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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues Yu Luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

Biomechanical analysis of an osteocyte model by considering bone matrix’s piezoelectricity

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Acta Mechanica Sinica 2024年第9期40卷 131-148页

作者： Xiyu Wang Zhengbiao Yang Yanru Xue Yixian Qin Meng Zhang Jing Chen Pengcui Li Xiaochun Wei Haoyu Feng Liming He Yanqin Wang Xiaogang Wu Weiyi Chen college of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China shanxi Provincial Key Laboratory for Repair of Bone and Soft Tissue Injury Taiyuan 030001China shanxi Bethune hospital Shanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuan 030032China

Osteocytes,the primary cells in bone,play a crucial role in sensing external load environments and regulating other bone *** to the piezoelectric effect of the mineralized matrix and collagen that make up bone,the mechanical stimulus received is converted into an electrical stimulus to affect the reconstruction of *** the importance of osteocyte,many studies have focused on the mechanical loading and fluid flow of it,there is still a gap in the study of the piezoelectric effects of various mechanosensors on the *** this paper,we developed a finite element model of osteocytes that incorporates the piezoelectric bone *** model is comprehensive,comprising the osteocyte cell body enclosed by lacuna,osteocyte processes enclosed by canaliculi,and the interposed charged ionic ***,it features mechanosensors such as collagen hillocks and primary *** our study,we subjected the piezoelectric bone matrix model to triaxial displacement,subsequently assessing the electrical signal variations across different mechanosensors within the *** observed disparities in mechanical perception by various mechanosensors were primarily attributable to greater liquid velocity changes in the polarization direction as opposed to other *** hillocks showed insensitivity to piezoelectric signals,serving predominantly to mechanically transmit signals through solid-to-solid *** contrast,processes and primary cilia were highly responsive to piezoelectric ***,the processes oriented in the direction of the electric field demonstrated a differential piezoelectric signal perception compared to those in other *** cilia were especially sensitive to fluid flow pressure changes,which were influenced both by loading rates and external piezoelectric ***,our findings illuminate the complexity of mechanical perception within osteocytes in a piezoelectric *** adds a new di

关键词： Osteocyte Primary cilia Cell process Collagen hillock Piezoelectric effect

Management of Adult Growth Hormone Deficiency at Peking Union medical college hospital:A Survey among Physicians

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Chinese medical Sciences Journal 2016年第3期31卷 168-172页

作者： Hong-bo Yang Meng-qi Zhang Hui Pan Hui-juan Zhu Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union medical college hospital and impact factors associated with better *** A 21-question anonymous survey was distributed and collected at Peking Union medical college hospital,a major teaching hospital in Chinese Academy of medical *** of physicians' educational background,clinical training,patient workload per year and continuing medical education in AGHD were *** associated with appropriate answers were further analyzed by multivariate regression *** One hundred and eighteen internal medicine residents,endocrine fellows,attending physicians and visiting physicians responded to the *** them,44.9% thought that AGHD patients should accept recombinant human growth hormone replacement ***,56.8% selected insulin tolerance test and growth hormone-releasing hormone-arginine test for the diagnosis of *** regression analysis of physician demographic data,educational background,and work experience found no consistent independent factors associated with better decision-making,other than continued medical education,that were associated with treatment *** The physicians' reported management of AGHD in this major academic healthcare center in Beijing was inconsistent with current *** quality continued medical education is required to improve Chinese physician management of AGHD.

