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美国医学会杂志（中文版） 2005年第6期24卷 323-329页

作者： Peter M. Okin, MD Richard B. Devereux, MD Sverker Jern, MD Sverre E. Kjedsen, MD,PhD Stevo Julius, MD, ScD Markkus S. Nieminen, MD, PhD Steven Snapinn, PhD Katherine E. Harris, DrPH Peter Aurup, MD Jonathan M. Edelman, MD Hans Wedel, PhD Lars H. Lindholm, MD, PhD Bjorn Dahlof MD, PhD 倪靖炜（译）沈卫峰（校） Department of Medicine Division of Cardiology Cornell University Medical Center New York NY Sahlgrenska University Hospital/OEstra Goeteborg Sweden Ulleval University Hospital Oslo Norway University of Michigan Medical Center Ann Arbor Division of Cardiology Department of Medicine Helsinki University Central Hospital Helsinki Finland Amgen Inc Thousand Oaks Calif Merck Research Laboratories West Point Pa Merck ＆ Co Inc Whitehouse Station NJ Nordic School of Public Health Gbteborg Sweden Umea. University Umea Sweden 不详

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡... 详细信息

背景：心电图左心室肥厚（left ventficular hypertophy，LVH）是心血管并发症及死亡的强预测指标。然而，在抗高血压治疗期间心电图LVH程度变化的预测价值仍不清楚。目的：验证抗高血压治疗期间心电图LVH程度越轻，心血管并发症与死亡率越低，并与血压水平及其降低和治疗方式无关的假说。设计、设置及参试者：1995～2001年于9193例55至80岁（均值，67岁）男性和女性高血压患者进行的双盲、随机、平行组研究。心电图LVH用康奈尔电压一时间乘积或Sokolow—Lyon电压表示，患者均入选氯沙坦降低高血压终点事件干预研究（Losartan Intervention For Endpoint，LIFE）。干预：以氯沙坦或阿替洛尔为基础的治疗方案，随访评估至少4年（均值，4．8年[SD，0．9]）。主要结果测定：心血管死亡、心肌梗死或卒中复合终点与基线及随后1年或每年心电图LVH严重程度的关系。结果：1096例（11．9％）发生心血管死亡、非致死性心肌梗死或卒中。在控制治疗方式、基线Framingham危险记分、基线和治疗期间血压以及基线心电图LVH严重程度（康奈尔乘积或Sokolow—Lyon电压）的Cox回归模型中，康奈尔乘积和Sokolow—Lyon电压所示治疗中LVH严重程度较低者，复合心血管终点事件的发生率分别降低14％和17％（康奈尔乘积每降低1050mm×ms,[1-SD]：校正风险比[hazard ratio，HR]，0．86；95％可信区间[confidence interval，CI]，0．82～0．92；P〈0．001；Sokolow—Lyon电压每降低10．5mm[1-SD]：HR，0．83；95％CI，0．78～0．88；P〈0．01）。在平行分析中，较低的康奈尔乘积和Sokolow—Lyon电压均与较低的心血管死亡（分别为HR，0．78；95％CI，0．73～0．83；P〈0．001和HR，0．80；95％CI，0．73～0．87；P〈0．001）、心肌梗死（HR，0．90；95％CI，0．82～0．98；P=0．01和HR，0．90；95％CI，0．81～1．00；P=0．04））和卒中（HR，0．90；95％CI，0．84～0．96；P=0．002；HR，0．81；95％CI，0．75～0．89；P〈0．001）独立相关。结论：抗高血压治疗期间，根据康奈尔乘积和Sokolow—Lyon电压判定的心电图LVH程度较轻与心血管并发症和死亡可能性较低相关，而且独立于原发性高血压患者的血压降低及治疗方式。旨在改善或预防心电图LVH的抗高血压治疗可以改善患者的预后。

关键词：抗高血压治疗心血管事件治疗期间左心室肥厚心电图原发性高血压患者预测作用致死性心肌梗死心血管并发症 interval

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Impact of Switch to Fosamprenavir and Addition of Lovaza<sup>®</sup>for Treatment of Hypertriglyceridemia in HIV-Infected Subjects on Antiretroviral Therapy

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World Journal of AIDS 2012年第1期2卷 24-32页

作者： Franco Felizarta Anthony Scarsella Homayoon Khanlou Winston Young Lisa Ross Henry Zhao Keith Pappa Belinda Ha AIDS Healthcare Foundation Los Angeles California USA GlaxoSmithKline Research Triangle Park Durham North Carolina USA GlaxoSmithKline Research Triangle Park Durham North Carolina USA. Pacific oaks Medical Group Beverly Hills California USA Private Practice Bakersfield California USA Statworks Research Triangle Park Durham North Carolina USA

