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Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation

Cellular & Molecular Immunology 2021年第4期18卷 905-918页

作者： Cristina Tecchio Marco Antonio Cassatella Department of Medicine Section of Hem atology and Bone Marrow Transplant UnitUniversity of VeronaVeronaItaly Department of Medicine Section of General PathologyUniversity of VeronaVeronaItaly

Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow *** role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against ***,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered ***,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation ***,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC *** also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)***,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also *** on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial ***,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT.

关键词： neutrophils allogeneic hematopoietic stem cell transplantation(alloHSCT) alloHSCT-associated complications lowdensity neutrophils(LDNs) normal-density neutrophils(NDNs)

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Mediating role of inner strength in the relationship between medication literacy and medication adherence among kidney transplant patients

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中南大学学报（医学版） 2024年第6期49卷 961-971页

作者： WANG Liping FANG Chunhua NIE Manhua ZHU Li LIU Sai LI Haiyang Clinical Nursing Teaching and Research section Second Xiangya HospitalCentral South UniversityChangsha 410011 Department of Kidney transplantation Second Xiangya HospitalCentral South UniversityChangsha 410011China

Objective:Compared with long-term renal replacement therapy,kidney transplantation is the ideal treatment for end-stage renal disease(ESRD),significantly extending patient life and improving quality of *** transplant patients need to adhere to lifelong immunosuppressive medication regimens,but their medication adherence is generally poor compared with other organ transplant *** adherence is closely related to medication literacy and psychological status,yet related studies are *** study aims to investigate the current status of medication adherence,inner strength,and medication literacy in kidney transplant patients,analyze the relationships among these 3 factors,and explore the mediating role of inner strength in the relationship between medication literacy and medication ***:A cross-sectional survey was conducted from March to October 2023 involving 421 patients aged≥18 years who visited kidney transplantation outpatient clinics at 4 tertiary hospitals in Hunan *** inner strength,medication literacy,and medication adherence of kidney transplant patients were investigated using the Inner Strength Scale(ISS),the Chinese version of the Medication Literacy Assessment in Spanish and English(MedLitRxSE),and the Chinese version of the Morisky Medication Adherence Scale-8(C-MMAS-8),*** analysis was performed to examine the effects of demographic and clinical data on medication *** analysis was conducted to explore the relationships among medication literacy,medication adherence,and inner *** variables from univariate and correlation analyses were further analyzed using multiple linear regression,and the mediating effect of inner strength was ***:Among the 421 questionnaires collected,408 were valid,with an effective rate of 96.91%.The scores of C-MMAS-8,MedLitRxSE,and ISS were 6.64±1.16,100.63±14.67,and 8.47±4.03,*** the 408 patients

关键词： inner strength medication literacy medication adherence kidney transplant patients

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Greater Biosynthetic Liver Dysfunction in Primary Sclerosing Cholangitis Suggests Co-existent or Impending Cholangiocarcinoma

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Journal of Clinical and Translational Hepatology 2016年第1期4卷 1-4页

作者： Panagiotis Trilianos Abhishek Agnihotri Enver Ucbilek Ahmet Gurakar Department of Gastroenterology & Hepatology Section of Transplant Hepatology The Johns Hopkins School of MedicineBaltimore MD USA Department of Medicine MetroWest Medical Center Framingham MA USA Department of Gastroenterology & Hepatology Section of Transplant Hepatology The Johns Hopkins School of MedicineBaltimore MD USA

Background and Aim:Patients with primary sclerosing cholangitis (PSC) who develop cholangiocarcinoma (CCA)have a median survival of less than 6 *** half of cases,PSC and CCA will be diagnosed either concurrently or within a year of one *** aim of the present study is to demonstrate that the degree of biochemical liver dysfunction is associated with concomitant or impending ***:We did a chart review of patients diagnosed with PSC and CCA up to 18 months from presentation (“CCA” group) as well as patients with PSC that underwent transplantation with no sign of CCA in their explanted liver (“nCCA” group).Along with demographic data and follow-up length,we recorded their presenting liver function tests,including alanine and aspartate aminotransferases (ALT,AST),total bilirubin (TBil),alkaline phosphatase (ALP),international normalization ratio (INR),and serum Ca 19-9 *** between mean values of the two groups were analyzed with a student's ***:Twenty-four patients were *** “CCA”group consisted of eight patients,and the “non-CCA” group had 16 *** was no significant difference between the two groups in their presenting values of ALT,ALP,or serum Ca ***,the “CCA” group had significantly higher levels of AST,TBil,and ***:Patients with PSC and concurrent or impending CCA appear to exhibit significantly greater biochemical liver dysfunction than those who do not develop ***,newly-diagnosed PSC patients presenting with these findings may warrant more rigorous evaluation.

