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Altered O-GlcNAcylation and mitochondrial dysfunction,a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease

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Neural Regeneration Research 2023年第4期18卷 779-783页

作者： Chia-Wei Huang Nicholas C.Rust Hsueh-Fu Wu Gerald W.Hart Complex Carbohydrate Research Center University of GeorgiaAthensGAUSA Department of Biochemistry and Molecular Biology University of GeorgiaAthensGAUSA Center for Molecular Medicine University of GeorgiaAthensGAUSA

Alzheimer’s disease is a neurodegenerative disease that affected over 6.5 million people in the United States in 2021,with this number expected to double in the next 40 years without any sort of treatment.Due to its heterogeneity and complexity,the etiology of Alzheimer’s disease,especially sporadic Alzheimer’s disease,remains largely unclear.Compelling evidence suggests that brain glucose hypometabolism,preceding Alzheimer’s disease hallmarks,is involved in the pathogenesis of Alzheimer’s disease.Herein,we discuss the potential causes of reduced glucose uptake and the mechanisms underlying glucose hypometabolism and Alzheimer’s disease pathology.Specifically,decreased O-Glc NAcylation levels by glucose deficiency alter mitochondrial functions and together contribute to Alzheimer’s disease pathogenesis.One major problem with Alzheimer’s disease research is that the disease progresses for several years before the onset of any symptoms,suggesting the critical need for appropriate models to study the molecular changes in the early phase of Alzheimer’s disease progression.Therefore,this review also discusses current available sporadic Alzheimer’s disease models induced by metabolic abnormalities and provides novel directions for establishing a human neuronal sporadic Alzheimer’s disease model that better represents human sporadic Alzheimer’s disease as a metabolic disease.

关键词： Alzheimer’s disease amyloid beta brain glucose deficiency glucose uptake hypometabolism mitochondrial dysfunction neurodegenerative disease neurons O-GlcNAc Tau

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多工况车辆荷载下嵌入式压电传感路面结构动态响应分析

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北京工业大学学报 2024年第4期50卷 431-442页

作者：赵千阮大为胡明伟陈湘生 WANG Linbing 深圳大学土木与交通工程学院深圳518060 深圳大学未来地下城市研究院深圳518060 极端环境岩土和隧道工程智能建养全国重点实验室深圳518060 深圳大学滨海基础设施教育部重点实验室深圳518060 The Sensing and Perception Lab University of GeorgiaAthensGeorgia 30602United States

嵌入式智能装置与路面结构在车辆荷载作用下的动态响应对其服役性能和使用寿命意义突出。为此,采用1/4车辆振动模型,构建车辆动荷载作用下的嵌入式压电系统-路面结构有限元模型。基于足尺加速加载试验路段实测应变数据和文献振动数据,... 详细信息

嵌入式智能装置与路面结构在车辆荷载作用下的动态响应对其服役性能和使用寿命意义突出。为此,采用1/4车辆振动模型,构建车辆动荷载作用下的嵌入式压电系统-路面结构有限元模型。基于足尺加速加载试验路段实测应变数据和文献振动数据,对有限元模型的响应结果进行了验证;进一步考虑了不同车辆轴载、车速和路面平整度等工况下,嵌入式路面结构的动态响应变化和压电系统的电压峰值输出。结果表明,路面结构的竖向加速度峰值、嵌入式压电系统的输出峰值随着车辆荷载的增加而增加,线性度良好;超载带来的横向应变峰值变化和竖向应变拉压交替峰峰值变化,需重点考虑;行驶速度对路面的振动和应变响应影响明显,均不为单调变化;随着路面等级从A级降为C级,路面各结构层平均竖向加速度从-10×10^(-3) g增加到-39×10^(-3) g,其中深度200 mm以内的三向振动增幅最为明显。该研究为嵌入式压电系统的实际应用和布置优化提供了支撑,也为智能道路的长期服役性能分析提供了依据。

关键词：智能路面嵌入式传感压电系统多工况动态响应振动峰值

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Climate-change habitat shifts for the vulnerable endemic oak species(Quercus arkansana Sarg.)

