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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural regeneration research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing ren Chenguang Zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation center for Neurological disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

Adsorption equilibrium for Z-ligustilide on C18-bonded silica from supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2016年第12期24卷 1680-1686页

作者： Huisheng Lü Shuangyan Liu Yonghui Li Fanmei Meng dawei Yao Xufei Mo Key Laboratory for Green Chemical technology of Ministry of Education Tianjin University R&D Center for Petrochemical Technology

Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial *** paper presents adsorption isotherms of Z-ligustilide from supercritical carbon dioxide(SC-CO_2) on C18-bonded *** behavior was studied at 305.15 K,313.15 K and 323.15 K with SC-CO_2 density varying from 0.687 g·cm^(-3) to0.863 g·cm^(-3) with the elution by characteristic points(ECP) *** adsorption amount of Z-ligustilide from SC-CO_2 on C18-bonded silica decreased with the increasing density of the mobile phase as well as the increasing *** equilibrium data were fitted by Langmuir and Freundlich isotherm models,and the Langmuir isotherm model performed better for describing the whole adsorption process on the *** monolayer saturation adsorption capacity of Z-ligustilide is in the range of 3.0 × 10^(-4) mg·cm^(-3) to5.5 × 10^(-4) mg·cm^(-3) with an average value of 4.0 × 10^(-4) mg·cm^(-3).

关键词： Z-ligustilide C18-bonded silica Pre-SFC Adsorption equilibrium Isotherm model

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural regeneration research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of tianjin university of Traditional Chinese Medicine TianjinChina National Clinical research center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Multi-objective regulation in autohydrolysis process of corn stover by liquid hot water pretreatment

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Chinese Journal of Chemical Engineering 2017年第4期25卷 499-506页

作者： Huisheng Lü Xingfang Shi Yonghui Li Fanmei Meng Shuangyan Liu Li Yan Key Laboratory for Green Chemical technology of Ministry of Education Tianjin University R&D Center for Petrochemical TechnologyTianjin UniversityTianjin 300072China

Increasing reducing sugars(xylose and glucose) yield for bioethanol from corn stover depends strongly on optimization of pretreatment conditions. The optimum reaction conditions of two-stage liquid hot water(LHW) pretreatment based on total sugars yield were investigated. Under optimal conditions, the recovery of glucose of corn stover after two-stage LHW pretreatment and 72 h enzymatic digestion, reached 89.55%. In addition, acetic acid-rich spent liquor pretreatment and one-stage LHW pretreatment have been carried out to make comparisons with two-stage LHW treatment. Glucose yield 89.55% is superior to the recovery 83.38% using acetic acidrich spent liquor pretreatment or 80.58% using one-stage LHW pretreatment. The production of total sugars was increased by 7.8% when compared with one-stage pretreatment. Moreover, the structural features of the treated corn stover solid residues were also investigated by Xrd and SEM technology in order to clarify the effects of the reaction on corn stover. The results indicated that the two-stage LHW pretreatment was an effective pretreatment method of corn stover to get most massive resource utilization, and it could be successfully applied to corn stover.

关键词： pretreatment liquor digestion hydrolysis acetic phenols spent cellulose biomass untreated

Structures and oxygen storage capacities of CeO_2-ZrO_2-Al_2O_3 ternary oxides prepared by a green route:supercritical anti-solvent precipitation

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Journal of rare Earths 2012年第6期30卷 524-528页

作者：黄盼姜浩锡张敏华 Key Laboratory for Green Chemical technology of Ministry of Education R&D Center for Petrochemical TechnologyTianjin University

CeO2-ZrO2-Al2O3 ternary oxides were successfully prepared by a green route of supercritical anti-solvent precipitation with supercritical CO2 as anti-solvent and methanol as solvent. The structures and oxygen storage capacities of these ternary oxides were characterized by Xrd, raman spectra and oxygen storage capacity measurements. It was found that Al3＋ and Zr4＋ inserted into CeO2 lattice, forming CeO2-ZrO2-Al2O3 solid solution. The concentration of aluminium isopropoxide in the solution affected the concentration of oxygen vacancy and the distortion of oxygen sublattice which were responsible for the oxygen storage capacity. The rapidest oxygen uptake/release rate and maximum total oxygen storage capacity （122.0 mmolO2/molCeO2） were obtained with the aluminitun isopropoxide concentration at 0.2 wt.% in the solution.

关键词： CeO2-ZrO2-Al2O3 solid solution supercritical anti-solvent precipitation oxygen storage capacity rare earths

THE UNIFOrMITY OF dISTrIBUTION OF SUBSTITUENTS ALONG THE CHAIN OF CArBOXYMETHYL CELLULOSE SYNTHESIZEd IN TWO-PHASE MEdIUM C_6H_6——C_2H_5OH

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Chinese Journal of Polymer Science 1998年第2期16卷 117-125页

作者：程发冯建新李桂凤王东华张镜吾 department of Chemistry Tianjin University Tianjin 300072 China r&d center for petrochemical technology tianjin Tianjin 300072 China deparment of Chemistry Tianjin University Tianjin 300072 China

Based on the property that carboxymethylcellulose (CMC ) can be de-graded to anhydroglucose residues by cellulase, the rate constant (K) of enzymatic degra-dation of CMC synthesized in the benzene-ethanol medium has been determined. Further-morel experimental equation K = 2.71× 10^(-2)(dS)^(-1.2) reflecting the relationship betweenK and the degree of substitution (dS) is correlated and used to describe chemical mi-crostructure uniformity of the distribution of substituents along chains effectively. Chainstructure parameters of enzymatic degradation products of CMC-the number of chainbreaks and the percentage of glucose released have been also measured. Average length ofsubstituted and unsubstituted chain segments are calculated simultaneously. Through thestudy of static and dynamic procedures of enzymatic degradation, the method to charac-terize the distribution of substituents of CMC along the chain has been improved.