关键词： Cholestatic disease Malignancy Liver transplantation Liver function tests

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Acute portal vein thrombosis after liver transplant presenting with subtle ultrasound abnormalities:A case report and literature review

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World Journal of Hepatology 2019年第2期11卷 234-241页

作者： Thomas Couri Carla Harmath Talia Baker Anjana Pillai Department of Internal Medicine University of Chicago Department of Radiology University of Chicago Department of Surgery Section of Transplant SurgeryUniversity of Chicago Department of Internal Medicine Section of GastroenterologyHepatologyand NutritionUniversity of Chicago

BACKGROUND Portal vein thrombosis(PVT) after liver transplantation(LT) is an uncommon complication with potential for significant morbidity and mortality that transplant providers should be cognizant *** subtle changes in postoperative ultrasounds that could herald but do not definitively diagnose PVT is *** SUMMARY A 30-year-old female with a history of alcohol-related cirrhosis presented with painless jaundice and received a deceased donor orthotopic liver *** the first two days post-operatively,her liver Doppler ultrasounds showed a patent portal vein,increased hepatic arterial diastolic flows,and reduced hepatic arterial resistive *** was asymptomatic with improving *** postoperative day three,her resistive indices declined further,and computed tomography of the abdomen revealed a large extra-hepatic *** patient then underwent emergent percutaneous venography with tissue plasminogen activator administration,angioplasty,and stent *** was started to prevent stent ***-up ultrasounds showed a patent portal vein and improved hepatic arterial resistive *** graft function improved to normal by *** decreased hepatic artery resistive indices and increased diastolic flows on ultrasound are often associated with hepatic arterial stenosis post-LT,PVT can also cause these *** Reduced hepatic arterial resistive indices on ultrasound can signify PVT post-LT,and thrombolysis,angioplasty,and stent placement are efficacious treatments.

关键词： Portal vein thrombosis Portal vein stent Liver transplant Case report

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Current surgical treatment strategies for hepatocellular carcinoma in North America

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World Journal of Gastroenterology 2014年第41期20卷 15007-15017页

作者： Adeel S Khan Kathryn J Fowler William C Chapman Department of General and Vascular Surgery Aurora Bay Care Medical Center Department of Radiology Washington University School of Medicine Department of Surgery Section of Abdominal TransplantWashington University School of Medicine

Hepatocellular carcinoma(HCC) is an aggressive tumor that often occurs in the setting of chronic liver *** patients do not initially manifest any symptoms of HCC and present late when cure with surgical resection or transplantation is no longer *** this reason,patients at high risk for developing HCC are subjected to frequent screening *** surgical management of HCC is complex and requires an inter-disciplinary *** resection is the treatment of choice for HCC in patients without cirrhosis and is indicated in some patients with early cirrhosis(Child-Pugh A).Liver transplantation has emerged in the past decade as the standard of care for patients with cirrhosis and HCC meeting Milan criteria and in select patients with HCC beyond Milan ***-regional therapy with transarterial chemoembolization,transarterial embolization,radiofrequency ablation and other similar local treatments can be used as neo-adjuvant therapy to downstage HCC to within Milan criteria or as a bridge to transplantation in patients on transplant wait list.

关键词： Hepatocellular carcinoma Liver transplantation Liver resection Transarterial chemoembolization Radiofrequency ablation

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China organ donation and transplantation update: the Hangzhou Resolution

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Hepatobiliary & Pancreatic Diseases International 2014年第2期13卷 122-124页

作者： Jie-Fu Huang Shu-Sen Zheng Yong-Feng Liu Hai-Bo Wang Jeremy Chapman Philip O'Connell Michael Millis John Fung Francis Delmonico Department of Liver Surgery Peking Union Medical College Hospital National Organ transplant Committee Ministry of Health The First Affiliated Hospital of Zhejiang University The First Hospital of China Medical University Department of Surgery The University of Hong Kong China Organ transplant Response System Research Center Centre for Renal and transplant Research Westmead Millenium InstituteSydney University section of transplantation Liver Transplantation and Hepatobiliary SurgeryUniversity of Chicago Department of General Surgery Transplant CenterDigestive Disease Institute Department of Surgery Massachusetts General Hospital

The much-anticipated change in the practice of organ donation and transplantation in China is now underway and affirmed by an important Hangzhou Resolution promulgated at the 2013 China transplant *** of the National Health and Family Planning Commission On October 29,2013,in a meeting of the National Health and Family Planning Commission (NHFPC)officials with Jie-Fu Huang,Head of National Organ transplant Committee(OTC), Hai-Bo Wang,Director of China Organ transplant Response System (COTRS)

关键词： Li China organ donation and transplantation update the Hangzhou Resolution Jun

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Recipient functional status impacts on short and long-term intestinal transplant outcomes in United States adults

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World Journal of transplantation 2024年第3期14卷 80-94页

作者： Sarpong Boateng Prince Ameyaw Solomon Gyabaah Yaw Adjepong Basile Njei Department of Medicine Yale New Haven HealthBridgeport HospitalBridgeportCT 06610United States Department of Epidemiology and Biostatistics University of North TexasFort WorthTX 76107United States Department of Medicine Komfo Anokye Teaching HospitalKumasi KS 1934Ghana Yale University School of Medicine New HavenCT 06520United States section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

