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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

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Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： Yolanda Diz-Chaves Zainab Maastor Carlos Spuch José Antonio Lamas Lucas C.González-Matías Federico Mallo Biomedical Research Centre(CINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

Beyond vertebrates:the amphioxus as a relevant model system to explore the formation,organization,and regeneration of neuromuscular synapses

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Neural Regeneration Research 2022年第11期17卷 2425-2426页

作者： Esperanza Martínez Sylvain Marcellini Juan Pablo Henríquez Neuromuscular Studies Lab (NeSt Lab) group for the Study of Developmental processes (GDeP) Department of Cell BiologyFaculty of Biological SciencesUniversidad de Concepción Laboratory of Development and Evolution (LADE)

The neuromuscular junction(NMJ)is the peripheral synapse controlling muscle contraction and coordinated movement in a wide variety of *** humans,the mature NMJ is the primary target of morphological disassembly and fu... 详细信息

关键词： system contraction synapse

State Estimation Using Non-uniform and Delayed Information: A Review

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International Journal of Automation and computing 2018年第2期15卷 125-141页

作者： Jhon A.Isaza Hector A.Botero Hernan Alvarez Universidad Nacional de Colombia Research group on dynamic processes-Kalman Group

The study and application of methods for incorporating nonuniform and delayed information in state estimation tech- niques are important topics to advance in soft sensor development. Therefore, this paper presents a review of these methods and pro- poses a taxonomy that allows a faster selection of state estimator in this type of applications. The classification is performed according to the type of estimator, method, and used tool. Finally, using the proposed taxonomy, some applications reported in the literature are de- scribed.

关键词： State estimation asynchronism delayed measurement non-uniform information taxonomy.

The influence of pore structures and Lewis acid sites on selective hydrogenolysis of guaiacol to benzene over Ru/TS-1

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Green Energy & Environment 2022年第5期7卷 1014-1023页

作者： Yingying Xin Zhaoxia Zheng Zhicheng Luo Chengzhen Jiang Shaofeng Gao Zhihao Wang Chen Zhao Shanghai Key Laboratory of Green Chemistry and Chemical processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200062China Jinan Shengquan group Share Holding Co. Ltd.Jinan250204China

Here,we report a Ru/TS-1 catalyst for selective hydrogenolysis of guaiacol to benzene in the aqueous phase at conditions of 240℃ and 0.2 MPa H2,achieving a benzene yield of 86% with a hydrogenolysis rate of 103.1 mmol g^(-1) h^(-1).It was found that Silicalite-1(MFI type) with suitable pore sizes supported Ru nanoparticles(NPs) favored for hydrogenolysis of guaiacol,whereas de-aluminated Ru/HBEA,Ru/HY and Ru/MWW(without acidic sites) accelerated the parallel reactions of hydrogenation of *** addition,Ru NPs located at the orifice of Silicalite-1 was proved to be more electron-deficient and active than Ru NPs on the outer surface,as evidenced by CO-IR characterization and activity tests on Ru/Silicalite-1(with and without templates).Moreover,Br?nsted acid sites(BAS) on Ru/MFI highly promoted the hydrogenation rates of aromatics,while Lewis acid sites(LAS) on Ru/TS-1 and Ru/MFI led to a linear increase of guaiacol hydrogenolysis rate to benzene,probably due to the enhanced absorbance capability of guaiacol and phenol on the LAS of ***,pore structure properties of MFI coupled with abundant LAS(TS-1) as well as Ru NPs on the orifice of pores of TS-1 construct a promising catalyst for achieving efficient aromatic hydrocarbons from selective hydrogenolysis of lignin.

