检索结果-南通市图书馆

Bombyx mori u.s.aped regulates the melanization cascade and immune response via binding with the Lozenge protein

Insect science 2022年第3期29卷 704-716页

作者： Kui Zhang Juan Tan Xiangwei Hao Houyi Tang Muhammad Nadeem Abbas Jingjing su Yongyue su Hongjuan Cui state Key Laboratory of silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing400716China Chongqing Reproductive and Genetics institute Chongqing Obstetrics and Gynecology HospitalChongqing400013China Department of Orthopaedic 920th Hospital of Joint Logistics Support Force of Chinese People’s Liberation ArmyKunming650032China Cancer Center Reproductive Medicine CenterMedical Research InstituteSouthwest UniversityChongqing400716China

Zinc finger protein,an important transcription factor,regulates gene expression associated with various physiological and pathological processes.u.s.aped,belong to the Friend of GATA(FOG)transcription factor,plays a crucial role in hematopoiesis by interacting with the GATA transcription factor as a ***,little is known about its functions in *** the present study,a u.s.aped cDNA was identified and characterized from the silkworm Bombyx mori and its potential roles in innate immunity *** predicted silkworm u.s.aped amino acid sequence contained a classical nuclear localization signal(NLs)motif“GEssPKRRRR”at position 45Cu459,and arginine residu.s.at position 456 and 478 are the critical sites of the NLs.u.s.aped mRNA was detected in all tested tissu.s.of the ***;however,the highest levels were found in the hemocytes.u.s.aped mRNA expression levels were upregulated in the hemocyte after the Escherichia coli and staphylococcus aureus ***,u.s.aped knockdown significantly reduced the melanization process and suppressed the expression of melanization-associated genes,including PPO1,PPO2,PPAE and *** addition,u.s.aped interacts with Lozenge protein to regulate the innate immune response of the *** results revealed that u.s.aped binds directly to Lozenge protein to modulate the melanization process and innate immune responses in silkworm.

关键词： Bombyx mori Lozenge melanization response silkworm u.s.aped

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A non-invasive diagnostic model of immunoglobulin A nephropathy and serological markers for evaluating disease severity

引用

Chinese Medical Journal 2019年第6期132卷 647-652页

作者： Qiu-Xia Han Yong Wang Han-Yu Zhu Dong Zhang Jing Gao Zhang-suo Liu Guang-Yan Cai Xiang-Mei Chen Department of Nephrology The First Affiliated Hospital of Zhengzhou University Research Institute of Nephrology in Zhengzhou University Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province Zhengzhou Henan 450052 China Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing 100853 China Department of Clinical Biochemistry Chinese People's Liberation Army General Hospital Beijing 100853 China

Background: Immunoglobulin A nephropathy (IgAN) is the most common pathological type of glomerular disease. Kidney biopsy, the gold standard for IgAN diagnosis, has not been routinely applied in hospitals worldwide due to its invasion nature. Thus, we aim to establish a non-invasive diagnostic model and determine markers to evaluate disease severity by analyzing the serological parameters and pathological stages of patients with IgAN. Methods: A total of 272 biopsy-diagnosed IgAN inpatients and 518 non-IgA nephropathy inpatients from the Department of Nephrology of Chinese People's Liberation army General Hospital were recruited for this study. Routine blood examination, blood coagulation testing, immunoglobulin-complement testing, and clinical biochemistry testing were conducted and pathological stages were analyzed according to Lee grading system. The serological parameters and pathological stages were analyzed. The receiver operating characteristic (ROC) analysis was performed to estimate the diagnostic value of the clinical factors. Logistic regression was used to establish the diagnostic model. Results: There were 15 significantly different serological parameters between the IgAN and non-IgAN grou.s.(all Psis was performed to measure the diagnostic value for IgAN of these parameters and the results showed that the area under the ROC curve (AuC) of total protein (TP), total cholesterol (TC), fibrinogen (FIB), D-dimer (D2), immunoglobulin A (IgA), and immunoglobulin G (IgG) were more than 0.70. The AuC of the "TC + FIB + D2 + IgA + age" combination was 0.86, with a sensitivity of 85.98% and a specificity of 73.85%. Pathological grades of Ⅰ,Ⅱ,Ⅲ,Ⅳ, and Ⅴ accounted for 2.21 %, 17.65%, 62.50%, 11.76%, and 5.88%, respectively, with grade Ⅲ being the most prevalent. The levels of urea nitrogen (uN)(13.57土 5.95 vs. 6.06 土 3.63, 5.92 + 2.97, 5.41 ± 1.73, and 8.41 ±3.72μmol/L, respectively) and creatinine (Cr)(292.19± 162.21 vs. 80.42±24.75, 103.79±7

