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Chinese national clinical practice guidelines on the prevention,diagnosis,and treatment of early gastric cancer

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Chinese Medical Journal 2024年第8期137卷 887-908页

作者： Peng Li Ziyu Li Enqiang Linghu Jiafu Ji society of Digestive Endoscopy of the Chinese Medical Association Colorectal surgery Group of the Chinese Medical Association Chinese Association of Gastroenterologists&Hepatologists National Clinical research Center for Digestive Diseases Chinese Medical Journal Clinical Practice Guideline Collaborative Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing 100050China Department of Gastrointestinal surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Gastroenterology and Hepatology the First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China 不详

Background:Gastric cancer is one of the most common malignant tumors in the digestive system in *** comprehensive practice guidelines for early gastric cancer in China are currently ***,we created the Chinese national clinical practice guideline for the prevention,diagnosis,and treatment of early gastric ***:This clinical practice guideline(CPG)was developed in accordance with the World Health Organization’s recommended process and with the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)in assessing evidence *** used the Evidence to Decision framework to formulate clinical recommendations to minimize bias and increase transparency in the CPG development *** used the Reporting Items for practice Guidelines in HealThcare(RIGHT)statement and the Appraisal of Guidelines for research and Evaluation II(AGREE II)as reporting and conduct guidelines to ensure completeness and transparency of the ***:This CPG contains 40 recommendations regarding the prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer based on available clinical studies and *** provide recommendations for the timing of Helicobacter pylori eradication,screening populations for early gastric cancer,indications for endoscopic resection and surgical gastrectomy,follow-up interval after treatment,and other ***:This CPG can lead to optimum care for patients and populations by providing up-to-date medical *** intend this CPG for widespread adoption to increase the standard of prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer;thereby,contributing to improving national health care and patient quality of life.

关键词： Early gastric cancer Prevention screening Diagnosis Treatment Follow-up

Junctional epithelium and hemidesmosomes:Tape and rivets for solving the“percutaneous device dilemma”in dental and other permanent implants

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Bioactive Materials 2022年第12期7卷 178-198页

作者： Nicholas G.Fischer Conrado Aparicio MDRCBB-Minnesota Dental research Center for Biomaterials and Biomechanics University of Minnesota16-212 Moos Tower515 Delaware St.SEMinneapolisMN55455USA Division of Basic research Faculty of OdontologyUIC Barcelona-Universitat Internacional de CatalunyaC/.Josep Trueta s/n08195Sant Cugat del VallesBarcelonaSpain institute for Bioengineering of Catalonia(IBEC) The Barcelona Institute of Science and Technology(BIST)C/.Baldiri Reixac 10-1208028BarcelonaSpain

The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exqu.s.te examples to inspire longer lasting long-term percutaneous device design. For example, the tooth’s imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth’s enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant - as a model percutaneous device - placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.

关键词： Percutaneous device Percutaneous implant Hemidesmosome Junctional epithelium Bioinspired surfaces

Current status of anticoagulant treatments and improvements for hemodialysis patients in northern Chinese cities： a five-year comparative study

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Chinese Medical Journal 2014年第16期127卷 2881-2887页

作者： Huang Qi sun Xuefeng Lin Hongli Zhang Zhimin Hao Lirong Yao Li Li Jijun Zhao Delong Wang Yong Zhu Hanyu Chen Xiangmei Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Disease(2011DAV00088) National Clinical Research Center of Kidney Diseases(2013BAI09B05)Beijing 100853 China Department of Nephrology First Affiliated Hospital Dalian Medical College Dalian Liaoning 116023 China Department of Nephrology General Hospital of the General Headquarters Beijing 100091 China Department of Nephrology First Affiliated Hospital Harbin Medical College Harbin Heilongjiang 150081 China Department of Nephrology First Affiliated Hospital Chinese Medical University Shenyang Liaoning 110001 China Department of Nephrology First Affiliated Hospital General Hospital of People's Liberation Army Beijing 100048 China

