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Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis

Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis

作     者:Lavinia Alice Balaceanu 

作者机构:Department of Internal Medicine Carol Davila University of Medicine and Pharmacy Sf. Ioan Clinical Emergency Hospital 

出 版 物:《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期:2019年第7卷第12期

页      面:1367-1382页

核心收录:

学科分类:1002[医学-临床医学] 10[医学] 

主  题:Hepatocellular carcinoma Biomarkers Imaging Ultrasonography Computed tomography Magnetic resonance imaging 

摘      要:Hepatocellular carcinoma (HCC) is the 5th most frequently diagnosed cancer in the world, according to the World Health Organization. The incidence of HCC is between 3/100000 and 78.1/100000, with a high incidence reported in areas with viral hepatitis B and hepatitis C, thus affecting Asia and Africa predominantly. Several international clinical guidelines address HCC diagnosis and are structured according to the geographical area involved. All of these clinical guidelines, however, share a foundation of diagnosis by ultrasound surveillance and contrast imaging techniques, particularly computed tomography, magnetic resonance imaging, and sometimes contrast-enhanced ultrasound. The primary objective of this review was to systematically summarize the recent published studies on the clinical utility of serum biomarkers in the early diagnosis of HCC and for the prognosis of this disease.

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