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Journal of Forestry Research 2024年第1期35卷 117-127页

作者： Suresh Chandra Subedi Seth Drake Binaya Adhikari Mark V.Coggeshall Department of Biological Sciences Arkansas Tech UniversityRussellvilleARUSA Department of Biology University of KentuckyLexingtonKYUSA School of Natural Resources University of Missouri203 ABNR BuildingColumbiaMO 65211USA

Quercus arkansana(Arkansas oak)is at risk of becoming endangered,as the total known population size is represented by a few isolated populations.The potential impact of climate change on this species in the near future is high,yet knowledge of its predicted effects is limited.Our study utilized the biomod2 R package to develop habi-tat suitability ensemble models based on bioclimatic and topographic environmental variables and the known loca-tions of current distribution of Q.arkansana.We predicted suitable habitats across three climate change scenarios(SSP1-2.6,SSP2-4.5,and SSP5-8.5)for 2050,2070,and 2090.Our findings reveal that the current suitable habitat for Q.arkansana is approximately 127,881 km^(2) across seven states(Texas,Arkansas,Alabama,Louisiana,Mississippi,georgia,and Florida);approximately 9.5%is encompassed within state and federally managed protected areas.Our models predict that all current suitable habitats will disap-pear by 2050 due to climate change,resulting in a northward shift into new regions such as Tennessee and Kentucky.The large extent of suitable habitat outside protected areas sug-gests that a species-specific action plan incorporating pro-tected areas and other areas may be crucial for its conserva-tion.Moreover,protection of Q.arkansana habitat against climate change may require locally and regionally focused conservation policies,adaptive management strategies,and educational outreach among local people.

关键词： Biomod2 Climate change Conservation Habitat loss Habitat shift Species distribution modeling Oak species

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Multiple endocrine factors regulate nutrient mobilization and storage in Aedes aegypti during a gonadotrophic cycle

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Insect Science 2023年第2期30卷 425-442页

作者： Xiaoyi Dou Kangkang Chen Mark R.Brown Michael R.Strand Department of Entomology University of GeorgiaAthensGeorgia30602United States Department of Plant Protection College of Horticulture and Plant ProtectionYangzhou UniversityYangzhouJiangsu ProvinceChina

Anautogenous mosquitoes must blood feed on a vertebrate host to produce eggs.Each gonadotrophic cycle is subdivided into a sugar-feeding previtellogenic phase that produces primary follicles and a blood meal-activated vitellogenic phase in which large numbers of eggs synchronously mature and are laid.Multiple endocrine factors including juvenile hormone(JH),insulin-like peptides(ILPs),ovary ecdysteroidogenic hormone(OEH),and 20-hydroxyecdysone(20E)coordinate each gonadotrophic cycle.Egg formation also requires nutrients from feeding that are stored in the fat body.Regulation of egg formation is best understood in Aedes aegypti but the role different endocrine factors play in regulating nutrient mobilization and storage remains unclear.In this study,we report that adult female Ae.aegypti maintained triacylglycerol(TAG)stores during the previtellogenic phase of the first gonadotrophic cycle while glycogen stores declined.In contrast,TAG and glycogen stores were rapidly mobilized during the vitellogenic phase and then replenishment.Several genes encoding enzymes with functions in TAG and glycogen metabolism were differentially expressed in the fat body,which suggested regulation was mediated in part at the transcriptional level.Gain of function assays indicated that stored nutrients were primarily mobilized by adipokinetic hormone(AKH)while juvenoids and OEH regulated replenishment.ILP3 further showed evidence of negatively regulating certain lipolytic enzymes.Loss of function assays indicated AKH depends on the AKH receptor(AKHR)for function.Altogether,our results indicate that the opposing activities of different hormones regulate nutrient stores during a gonadotrophic cycle in Ae.aegypti.