关键词： Immunoglobulin A nephropathy Noninvasive Diagnostic model severity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of chronic kidney disease staging with different estimated glomerular filtration rate equations in Chinese centenarians

引用

Chinese Medical Journal 2019年第5期132卷 512-518页

作者： Qiu-Xia Han Dong Zhang Ya-Li Zhao Liang Liu Jing Li Fu Zhang Fu-Xin Luan Jia-Yu Duan Zhang-suo Liu Guang-Yan Cai Xiang-Mei Chen Han-Yu Zhu Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing 100853 China Department of Nephrology The First Affiliated Hospital of Zhengzhou University Research Institute of Nephrology of Zhengzhou University Key laboratory of precision diagnosis and treatment for chronic kidney disease in Henan province Zhengzhou. Henan 450052 China Central Laboratory Hainan Branch of Chinese People's Liberation Army General Hospital Sanya Hainan 572000 China Department of Management Hainan Branch of Chinese People's Liberation Army General Hospital Sanya Hainan 572000 China

Background: Accurate estimation of the glomerular filtration rate (GFR) and staging of chronic kidney disease (CKD) are important. Currently, there is no research on the differences in several estimated GFR equations for staging CKD in a large sample of centenarians. Thus, this study aimed to investigate the differences in CKD staging with the most commonly used equations and to analyze sources of discrepancy. Methods: A total of 966 centenarians were enrolled in this study from June 2014 to December 2016 in Hainan province, China. The GFR with the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Berlin Initiative study 1 (BIs1) equations were estimated. Agreement between these equations was investigated with the k statistic and Bland-Altman plots. sources of discrepancy were investigated by partial correlation analysis. Results: The k valu.s.of the MDRD and CKD-EPI equations, MDRD and BIs1 equations, and CKD-EPI and BIs1 equations were 0.610, 0.253, and 0.381, respectively. serum creatinine (scr) explained 10.96%, 41.60% and 17.06% of the variability in these three comparisons, respectively. serum uric acid (suA) explained 3.65% and 5.43% of the variability in the first 2 comparisons, respectively. Gender was associated with significant differences in these 3 comparisons (Pusions: The strengths of agreement between the MDRD and CKD-EPI equations were su.s.antial, but those between the MDRD and BIs 1 equations and the CKD-EPI and BIs 1 equations were fair. The difference in CKD staging of the first 2 comparisons strongly depended on scr, suA and gender, and that of CKD-EPI and BIs1 equations strongly depended on scr and gender. The incidence at various stages of CKD staging was quite different. Thus, a new equation that is more suitable for the elderly needs to be built in the future.