Background: Managing hypertriglyceridemia in HIV-infected patients often requires multiple pharmacologic strategies. Many protease inhibitors (PIs), one of 6 classes of drugs used to treat HIV, have been associated with hypercholesterolemia and drug interactions. For this study, we examined a dual strategy to manage hypertriglyceridemia in HIV-infected patient taking PIs: 1) switching patients to fosamprenavir (FPV), a PI with fewer drug interactions, and 2) adding prescription fish oil (LOVAZA?), which has been shown to reduce triglycerides. Methods: This multicenter, 24-week study enrolled 36 patients virologically suppressed (HIV-1 RNA <50 copies/mL) on PI-containing therapy with screening triglyceride levels of 200 - 1200 mg/dL and LDL cholesterol levels ≤160 mg/dL. At baseline, patients were switched to ritonavir (RTV)-boosted fosamprenavir (FPV 1400 mg/RTV 100 mg QD) and any lipid-lowering agents were stopped. At Week 6, LOVAZA 4 g QD was added. Results: Five patients prematurely discontinued due to adverse events (2), non-compliance, lost-to-follow up, and protocol violation. Median triglyceride concentration was 303 mg/dL at screening, 262 mg/dL at baseline, 290 mg/dL at Week 6 (+8% from baseline), and 218 mg/dL at Week 24 (–30% from Week 6). At Week 24, 39% (12/31) of patients had triglycerides <200 mg/dL. Among patients reaching Week 24, 100% (31/31) and 90% (28/31) had HIV-1 RNA <400 and <50 copies/mL, respectively. Conclusions: In this study, a switch to FPV/RTV followed by LOVAZA decreased median triglyceride levels and modestly increased the percentage of patients with triglyceride levels <200 mg/dL while maintaining virologic suppression in HIV-infected subjects with hypertriglyceridemia. Our data suggest that baseline PI may affect the likelihood of achieving triglycerides <200 mg/dL after 18 weeks on study. A larger study would be needed to understand the relative contributions of choice of protease inhibitor and LOVAZA to triglyceride concentration

关键词： Fish Oil Fosamprenavir HIV Hypertriglyceridemia Lovaza Switch Triglycerides

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超高效液相色谱-质谱应用于违禁药物的检测

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生命科学仪器 2010年第5期8卷 6-9页

作者： Guifeng JIANG LC/LC-MS Marketing Dept. Thermo Fisher Seientifie 355 River Oaks Pkwy. San Jose CA 95134U.S.A.

气相色谱-质谱是一种能够对药物及其代谢物进行分离和鉴定的方法,然而该方法需要非常困难、繁琐的衍生化和清洗过程。超高效液相色谱-质谱 (UHPLC-MS) 联用技术突破了以上局限并实现了更加快速的分析效果。本文讨论了如何通过对UHPLC-M... 详细信息

气相色谱-质谱是一种能够对药物及其代谢物进行分离和鉴定的方法,然而该方法需要非常困难、繁琐的衍生化和清洗过程。超高效液相色谱-质谱 (UHPLC-MS) 联用技术突破了以上局限并实现了更加快速的分析效果。本文讨论了如何通过对UHPLC-MS方法中固定相、流动相以及检测器方面的优化,在12 min的分离时间内实现了14种违禁药物及其代谢物在pg级水平上的定量。这些违禁药物及其代谢物使用Hypersil GOLD PFP (perfluorophenyl)色谱柱(1.9 μm, 100 mm×2.1 mm)进行分离,并采用单四极杆质谱快速扫描检测。

关键词：高效液相色谱-质谱违禁药物检测器气相色谱-质谱应用分离时间代谢物清洗过程

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Eating disorders and pregnancy: Proposed treatment guidelines for obstetricians and gynecologists

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Open Journal of Obstetrics and Gynecology 2014年第2期4卷 90-94页

作者： Victor Fornari Ida Dancyger Jessica Renz Rebecca Skolnick Burton Rochelson Center for Eating Disorders Division of Child & Adolescent Psychiatry Department of Psychiatry Cohen Children’s Medical Center New Hyde Park New York USA Division of Child & Adolescent Psychiatry Department of Psychiatry Zucker Hillside Hospital Glen Oaks New York USA Hofstra North Shore-LIJ School of Medicine Uniondale New York USA

Pregnant women with eating disorders are at risk for multiple complications to both the woman and the fetus. Eating disorders are particularly prevalent among adolescent girls and young women. This paper suggests a road map for the obstetrician gynecologist caring for women who either have an active eating disorder, report a history of a prior eating disorder, or when the clinician suspects that the woman may have an eating disorder which has not been previously identified. Proposed treatment guidelines are outlined.

