检索结果-南通市图书馆

Identification of a novel signal for activation of Ti plasmid- encoded vir genes from rice (Oryza sativa L.)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1995年第21期40卷 1824-1828页

作者：施骏许耀刘吉开尹中朝李宝健 Amway (China) Co.Limited the salk institute.usa Biotechnology Research Center Zhongshan University Guangzhou 510275 China

Virulence (vir) genes of Ti plasmids code for a specialized conjugation system that mediates the mobilization and transfer of T-DNA from Agrobacterium to the genome of higher plants. This system is activated by a number of plant-specific phenolics, well characterized in dicots, via a two-component regulatory system. In contrast, little is known about the occurrence of vir-inducing signals in monocots, especially in the cereal *** have examined the effects of exudates and extracts from various rice tissues at

关键词： rice signal molecule Agrobacterium tumefaaences Ti plasmid virulence.

Neural stem cells:mechanisms and modeling

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2012年第7期3卷 251-261页

作者： Jun Yao Yangling Mu Fred H.Gage Laboratory of Genetics The Salk Institute for Biological StudiesLa JollaCA 92037USA

In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory *** derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological ***,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal *** addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal *** this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.

关键词： neural stem cell hippocampus olfactory bulb induced pluripotent stem cell neurodegenerative dis-ease neurodevelopmental disorder

Local HY5 Activity Mediates Hypocotyl Growth and Shoot-to-Root Communication

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2020年第5期1卷 64-72页

作者： Yogev Burko Christophe Gaillochet Adam Seluzicki Joanne Chory Wolfgang Busch Howard Hughes Medical institute Salk Institute for Biological StudiesLa JollaCA 92037USA Plant Biology Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Integrative Biology Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA

Plants optimize their growth in fluctuating environments using information acquired by different *** information is then transmitted through the rest of the plant using both short-and long-distance signals,including hormones and mobile *** a few of these signals have been characterized,long-distance signaling is not well understood in ***,the light-regulated transcription factor HY5 was reported to move from the shoot to the root to regulate root *** generated a cell-type specifically expressed HY5 fusion protein that could not be detected outside the tissue in which it was *** expressing this DOF-HY5 protein in specific cell types of the hypocotyl,we showed that its local activity was sufficient to regulate hypocotyl *** also found that,although DOF-HY5 was expressed specifically in the shoot and not detected in the roots,it could rescue hy5 growth defects in primary roots but not in lateral *** therefore conclude that HY5 protein mobility is not required in the hypocotyl or for shoot-to-root *** results indicate that a signal downstream of,or in parallel with,HY5 in the shoot is mobile and links shoot and root growth.

关键词： HY5 shoot-to-root communication hypocotyl root lateral root Arabidopsis

Unfolding the Mysteries of Strigolactone Signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2014年第6期7卷 934-936页

作者： Zuyu Zheng Alexandre de Saint Germain Joanne Chory Howard Hughes Medical institute Plant Biology Laboratory The Salk Institute for Biological Studies La Jolla CA 92037 USA

Phytohormones integrate plant growth and developmental programs with extrinsic biotic and abiotic stimuli, thereby ensuring plant architecture is optimized for the local envi- ronment. Strigolactones （SLs）, newly identified carote- noid-derived plant hormones, play non-redundant and multifaceted roles throughout the plant life cycle （de Saint Germain et al.2013）, similarly to other plant hormones.

关键词： ARABIDOPSIS DEGRADATION PERCEPTION

Ageing in worms:N-acylethanolamines take control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2011年第9期2卷 689-690页

作者： Run Shen The salk institute for Biological Studies 10010 North Torrey Pines RoadLa JollaCA 92037USA

Studies of dietary restriction’s effect on lifespan extension in *** and other model organisms have greatly expanded our knowledge about genetic network underlying stress response,ageing,and ageing related *** key molecules and signaling pathways implicated are Foxo(daf-16)and Foxa(pha-4)transcriptional factors and the nutrient sensing insulin/TOR pathway(Wolkow et al.,2000;Panowski et al.,2007;Hansen et al.,2008).