关键词： adult growth hormone deficiency management continued medical education

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI WENKE JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

Near-infrared aggregation-induced emission materials:Bibliometric analysis and their application in biomedicalfield

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Aggregate

Aggregate 2024年第3期5卷 78-106页

作者： Qian He Meiyiming Wang Li Zhao Bin Xu Wenjing Tian Liyun Zhang shanxi Bethune hospital Shanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxiChina State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunJilinChina

Aggregation-induced emission(AIE)is an intriguing photophysical phenomenon,where specific materials exhibit a remarkable surge in luminescence when brought together in non-ideal solvents or within a solid *** the concept of AIE wasfirst introduced in 2001,numerous advanced applications have been gradually explored across various domains,including optics,electronics,energy,and the life *** particular note is the growing interest in the application of AIE systems with near-infrared(NIR)emissive feature in thefield of biomedicine,encompass-ing detection,imaging,and therapeutic ***,bibliometric analysis serves as a valuable tool to provide researchers with a comprehensive understand-ing of research achievements and developmental trends in specificfields,which is crucial for academic ***,we present a general bibliometric overview spanning two decades of NIR-AIE *** the assistance of core scien-tific databases and various bibliometric software tools,we conducted a systematic analysis of annual publications and citations,the most influential countries/regions,leading authors,journals,and institutions,as well as the hot topics related to NIR applications and forward-looking ***,the application of AIE with NIR properties in the biomedicalfield is also systematically reviewed.

关键词： aggregation-induced emission bibliometric analysis biomedical application near-infrared

Anti-BCMA CAR-T Cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function

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Current medical Science 2021年第3期41卷 474-481页

作者： Shao-long HE Yu-hang CHENG Di WANG Meng-lei XU Yi-mei QUE Yan-jie XU Liang-ming MA Chun-rui LI Jian-feng ZHOU Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China third hospital of shanxi medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTongji Medical CollegeHuazhong University of Science and TechnologyTaiyuan 030032China

Anti-B cell maturation antigen(BCMA)chimeric antigen receptor(CAR)T-cell therapyis effective and well-tolerated for refractory or relapsed multiple myeloma(RRMM).The purposcof the present study was to analyze efficacy in RRMM patients with renal impairment treated byanti-BCMA CAR-T cell therapy.A total of 59 RRMM patients were selected,and divided intoimpaired renal function(lRF)group[basclinc cstimated giomerular filtration rate(eSFR)<90 m/min/1.73 m^2(n=18)]and normal renal function(NRF)group(baseline eGFR≥90 mL/min/1.73 m,n=41).For patients with IRF,eGFR at the 6th month post-CAR-T cells infusion was significantlyhigher than the baseline(P<0.05).The multivariate analysis showed that light chain type and beta-2 micro-globulin(bcta-2M)were associated factors with the decrease of serum ***-free survival(PFS)in the NRF group and IRF group was 266 days and 181 *** survival(OS)in the NRF group and lRF group was 877 days and 238 *** was no significant difference in the objective response rate(ORR)between thelRF group and the NRF *** is suggested that CAR-T cells therapy could improve the renalfunction during the treatment of *** renal function could be more significantly improvedin RRMM patients with light chain type than with other types.

关键词： relapsed or refractory multiple myeloma chimeric antigen receptor T-cell therapy impaired renal function B cell maturation antigen

Investigation on the Percutaneous Enhancing Permeation Mechanism of Azone for Ketoprofen Based on the Intermolecular Hydrogen-bonding Interaction

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Chinese Journal of Structural Chemistry 2014年第2期33卷 304-318页

作者：田青平宋舒琴史文静谢茵宋艳红唐海飞龚明星钟华张玲玲任福德 Department of Pharmacy Shanxi Medical University The third hospital of shanxi medical University Feedstuff and Veterinary Drugs Watch Office Department of Agriculture Shanxi Province college of Chemical Engineering and Environment North University of China

The permeation enhancing activity of Azone for ketoprofen through excised cavia skins was investigated using Franz diffusion cell. The possible hydrogen-bonded complexes formed between ketoprofen and the model molecule of Azone as azacyclopentane-2-one were fully optimized at the B3LYP/6-311＋＋G＊＊ level. The intermolecular hydrogen-bonding interactions were calculated using the B3LYP/6-311＋＋G＊＊, B3LYP/6-311＋＋G（2df, 2p）, MP2（full）/6-311＋＋G＊＊ and MP2（full）/6-311＋＋G（2df, 2p） methods, respectively. The results show that the steady-state permeation rate of ketoprofen through excised cavia skins enhances over 9 times in the solvent with 2% Azone as compared with the solvent without Azone. The stable O–H…O=C and N–H…O=C hydrogen-bonded complexes could exist between azacyclopentane and ketoprofen. The hydrogen-bonding interaction energy follows the order of（a）〉（b）〉（c）〉（d）〉（g）〉（e）〉（h）〉（f）. The formation of the complexes leads to the change of the conformation and molecular polarity of ketoprofen, and thus causes a better percutaneous permeation for the drug. The analyses of AIM（atom in molecule） and shift of electron density were used to further reveal the nature of the enhancing permeation activity of Azone for ketoprofen. The investigations of the temperature and solvent effects confirm that ketoprofen might enter into the skin by means of the Azone complex.

