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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical college Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China college of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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The Log-Concavity of Kazhdan-Lusztig Polynomials of Uniform Matroids

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Journal of Systems Science & Complexity 2023年第1期36卷 117-128页

作者： XIE Matthew H Y ZHANG Philip B college of Science Tianjin University of TechnologyTianjin 300384China college of Mathematical Science Tianjin Normal UniversityTianjin 300387China

Elias,et al.(2016)conjectured that the Kazhdan-Lusztig polynomial of any matroid is *** by a computer proof of Moll’s log-concavity conjecture given by Kauers and Paule,the authors use a computer algebra system to pr... 详细信息

关键词： HolonomicFunctions Kazhdan-Lusztig polynomial log-concavity uniform matroid

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The Impact of Competition on Analysts’Forecasts:A Simple Agent-Based Model

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Journal of Systems Science & Complexity 2020年第6期33卷 1980-1996页

作者： ZHANG Jin XIONG Xiong AN Yahui FENG Xu college of Management and Economics Tianjin UniversityTianjin 300072China School of Economics Tianjin University of CommerceTianjin 300134China college of Management and Econonics Tianjin UniversityTianjin 300072China

This paper builds an agent-based model to study the impact of analyst competition on analyst *** strategies(a catering strategy and a pressure strategy)are used to model analysts conflicts of interest between listed corporations and institutional *** finding suggests that the relationship between competition and analyst optimism is ***-level competition generates more analyst unbiased ***,the condition of no competition or high-level competition generates more analyst optimistic *** empirical test also confirms that analysts issue less biased earnings forecasts under the condition of low-level competition.

关键词： Agent-based model analyst forecasts conflicts of interest

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New Algorithm for CBR-RBR Fusion with Robust Thresholds

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Chinese Journal of Mechanical Engineering 2012年第6期25卷 1255-1263页

作者： XU Mad YU Haiyan SHEN Jiang TEDA college Nankai University Tianjin 300457 China college of Management and Economics Tianjin University Tianjin 300072 China

The case-based reasoning（CBR） and rule-based reasoning（RBR） fusion systems include a diverse range of fusion methods and their tasks are characterized by interleaving combination of the reasoning procedures. Existing approaches cannot clarify the complex relationships between data from the knowledge sources nor uniformly represent the heterogeneous case and rule knowledge in one fusion space. As a result, existing approaches fail to solve system fragility due to knowledge uncertainty and reasoning unreliability. For the purpose of addressing the difficulties, a novel algorithm for CBR-RBR fusion with robust thresholds（CRFRT） is proposed. Heterogeneous case and rule knowledge are uniformly represented in one defined fusion unitary space. The robust thresholds have been achieved to distinguish the complex relationships between meta-knowledge in the fusion space and to enhance system capacity of knowledge identification. Furthermore, fusion reasoning strategies are constructed for CRFRT and its procedure based on which robust solution of the fusion reasoning problem is obtained. Finally, CRFRT is validated by benchmark problems in machine learning. Compared with other CBR and RBR approaches, the reasoning efficiency and accuracy are increased by 5% and 2.2% respectively. The variations of system accuracy are decreased by 2% to 3.8%. The above results show that the CRFRT algorithm boosts the system＇s effectiveness and robustness. The proposed CRFRT can solve the fragility of complex intelligence decision system and give quality performance for fault diagnosis.

关键词： case-based reasoning (CBR) rule-based reasoning (RBR) robust thresholds fusion reasoning system (FRS)

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The secondary periodic element ■ and its applications

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Science China Mathematics 2025年第01期 207-222页

作者： Jianguo Hong Xiangjun Wang Yu Zhang Science college Shijiazhuang University School of Mathematical Sciences Nankai University Center for Applied Mathematics Tianjin University

Let p≥7 be a *** prove that ■ survives to E∞in the Adams-Novikov spectral ***,using the Thom map Φ:■,we can see that h0h3also survives to E∞in the classical Adams spectral *** an application of these results,we ...

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Copper stimulates the incidence of antibiotic resistance, metal resistance and potential pathogens in the gut of black soldier fly larvae

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Journal of Environmental Sciences 2021年第9期33卷 150-159页

作者： Nan Wu Jiaqi Liang Xiaobo Wang Shiyu Xie Xiaoyan Xu college of Engineering and Technology Tianjin Agricultural UniversityTianjin 300384China college of Agronomy and Resource and Environment Tianjin Agricultural UniversityTianjin 300384China

The black soldier fly larvae(BSFL) have been successfully applied to treat various organic ***, the impacts of heavy metals on antibiotic resistance in the BSFL guts are poorly ***, we investigated the effect of copper(exposure concentrations of 0, 100 and 800 mg/kg) on the antibiotic and metal resistance profiles in BSFL guts.A total of 83 antibiotic resistance genes(ARGs), 18 mobile genetic elements(MGEs) and 6 metal resistance genes(MRGs) were observed in larval gut *** to Cu remarkably reduced the diversity of ARGs and MGEs, but significantly enhanced the abundances of gut-associated ARGs and *** levels of MRGs copA, czcA and pbrT were dramatically strengthened after Cu exposure as compared with CK(increased by 2.8–13.5 times).Genera Enterococcus acted as the most predominant potential host of multiple ARG, MGE and MRG ***, high exposure to Cu aggravated the enrichment of potential pathogens in BSFL guts, especially for Escherichia, Enterococcus and Salmonella *** mantel test and procrustes analysis revealed that the gut microbial communities could be a key determinant for antibiotic and metal ***, no significant positive links were observed between MGEs and ARGs or MRGs, possibly suggesting that MGEs did not play a crucial role in shaping the ARGs or MRGs in BSFL guts under the stress of *** findings extend our understanding on the impact of heavy metals on the gut-associated antibiotic and metal resistome of BSFL.

关键词： Black soldier fly Gut microbiome Antibiotic resistance Pathogen Heavy metals

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Synthesis, Structure and Antibacterial Activities of 4-BBTS Schiff Base and Its Complexes

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Chinese Journal of Structural Chemistry 2007年第2期26卷 224-228页

作者： LI Pei-Fan LIU Bin WANG Jin-Ling Pharmacy Department of tianjin Medical college Tianjin 300222 China college of Chemistry and Life Tianjin Normal University Tianjin 300074 China

4-Bromobenzaldehyde thiosemicarbazone Schiff base （4-BBTS） and its Cu（Ⅱ）, Zn（Ⅱ）, Co（Ⅱ） and Ni（Ⅱ） complexes were synthesized and characterized by elemental analysis, UV, IR, MS, ^1H NMR, and molar conductivity. Using disc diffusion method, the antibacterial activity tests were conducted. The results revealed that the ligand as well as all the complexes exhibits good antibacterial activities against E. Coli. and S. Aureus. Moreover, Cu（Ⅱ） complex shows the best antibacterial activity, which provides beneficial reference for studying the relationship between the structures and performances.

关键词： 4-BBTS Schiff base synthesis structure antibacterial activity

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