Neural stem cells:mechanisms and modeling

作     者：Jun Yao Yangling Mu Fred H.Gage 

作者机构：Laboratory of GeneticsThe Salk Institute for Biological StudiesLa JollaCA 92037USA 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2012年第3卷第7期

页      面：251-261页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by an American Heart Association postdoctoral fellowship(11POST5720016) 

主　　题：neural stem cell hippocampus olfactory bulb induced pluripotent stem cell neurodegenerative dis-ease neurodevelopmental disorder 

摘      要：In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory *** derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological ***,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal *** addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal *** this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.