关键词： adipokinetic hormone ecdysone endocrine glycogen insulin-like peptide juvenile hormone mosquito nutrient ovary ecdysteroidogenic hormone triacylglycerol

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The new kid on the block in insect pest management:sprayable RNAi goes commercial

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Science China Life Sciences 2024年第8期 1766-1768页

作者： Junjie Yan Ralf Nauen Stuart Reitz Andrei Alyokhin Jiang Zhang David Mota-Sanchez Yonggyun Kim Subba Reddy Palli Silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fuentes Michael S.Crossley William E.Snyder Angharad M.R.Gatehouse Myron P.Zalucki Bruce E.Tabashnik Yulin Gao Department of Entomology Cornell UniversityCornell Agri Tech Department of Entomology and Plant Pathology University of Tennessee Department of Entomology and Wildlife Ecology University of Delaware Department of Entomology University of Georgia School of Natural and Environmental Sciences Newcastle University School of the Environment University of Queensland Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural University Department of Entomology University of Arizona National Center of Excellence for Tuber and Root Crop Research Chinese Academy of Agricultural Sciences State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Bayer AG Crop Science DivisionR&DPest Control Department of Crop and Soil Science Oregon State University School of Biology and Ecology University of Maine Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural Sciences Department of Entomology Michigan State University Department of Plant Medicals Andong National University Department of Entomology University of Kentucky Oregon State university Oregon Integrated Pest Management Center

Insect pest damage to crops is a threat to global food security(Tilman et al.,2011).Climate change,the evolution of insecticide resistance,and the phasing out of insecticides due to environmental and safety concerns exacerbate this problem.Farmers urgently need safe and effective crop protection tools to sustainably generate yields that meet ever-increasing global demand.

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Total amino acid level affects the results of standardized ileal digestibility assays for feed ingredients for swine

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Animal Nutrition 2023年第2期13卷 19-30页

作者： Darlene J.Bloxham Michael Azain Gene M.Pesti Shu-Biao Wu Department of Poultry Science The University of GeorgiaAthensGA 30602USA Department of Animal and Dairy Sciences The University of GeorgiaAthensGA 30602USA The university of New England ArmidaleNSW 2350Australia

It has been demonstrated that the fiber content of oilseed meals and total amino acids(AA)in distillers'grains products affects standardized ileal digestibility(SID)values from swine assays and that total protein concentration affects the AA digestibility in assays using chickens.This analysis was conducted to test the hypothesis that the total AA content of test samples affects the SID assay results.Databases containing total AA profiles and SID values of 20 feedstuffs commonly fed to pigs from 2 sources,AMINODat 5.0(Evonik Industries,2015)and the Nutrient Requirements of Swine,12th edition(NRC,2012)were used to compare AA concentration effects on standardized ileal digestibility coefficients.Databases were compared with AA and SID available in both data sets.The total AA values were similar for the 2 databases with an R2 of 0.979(P<0.001).The linear relationship between digestibility co-efficients from the 2 databases was highly significant,an R2 of 0.810(P<0.001).Both databases had increased SID values with increasing AA contents within and across feed ingredients.The SID=f(AA concentration)relationship was confirmed with an individual paper.Since SID,as typically measured,is a function of both digestion and absorption,both processes following MichaeliseMenten kinetics,SID=f(AA concentration)may simply be a natural phenomenon.Other reasons for the relationship were explored.Methods of estimating endogenous AA losses and misapplication statistical procedures may contribute to variation in results and at least partially explain why SID=f(AA concentration).

