检索结果-南通市图书馆

Cardiac Syndromes in Liver Disease:A Clinical Conundrum

Journal of Clinical and Translational Hepatology 2023年第4期11卷 975-986页

作者： Milos Brankovic Paul Lee Nikolaos Pyrsopoulos Mark Klapholz Department of Medicine Rutgers New Jersey Medical SchoolNewarkNJUSA Transatlantic Cardiovascular Study Group BloomfieldNJUSA Division of Gastroenterology and Hepatology Department of MedicineRutgers New Jersey Medical SchoolNewarkNJUSA Division of Cardiology Heart Failure Prevention and Treatment ProgramRutgers New Jersey Medical SchoolNewarkNJUSA

Understanding the interaction between the heart and liver is pivotal for managing patients in whom both organs are affected.Studies have shown that cardio-hepatic interactions are bidirectional and that their identification,assessment,and treatment remain challenging.Congestive hepatopathy is a condition that develops in the setting of long-standing systemic venous congestion.If left untreated,congestive hepatopathy may lead to hepatic fibrosis.Acute cardiogenic liver injury develops as a combination of venous stasis and sudden arterial hypoperfusion due to cardiac,circulatory,or pulmonary failure.The treatment of both conditions should be directed toward optimizing the cardiac substrate.Hyperdynamic syndrome may develop in patients with advanced liver disease and lead to multiorgan failure.Cirrhotic cardiomyopathy or abnormalities in pulmonary vasculature,such as hepatopulmonary syndrome and portopulmonary hypertension may also develop.Each complication has unique treatment challenges and implications for liver transplantation.The presence of atrial fibrillation and atherosclerosis in liver disease brings another layer of complexity,particularly in terms of anticoagulation and statin use.This article provides an overview of cardiac syndromes in liver disease,focusing on current treatment options and future perspectives.

关键词： Liver disease Congestive hepatopathy Cardiogenic liver injury Cirrhotic cardiomyopathy Hepatopulmonary syndrome Portopulmonary hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2型糖尿病患者动脉粥样硬化性血脂异常与全因死亡的独立相关性及性别的调节作用:一项前瞻性队列研究

引用

中华高血压杂志 2021年第3期29卷 299-299页

作者： Orsi E Penno G Solini A Bonora E Fondelli C Trevisan R Vedovato M Cavalot F Morano S Baroni MG Nicolucci A Pugliese G 刘青(摘译) 练桂丽(审校) Renal Insufficiency cardiovascular Events (RIACE) study group 不详

动脉粥样硬化性血脂异常与心血管病发病率和死亡率的残余风险有关,尽管低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)水平达标,这种风险仍然存在,尤其是在2型糖尿病患者中。然而,它与全因死亡的关系还没有得到充分... 详细信息

动脉粥样硬化性血脂异常与心血管病发病率和死亡率的残余风险有关,尽管低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)水平达标,这种风险仍然存在,尤其是在2型糖尿病患者中。然而,它与全因死亡的关系还没有得到充分的研究。

关键词：全因死亡前瞻性队列研究动脉粥样硬化性残余风险心血管病血脂异常低密度脂蛋白胆固醇发病率和死亡率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antihypertensive efficacy of extract of Hedera helix in high salt-induced hypertensive Sprague-Dawley rats

引用

Asian Pacific Journal of Tropical Medicine 2018年第8期11卷 473-479页

作者： Umme Salma Taous Khan Abdul Jabbar Shah cardiovascular Research group Department of Pharmacy COMSATS University IslamabadAbbottabad campus