Background Anticoagulation treatments are an important aspect of hemodialysis; however,few reports have addressed these *** investigation intends to increase the understanding of the current status and improvements of hemodialysis-related anticoagulation treatments in *** In this study,an epidemiological investigation was conducted that examined 842 patients in 2007 and 1 175patients in 2012 who underwent hemodialysis anticoagulation treatments in seven blood purification centers in northern Chinese *** Heparin was the most commonly used anticoagulant,although the percentage of use of low-molecular-weight heparin （LMWH） increased from 26.5% in 2007 to 42.1% in *** 2007,there were no significant differences in anticoagulant selection among either patients with various primary diseases or patients with hemorrhage,thrombosis,thrombocytopenia,or a low hemoglobin ***,compared with patients with other diseases,significantly lower doses of LMWH were administered to patients with hypertension （55.5 u/kg vs.67.3 u/kg,P 〈0.05） or diabetes （58.5 u/kg vs.67.3 u/kg,P 〈0.05）,and patients with hemorrhage received lower doses of heparin than the other patients （61.6 u/kg vs.71.8 u/kg,P 〈0.01）.In 2012,patients with diabetic nephropathy （51.5% vs.36.5%,P 〈0.01）,hemorrhage （43.4% vs.31.7%,P 〈0.01）,or a hemoglobin level below 90 g/L （57.2% vs.37.1%,P 〈0.01） experienced significantly higher doses of LMWH administration; patients with hemorrhage received significantly reduced LMWH dosages （50.4 u/kg vs.57.8 u/kg,P 〈0.05）,and patients with thrombosis received significantly higher doses of heparin （73.8 u/kg vs.62.1 u/kg,P 〈0.01） or LMWH （57.8 u/kg vs.52.6 u/kg,P 〈0.05）.Antiplatelet dru.s.were administered to 20.4% of the examined patients in 2007 and 20.7% in *** 2012,patients with hypertension （25.9% vs.18.5%,P 〈0.01） and thrombosis （36.6% vs.16.1%,P 〈0.01） had a higher rate of using antiplatelet dru.s.than patients with other primary di

关键词： hemodialysis heparin low-molecular-weight heparin anticoagulant

Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

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Zoological research 2023年第3期44卷 591-603页

作者： Attaur Rahman Yuhao Li To-Kiu Chan Hui Zhao Yaozu Xiang Xing Chang Hao Zhou Dachun Xu.s.ng-Bing Ong Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Centre for Cardiovascular Genomics and Medicine(CCGM) Lui Che Woo Institute Innovative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina College of Veterinary sciences and Animal Husbandry Abdul Wali Khan University MardanMardanKhyber Pakhtunkhwa 23200Pakistan school of Biomedical sciences CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina institute for Tissue Engineering and Regenerative Medicine(iTERM) The Chinese University of Hong Kong(CUHK)Hong Kong SARChina sBs Core Laboratory CUHK Shenzhen Research InstituteShenzhenGuangdong 518172China Kunming institute of Zoology–The Chinese university of Hong Kong(KIZ-CuHK)Joint Laboratory of Bioresources and Molecular research of Common Diseases Hong Kong SARChina shanghai East Hospital Key Laboratory of Arrhythmias of the Ministry of Education of ChinaSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Department of Cardiology Chinese People’s Liberation Army General HospitalBeijing 100853China Center for Cardiovascular research and Alternative Medicine University of Wyoming College of Health SciencesLaramieWY 82071USA Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Hong Kong Hub of Paediatric Excellence(HK HOPE) Hong Kong Children’s Hospital(HKCH)Kowloon BayHong Kong SARChina CuHK shenzhen research institute(sZRI) ShenzhenGuangdong 518172China Neural Vascularand Metabolic Biology Thematic Research ProgramSchool of Biomedical SciencesThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical ***,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models,which are not transferable or reproducible in large animal models due to different factors such as:(i)complex and varied features of human ischemic cardiac disease(ICD),which are challenging to mimic in animal models,(ii)significant differences in surgical techniqu.s.applied,and(iii)differences in cardiovascular anatomy and physiology between small versus large *** article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI),as well as the different methods used to induce and assess IRI,and the obstacles faced in using large animals for translational research in the settings of cardiac IR.