BACKGROUND Recipient functional status prior to transplantation has been found to impact post-transplant outcomes in heart,liver and kidney ***,information on how functional status,before and after transplant impacts post-transplant survival outcomes is *** To investigate the impact of recipient functional status on short and long term intestinal transplant outcomes in United States *** We conducted a retrospective cohort study on 1254 adults who underwent first-time intestinal transplantation from 2005 to *** primary outcome was *** the Karnofsky Performance Status,functional impairment was categorized as severe,moderate and *** were conducted using Kaplan-Meier curves and multivariable Cox *** The median age was 41 years,majority(53.4%)were *** impairment was present in 28.3%of *** median survival time was 906.6 *** median survival time was 1331 and 560 days for patients with normal and severe functional impairment *** with severe impairment had a 56%higher risk of mortality at one year[Hazard ratio(HR)=1.56;95%CI:1.23–1.98;Ptransplant also had poor survival *** Pre-and post-transplant recipient functional status is an important prognostic indicator for short-and long-term intestinal transplant outcomes.

关键词： Intestinal transplantation Functional status Karnofsky performance status Post-transplant outcomes Survival analysis transplant outcome

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Approach to a patient with cardiac amyloidosis

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Journal of Geriatric Cardiology 2019年第7期16卷 567-574页

作者： Christopher Strouse Alexandros Briasoulis Rafael Fonseca Yogesh Jethava Department of Internal Medicine Division of HematologyOncologyand Blood and Marrow TransplantationUniversity of IowaIowa CityIAUSA Cardiomyopathy section Cardiology DivisionUniversity of IowaIowa CityIowaUSA Bone Marrow transplant Program Mayo ClinicPhoenixArizonaUSA

1 Introduction Cardiac amyloid(CA)is characterized by inexorably progressive heart failure making early diagnosis and treatment *** article will review the pathophysiology,clinical presentation,diagnosis,prognostication and treatment of patients with CA.2 Pathophysiology CA is the result of extracellular deposition of a misfolded protein into cardiac tissue,forming insoluble aggregations of rigid,nonbranching 10 nm wide *** causes impaired cardiac function by disrupting cardiac architecture,direct myotoxicity and ischemic injury secondary to infiltration of intramyocardial vessels.

关键词： Cardiac amyloidosis Heart failure The elderly

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Risk factors for postoperative bile leakage:a retrospective single-center analysis of 411 hepatectomies

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 81-86页

作者： Fabrizio Panaro Lisa Hacina Hassan Bouyabrine Al-Warith Al-Hashmi Astrid Herrero Francis Navarro Department of General and Liver transplant Surgery Montpellier University HospitalCollege of Medicine

BACKGROUND： The primary focus of the study was to ana- lyze the risk factors for bile leakage after hepatectomy for be- nign or malignant tumors. METHODS： A total of 411 patients who had undergone hepa- tectomy between December 2006 and December 2011 were ret- rospectively analyzed. The severity of bile leakage was graded according to the ISGLS classification. Twenty-eight pre- and postoperative parameters were analyzed. RESULTS： The overall bile leakage incidence was 10.2% （42/411）. The severity of the leakage was classified according to the IS- GLS classification. Bile leakage was detected early in case of abdominal drainage （11.4% vs 1.9%, P=0.034）. It prolonged the time of hospitalization （16 vs 9 days, P=0.001）. In all patients, wedge resection was associated with a higher incidence of bile leakage in contrast to anatomical resections （25.6% vs 4.1%, P〈0.0001） regardless of the underlying liver disease. Furthermore, total vascular exclusion increased risk of bile leakage （P=0.008）. CONCLUSIONS： Bile leakage as a major issue after hepatic resection is related to the postoperative morbidity and the hospitalization time. It is associated with non-anatomical re- section and a total vascular exclusion.

关键词： liver resection bile leakage wedge total vascular exclusion

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Delivery of genetic load during ex situ liver machine perfusion with potential for CRISPR-Cas9 gene editing:An innovative strategy for graft treatment

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 503-505页

作者： Eliano Bonaccorsi-Riani Andrew Gillooly Isabel M.A.Brüggenwirth Paulo N.Martins Abdominal transplant Unit Cliniques Universitaires Saint LucUniversitéCatholique de LouvainBrusselsBelgium Pole de Chirurgie Expérimentale et transplantation UniversitéCatholique de LouvainBrusselsBelgium Department of Surgery Transplant DivisionUniversity of MassachusettsWorcester-MassachusettsUSA Department of Surgery Section of hepatobiliary surgery and liver transplantationUniversity Medical Center GroningenUniversity of GroningenGroningenThe Netherlands

To the Editor:Over the years,the shortage of suitable donor organs has challenged the transplant community in performing life-saving liver transplantation(LT).Recent reports from European and American liver transplant... 详细信息

关键词： organs mortality graft

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