关键词： Chinese centenarians Estimated glomerular filtration rate Modification of Diet in Renal Disease equation Chronic Kidney Disease Epidemiology Collaboration equation Berlin Initiative study 1 equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation of mechanical properties in bulk metallic glasses with ^(27)Al NMR characteristics

引用

Chinese science Bulletin 2011年第36期56卷 3937-3941页

作者： sANDOR Magdalena T KECsKEs Laszlo J HE Qiang Xu Jian Wu Yue Department of Physics and Astronomy University of North Carolina Chapel Hill NC 27599-3255 USA us army research Laboratory Aberdeen Proving Ground MD 21005 USA shenyang National Laboratory for Materials science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

We report 27Al NMR and magnetic susceptibility measurements of Zr and ZrHf-based bulk metallic glasses (BMGs). 27Al NMR Knight shift shows that there exists a clear correlation between the local electronic properties at Al sites and mechanical properties. In addition,magnetic susceptibility measurements also provide clu.s.on the influence of the electronic states,especially the strong influence of d-orbital characteristics on the mechanical properties of toughness and hardness.

关键词：机械性能核磁共振大块非晶合金铝磁化率测量大块金属玻璃非晶合金电子性质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients:A systemic Review and Meta-Analysis

引用

Chinese Medical Journal 2018年第22期131卷 2734-2740页

作者： Yan shi Jia-Yu Duan Dong-Wei Liu Ying-Jin Qiao Qiu-Xia Han shao-Kang Pan Li Tang Guang-Yan Cai Xiang-Mei Chen Zhang-suo Liu Han-Yu Zhu Department of Nephrology Chinese People's Liberation Army General HospitalChinese People's Liberation Army Institute of NephrologyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology Zhengzhou UniversityThe First Affiliated Hospital of Zhengzhou UniversityResearch Institute of NephrologyKey Laboratory of Accurate Diagnosis and Treatment of Chronic Kidney Diseases in Henan ProvinceCore Unit of National Kidney Disease Clinical Medical Research CenterZhengzhouHenan 450052China

Background:Type 2diabetes (T2DM)patients are susceptible to Helicobacterpylori (HP),and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients;however,this view remains *** meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM *** addition,we hope to provide some recommendations to readers in clinical or related fields. Methods:Our meta-analysis was conducted with the methodology of the Cochrane *** strategies were formulated by relevant ***-control studies that compared the occurrence ofproteinuria in T2DM patients with and without HP infection were involved in our *** English or Chinese studies were searched on online databases before 2018,including PubMed,the Cochrane library,Medline,Google scholar,the China National Infrastructure,and Wanfang *** search strategies were "diabetic proteinuria,diabetic microalbuminuria,diabetic albumainuria,diabetic kidney disease,diabetic renal dysfunction,diabetic renal disease,diabetic nephropathy,diabetic complications,and diabetic mellitus,combined with HP."The quality of these involved articles was separately assessed by two investigators using the Newcastle-Ottawa scale (NOs).Odds ratios (ORs)and associated 95% confidence intervals (CIs)were extracted and pooled using fixed-effects models. Results:seven studies involving 1029participants were *** quality of these seven articles was all above five stars as assessed by NOs,and there was no significant publication bias in our *** found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection (OR:2.00,95%CI:1.48-2.69). Conclusions:Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM *** radical surgery might be a therapeutic option for protecting

关键词： Helicobacterpylori Kidney Meta-Analysis Proteinuria Type 2 Diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Implantable photoelectronic charging(I-PEC)for medical implants

引用

Energy Reviews 2022年第2期1卷 60-69页

作者： Kai Wang sumanta Kumar Karan Mohan sanghadasa Congcong Wu.s.ashank Priya Department of Materials science and Engineering Pennsylvania State UniversityUniversity ParkPA16802United States Materials research institute Pennsylvania State UniversityUniversity ParkPA16802United States u.s.army Combat Capabilities Development Command Aviation&Missile Center Redstone ArsenalAlabama35898United States Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan430062China

Medical implants with functionalities such as sensing,health monitoring,stimulation,diagnosis,and physiological treatment are rapidly *** the increasing functional sophistication and addition of modules such as data transmission,on-chip processing,and data storage,energy demand of the implantable system is also *** implantable energy harvester either to recharge or ultimately replace hazardous battery is essential to provide a long-term sustainable *** harvesting techniqu.s.using piezoelectric,thermoelectric,radio frequency power transmission,biofuel,and photoelectronic(or sometimes termed as“photovoltaic”in terms of solar light harvesting,i.e.,PV)conversion,have been attempted for the implantable,but these methods are currently limited by insufficient power output,large footprint,and low ***,the planar PV with potential of lighter weight,higher energy density,and higher efficiency,provides promising power solution for in-body medical *** this short review,we will discu.s.the potential opportunities and challenges associated with PV's for medical implants,covering materials,to devices,and to system level requirements.

