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Diagnostic performance and problem analysis of commercial tuberculosis antibody detection kits in China

Military Medical research 2018年第3期5卷 242-250页

作者： Xue-Juan Bai You-Rong Yang Jian-Qin Liang Hui-Ru An Jie Wang Yan-Bo Ling Zhong-Yuan Wang Xue-Qiong Wu Army tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Institute of Tuberculosis Research 309 Hospital of Chinese PLA tuberculosis department No.2.institute of tuberculosis research 309 hospital of Chinese PLA tuberculosis department no.1.institute of tuberculosis research 309 hospital of Chinese PLA tuberculosis department No.3 Institute of Tuberculosis Research 309 Hospital of Chinese PLA

Background: The diagnosis of bacterium-negative pulmonary tuberculosis(TB) and extra-pulmonary TB is challenging clinically. The detection of the anti-TB antibody has an important, auxiliary, clinical diagnostic value. Therefore, TB antibody detection kits should be screened and evaluated, and the reagents with the highest sensitivity and specificity should be chosen and used ***: The diagnostic performance of 7 commercially available TB antibody detection kits(kits A, B, C, D, E, F and G) based on the gold immunoassay detection of immunoglobulin(Ig) G or IgM antibodies were simultaneously evaluated and compared in 62 TB cases and 56 non-TB cases in a laboratory. A retrospective analysis including 2549 cases was carried out to assess the clinical diagnosis values of bacteriological examinations and TB antibody tests(kits B and H used in the clinic).Results: The sensitivities of TB antibody kits A, B, C, D, E, F and G in the sera from 62 TB patients were 50.0%, 83.9%, 38.7%, 9.7%, 48.4%, 69.4% and 79.0%, respectively; the sensitivities in the sera from 24 smear-negative TB patients were 29.2%, 79.2%, 29.2%, 12.5%, 29.2%, 54.2% and 79.2%, respectively; the specificities in the sera from 56 nonTB patients were 73.2%, 25.0%, 85.7%, 96.4%, 78.6%, 78.6% and 50.0%, respectively. Of the 2549 clinically diagnosed cases, there were 1752 pulmonary TB cases, 505 extra-pulmonary TB cases, 87 old pulmonary TB cases and 205 non-TB cases. The positive results for smear, culture, TB antibody kit B and kit H in pulmonary TB cases were 39.8%(543/1365), 48.6%(372/765), 45.8%(802/1752) and 25.2%(442/1752), respectively; the results in extra-pulmonary TB cases were 3.4%(6/178), 5.8%(4/69), 35.4%(179/505), and 11.3%(57/505), respectively; the results in old pulmonary TB cases were 0%(0/64), 0%(0/30), 32.2%(28/87), and 9.2%(8/87), respectively; and the results in non-TB cases were 0%(0/121), 0%(0/56), 21.5%(44/205), and 2.4%(5/205), respectively. Of 624 smear-positive and/or

关键词： tuberculosis tuberculosis antibody test Smear Culture

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Luciferase reporter phage phAE85 for rapid detection of rifampicin resistance in clinical isolates of Mycobacterium tuberculosis

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 728-731页

作者： Gomathi Sivaramakrishnan Balaji Subramanyam Ponnuraja C Vanaja Kumar department of Bacteriology National Institute for Research in Tuberculosis(Formerly Tuberculosis Research Centre)

Objective:To evaluate luciferase reporter phage(LRP)phAE85 in rapid detection of rifampicin resistance in a region where TB is ***:One hundred and ninety primary isolates on Lowenstein-Jensen medium were *** 7H9 complete medium with and without rifampicin at 2μg/mL was inoculated with standard inoculum from suspensions of the clinical *** incubation for 72 h,LRP was *** 4 h of further incubation,light output from both control and test was measured as relative light *** exhibiting a reduction of less than 50%relative light units in the drug containing vial compared to control were classified as *** were compared with the conventional minimum inhibitory concentration method(MIC)of drug susceptibility ***:The two methods showed high level of agreement of 97%(CI 0.94,0.99)and P value was 0.000 *** sensitivity and specificity of LRP assay for detection of rifampicin resistance were 91%h(CI 0.75,0.98)and 99ct(CI0.95,1.00)*** to detection of resistance by LRP assay was 3 d in comparison with 28 d by the minimum inhibitory concentration ***:LRP assay with phAE85 is 99%specific,91%sensitive and is highly *** the assay offers a simple procedure for drug sensitivity testing,within die scope of semi-automation.