关键词： Apparent ileal digestibility Standardized ileal digestibility Swine Least squares means

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Kiran Nandivada’s Stuck Blade in a Grinder Jar Degenerative Cascade by LSTV at L5-S1

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Open Journal of Orthopedics 2024年第1期14卷 12-21页

作者： Venkata Satya Kumar Kiran Nandivada Nadavinamani Shivanand Raghavendra Nandivada Nikhil Bharadwaja Moola Sohith Mahadeva Reddy Ahmed Usama Rizvi Nandivada Ortho Spine Surgeon & Rheumatologist Abu Dhabi United Arab Emirates Senior Orthopedic Surgeon & Rheumatologist Abu Dhabi United Arab Emirates General Practitioner Visakhapatnam India Department of Medicine Kamineni Institute of Medical Sciences Telangana India Department of Medicine Tbilisi State Medical University Tbilisi Georgia

Background: Mario Bertolotti, (1917) described LSTV-Lumbar spinal transitional vertebra as Bertolotti Syndrome a century ago and associated low back pain with it. Yet, it needs to be given significance in general orthopaedic practice even now, and radiologists underreport it. LSTV is a congenital anatomical anomaly that Castellvi classified into four varying types. Purpose: I titled this phenomenon “Kiran Nandivada’s stuck blade in a grinder jar degenerative cascade by LSTV at L5-S1” to clearly explain how an abnormal mega-transverse apophysis with its various variations affects the weight-bearing mechanics as the L5-S1 which is a vital junction where the maximum body weight is directed into both the sacroiliac joints and if a transitional vertebra occurs it becomes detrimental and abnormally redirects the load-bearing forces and leads to a progressive degenerative cascade both proximally and distally. As the L5 vertebral rotations and other movements of flexion, extensions, lateral flexion are stuck like a bent grinder blade, the other areas of the region are damaged progressively as the pelvis, just like the grinder motor tries to move it, resulting in overheating and maybe even a burnout results in the form of facet arthritis, disc degeneration in the normal disc above, the transitional disc at L5-S1, foraminal osteophytes causing radiculopathy, sacroiliac joint arthritis. Material and Methods: Around 200 X-rays of children and adults with this congenital anomaly have been studied between 2020 and 2023. This is a retrospective study. Results: 1) Our study showed an Increased incidence of LSTV at 15%. 2) Patients ranged from asymptomatic, atypical lumbago to classical lumbago with sciatica and claudication. Findings supported facet and sacroiliac joint arthritis and the pain, relieved with physiotherapy, posture corrections, weight reduction, and lifestyle precautions, negating the need for local steroid injections, radiofrequency ablation or surgical excision as per our experience. Conclusion: Other dysplastic

关键词： LSTV Bertolotti Syndrome Transitional Vertebra Facet Tropism Congenital Dysplasia

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Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration

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Neural Regeneration Research 2024年第6期19卷 1318-1324页

作者： Theodora Mourtzi Nasia Antoniou Christina Dimitriou Panagiotis Gkaravelas georgia Athanasopoulou Panagiota Nti Kostantzo Olga Stathi Efthymia Theodorou Maria Anesti Rebecca Matsas Fevronia Angelatou georgia Kouroupi Ilias Kazanis Laboratory of Developmental Biology Department of Biology University of Patras Laboratory of Cellular and Molecular Neurobiology-Stem Cells Hellenic Pasteur Institute 3. Department of Physiology School of Medicine University of Patras

We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the “weaver” mouse, a model of progressive nigrostriatal degeneration. Here, we extended our investigation in two clinically-relevant ways. First, we assessed the effects of BNN-20 on human induced pluripotent stem cell-derived neural progenitor cells and neurons derived from healthy and parkinsonian donors. Second, we assessed if BNN-20 can boost the outcome of mouse neural progenitor cell intranigral transplantations in weaver mice, at late stages of degeneration. We found that BNN-20 has limited direct effects on cultured human induced pluripotent stem cell-derived neural progenitor cells, marginally enhancing their differentiation towards neurons and partially reversing the pathological phenotype of dopaminergic neurons generated from parkinsonian donors. In agreement, we found no effects of BNN-20 on the mouse neural progenitor cells grafted in the substantia nigra of weaver mice. However, the graft strongly induced an endogenous neurogenic response throughout the midbrain, which was significantly enhanced by the administration of microneurotrophin BNN-20. Our results provide straightforward evidence of the existence of an endogenous midbrain neurogenic system that can be specifically strengthened by BNN-20. Interestingly, the lack of major similar activity on cultured human induced pluripotent stem cell-derived neural progenitors and their progeny reveals the in vivo specificity of the aforementioned pro-neurogenic effect.