关键词： photoelectron harvesting charging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity

引用

World Journal of Gastroenterology 2008年第41期14卷 6360-6365页

作者： shaoan Fan Feng Wu Frank Martiniuk Martha L Hale Andrew D Ellington Kam-Meng Tchou-Wong Department of Environmental Medicine New York University School of Medicine 57 Old Forge Road Tuxedo New York 10987 United States Department of Medicine New York University School of Medicine 550 First Avenue New York 10016 United States Integrated Toxicology Division U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Fort Detrick Maryland 21702 United States Department of Chemistry and Biochemistry University of Texas at Austin Austin Texas 78712 United States

AIM： To investigate the therapeutic potential of an RNA ligand （aptamer） specific for the catalytic ricin A-chain （RTA）, the protective effects of a 31-nucleo- tide RNA aptamer （31RA）, which formed a high affinity complex with RTA, against ricin-induced toxicity in cell- based luciferase translation and cell cytotoxicity assays were evaluated. METHODs： To test the therapeutic potential of anti- RTA aptamers in Chinese hamster ovary （CliO） AA8 cells stably transfected with a tetracycline regulatable promoter, ricin ribotoxicity was measured us- ing luciferase and ricin-induced cytotoxicity was ascertained by MTs cell proliferation assay with tet- razolium compound [3-（4,5-dimethylthiazol-2-yl）- 5-（3-carboxymethoxyphenyl）-2-（4-sulfophenyl）-2H- tetrazolium]. REsuLTs： Inhibition of protein synthesis by ricin in CliO AA8 cells resulted in diminished luciferase activity and treatment with polyclonal antibody against degly- cosylated RTA （dgA） neutralized the inhibitory effects of ricin on luciferase activity and protected against ricin-induced cytotoxicity as measured by MTs assay. The 31RA anti-RTA aptamer inhibited the translation of luciferase mRNA in cell-free reticulocyte translation assay. 31RA aptamer also partially neutralized the inhibitory effects of ricin on luciferase activity and partially protected against ricin-induced cytotoxicity in CliO AA8 cells. CONCLusION： We have shown that anti-RTA RNA aptamer can protect against ricin ribotoxicity in cell- based luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication.

关键词： Ricin inhibitor RNA aptamer Luciferase assay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of human brain tissue derived from DBs surgery

引用

Translational Neurodegeneration 2022年第1期11卷 625-640页

作者： salla M.Kangas Jaakko Teppo Maija J.Lahtinen Anu.s.oranta Bishwa Ghimire Pirkko Mattila Johanna u.s.maa Markku Varjosalo Jani Katisko Reetta Hinttala PEDEGO research unit University of OuluOuluFinland Medical research Center Oulu University HospitalUniversity of OuluOuluFinland Biocenter Oulu University of OuluOuluFinland institute of Biotechnology HiLIFE Helsinki Institute of Life ScienceUniversity of HelsinkiHelsinkiFinland Drug research Program Faculty of PharmacyUniversity of HelsinkiHelsinkiFin-land Neurosurgery Research Unit of Clinical NeuroscienceOulu University HospitalUniversity of OuluOuluFinland Oulu research Group of Advanced surgical Technologies and Physics(ORGAsTP) Research Unit of Clinical NeuroscienceOulu University HospitalUniversity of OuluOuluFinland institute for Molecular Medicine Finland(FIMM) HiLIFE Helsinki Institute of Life ScienceUniversity of HelsinkiHelsinkiFinland Clinic for Children and Adolescents Division of Pediatric NeurologyOulu University HospitalOuluFinland

