Delivery of genetic load during ex situ liver machine perfusion with potential for CRISPR-Cas9 gene editing:An innovative strategy for graft treatment

作     者：Eliano Bonaccorsi-Riani Andrew Gillooly Isabel M.A.Brüggenwirth Paulo N.Martins Eliano Bonaccorsi-Riani;Andrew Gillooly;Isabel M.A.Brüggenwirth;Paulo N.Martins

作者机构：Abdominal Transplant UnitCliniques Universitaires Saint LucUniversitéCatholique de LouvainBrusselsBelgium Pole de Chirurgie Expérimentale et TransplantationUniversitéCatholique de LouvainBrusselsBelgium Department of SurgeryTransplant DivisionUniversity of MassachusettsWorcester-MassachusettsUSA Department of SurgerySection of hepatobiliary surgery and liver transplantationUniversity Medical Center GroningenUniversity of GroningenGroningenThe Netherlands 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2021年第20卷第5期

页      面：503-505页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 10[医学] 

基　　金：supported by a grant from the University of Massachusetts American Association for the Study of Liver Diseases(AASLD) American Society of Transplant Surgeons(ASTS) awarded and supported by the International Travel Scholar Award(2018)by the International Liver Transplantation Society(ILTS)to develop this project supported by a travel grant from the European Society of Transplantation(ESOT) a grant from Jo Kolk Studiefonds 

主　　题：organs mortality graft 

摘      要：To the Editor:Over the years,the shortage of suitable donor organs has challenged the transplant community in performing life-saving liver transplantation(LT).Recent reports from European and American liver transplant registries show persistently high waitlist mortality rates ranging between 10%and 18%[1,2].