during the breeding *** the current global decline of arthropods,further long-term research would be necessary,along with the implementation of effective conservation measure

关键词： 18S Faecal material Nestling diet Prey choice Resource partitioning

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 505-512页

作者： Angel CASTRO Diego CóRDOBA Instituto de Ciencias Matemticas CSIC-UAM-UC3M-UCMConsejo Superior de Investigaciones Científicas

The authors construct self-similar solutions for an N-dimensional transport equation,where the velocity is given by the Riezs *** solutions imply nonuniqueness of weak *** addition,self-similar solution for a one-dime... 详细信息

关键词： Hilbert transform Riesz transform Transport equations Self-similar solutions

FedIDS:a federated cloud storage architecture and satellite image delivery service for building dependable geospatial platforms

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International Journal of Digital Earth 2018年第7期11卷 730-751页

作者： J.L.Gonzalez-Compean Victor J.Sosa-Sosa Arturo Diaz-Perez Jesus Carretero Ricardo Marcelin-Jimenez Cinvestav-Tamulipas Ciudad VictoriaMexico ARCOS Research Group University Carlos IIIMadridSpain uam Iztapalapa CDMX and associated to InfotecMexico

Earth observation satellites produce large amounts of images/data that not only must be processed and preserved in reliable geospatial platforms but also efficiently disseminated among partners/researchers for creating derivative products through collaborative *** can face up this challenge in a cost-effective manner by using cloud ***,outages and violations of integrity/confidentiality associated to this technology could *** article presents FedIDS,a suite of cloud-based components for building dependable geospatial *** Fed component enables organizations to build shared geospatial data infrastructure through federation of independent cloud resources to withstand outages,whereas IDS avoids violations of integrity/confidentiality of images/data in sharing information and collaboration workflows.A FedIDS prototype,deployed in Spain and Mexico,was evaluated through a study case based on a satellite imagery captured by a Mexican antenna and another based on a satellite imagery of a European observation *** acquisition,storage and sharing of images among users of the federation,the exchange of images between Mexican and Spanish sites and outage scenarios were *** evaluation revealed the feasibility,reliability and efficiency of FedIDS,in comparison with available solutions,in terms of performance,storage consume and integrity/confidentiality when sharing images/data in collaborative scenarios.

关键词： Satellite imagery Earth observation archives spatial data infrastructure collaborative workflows security reliability

Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer

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Genes & Diseases 2023年第4期10卷 1180-1182页

作者： J.Bargiela-Iparraguirre J.M.Herrero N.Pajuelo-Lozano M.Perez R.Perona A.G.Quiroga C.Calés I.Sanchez-Perez Dpto.de Bioquímica.Fac.Medicina UAMMadrid 28029Spain Biomedical Research Institute of Madrid CSIC/UAMMadrid 28029Spain Cancer Stem Cell and Fibroinflammatory Microenvironment Group Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS)Madrid 28034Spain Unidad Asociada de Biomedicina UCLM-CSIC Madrid 28029 Spain CIBER for Rare Diseases(CIBERER) Instituto de Salud CarlosⅢ Madrid 28029Spain Dpto.de Anatomía Histología y Neurociencia.Fac.Medicina UAMMadrid 28029Spain g Dpto.de Química Inorgánica Fac.Ciencias UAMMadrid 28049Spain

Gastric cancer(GC)is worldwide the sixth most diagnosed and third leading cause of cancer deaths,with poor and late prognosis,probably due to post-surgery adjuvant treatment resistance and lack of a thorough panel of prognostic *** have previously shown that mitotic arrest deficient 2(MAD2,encoded by MAD2L1),a key protein of the spindle assembly checkpoint,is relevant in GC cells;its interference impairs migration and growth,while its overexpression cor-relates with tumorigenesis.

关键词： MAD2 tumorigenesis Gastric

Cosmic Engineering: Moving Asteroids

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International Journal of Astronomy and Astrophysics 2013年第4期3卷 517-519页

作者： Marcin Misiak uam Poznan Poland

This paper presents methods of orbit transfer for small planetoids from the main belt to the future colonies on Mars using current technologies. The results show that by using nuclear weapon or even kinetic energy weapon (for retrograde bodies) asteroids with masses up to about 100 tons can be moved. Both options assume that asteroid will survive explosion.

关键词： Astrodynamics Celestial Mechanics Orbital Motion Optimal Control