Background:Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living *** samples usually represent the advanced disease stage of the ***-thermore,the postmortem interval can affect the transcriptomic and proteomic ***,fresh brain tissue samples from living patients represent a valuable resource of metabolically intact *** of deep brain stimulation(DBs)electrodes into the human brain is a neurosurgical treatment for,e.g.,movement ***,we describe an improved approach to collecting brain tissu.s.from surgical instruments used in implantation of DBs device for transcriptomics and proteomics ***:samples were extracted from guide tubes and recording electrodes used in routine DBs implantation procedure to treat patients with Parkinson’s disease,genetic dystonia and *** sequencing was performed in tissu.s.extracted from the recording microelectrodes and liquid chromatography-mass spectrometry(LC-Ms)per-formed in tissu.s.from guide *** assess the performance of the current approach,the obtained datasets were compared with previously published datasets representing brain ***:Altogether,32,034 RNA transcripts representing the unique Ensembl gene identifiers were detected from eight samples representing both hemispheres of four *** using LC-Ms,we identified 734 unique proteins from 31 samples collected from 14 *** datasets are available in the Biostudies database(accession number s-BssT667).Our results indicate that surgical instruments used in DBs installation retain brain material sufficient for protein and gene expression *** with previously published datasets obtained with similar approach proved the robustness and reproducibility of the ***:The instruments used during routine DBs surgery are a useful source for obtaining fresh brain tis-su.s.from living patien

关键词： Deep brain stimulation Movement disorders Brain Proteomics Transcriptomics RNA sequencing LC-Ms Personalized medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative study on Two Melting simulation Methods:Melting Curve of Gold

引用

Communications in Theoretical Physics 2016年第5期65卷 613-616页

作者：刘中利孙俊生李瑞张修路蔡灵仓 College of Physics and Electric Information Luoyang Normal UniversityLuoyang 471022China The unit 63615 of People's Liberation army Kuerle 841001China Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010China Laboratory for shock Wave and Detonation Physics research Institute of Fluid PhysicsP.O.Box 919-102Mianyang 621900China

Melting simulation methods are of crucial importance to determining melting temperature of materials efficiently.A high-efficiency melting simulation method saves much simulation time and computational *** compare the efficiency of our newly developed shock melting(sM)method with that of the well-established two-phase(TP)method,we calculate the high-pressure melting curve of Au using the two methods based on the optimally selected interatomic *** we only use 640 atoms to determine the melting temperature of Au in the sM method,the resulting melting curve accords very well with the results from the TP method using much more ***,this shows that a much smaller system size in sM method can still achieve a fully converged melting curve compared with the TP method,implying the robustness and efficiency of the sM method.

关键词： solid-liquid transition high-pressure molecular dynamics shock wave

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emergency Treatment of Acute Decompensated severe Aortic stenosis with Transcatheter Aortic Valve implantation under the Coplane View using J-Tipped Wires Fluoroscopy

引用

Cardiology Discovery 2023年第4期3卷 273-276页

作者： Xian Liu Yingdong Wang Yuhe sheng Bin Wang Kai Xu Department of Cardiology Cardiovascular Research Institute of People's Liberation ArmyNorthern Theater General HospitalShenyangLiaoning 110016China

Patients experiencing severe aortic stenosis with acute decompensation often face elevated surgical aortic valve replacement risks,leading to high postoperative mortality ***,for some patients eligible for transcatheter aortic valve implantation(TAVI),computed tomography angiography for assessing the aortic root and coronary artery might be challenging before the TAVI *** case highlights a patient who underwent emergency TAVI guided by coplane view generated using J-tipped wires fluoroscopy without computed tomography evaluation before the *** approach reduces contrast usage during the TAVI procedure,significantly mitigating the risks of renal injury and heart function deterioration.

关键词： Aortic valve stenosis Transcatheter aortic valve implantation severe aortic stenosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：