关键词： Mycobacterium tuberculosis Rifampicin resistance Rapid detection

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CLINICAL STUDIES ON ACUPUNCTURE ANESTHESIA IN LUNG RESECTION

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中华医学杂志(英文版) 1980年第5期93卷 287-292页

作者： [Anonymous] department of Acupuncture Anesthesia Beijing Tuberculosis Research Institute

Acupuncture anesthesia(AA)in 1,048 casesof lung resection with a 97.2% success rate isanalyzed for factors affecting efficiency of AA,such as acupuncture point selection and indi-vidual variations in mental activity type,atti-tude towards acupuncture,emotional state,sen-sitivity to acupuncture,tolerance of needling,physiologic parameters and ability to ***,age and occupation do notaffect efficacy.

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Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant tuberculosis in Beijing,China

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Biomedical and Environmental Sciences 2024年第10期37卷 1195-1203页

作者： Can Guo Lihui Nie Yanhua Song Rongmei Liu Xiaoguang Wu Yuanyuan Shang Xuxia Zhang Yu Pang Mengqiu Gao department of tuberculosis Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China department of Bacteriology and Immunology Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objectives The combined use of bedaquiline and delamanid(BDQ-DLM)is limited by an increased risk of prolonging the QTc *** retrospectively evaluated patients who received DLM/BDQcontaining regimens at a TB-specialized *** aimed to present clinical efficacy and safety data for Chinese *** This case-control study included patients with multidrug-resistant tuberculosis(MDR-TB)treated with BDQ alone or BDQ plus *** A total of 96 patients were included in this analysis:64 in the BDQ group and 32 in the BDQ+DLM *** the 96 patients with positive sputum culture at the initiation of BDQ alone or BDQ combined with DLM,46 patients(71.9%)in the BDQ group and 29(90.6%)in the BDQ-DLM group achieved sputum culture conversion during *** rate of sputum culture conversion did not differ between the two *** time to sputum culture conversion was significantly shorter in the BDQ-DLM group than in the BDQ *** most frequent adverse event was QTc interval prolongation;however,the frequency of adverse events did not differ between the *** In conclusion,our results demonstrate that the combined use of BDQ and DLM is efficacious and tolerable in Chinese patients infected with *** in the BDQ-DLM group achieved sputum culture conversion sooner than those in the BDQ group.

关键词： Multidrug resistant tuberculosis Bedaquiline Delamanid Efficacy Safety

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H pylori seroprevalence in patients with lung cancer

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World Journal of Gastroenterology 2007年第16期13卷 2349-2351页

作者： Katayoon Najafizadeh Sayeed Falah Tafti Masoud Shiehmorteza Masoud Saloor Masoud Jamali department of Respiratory Medicine National Research Institute of Tuberculosis and Lung Diseases Tehran 19556 Iran

AIM: To assess H pylori seroprevalence in lung cancer and determine whether there is a potential association between lung cancer and H pylori infection. METHODS: The study was conducted on forty consecutive patients with lung cancer, confirmed by pathology (32 men, 8 women; mean age 55.50 ± 11.91 years, range 16-77 years). Forty healthy subjects (25 men, 15 women; mean age 43.08 ± 12.60 years, range 20-79 years) from the patients’ family members were matched to each case subject on the basis of age and socioeconomic status. H pylori infection was detected with a commercially available immunoglobulin G (IgG) enzyme-linked immunosorbent assay (Trinity kit, Biotech co., USA), previously validated in adults (86% sensitivity, 96% specificity) against a gold standard of culture and histology. RESULTS: H pylori seropositivity was present in 52.5% of patients with lung cancer in comparison to 45.0% of healthy control subjects. Although H pylori seropositivity was more frequent in lung cancer patients than in controls, the difference did not reach statistical significance (OR = 1.35, 95% CI = 0.56-3.25; P = 0.65). In addition, there was no significant difference between cases and controls in terms of gastrointestinal symptoms. CONCLUSION: The earlier described association between H pylori infection and lung cancer was not supported in this study. Further studies with larger sample sizes should be undertaken to assess the frequency of H pylori infection in patients with lung cancer and their potential association.