关键词： Carboxymethylcellulose distribution of substituents Anhydroglucose unit Enzymatic degradation

Adsorption equilibria of paeoniflorin and albiflorin on cyano-silica column from supercritical carbon dioxide/ethanol

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Chinese Journal of Chemical Engineering 2019年第4期27卷 827-834页

作者： Huisheng Lü Zhi Wang Zhongfeng Geng Yonghui Li Shuangyan Liu Jiatao Liu Key Laboratory for Green Chemical technology of Ministry of Education R&D Center for Petrochemical Technology Tianjin University Tianjin 300072 China Collaborative Innovation center of Chemical Science and Engineering Tianjin 300072 China

Adsorption equilibria of paeoniflorin and albiflorin on a cyano-silica column(CN column) from the solution of supercritical carbon dioxide(scCO2) modified with ethanol were studied. The adsorption capacity at 308.15 K,313.15 K, 318.15 K and 323.15 K under pressures corresponding to carbon dioxide/ethanol densities from0.347 g·cm^-3 to 0.662 g·cm^-3 were determined using the elution by characteristic point method(ECP). The effects of temperature and pressure on the solute loading were investigated. The results showed that the lower the temperature, the higher the adsorption capacity. With the decrease of density of scCO2, the adsorption capacity strengthens. The maximum adsorption capacity of paeoniflorin(albiflorin) on the CN column was15.24 mg·ml^-1(31.14 mg·ml^-1) in the range of 0–1.84 mg·ml^-1(0–1.67 mg·ml^-1) of paeoniflorin(albiflorin)standard solution. The adsorption capacity of albiflorin was twice as much as that of paeoniflorin under the same conditions. Adsorption data of paeoniflorin and albiflorin could be well described by the Langmuir model and Freundlich model. Compared with the two model fitting results, the adsorption of paeoniflorin and albiflorin belonged to the monolayer adsorption under conditions of 308.15–323.15 K and 10–17 MPa.

关键词： Adsorption Supercritical carbon dioxide Paeoniflorin Albiflorin Isotherm model

research progress in the SO2 resistance of the catalysts for selective catalytic reduction of NOx

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Chinese Journal of Chemical Engineering 2017年第12期25卷 1695-1705页

作者： Minhua Zhang Baojuan Huang Haoxi Jiang Yifei Chen Key Laboratory for Green Chemical technology of Ministry of Education R&D Center for Petrochemical Technology Tianjin University Tianjin 300072 China Collaborative Innovation center of Chemical Science and Engineering Tianjin 300072 China

The selective catalytic reduction （SCr） of NOx with NH3 has been proven to be an efficient technology for NOx conversion to N2. However, the catalysts used for SCr usually suffer from the problem of sulfur poisoning which seriously limits their practical application. This review summarized sulfur poisoning mechanisms of various SCr deNG catalysts and strategies to reduce deactivation caused by SO2 such as doping metals, controlling the structures and morphologies of the catalysts, and selecting appropriate supports. The methods and procedures of catalysts preparation and the reaction conditions also have effect on SO2-resistance of the catalysts. Several novel catalyst systems that exhibited good SO2 resistance are also introduced. This paper could provide guidance for the development of highly efficient sulfur-tolerant deNOx catalysts.

关键词： Words Selective catalytic reduction (SCr)SO2 resistance catalyst NOx

Optimization of hydrothermal pretreatment for co-utilization of xylose and glucose of cassava anaerobic residue for producing ethanol

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Chinese Journal of Chemical Engineering 2019年第4期27卷 920-927页

作者： Huisheng Lü Jinyi Zhou Jiatao Liu Chunliu Lü Feng Lian Yonghui Li Key Laboratory for Green Chemical technology of Ministry of Education R&D Center for Petrochemical Technology Tianjin University Tianjin 300072 China Collaborative Innovation center of Chemical Science and Engineering Tianjin 300072 China

The development of a process that could recover biofuel from industrial cellulose waste can not only reduce the negative environmental impacts by using fossil fuels, but also bring a green idea for the waste’s disposing. In this study, hydrothermal pretreatment was optimized for cassava anaerobic residue, a cellulosic waste from cassava ethanol industry, to co-utilize xylose and glucose for producing bioethanol. The effect of the main pretreatment conditions, namely, temperature, solid content and time, was explored for the highest recovery of xylose in prehydrolysate and glucose in enzymatic hydrolysate. The single factor experiment results showed that the conditions for maximum xylose recovery in prehydrolysate and glucose recovery in enzymatic hydrolysate were 60℃, 75 min, 10% solids and 160℃, 75 min, 10% solids, respectively. Whereafter, response surface methodology(rSM) was applied to further optimize the pretreatment conditions for the maximum theoretical ethanol production through utilizing both xylose and glucose. A treatment at 163℃, for 59 min and with 9.5%solids was found optimal, with the highest ethanol production of 20.2 mg·g^-1 raw material. Furthermore, in order to assess the impacts of the pretreatment on cassava anaerobic residue, the changes in crystallinity and morphology for untreated and pretreated solids were investigated.

关键词： Waste treatment Biofuel Hydrothermal Cassava anaerobic residue Co-utilization response surface methodology