关键词： Eating Disorders Pregnancy Treatment Guidelines

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Regional disease characteristics and comorbidities of patients with schizophrenia in the Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC): Findings from an international large simple trial

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Open Journal of Psychiatry 2012年第4期2卷 423-432页

作者： John M. Kane Wolfgang Fleischhacker Francesca Kolitsopoulos Onur N. Karayal Jamie Geier Cynthia Siu Robert Reynolds Gerald Faich Brian L. Strom Data Power (DP) Inc. Ringoes USA Department of Biological Psychiatry Medical University Innsbruck Innsbruck Austria Department of Biostatistics and Epidemiology Center for Clinical Epidemiology and Biostatistics Center for Pharmacoepidemiology Research and Training University of Pennsylvania School of Medicine Philadelphia USA Department of Epidemiology United BioSource Corporation Blue Bell USA Department of Psychiatry Zucker Hillside Hospital Glen Oaks USA Pfizer Inc. New York USA

Background: Using baseline data from the Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC), we assessed disease characteristics and prevalence of select comorbidities among subjects with schizophrenia in different clinical settings across 18 countries. ZODIAC was a randomized, open-label, one-year, large simple trial (LST) that enrolled 18,239 individuals with schizophrenia. Methods: Subjects were randomized to open-label treatment with ziprasidone (n = 9120) or olanzapine (n = 9119) in naturalistic (usual care) settings and followed for one year. Study sites (n = 749) applied minimal selection criteria in an attempt to make the study population as representative as possible of those receiving treatment in “real world” circumstances across the countries. Results: Mean patient age was 41 years, 55% were male, 34% were markedly ill or presented with more severe disease, and 66% of subjects had one or more select comorbid conditions [i.e. heart attack, stroke, hypertension, CAD/angina, high cholesterol/triglycerides, diabetes, or overweight (BMI ≥ 25)] at baseline. History of suicide attempt was greatest in the US (38%), compared with Sweden (34%), Brazil/South America (26%), Asia (23%), and Eastern Europe (20%). Overweight or obesity was the most prevalent comorbid risk factor, representing 60% of enrolled subjects, 70% of US subjects compared with 30% in Asia and 52% - 64% in the other regions studied. High cholesterol/triglycerides levels were found in 23% of US subjects compared with a relatively low prevalence in other countries (3% - 11%). History of cardiovascular or diabetes-related comorbidities was found in 31% of subjects. Current smoking (46.5%) and past smoking (11.8%) were common with men dominating the proportion of current smokers: US (61%);Asia (60%);Sweden (50%);Eastern Europe (49%);and Latin America (44%). Conclusions: Our findings indicate substantial baseline variations across countries in demographics, comorbid conditions, and psychiatr

关键词： Large Simple Trial Schizophrenia ZODIAC Comorbidities

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震前卫星热红外环形应力场特征

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地球学报 2008年第4期29卷 486-494页

作者：强祖基姚清林魏乐军赵勇郭坚峰曾佐勋谢红接中国地震局地质研究所北京100029 中国地质科学院北京100037 TeehniGraphics Inc. 11575 Great Oaks Way Suite 130 Mpharetta GA 30022 USA 海南省地震局海南海口570203 中国地质大学湖北武汉430074 Department of Geology University of Texas at San Antonio78249 USA

本文包括两部分内容:①描述了1996年2月3日云南丽江Ms7.0级地震,震前几天的卫星热红外图像呈现圆形,它的NNW、NW、SN、及NE向的热旋扭面往S收敛。该地震地表破裂由一系列张扭性裂缝组成,呈左旋左列,水平位错不明显,垂直断距数厘米。垂... 详细信息

本文包括两部分内容:①描述了1996年2月3日云南丽江Ms7.0级地震,震前几天的卫星热红外图像呈现圆形,它的NNW、NW、SN、及NE向的热旋扭面往S收敛。该地震地表破裂由一系列张扭性裂缝组成,呈左旋左列,水平位错不明显,垂直断距数厘米。垂直力对构造变动的作用较为明显;而丽江地震震源机制解破裂面II的走向NNE6o,倾向W,倾角44o,P轴方位为NNE3o、仰角75o,近于直立,综合热旋扭面展布、地震地表破裂特征及震源机制解,得出该旋扭椭圆为地幔外侧右旋上涌所造成;②菲律宾萨马岛Ms7.0～7.5强震群及青海共和Ms7.0地震前热应力环椭圆的推进路径。根据这一特征得出交变潮汐力的地球动力学解释。卫星热红外图像震前应力热场的方法是临震预测地震的有效方法,卫星热红外技术辅以震源机制解和地表破裂带力学分析是研究地球动力学有力工具。地球自转速度变化,交变潮汐力和地幔旋扭上涌力是地球动力学的主因。