关键词： Lung neoplasm H pylori Helicobacter infections/complications Carcinoma/Non-small cell Carcinoma/Squamous cell Case-control studies

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won department of Chemical and Biological Engineering Korea University department of Chemical Engineering (Integrated process) Kyung Hee University department of Chemical Engineering and Materials Science Ewha Womans University department of Chemical Engineering Pukyong National University Resources Engineering Plant research department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Effects of Mycobacterium vaccae vaccine in a mouse model of tuberculosis: protective action and differentially expressed genes

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Military Medical research 2020年第2期7卷 125-139页

作者： Wen-Ping Gong Yan Liang Yan-Bo Ling Jun-Xian Zhang You-Rong Yang Lan Wang Jie Wang Ying-Chang Shi Xue-Qiong Wu Army tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of tuberculosis Diagnosis and Treatment Institute for Tuberculosis Researchthe 8th Medical Center of Chinese PLA General HospitalBeijing 100091China

Background:tuberculosis is a leading cause of death *** is an effective vaccine,but not widely used in many parts of the world due to a variety of *** vaccae(***)is another vaccine used in human subjects to prevent *** the current study,we investigated the potential mechanisms of *** vaccination by determining differentially expressed genes in mice infected with *** before and after *** ***:Three days after exposure to *** H37 Rv strain(5×10~5 CFU),adult BALB/c mice randomly received either *** vaccine(22.5μg)or vehicle via intramuscular injection(n=8).Booster immunization was conducted 14 and 28 days after the primary *** expressed genes were identified by microarray followed by standard bioinformatics ***:*** vaccination provided protection against *** infection(most prominent in the lungs).We identified 2,326 upregulated and 2,221 downregulated genes in vaccinated *** changes could be mapped to a total of 123 signaling pathways(68 upregulated and 55 downregulated).Further analysis pinpointed to the MyD88-dependent TLR signaling pathway and PI3 K-Akt signaling pathway as most likely to be ***:*** vaccine provided good protection in mice against *** infection,via a highly complex set of molecular *** findings may provide clue to guide development of more effective vaccine against tuberculosis.

关键词： Mycobacterium tuberculosis Immunotherapeutic effect Immunotherapy Vaccae vaccine Differentially expressed genes Signaling pathway

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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Prolonged use of bedaquiline in two patients with pulmonary extensively drug-resistant tuberculosis: Two case reports

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World Journal of Clinical Cases 2021年第10期9卷 2326-2333页

作者： Jing-Tao Gao Li Xie Li-Ping Ma Wei Shu Li-Jie Zhang Yu-Jia Ning Shi-Heng Xie Yu-Hong Liu Meng-Qiu Gao Clinical Center on TB Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China department of tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

BACKGROUND Bedaquiline is among the prioritized drugs recommended by the World Health Organization for the treatment of extensively drug-resistant tuberculosis(XDRTB).Many patients have not achieved better clinical improvement after bedaquiline is stopped at 24 ***,there is no recommendation or guideline on bedaquiline administration beyond 24 wk,which is an important consideration when balancing the benefit of prognosis for XDR-TB against the uncertain safety concerning the newer *** SUMMARY This paper reported 2 patients with XDR-TB(a female of 58 years of age and a female of 18 years of age)who received bedaquiline for 36 wk,as local experience to be *** 2 cases had negative cultures after 24 wk of treatment,but lung imaging was still *** discussion among experts,the consensus was made to bedaquiline prolongation by another 12 *** 36-wk prolonged use of bedaquiline in both cases achieved a favorable response without increasing the risk of cardiac events or new safety *** Longer regimen,including 36-wk bedaquiline treatment,might be an option for patients with *** studies are needed to explore the effectiveness and safety of prolonged use of bedaquiline for 36 wk vs standard 24 wk in the treatment of multidrug-resistant/XDR-TB or to investigate further the biomarkers and criteria indicative for extension of bedaquline to facilitate clinical use of thisnovel drug.

关键词： Pulmonary tuberculosis Bedaquiline Extensively drug-resistant tuberculosis tuberculosis Case report

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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration research 2025年第1期20卷 21-28页

作者： Tomomi Tanaka Hyung-Lok Chung department of Neurology Houston Methodist Research InstituteHoustonTXUSA department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

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