关键词： benzene hydrogenation catalyst

Investigation of gravity influence on EOR and CO_(2) geological storage based on pore-scale simulation

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Petroleum Science 2024年第2期21卷 987-1001页

作者： Yong-Mao Hao Gui-Cheng Wu Zong-Fa Li Zhong-Hui Wu Yong-Quan Sun Ran Liu Xing-Xing Li Bo-Xin Pang Nan Li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina School of Petroleum Engineering Yangtze UniversityWuhan430100HubeiChina Dongsheng Jinggong Petroleum Development group Co. LtdShengli Oilfield CompanySINOPECDongying257001ShandongChina

Gravity assistance is a critical factor influencing CO_(2)-Oil mixing and miscible flow during EOR and CO_(2)geological *** on the Navier-Stokes equation,component mass conservation equation,and fluid property-composition relationship,a mathematical model for pore-scale CO_(2) injection in oilsaturated porous media was developed in this *** model can reflect the effects of gravity assistance,component diffusion,fluid density variation,and velocity change on EOR and CO_(2) *** nonhomogeneous porous media,the gravity influence and large density difference help to minimize the velocity difference between the main flow path and the surrounding area,thus improving the oil recovery and CO_(2) *** CO_(2) injection angles and oil-CO_(2) density differences can increase the oil recovery by 22.6% and 4.2%,respectively,and increase CO_(2) storage by 37.9% and 4.7%,*** diffusion facilitates the transportation of the oil components from the low-velocity region to the main flow path,thereby reducing the oil/CO_(2) concentration difference within the porous *** diffusion can increase oil recovery and CO_(2) storage by 5.7% and 6.9%,*** addition,combined with the component diffusion,a low CO_(2) injection rate creates a more uniform spatial distribution of the oil/CO_(2) component,resulting in increases of 9.5% oil recovery and 15.7% CO_(2) storage,*** study provides theoretical support for improving the geological CO_(2) storage and EOR processes.

关键词： Gravity Flow simulation CO_(2)-oil mixing Enhanced oil recovery(EOR) Geological storage

Heavy ion energy influence on multiple-cell upsets in small sensitive volumes:from standard to high energies

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Nuclear Science and Techniques 2024年第5期35卷 109-121页

作者： Yang Jiao Li-Hua Mo Jin-Hu Yang Yu-Zhu Liu Ya-Nan Yin Liang Wang Qi-Yu Chen Xiao-Yu Yan Shi-Wei Zhao Bo Li You-Mei Sun Pei-Xiong Zhao Jie Liu Institute of Modern Physics Chinese Academy of ScienceLanzhou 730000China University of Chinese Academy of Science Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China China Electronics Technology group Corporation No.58 Research Institute Wuxi 214000China Beijing Microelectronics Technology Institute Beijing 100084China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Science and Technology on Silicon Devices Chinese Academy of SciencesBeijing 100029China

The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened ***,owing to the minimum physical gate length of only 35 nm,the physical area of a standard 6T SRAM unit is approximately 0.16μm^(2),resulting in a significant enhancement of multi-cell charge-sharing ***-cell upsets(MCUs)have become the primary physical mechanism behind single-event upsets(SEUs)in advanced nanometer node *** range of ionization track effects increases with higher ion energies,and spacecraft in orbit primarily experience SEUs caused by high-energy ***,ground accelerator experiments have mainly obtained low-energy ion irradiation ***,the impact of ion energy on the SEU cross section,charge collection mechanisms,and MCU patterns and quantities in advanced nanometer devices remains *** this study,based on the experimental platform of the Heavy Ion Research Facility in Lanzhou,low-and high-energy heavy-ion beams were used to study the SEUs of 28 nm SRAM *** influence of ion energy on the charge collection processes of small-sensitive-volume devices,MCU patterns,and upset cross sections was obtained,and the applicable range of the inverse cosine law was *** findings of this study are an important guide for the accurate evaluation of SEUs in advanced nanometer devices and for the development of radiation-hardening techniques.