关键词： Cardiovascular disorder Ischemic cardiac disease Ischemic-reperfusion injury Large animal model Myocardial infarction Translational gap

spatially Bandgap-Graded Mo s2（1-x）se2x Homojunctions for self-Powered Visible–Near-Infrared Phototransistors

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Nano-Micro Letters 2020年第2期12卷 185-198页

作者： Hao Xu Juntong Zhu Guifu Zou Wei Liu Xiao Li Caihong Li Gyeong Hee Ryu Wenshuo Xu Xiaoyu Han Zhengxiao Guo Jamie HWarner Jiang Wu Huiyun Liu Department of Electronic and Electrical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUK school of Energy Soochow Institute for Energy and Materials Innovationsand Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006People’s Republic of China London Centre for Nanotechnology University College LondonLondon WC1H 0AHUK institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 610054People’s Republic of China Department of Materials University of OxfordParks RoadOxford OX13PHUK Department of Chemistry University College London20 Gordon StBloomsburyLondon WC1H 0AJUK Department of Chemistry The University of Hong KongPokfulam RoadHong KongPeople’s Republic of China Zhejiang institute of research and Innovation The University of Hong KongQingshan Lake SciTech CityHangzhouPeople’s Republic of China

Ternary transition metal dichalcogenide alloys with spatially graded bandgaps are an emerging class of two-dimensional materials with unique features,which opens up new potential for device ***,visible–near-infrared and self-powered phototransistors based on spatially bandgap-graded Mos2(1−x)se2x alloys,synthesized by a simple and controllable chemical solution deposition method,are *** graded bandgaps,arising from the spatial grading of se composition and thickness within a single domain,are tuned from 1.83 to 1.73 eV,leading to the formation of a homojunction with a builtin electric ***,a strong and sensitive gate-modulated photovoltaic effect is demonstrated,enabling the homojunction phototransistors at zero bias to deliver a photoresponsivity of 311 mA W−1,a specific detectivity up to^10^11 Jones,and an on/off ratio up to^10^***,when illuminated by the lights ranging from 405 to 808 nm,the biased devices yield a champion photoresponsivity of 191.5 A W−1,a specific detectivity up to^1012 Jones,a photoconductive gain of 10^6–10^7,and a photoresponsive time in the order of^50 *** results provide a simple and competitive solution to the bandgap engineering of two-dimensional materials for device applications without the need for p–n junctions.

关键词： Transition metal dichalcogenides Graded bandgaps Homojunctions Phototransistors self-powered

COMPuTATION OF RETuRN FLOWs DuE TO NAVIGATION TRAFFICs IN REsTRICTED WATERWAYs

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International Journal of sediment research 2006年第4期21卷 249-260页

作者： B. s. MAZuMDER s. K. DAs s. N. DAs Indian statistical institute Kolkata-700 108 IndiaProf. International institute of Information Technology Pune India Prof. Assis. Res. Officer Central Water and Power Research Station Pune-411 024 India

The paper deals with the development of an empirical model to compute the return flow due to the movement of navigation traffics in restricted waterway when the speed of the navigation traffic is under sub-critical range. The velocity profile of the return flow is modelled, where the functional dependence with respect to ambient flow, principal dimensions of the vessel, wetted cross-sectional area of the river, width and average depth of the river, and the lateral distance of the vessel from the bank are implicitly considered. This model has been validated with the observed data collected from the four specific sites, such as Kampsville, Apple River Island, Goose Island and Clarks Ferry of Illinois River during barge-tow movement. The present model shows significant improvement of return flow prediction in comparison to earlier empirical results. This model has also the ability to determine the locus of zero velocity point.

关键词： Return flow Navigation traffic Empirical model Restricted waterway Barge-tow Zero velocity point Froude number

Joint Entity and Event Extraction with Generative Adversarial Imitation Learning

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Data Intelligence 2019年第2期1卷 99-120页

作者： Tongtao Zhang Heng Ji Avirup sil Computer science Department Rensselaer Polytechnic InstituteTroyNew York 12180-3590USA IBM research AI ArmonkNew York 10504-1722USA

We propose a new framework for entity and event extraction based on generative adversarial imitation learning-an inverse reinforcement learning method using a generative adversarial network(GAN).We assume that instances and labels yield to various extents of difficulty and the gains and penalties(rewards)are expected to be *** utilize discriminators to estimate proper rewards according to the difference between the labels committed by the ground-truth(expert)and the extractor(agent).Our experiments demonstrate that the proposed framework outperforms state-of-the-art methods.