关键词： adult neurogenesis BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent stem cells (iPSCs) neurotrophic factors Parkinson's disease substantia

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QUANTITATIVE RELATIONSHIP BETWEEN THE POST-LOWER ILLUMINATION CO_2 BURST AND PHOTORESPIRATION IN INTACT LEAVES

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Chinese Science Bulletin 1987年第1期32卷 57-61页

作者：屠曾平 C.C.BLACK A.M.ARMITAGE H.M.VINES Rice Research Instittute Guangdong Academy of Agricultural Sciences Guangzhou Department of Biochemistry University of Georgia Athens CA 30602 USA Department of Horticulture University of Georgia Athens GA 30602 USA Department of Horticulture University of Georgia Athens GA 30602 USAecker discovered the phenomenon of a CO_2 burst (post illumination CO_2 burst or PIB) when a photosynthesizing tobacco leaf was changed from light to dark thereby he demonstrated the existence of photorespiration in higher plants. Because of the great theoretical and practical significance of photorespiration both in basic plant physiological work and in applied agricultural work research on photorespiration and its related problems

Decker discovered the phenomenon of a CO2 burst （post illumination CO2 burst or PIB） when a photosynthesizing tobacco leaf was changed from light to dark; thereby, he demonstrated the existence of photorespiration in higher plants. Because of the great theoretical and practical significance of photorespiration both in basic plant physiological work and in applied agricultural work, research on photorespiration and its related

关键词： burst illumination physiological POST tobacco agricultural seedling thereby mature young

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Abductive statistical methods improve the results of calibration curve bioassays:An example of determining zinc bioavailability in broiler chickens

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Animal Nutrition 2022年第3期10卷 294-304页

作者： Gene M.Pesti Lynne Billard Shu-Biao Wu Robert A.Swick Thi Thanh Hoai Nguyen Natalie Morgan The university of New England ArmidaleNSW2351Australia the university of georgia AthensGA30602USA

In this paper,we discuss the theory behind calibration curve experiments and their application to a zinc(Zn)bioavailability study with broiler chickens.Seven replicates of 16 male commercial broiler chicks were fed starter diets for 14 days.Six diets had different levels of a potential Zn source and one was a positive control with standard industry levels of Zn for comparison.Four commonly used methods of calculating bioavailability means and confidence intervals(CI)from a calibration curve(standard curve)experiment to estimate the bioavailability of a new zinc source in broiler chickens were compared.The methods compared were the following:1)the Counter-Intuitive Method uses a multiple-range test to compare unknown test and standard samples;2)the Intuitive Method uses standard linear regression and inverts the equation to predict Zn bioavailability for each replicate of test samples;3)the Abductive Method uses Graybill's Equation,based on theory and observation,to estimate CI's;and 4)the Sophistic Method uses reverse regression,and calculates Zn bioavailability values directly from the equation.The Counter-Intuitive Method only gives information about which standards the test samples are,or are not,significantly different from respectively(average available Zn not predicted).The Intuitive Method ignores error about the standard curve and theoretically cannot estimate the CI directly(X±SEM=107.5±15.8 mg Zn/kg).The Sophistic Method underestimates and overestimates the test sample mean values above and below the mean of the standards,respectively(X=96.6 mg Zn/kg).The Abductive Method has an advantage over the other methods:The mean prediction estimation is consistent with theory(107.5±6.1 mg Zn/kg;X±SEM).When test or“unknown”samples are near the mean of the standard samples,the CI is smaller than when near the extremes of the calibration curve.When calibration curve error is small(R^(2)>approximately 0.95),there is little advantage to using the Abductive Method,but when calibration curve error is larger,as in many

关键词： Calibration curve Standard curve Confidence interval Bioavailability

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