Objective: To explore the antihypertensive effect of extracts from the leaves of Hedera helix(H. helix) on normotensive and hypertensive rats in-vivo followed by vasodilatory studies in-vitro.Methods: The crude methanolic extract was prepared and the activity directed fractionation was carried out. Spectrophotometric analysis of total phenolic and flavonoid content was also done. HPLC analysis was performed for the detection of hederacoside C. In-vivo blood pressure study was carried out in normotensive and high salt-induced hypertensive SpragueDawley rats. Isolated aortic tissues from rat and rabbit were used for in-vitro studies. The effects were recorded and analyzed through PowerL ab data acquisition system. Results: Crude extract of H. helix(1-30 mg/kg) decreased blood pressure to greater extent in high salt-induced hypertensive rats in-vivo compared to the normotensive [Max. fall(58.59±0.02) mm Hg vs.(67.53±3.07) mmH g]. The n-hexane, chloroform, ethyl acetate and aqueous fractions were also checked. These fractions were more effective in hypertensive rats. Aqueous fraction was more potent and n-hexane the least. In isolated rat aortic rings precontracted with phenylephrine, crude extract induced endothelium-dependent effect. The endothelium-dependent component of vasodilatory effect was ablated with L-NAME, and denudation of endothelium. The aqueous fraction was most potent vasodilator. In aortic rings from hypertensive rats, extract and fractions produced partial endothelium-independent effect which was not affected by pretreatment with L-NAME, indicating endothelium dysfunction in the hypertensive rats and suggesting additional vasodilatory mechanisms. In rabbit aorta, the extract and fractions also inhibited phenylephrine and high K^+-induced precontractions, and shifted Ca^(++) concentration–response curves. Conclusions: Our findings indicate that extract and fractions of H. helix are antihypertensive remedies, which is the outcome of vasodilatory effect. This vasodilatory effect is mediated through ni

关键词： Hedera helix Antihypertensive Vasorelaxant Endothelium-dependent Nitric oxide Calcium channel blocker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果：PCI-CLARITY研究

引用

美国医学会杂志（中文版） 2006年第4期25卷 195-202页

作者： Marc S. Sabatine Christopher P．Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿（译） cardiovascular Division TIMI Study Group Brigham and Women＇s Hospital 不详

背景：关于经皮冠状动脉介入治疗（percutaneous coronary intervention，PCI）前氯吡格雷预治疗的益处目前仍有争议，并且其使用亦未获得普遍认可。目的：于新近发生ST段抬高心肌梗死（ST—segment elevation myocardial infarction，S... 详细信息

背景：关于经皮冠状动脉介入治疗（percutaneous coronary intervention，PCI）前氯吡格雷预治疗的益处目前仍有争议，并且其使用亦未获得普遍认可。目的：于新近发生ST段抬高心肌梗死（ST—segment elevation myocardial infarction，STEMI）的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。设计、地点及参试者：CLARITY（PCI—Clopidogrel as Adjunctive Reperfusion Therapy）研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI（Thrombolysis in Myocardial Infarction）28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。干预：患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷（300mg负荷剂量，以后75mg，每日1次）或安慰剂，直至冠状动脉造影前为止。造影在开始研究药物后2～8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷（包括负荷剂量）。主要观测指标：一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。结果：氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率（34[3．6％]比58[6．2％]；校正优势比[odds ratio，OR]，0．54[95％CI，0．35—0．85]；P=0．008）。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率（37[4．0％]比58[6．2％]；OR，0．62[95％CI，0．40～0．95]；P=0．03）。总体上，氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降（70[7．5％]比112[12．0％]；校正OR，0．59[95％CI，0．43～0．81]；P=0．001；所需治疗例数=23）。TIMI严重或轻微出血的发生率未显著增加（（18[20％]比17[1．9％]；P〉0．99）。结论：氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症，而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。

关键词：经皮冠状动脉介入治疗心肌梗死患者氯吡格雷介入治疗前 ST段抬高纤溶治疗不良心血管事件 Clopidogrel 服用 Therapy)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hand dysfunction after transradial artery catheterization for coronary procedures

引用

World Journal of Cardiology 2017年第7期9卷 609-619页

作者： Muhammad Ayyaz Ul Haq Muhammad Rashid Chun Shing Kwok Chun Wai Wong James Nolan Mamas A Mamas Keele cardiovascular Research group Keele University University Hospital of North Midlands

AIM To sythesize the available literature on hand dysfunction after transradial catheterization.METHODS We searched MEDLINE and EMBASE. The search results were reviewed by two independent judicators for studies that met the inclusion criteria and relevant reviews. We included studies that evaluated any transradial procedure and evaluated hand function outcomes post transradial procedure. There were no restrictions based on sample size. There was no restriction on method of assessing hand function which included disability, nerve damage, motor or sensory loss. There was no restriction based on language of study. Data was extracted, these results were narratively synthesized.RESULTS Out of 555 total studies 13 studies were finally included in review. A total of 3815 participants with mean age of 62.5 years were included in this review. A variety of methods were used to assess sensory and motor dysfunction of hand. Out of 13 studies included, only 3 studies reported nerve damage with a combined incidence of 0.16%, 5 studies reported sensory loss, tingling and numbness with a pooled incidence of 1.52%. Pain after transradial access was the most common form of hand dysfunction(6.67%) reported in 3 studies. The incidence of hand dysfunction defined as disability, grip strength change, power loss or any other hand complication was incredibly low at 0.26%. Although radial artery occlusion was not our primary end point for this review, it was observed in 2.41% of the participants in total of five studies included.CONCLUSION Hand dysfunction may occur post transradial catheterisation and majority of symptoms resolve without any clinical sequel.