关键词： Information extraction Event extraction Imitation learning Generative adversarial network

Prompt photon production in proton–nucleus collisions at LHC:a comparison among color dipole models

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Communications in Theoretical Physics 2023年第12期75卷 75-83页

作者： Hong-Min Wang Yan-Zhao Wang Yong-Han Xu Xian-Jing sun Physics Department Army Academy of Armored ForcesPLABeijing 100072China Department of Mathematics and Physics Shijiazhuang Tiedao UniversityShijiazhuang 050043China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The nuclear modification factor for prompt photon production in proton-nucleus collisions is investigated within color dipole *** means of the Glauber-Gribov approach,the nuclear effects are studied in various rapidity bins with the evolution equation-based saturation models and the phenomenological dipole *** theoretical results are compared with the experimental data provided by PHENIX,ATLAs and CMs *** forward rapidity and midrapidity,a reasonable agreement with the experimental data is shown for the theoretical results with the modified Kharzeev,Levin and Nardi model,and the Kowalski and Teaney ***,we analyze the influence of the initial state energy loss effect on the nuclear modification factor and find that it is obvious only at backward rapidity together with small ***,the theoretical results are also compared with those of JETPHOX Monte Carlo program and the predictive results for the LHCb at very forward rapidities are presented.

关键词： color dipole formalism Glauber-Gribov approach small-r limit

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

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Military Medical research 2023年第3期10卷 281-298页

作者： Fei Pei Ren‑Qi Yao Chao Ren soheyl Bahrami Timothy RBilliar Irshad HChaudry De‑Chang Chen Xu‑Lin Chen Na Cui Xiang‑Ming Fang Yan Kang Wei‑Qin Li Wen‑Xiong Li Hua‑Ping Liang Hong‑Yuan Lin Ke‑Xuan Liu Ben Lu Zhong‑Qiu Lu Marc Maegele Tian‑Qing Peng You.s.ang Lei su Bing‑Wei sun Chang‑song Wang Jian Wang Jiang‑Huai Wang Ping Wang Jian‑Feng Xie Li‑Xin Xie Li‑Na Zhang Basilia Zingarelli Xiang‑Dong Guan Jian‑Feng Wu Yong‑Ming Yao Department of Critical Care Medicine the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan Er RoadYuexiu DistrictGuangzhou 510080GuangdongChina Translational Medicine research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital28 Fuxing RoadHaidian DistrictBeijing 100853China Department of Burn surgery the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ludwig-Boltzmann institute for Experimental and Clinical Traumatology 1200 ViennaAustria Department of surgery University of Pittsburgh Medical CenterPittsburghPA 15213USA Center for surgical research and Department of surgery University of Alabama at BirminghamBirminghamAL 35294USA Department of Critical Care Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025China Department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Anesthesiology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 31003China Department of Critical Care Medicine West China Hospital of Sichuan UniversityChengdu 610041China Department of Critical Care Medicine General Hospital of Eastern Theater Command of Chinese PLANanjing 210002China Department of surgical Intensive Critical unit Beijing Chao‑Yang HospitalCapital Medical UniversityBeijing 100020China state Key Laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China Department of Critical Care Medicine Fourth Medical Center of the Chinese PLA General HospitalBeijing 100048China Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine and Hematology the Third Xiangya HospitalCentral South UniversityChangs

Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of *** provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was *** related to the immune monitoring and treatment of sepsis were retrieved from PubMed,Web of science,and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online ***,the Delphi method was used to form consensus opinions,and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus *** consensus achieved satisfactory results through two rounds of qu.s.ionnaire survey,with 2 statements rated as perfect consistency,13 as very good consistency,and 9 as good *** summarizing the results,a total of 14 strong recommended opinions,8 weak recommended opinions and 2 non-recommended opinions were ***,a face-to-face discu.s.on of the consensus opinions was performed through an online meeting,and all judges unanimously agreed on the content of this *** summary,this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

关键词： sepsis Immune function monitoring Immunomodulatory therapy Immunosuppression