关键词：环形热应力场热旋扭面路径震前卫星热红外

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引导式教育与整体护理相结合的护理模式在脑瘫患儿康复中的应用

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安徽医学 2010年第4期31卷 391-393页

作者：吕复莉王良红谢晓凤 Lesley Cannings 吴德唐久来安徽医科大学第一附属医院小儿神经康复中心合肥230022 Ingfield Manor School Five oaks Billings Hurst West Sussex RH14 9AX England

目的研究引导式教育与整体护理相结合的护理模式在脑瘫患儿康复中的作用。方法随机选取98例脑瘫患儿进行分组比较研究,研究组(n=50)采用整体护理模式与引导式教育的原理和方法对患儿进行护理;对照组(n=48)采用常规护理方法,研究前后均... 详细信息

目的研究引导式教育与整体护理相结合的护理模式在脑瘫患儿康复中的作用。方法随机选取98例脑瘫患儿进行分组比较研究,研究组(n=50)采用整体护理模式与引导式教育的原理和方法对患儿进行护理;对照组(n=48)采用常规护理方法,研究前后均对患儿进行疗效评价以及向患儿家长进行4项问卷调查。结果研究组与常规组相比能显著提高疗效,差异有统计学意义(P<0.05)。结论引导式教育与整体护理相结合的护理模式有利于脑瘫患儿更好地康复和回归社会,值得临床推广应用。

关键词：引导式教育整体护理脑瘫

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引导式教育对脑瘫儿童运动发育综合评价研究

引导式教育对脑瘫儿童运动发育综合评价研究

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中华医学会第十四次全国儿科学术会议

作者：吴德唐久米许晓燕张玲朱江英吕复莉 England Lesley Canning 安徽医科大学第一附属医院小儿神经康复科 Ingfield Manor School Five oaks Bilingshurst West Sussex RH14 9AX

目的:探讨引导式教育疗法对脑瘫儿童运动发育的影响,为进一步推广应用奠定基础。方法:对 107名脑瘫儿童,随机分为引导式教育疗法组和Bobath疗法组,各组分别应用引导式教育疗法和Bobath 疗法。3月后进行疗效总结,治疗前后均采用运动发育...

目的:探讨引导式教育疗法对脑瘫儿童运动发育的影响,为进一步推广应用奠定基础。方法:对 107名脑瘫儿童,随机分为引导式教育疗法组和Bobath疗法组,各组分别应用引导式教育疗法和Bobath 疗法。3月后进行疗效总结,治疗前后均采用运动发育指数、肌力测定、运动发育加速度测定,痉挛型脑瘫患儿采用改良Ashworth法评价量表。结果:46名脑瘫儿童运动发育指数较治疗前显著提高,其治

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Distinct neuroanatomic subtypes in antipsychotic-treated patients with schizophrenia classified by the predefined classification in a never-treated sample

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Psychoradiology 2021年第4期1卷 212-224页

作者： Qiannan Zhao Jiao Li Yuan Xiao Hengyi Cao Xiao Wang Wenjing Zhang Siyi Li Wei Liao Qiyong Gong Su Lui Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan UniversityChengdu 610041China The Clinical Hospital of Chengdu Brain Science Institute School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China MOE Key Lab for Neuroinformation High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan ProvinceUniversity of Electronic Science and Technology of ChinaChengdu 610054China Center for Psychiatric Neuroscience Feinstein Institute for Medical ResearchManhassetNY 11030United States Division of Psychiatry Research Zucker Hillside HospitalGlen OaksNY 11004United States