关键词： Transradial access Transfemoral access Hand dysfunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Percutaneous coronary interventions in the elderly:a 10-year experience in Northern New England

引用

Journal of Geriatric Cardiology 2005年第1期2卷 17-22页

作者： David J.Malenka James T.DeVries Samuel J.Shubrooks for the Northern New England cardiovascular Disease study group Section of Cardiology Dartmouth-Hitchcock Medical Center LebanonNH Center for the Evaluative Clinical Sciences Dartmouth Medical SchoolHanoverNHUSA for the Northern New England cardiovascular Disease study group Section of Cardiology Dartmouth-Hitchcock Medical Center LebanonNHUSA for the Northern New England cardiovascular Disease study group Division of Cardiology Beth Israel-Deaconess Medical Center BostonMAUSA Jr

Background There is a paucity of information available for clinical decision making applying to the elderly patient population. Therefore, data of percutaneous coronary interventions (PCI) including demographic information on the elderly patients, procedural practices, and outcomes are needed. Objectives and Methods From consecutive PCIs of participating institutions, demographics data, clinical, angiographic success and adverse clinical outcomes were collected. Standard statistical methods were used to compare crude differences in patient and procedural characteristics across age groups. Results At baseline, the prevalence of comorbid conditions ( renal failure and heart failure) increased with age. Unstable angina or a non-ST elevation MI were the most common indications for PCI across all age groups. Fewer patients ≥ 80 years old were undergoing primary PCI and older patients were somewhat less likely to receive a Ⅱb/Ⅲa receptor blocker. Slightly more patients ≥ 80 years old underwent a 2-vessel PCI ( consistent with them having more multivessel disease) and these patients were more likely to have an intervention on a Type C lesion. Compared to patients ＜ 50 years old, those aged ≥ 70 years old had a significantly increased risk of death, MI, stroke, or vascular complications at the access site. Conclusions This study suggests increasing age is associated with increasing risk for an adverse outcome following PCI. This is in part attributable to case-mix but likely, also related to the changing physiology of aging. Despite the increased risk of the procedure, the clinical success rate for PCI is quite high and makes it a reasonable alternative for the treatment of CAD in the elderly.

关键词： coronary artery disease elderly percutaneous coronary intervention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of baseline blood pressure on all-cause mortality in patients with atrial fibrillation:results from a multicenter registry study

引用

Chinese Medical Journal 2023年第6期136卷 683-689页

作者： Wei Xu Qirui Song Han Zhang Juan Wang Xinghui Shao Shuang Wu Jun Zhu Jun Cai Yanmin Yang Emergency Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular DiseasesNational Clinical Research Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Hypertension Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular Diseases of ChinaNational Clinical Research Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background:The ideal blood pressure(BP)target for patients with atrial fibrillation(AF)is still unclear.The present study aimed to assess the effect of the baseline BP on all-cause mortality in patients with AF.Methods:This registry study included 20 emergency centers across China and consecutively enrolled patients with AF from 2008 to 2011.All participants were followed for 1 year±1 month.The primary endpoint was all-cause mortality.Results:During the follow-up,276(13.9%)all-cause deaths occurred.Kaplan-Meier curves showed that a systolic blood pressure(SBP)110 mmHg or>160 mmHg was associated with a higher risk of all-cause mortality(log-rank test,P=0.014),and a diastolic blood pressure(DBP)group with SBP110 mmHg(hazard ratio[HR],1.963;95%confidence interval[CI],1.306-2.951),and DBP<70 mmHg(HR,1.628;95%CI,1.163-2.281).In the restricted cubic splines,relations between baseline SBP or DBP and all-cause mortality showed J-shaped associations(non-linear P<0.001 and P=0.010,respectively).The risk of all-cause mortality notably increased at a lower baseline SBP and DBP.Conclusions:Having a baseline SBP110 mmHg or DBP<70 mmHg was associated with a significantly higher risk of all-cause mortality in patients with AF.An excessively low BP may not be an optimal target for patients with AF.