关键词： stress Ageing expanded

“Smurf”-ing tumors on the chromatin through RNF20

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2012年第2期3卷 81-83页

作者： Wen-Wei Tsai Peptide Biology Laboratories Salk Institute for Biological StudiesLa JollaCA 92037USA

In the modern mythology of Dutch comic world,Smurfs are little blue creatures who say“smurf”for anything they *** the parlance of molecular biology,there live two Smurfs so named because they are Smad ubiquitination regulator factor 1 and *** like those blue devils on the television,the molecular Smurfs are also versatile;capable of controlling bone development,actin cytoskeleton dynamics,cellular senescence,and planar cell polarity in addition to their prototypic function in transforming growth factorβ(TGF-β)***,the realm of Smurf influence has expanded even further to epigenetic modifications of histones governing the chromatin landscape.A recent study from Ying E.

关键词： Dutch expanded versatile

Characterization of tub_4^(P287L), a β-tubulin mutant,revealed new aspects of microtubule regulation in shade

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2015年第9期57卷 757-769页

作者： Jie Yu Hong Qiu Xin Liu Meiling Wang Yongli Gao Joanne Chory Yi Tao School of Life Sciences Xiamen Plant Genetics Key Laboratory Xiamen University State Key Laboratory of Cellular Stress Biology Xiamen University Howard Hughes Medical institute The Salk Institute for Biological Studies Plant Biology Laboratory The Salk Institute for Biological Studies

When sun plants, such as Arabidopsis thaliana, are under canopy shade, elongation of stems/petioles will be induced as one of the most prominent responses. Plant hormones mediate the elongation growth. However, how environmental and hormonal signals are translated into cell expansion activity that leads to the elongation growth remains elusive. Through forward genetic study, we identi-fied shade avoidance2 (sav2) mutant, which contains a P287L mutation in b-TUBULIN 4. Cortical microtubules (cMTs) play a key role in anisotropic cell growth. Hypocotyls of sav2 are wild type-like in white light, but are short and highly swollen in shade and dark. We showed that shade not only induces cMT rearrangement, but also affects cMT stability and dynamics of plus ends. Even though auxin and brassinosteroids are required for shade-induced hypocotyl elongation, they had little effect on shade-induced rearrangement of cMTs. Blocking auxin transport suppressed dark phenotypes of sav2, while overexpressing EB1b-GFP, a microtubule plus-end binding protein, rescued sav2 in both shade and dark, suggesting that tub4P287L represents a unique type of tubulin mutation that does not affect cMT function in supporting cell elongation, but may affect the ability of cMTs to respond properly to growth promoting stimuli.

关键词： Arabidopsis microtubules plant hormones shade

The labyrinth of nuclear reprogramming

在线全文

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2011年第6期3卷 327-329页

作者： Ignacio Sancho-Martinez Emmanuel Nivet Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Center for Regenerative Medicine in Barcelona Dr Aiguader 88Barcelona 08003Spain

Human embryonic stem cells(ESCs)have the capability to differentiate into all somatic cell types,a process that recapitu-lates the early stages of human ***,the use of ESCs raises several controversies,particularly concern-ing the ethical dilemma regarding the use of human embryonic material and the need for embryo *** discov-ery of induced pluripotent stem cell(iPSC)technology in 2006(Takahashi and Yamanaka,2006)opened the door for possible application of pluripotent stem-cell-related therapies in the clinic as well as for the generation of patient-derived pluripotent stem cells suitable for disease modeling in vitro.

关键词： programming destruction opened

Human induced pluripotent stem cells derived hepatocytes:rising promise for disease modeling,drug development and cell therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2012年第4期3卷 246-250页

作者： Fei Yi Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological StudiesLa JollaCA 92037USA Center for Regenerative Medicine in Barcelona 08003 BarcelonaSpain National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells(iPSC)represent new promises for liver disease study and drug *** hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many func-tional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and fa-cilitate drug development *** this review,we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

关键词： induced pluripotent stem cells hepatocytes disease modeling drug development cell therapy