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Celiac disease and Sjögren’s syndrome:A case report and review of literature

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World Journal of Clinical Cases 2020年第18期8卷 4151-4161页

作者： Daniel Vasile Balaban Ancuta Mihai Alina Dima Alina Popp Mariana Jinga Ciprian Jurcut Internal Medicine and Gastroenterology Carol Davila University of Medicine and PharmacyDr.Carol Davila Central Military Emergency University HospitalBucharest 020021Romania Internal Medicine Dr.Carol Davila Central Military Emergency University HospitalBucharest 010825Romania Pediatrics Carol Davila University of Medicine and PharmacyCarol Davila University of Medicine and PharmacyBucharest 020021Romania Alfred Rusescu Institute for Mother and Child Care Bucharest 020021Romania Tampere Center for Child Health Research University of Tampere and Tampere University HospitalBucharest 020021Romania

BACKGROUND Celiac disease(CD)is a systemic,chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals,with a prevalence of 1%***'s syndrome(SS)is also a systemic autoimmune disease,mainly characterized by ocular and oral sicca symptoms and *** a common genetic background,CD and SS are known associated autoimmune diseases,but currently available guidelines are not reporting *** SUMMARY We report the case of a 39-year-old woman,who was in the care of her rheumatologist for 2 years with *** routine follow-up she was found to have iron deficiency,without *** had no gastrointestinal complaints and denied any obvious source of blood *** tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy.A diagnosis of CD was set and gluten-free diet was *** We present a review of existing data in the literature regarding the association of the two diseases,summarizing prevalence studies of CD in SS patients and the other way *** recommendations and future research perspectives are also discussed,highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

关键词： Celiac disease Sjögren syndrome Prevalence Autoimmunity Screening Antibodies Case report

Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis

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World Journal of Clinical Cases 2019年第12期7卷 1367-1382页

作者： Lavinia Alice Balaceanu Department of Internal Medicine Carol Davila University of Medicine and Pharmacy Sf. Ioan Clinical Emergency Hospital

Hepatocellular carcinoma (HCC) is the 5th most frequently diagnosed cancer in the world, according to the World Health Organization. The incidence of HCC is between 3/100000 and 78.1/100000, with a high incidence reported in areas with viral hepatitis B and hepatitis C, thus affecting Asia and Africa predominantly. Several international clinical guidelines address HCC diagnosis and are structured according to the geographical area involved. All of these clinical guidelines, however, share a foundation of diagnosis by ultrasound surveillance and contrast imaging techniques, particularly computed tomography, magnetic resonance imaging, and sometimes contrast-enhanced ultrasound. The primary objective of this review was to systematically summarize the recent published studies on the clinical utility of serum biomarkers in the early diagnosis of HCC and for the prognosis of this disease.

关键词： Hepatocellular carcinoma Biomarkers Imaging Ultrasonography Computed tomography Magnetic resonance imaging

Chiral Fermion Conductivity in Graphene-Like Samples Subjected to Orthogonal Fields

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Chinese Physics Letters 2012年第1期29卷 20-23页

作者： Ciprian Dariescu Marina-Aura Dariescu Faculty of Physics Alexandru Ioan Cuza University of IaşiBd.Carol I No.11700506 IaşiRomania

Starting with the U(1)-gauge covariant four-dimensional Dirac equation,we derive the analytic solutions describing the chiral massless fermions evolving in static orthogonal magnetic and electric *** in cylindric coordinates,we compute the electric current density essential component and the off-diagonal *** summing up the conductivities of the two distinct species of electrons connected to the orientation of spin,the well-known 4n-quantization law is restored.

关键词： Fermi diagonal Conductivity

Mechanical properties of a Gum-type Ti–Nb–Zr–Fe–O alloy

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International Journal of Minerals,Metallurgy and Materials 2017年第8期24卷 909-917页

作者： Anna Nocivin Ion Cinca Doina Raducanu Vasile Danut Cojocaru Ion Alexandru Popovici Faculty of Mechanical Industrial and Maritime Engineering Ovidius University of Constanta Faculty of Materials Science and Engineering Politehnica University of Bucharest carol Davila University of Medicine and Pharmacy