关键词： All-cause death All-cause mortality Atrial fibrillation Blood pressure Diastolic blood pressure Hypertension Systolic blood pressure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Angiographic and clinical outcomes in elderly subjects treated with percutaneous coronary intervention following fibrinolytic administration for ST-elevation myocardial infarction

引用

Journal of Geriatric Cardiology 2005年第1期2卷 10-14页

作者： Ajay J.Kirtane Adam H.Skolnick Hilary Oman Christopher Ruisi Leida Perez Nicole Kraimer Dimitrios Karmpaliotis Duane S.Pinto Eugene Braunwald C.Michael Gibson cardiovascular Division Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMAUSA TIMI study group cardiovascular Division Department of MedicineBrighton and Women's HospitalBostonMAUSA TIMI study group cardiovascular Division Department of MedicineBrigham and Women's HospitalBostonMAUSA

Background Prior studies have demonstrated that the achievement of faster coronary artery flow following reperfusion therapies is associated with improved outcomes among ST-elevation myocardial infarction (STEMI) patients. The association of patient age with angiographic characteristics of flow and perfusion after rescue/adjunctive percutaneous coronary intervention (PCI) following the administration of fibrinolytic therapy has not been previously investigated. Objectives and Methods We examined the association between age (≥ 70 years or ＜ 70years)and clinical and angiographic outcomes in 1472 STEMI patients who underwent rescue/adjunctive PCI following fibrinolytic therapy in 7 TIMI trials. We hypothesized that elderly patients would have slower post-PCI epicardial flow and worsened outcomes compared to younger patients. Results The 218 patients aged ≥ 70 years (14.8%) had more comorbidities than younger patients. Although these patients had significant angiographic improvement in TIMI frame counts and rates of TIMI Grade 3 flow following rescue/adjunctive PCI, elderly patients had higher (slower)post-PCI TIMI frame counts compared to the younger cohort (25 vs 22 frames, P = 0.039), and less often achieved post-PCI TIMI Grade 3 flow (80.1 vs 86.4%, P = 0.017). The association between age ( ≥70 years) and slower post-PCI flow was independent of gender, time to treatment, left anterior descending (LAD) lesion location, and pulse and blood pressure on admission. Elderly patients also had 4-fold higher mortality at 30 days (12.0 vs 2.7%,P = 0. 001 ). Conclusions This study suggests one possible mechanism underlying worsened outcomes among elderly STEMI patients insofar as advanced chronological age was associated with higher TIMI frame counts and less frequent TIMI Grade 3 flow after rescue/adjunctive PCI.

关键词： TIMI flow grade TIMI frame count percutaneous coronary intervention age elderly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于影像组学、视觉和直方图评估证实冠状动脉CT血管成像上动脉粥样硬化病变的体外研究

引用

国际医学放射学杂志 2019年第6期 735-736页

作者： M.Kolossváry J.Karády Y.Kikuchi A.Ivanov C.L.Schlett M.T.Lu 许棚棚 MTA-SE cardiovascular Imaging Research group Heart and Vascular Center Semmelweis University

摘要目的以组织学检查确定的晚期动脉粥样硬化病变为诊断标准,在体外冠状动脉CT血管成像基础上,比较基于影像组学的机器学习方法与基于视觉和直方图评估方法

关键词：冠状动脉机器学习模型动脉粥样硬化病变 CT 影像组学体外研究直方图

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Transformation of myocardial energy metabolism pattern during myocardial remodeling caused by volume overload

引用

中国循环杂志 2018年第S1期33卷 132-132页

作者： Yongchun Cui Bo Li Xiaokang Luo Lei Qi Chengliang Luo Xiuyu Shi Yue Tang Center for cardiovascular Experimental study and Evaluation State Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular Diseases and Fuwai HospitalCAMS and PUMCBeijingChina

Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even reversal of structural heart dysfunction.Methods Thirty C57/BL6 mice,20-30 g,half male and half female,were randomly divided into model group(n=15)and sham operation group(n=15).Each group was divided into subacute phase(2 weeks after surgery,n=5),cardiac functional compensation phase(5 weeks after surgery,n=5)and decompensation phase(15 weeks after surgery,n=5).

关键词： volume overload energy metabolism patterns structural heart dysfunction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：