Background:Distinct neuroanatomic subtypes have been identified in never-treated patients with schizophrenia based on cerebral structural abnormalities,but whether antipsychotic-treated patients would be stratified under the guidance of such previously formed classification remains ***:The present study aimed to investigate alterations of brain structures in antipsychotic-treated patients with schizophrenia based on a predefined morphological classification and their relationships with cognitive ***:Cortical thickness,surface area,and subcortical volume were extracted from 147 antipsychotictreated patients with schizophrenia using structural magnetic resonance imaging for *** Brief Assessment of Cognition in Schizophrenia(BACS)and Positive and Negative Syndrome Scale(PANSS)were used to assess cognition and ***:Antipsychotic-treated patients were categorized into three subtypes with distinct patterns of brain morphological *** 1 and 2 were characterized by widespread deficits in cortical thickness but relatively limited deficits in surface *** contrast,subtype 3 demonstrated cortical thickening mainly in parietal-occipital regions and widespread deficits in surface *** three subgroups demonstrated cognitive deficits compared with healthy *** associations between neuroanatomic and cognitive abnormalitieswere only observed in subtype 1,where cortical thinning in the left lingual gyruswas conversely related to symbol coding ***:Similar to drug-naıve patients,neuroanatomic heterogeneity exists in antipsychotic-treated patients,with disparate associations with *** findings promote our understanding of relationships between neuroanatomic abnormalities and cognitive performance in the context of ***,these results suggest that neurobiological heterogeneity needs to be considered in cognitive research in schizophrenia.

关键词： schizophrenia neuroanatomic heterogeneity psychoradiology cognitive function antipsychotic medication

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Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia

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四川生理科学杂志 2021年第1期43卷 114-114页

作者： Raul D Santos Lipid Clinic Heart Institute University of Sao Paulo Medical School Hospital and Hospital Israelita Albert Einstein Sao Paulo Amgen Thousand Oaks CA Departments of Vascular Medicine Pediatrics Amsterdam UMC Amsterdam Cardiology Department Geneva University Hospital Geneva Biostatistics Department Amgen Cambridge Rare Diseases and Clinical Genetics Unit Academic Pediatric Department Bambino Gesu Children''s Hospital Lipid Clinic Department of Medicine Centre Hospitalier Universitaire de Quebec-Universite Laval Quebec Canada 2nd Department of Pediatrics Semmelweis University Budapest Hungary Department of Clinical Inherited Metabolic Disorders Birmingham Children''s Hospital Birmingham United Kingdom Department of Molecular Medicine Umberto I Hospital Sapienza University of Rome Rome Department of Internal Medicine Centres Hospitaliers Jolimont La Louviere Belgium Division of Pediatric Pulmonology Allergology and Endocrinology Department of Pediatrics and Adolescent Medicine Medical University of Vienna Vienna Clinical Lipidology and Rare Lipid Disorders Unit Community Genomic Medicine Centre and ECOGENE-21 Department of Medicine Universite de Montreal Chicoutimi QC Canada From the Lipid Clinic Heart Institute University of São Paulo Medical School Hospital and Hospital Israelita Albert Einstein São Paulo (R.D.S.) Amgen Thousand Oaks CA (A.R. C.E.K A.H.) the Departments of Vascular Medicine (G.K.H. J.J.P.K.) and Pediatrics (A.W. I.L.) Amsterdam UMC Amsterdam the Cardiology Department Geneva University Hospital Geneva (F.M.) the Biostatistics Department Amgen Cambridge (I.B.) and the Department of Clinical Inherited Metabolic Disorders Birmingham Children''s Hospital Birmingham (S.S.) - both in the United Kingdom the Rare Diseases and Clinical Genetics Unit Academic Pediatric Department Bambino Gesù Children''s Hospital (A.B.) and the Department of Molecular Medicine Umberto I Hospital Sapienza University of Rome (C.S.) Rome the Lipid Clinic Depart

Background:Evolocumab,a fully human monoclonal antibody directed against proprotein convertase subtilisin-kexin type 9,is widely used in adult patients to lower low-density lipoprotein(LDL)cholesterol *** effects in pediatric patients with heterozygous familial hypercholesterolemia are not ***:We conducted a 24-week,randomized,double-blind,placebo-controlled trial to evaluate the efficacy and safety of evolocumab in pediatric patients with heterozygous familial *** 10 to 17 years of age who had received stable lipid-lowering treatment for at least 4 weeks before screening and who had an LDL cholesterol level of 130 mg per deciliter(3.4 mmol per liter)or more and a triglyceride level of 400 mg per deciliter(4.5 mmol per liter)or less were randomly assigned in a 2:1 ratio to receive monthly subcutaneous injections of evolocumab(420 mg)or *** primary end point was the percent change in LDL cholesterol level from baseline to week 24;key secondary end points were the mean percent change in LDL cholesterol level from baseline to weeks 22 and 24 and the absolute change in LDL cholesterol level from baseline to week 24.

关键词： cholesterol Evolocumab lipoprotein

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