A new Gum-type alloy(Ti–Nb–Zr–Fe–O) in which Fe is used instead of Ta was subjected to a particular thermomechanical processing scheme to assess whether its mechanical characteristics(fine ?-grains with high strength and low modulus) render it suitable as a biomedical implant material. After a homogenization treatment followed by cold-rolling with 50% reduction, the specimens were subjected to one of three different recrystallization treatments at 1073, 1173, and 1273 K. The structural and mechanical properties of all of the treated specimens were analyzed. The mechanical characterization included tensile tests, microhardness determinations, and fractography by scanning electron microscopy. The possible deformation mechanisms were discussed using the Bo – Md diagram. By correlating all of the experimental results, we concluded that the most promising processing variant corresponds to recrystallization at 1073 K, which can provide suitable mechanical characteristics for this type of alloys: high yield and ultimate tensile strengths(1038 and 1083 MPa, respectively), a low modulus of elasticity(62 GPa), and fine crystalline grain size(approximately 50 ?m).

关键词： biomaterials mechanical properties Gum-type alloy thermomechanical processing tensile test

Pathogenesis of pandemic H1N1 2009 influenza virusinfection and the implication on management

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Frontiers of Medicine 2010年第2期4卷 147-156页

作者： Kelvin Kai-Wang TO Iris Wai-Sum LI Ivan Fan-Ngai HUNG Vincent Chi-Chung CHENG Kwok-Yung YUEN carol Yu Center for Infection Department of MicrobiologyThe University of Hong KongHong Kong SARChina

The pandemic H1N12009 inﬂuenza virus has caused theﬁrst inﬂuenza pandemic of the 21st century,leading to disproportionate fatalities in the low-risk population despite the generally mild nature of the *** in science and technology have allowed very detailed study on the pathogenesis of this novel virus,and many have already been published in less than a year after the start of the *** generated from cell lines,animal models,and clinical data analysis has provided us with greater understanding of the behavior of this virus and the associated host *** new knowledge will allow us to formulate scientiﬁcally sound and evidence-based management plans.

关键词： inﬂuenza A virus,H1N1 subtype pandemic pathogenesis virulence factors immunity management,antiviral

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Boson Nebulae Charge

Chinese Physics Letters 2010年第1期27卷 67-69页

作者： Ciprian Dariescu Marina-Aura Dariescu Faculty of Physics A1. I. Cuza University Bd. Carol I No. 11 700506 Iaqi Romania

We use the first-order approximate solutions to the nonlinear system of Klein-Gordon-Maxwell-Einstein equations describing the minimally coupled charged spin-less field to a spherically symmetric spacetime to analyze a becoming boson star. In the far future and long-range approximation, we derive an analytical time-dependent charge which allows us to point out several significant moments in the evolution of the boson nebula.

关键词： Nebulae

Circulating microRNAs as non-invasive biomarkers for hepatitis B virus liver fibrosis

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World Journal of Gastroenterology 2020年第11期26卷 1113-1127页

作者： Diana Gabriela Iacob Adelina Rosca Simona Maria Ruta Infectious Diseases Department "Carol Davila"University of Medicine and PharmacyBucharest 050474Romania Bucharest Emergency University Hospital Bucharest 050098Romania Virology Department Carol Davila University of Medicine and PharmacyBucharest 050474Romania Viral Emerging Diseases Department Stefan S.Nicolau Institute of VirologyBucharest 030304Romania

Viruses can alter the expression of host microRNAs(miRNA s) and modulate the immune response during a persistent infection. The dysregulation of host miRNA s by hepatitis B virus(HBV) contributes to the proinflammatory and profibrotic changes within the liver. Multiple studies have documented the differential regulation of intracellular and circulating miRNA s during different stages of HBV infection. Circulating miRNA s found in plasma and/or extracellular vesicles can integrate data on viral-host interactions and on the associated liver injury. Hence, the detection of circulating miRNA s in chronic HBV hepatitis could offer a promising alternative to liver biopsy, as their expression is associated with HBV replication, the progression of liver fibrosis,and the outcome of antiviral treatment. The current review explores the available data on miRNA involvement in HBV pathogenesis with an emphasis on their potential use as biomarkers for liver fibrosis.