关键词： intermolecular hydrogen-bonding interaction Azone ketoprofen,transdermal delivery MP2

Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats

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Current medical Science 2024年第2期44卷 355-368页

作者： Shao-ze JING Shu-han YANG Yun-kun QU Hai-hu HAO Hua WU Department of Orthopedics Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Osteoarthritis(OA)is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local *** study aimed to investigate the anti-OA effect of scutellarein(SCU),a single-unit flavonoid compound obtained from Scutellaria barbata ***,in ***:The extracted rat chondrocytes were treated with SCU and IL-1β.The chondrocytes were divided into control group,IL-1βgroup,IL-1β+SCU 50µmol/L group,and IL-1β+SCU 100µmol/L *** of rat chondrocytes was observed by toluidine blue and safranin O ***-8 method was used to detect the cytotoxicity of ***,qRT-PCR,Western blotting,immunofluorescence,SAβ-gal staining,flow cytometry,and bioinformatics analysis were applied to evaluate the effect of SCU on rat chondrocytes under IL-1β***,anterior cruciate ligament transection(ACL-T)was used to establish a rat OA *** changes were detected by safranin O/fast green,hematoxylin-eosin(HE)staining,and ***:SCU protected cartilage and exhibited anti-inflammatory effects via multiple ***,it could enhance the synthesis of extracellular matrix in cartilage cells and inhibit its *** addition,SCU partially inhibited the nuclear factor kappa-B/mitogen-activated protein kinase(NF-κB/MAPK)pathway,thereby reducing inflammatory cytokine production in the joint ***,SCU significantly reduced IL-1β-induced apoptosis and senescence in rat chondrocytes,further highlighting its potential role in OA *** vivo experiments revealed that SCU(at a dose of 50 mg/kg)administered for 2 months could significantly delay the progression of cartilage damage,which was reflected in a lower Osteoarthritis Research Society International(OARSI)score,and reduced expression of matrix metalloproteinase 13(MMP13)in ***:SCU is effective in the therapeutic management of OA and could serve as a potential candidate f

关键词： scutellarein osteoarthritis apoptosis mitogen-activated protein kinase(MAPK) nuclear factor kappa-B(NF-κB)

Navigating the ethical terrain:Off-label and experimental treatments in medical case reports

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World Journal of Methodology 2025年第1期15卷 1-5页

作者： Madhan Jeyaraman Naveen Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002India

This article explores the ethical considerations surrounding the reporting of offlabel and experimental treatments in medical case reports,with a focus on fields such as oncology,psychiatry,and *** emphasizes the balance between innovation and evidence-based medicine,highlighting the critical role of case reports in disseminating clinical experiences and advancing medical *** discussion delves into the ethical framework guiding case reporting,including principles of patient autonomy,informed consent,non-maleficence,beneficence,justice,and *** such as negative outcome reporting,commercial interests,and the balance between innovation and caution are *** for ethical vigilance,the development of comprehensive guidelines,and the role of regulatory bodies are proposed to ensure patient safety and uphold scientific *** article concludes by underscoring the importance of a collaborative effort among clinicians,researchers,ethicists,and regulatory bodies to foster the responsible advancement of medical science while adhering to the highest ethical standards.

关键词： Ethical considerations Patient autonomy Informed consent Non-maleficence Beneficence Transparency Evidence-based medicine