Transformation of myocardial energy metabolism pattern during myocardial remodeling caused by volume overload

作     者：Yongchun Cui Bo Li Xiaokang Luo Lei Qi Chengliang Luo Xiuyu Shi Yue Tang 

作者机构：Center for Cardiovascular Experimental Study and EvaluationState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular Diseases and Fuwai HospitalCAMS and PUMCBeijingChina 

出 版 物：《中国循环杂志》 (Chinese Circulation Journal)

年 卷 期：2018年第33卷第S1期

页      面：132-132页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：volume overload energy metabolism patterns structural heart dysfunction 

摘      要：Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even reversal of structural heart dysfunction.Methods Thirty C57/BL6 mice,20-30 g,half male and half female,were randomly divided into model group(n=15)and sham operation group(n=15).Each group was divided into subacute phase(2 weeks after surgery,n=5),cardiac functional compensation phase(5 weeks after surgery,n=5)and decompensation phase(15 weeks after surgery,n=5).