关键词： Hepatitis B virus MicroRNA Noncoding RNA Liver fibrosis Viral hepatitis Non-invasive biomarkers Extracellular vesicles Hepatitis management

Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C

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World Journal of Gastroenterology 2016年第37期22卷 8406-8413页

作者： Camelia Sultana Gabriela Oprisan Monica Delia Teleman Sorin Dinu HepGen 88/2012 Project Team Cristiana Oprea Mihai Voiculescu Simona Ruta Virology Discipline Carol Davila University of Medicine and Pharmacy Emergent Diseases Department Stefan S.Nicolau Institute of Virology Faculty of Pharmacy Titu Maiorescu University Molecular Epidemiology Laboratory NIRDMI Cantacuzino Department of Microbiology and Epidemiology Carol Davila University of Medicine and Pharmacy Victor Babes Clinic of Infectious and Tropical Diseases Fundeni Institute

AIM To determine whether hepatitis C virus(HCV) core substitutions play a role in the response to interferon-based treatment in Caucasian patients. METHODS One hundred eight HCV chronically infected patients initiating treatment with pegylated IFN plus ribavirin for 48 wk were tested for baseline substitutions at codons 70 and 91 of the viral core protein(Big Dye Terminator vers.3.1, Applied Biosystems,) and for genetic polymorphisms in host IL28 B gene rs12979860(Custom TaqM an 5' allelic discrimination assay; Applied Biosystems).RESULTS Of the patients, all were infected with HCV genotype 1b, 44.4% had low baseline HCV viral load, and 37.9% had mild/moderate fibrosis. Only 38.9% achieved therapeutic success, defined as sustained virological response(SVR). Eighty-eight percent of the patients presented at least one substitution at core position 70(R70Q/H) or/and position 91(L91M). The favorable IL28 B CC polymorphism was detected in only 17.6% of the patients. In the univariate analysis, young age(P < 0.001), urban residence(P = 0.004), IL28 B CC genotype(P < 0.001), absence of core mutations(P = 0.005), achievement of rapid virologic response(P < 0.001) and early virological response(P < 0.001) were significantly correlated with SVR. A multivariate analysis revealed three independent predictors of therapeutic success: young age(P < 0.001), absence of core substitutions(P = 0.04) and IL28 B CC genotype(P < 0.001); the model correctly classified 75.9% of SVR cases with a positive predictive value of 80.7%. CONCLUSION HCV core mutations can help distinguish between patients who can still benefit from the affordable IFNbased therapy from those who must be treated with DAAs to prevent the evolution towards end-stage liver disease.

关键词： Chronic hepatitis C Caucasian patients Core substitutions IL28B polymorphism Treatment

Neurological complications of hematopoietic cell transplantation in children and adults

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Neural Regeneration Research 2018年第6期13卷 945-954页

作者： Adriana Octaviana Dulamea Ioana Gabriela Lupescu University of Medicine and Pharmacy carol Davila Bucharest Romania Department of Neurology Fundeni Clinical Institute Bucharest Romania Radiology and Medical imaging Department Fundeni Clinical Institute Bucharest Romania

Hematopoietic cell transplantation（HCT） is widely performed for neoplastic and non-neoplastic diseases. HCT involves intravenous infusion of hematopoietic progenitor cells from human leukocyte antigen（HLA）-matched donor（allogeneic） or from the patient（autologous）. Before HCT, the patient is prepared with high dose chemotherapy and/or radiotherapy to destroy residual malignant cells and to reduce immunologic resistance. After HCT, chemotherapy is used to prevent graft rejection and graft versus host disease（Gv HD）. Neurological complications are related to the type of HCT, underlying disease, toxicity of the conditioning regimens, immunosuppression caused by conditioning regimens, vascular complications generated by thrombocytopenia and/or coagulopathy, Gv HD and inappropriate immune response. In this review, neurological complications are presented according to time of onset after HCT：（1） early complications（in the first month）-related to harvesting of stem cells, during conditioning（drug toxicity, posterior reversible encephalopathy syndrome）, related to pancytopenia,（2） intermediate phase complications（second to sixth month）-central nervous system infections caused by prolonged neutropenia and progressive multifocal leukoencephalopathy due to JC virus,（3） late phase complications（after sixth month）-neurological complications of Gv HD, second neoplasms and relapses of the original disease.

关键词： neurological complications hematopoietic cell transplantation posterior reversible encephalopathy syndrome central nervous system infections progressive multifocal leukoencephalopathy graft versus host disease second neoplasm immune reconstitution inflammatory syndrome post-transplant acute limbic encephalitis drug reaction with eosinophiIia and systemic symptoms