关键词： 28 nm static random access memory(SRAM) Energy effects Heavy ion Multiple-cell upset(MCU) Charge collection Inverse cosine law

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.L Silva L.A.O.Nunes S.M.Lima L.H.C.Andrade Optical and Photothermal Spectroscopy group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

Anthropogenic Influence on Decadal Changes in Concurrent Hot and Dry Events over China around the Mid-1990s

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Advances in Atmospheric Sciences 2024年第2期41卷 233-246页

作者： Qin SU Buwen DONG Fangxing TIAN Nicholas P.KLINGAMAN Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong Subregion Yunnan UniversityKunming 650500China Department of Atmospheric Sciences Yunnan UniversityKunming 650500China National Centre for Atmospheric Science Department of MeteorologyUniversity of ReadingReadingRG66BBUK Geofysisk Institut University of BergenBergen 5007Norway Citadel Investment group Moor House120 London WallLondonRG66BBUK

The frequency and duration of observed concurrent hot and dry events(HDEs) over China during the growing season(April–September) exhibit significant decadal changes across the mid-1990s. These changes are characterized by increases in HDE frequency and duration over most of China, with relatively large increases over southeastern China(SEC), northern China(NC), and northeastern China(NEC). The frequency of HDEs averaged over China in the present day(PD,1994–2011) is double that in the early period(EP, 1964–81);the duration of HDEs increases by 60%. Climate experiments with the Met Office Unified Model(MetUM-GOML2) are used to estimate the contributions of anthropogenic forcing to HDE decadal changes over China. Anthropogenic forcing changes can explain 60%–70% of the observed decadal changes,suggesting an important anthropogenic influence on HDE changes over China across the mid-1990s. Single-forcing experiments indicate that the increase in greenhouse gas(GHG) concentrations dominates the simulated decadal changes,increasing the frequency and duration of HDEs throughout China. The change in anthropogenic aerosol(AA) emissions significantly decreases the frequency and duration of HDEs over SEC and NC, but the magnitude of the decrease is much smaller than the increase induced by GHGs. The changes in HDEs in response to anthropogenic forcing are mainly due to the response of climatological mean surface air temperatures. The contributions from changes in variability and changes in climatological mean soil moisture and evapotranspiration are relatively small. The physical processes associated with the response of HDEs to GHG and AA changes are also revealed.

关键词： concurrent hot and dry events decadal variation greenhouse gases aerosol emissions

A review on adhesion behavior of chip seal pavement and aggregate

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 441-466页

作者： Yuming Zhou Zhuyi Peng Jinyu Wang Jianguo Wei Hao Liu Di Wang Jinming Li Key Laboratory of Road Structure and Material of Ministry of Transport(Changsha) Changsha University of Science and TechnologyChangsha 410114China School of Traffic and Transportation Engineering Changsha University of Science and TechnologyChangsha 410114China Wuhan Huike Testing Co. Ltd.Wuhan 430000China Department of Civil Engineering University of OttawaON KIN 6N5Canada CCCC Infrastructure Maintenance group Co. Ltd.Beijing 100102China

Chip seal is widely used for preventive maintenance to mitigate pavement deterioration,but it is prone to aggregate loss during pavement *** further promote the development and application of chip seals in road engineering in China,the research progress of the adhesion behavior of aggregate and binder in chip seals was reviewed in this paper,focusing on the adhesion mechanism of emulsified asphalt and alkaline *** Influencing factors and evaluation methodology of chip seals'aggregate adhesion behavior were also *** results demonstrate that the adhesion process between emulsified asphalt and alkaline aggregate is divided into three processes including infiltration,demulsification,and cluster,which is more complicated when compared to hot *** designing a chip seal,not only the characteristics of single material should be paid attention to,but also the combination of binder and aggregate matters a *** form good adhesion between aggregate and asphalt binder,various influencing factors such as material selection,design method,and construction technical index should be considered comprehensively in the whole design,construction,and operation *** methods for evaluating adhesion behavior are summarized,including macroscopic adhesion performance tests,image analysis technology,and model *** is not objective to evaluate the aggregate adhesion behavior of chip seal only by a single evaluation method.A comprehensive evaluation based on the micro-macro multi-scale method should be considered in the future.

关键词： Chip seal Adhesion behavior Asphalt binder Aggregate