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Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice

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Genes & Diseases 2022年第3期9卷 807-813页

作者： Amar H.Mahdi Yanying Huo Ying Chen Pier Selenica Anchal Sharma Elise Merritt Nicola Barnard Chang Chan Shridar Ganesan Jorge S.Reis-Filho Britta Weigelt Subhajyoti De Bing Xia Rutgers Cancer Institute of new jersey New BrunswickNJ 08903USA Department of Radiation Oncology Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08903USA Department of Pathology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Department of Pathology and Laboratory Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA

The BRCA1-PALB2-BRCA2 axis,or the BRCA pathway,plays key roles in genome stability maintenance and suppression of breast and several other *** to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brcal,Brca2 and Palb2 conditional knockout models,it is often thought that p53 inactivation accelerates BRCA1/2 and PALB2-associated ***,we studied tumor development in mice with a mutation in Palb2 that disengages the PALB2-BRCA1 interaction in different Trp53 *** than mammary tumors,Palb2 and Trp53 compound mutant mice developed,with greatly reduced latencies,lymphomas and sarcomas that are typically associated with germline Trp53 *** exome sequencing failed to identify any significant differences in genomic features between the same tumor types of Trp53 single mutant and Palb2;Trp53 compound mutant *** results suggest that loss of the BRCA pathway accelerates p53-associated tumor development,possibly without altering the fundamental tumorigenic processes.

关键词： BRCA1 BRCA2 Osteosarcoma P53 PALB2 Thymic lymphoma

Development of Chinese Medicine Education in the United States:Two Examples of Pacific College of Health and Science new york and Eastern School of Acupuncture and Traditional Medicine

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中医药文化（英文） 2022年第4期5卷 221-227页

作者： Qi-Hui Jin Yan Zhou Thomas Kouo Bin Xiao WTHN Acupuncture Studio New YorkNY 10010USA CYPA&Wongs Acupuncture New YorkNY 10022USA Eastern School of Acupuncture and Traditional Medicine New JerseyNJ 07003USA Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Chinese medicine originated in China and has taken root all over the *** the United States,Chinese medicine belongs to the category of complementary and alternative medicine and has a history of over 50 years as a recognized *** education of Chinese medicine is undoubtedly the foundation for the development and growth of Chinese medicine *** this article,we briefly introduced the history of acupuncture profession and its development in the United *** College of Health and Science new york and Eastern School of Acupuncture and Traditional Medicine were discussed and *** article aims to discuss two examples of acupuncture schools in the United States to provide an overview of the history and current development of Chinese medicine education in the United States.

关键词： Acupuncture school Chinese medicine Education United States

A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION

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Chinese Journal of Polymer Science 2003年第2期21卷 159-167页

作者： Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier Department of Chemistry State University of New York at Stony Brook Stony BrookNY 11794-3400 USA Ethicon Worldwide A Johnson & Johnson Company P. O. Box 151 Somerville. New Jersey 08876-0151 USA

Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-raydiffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGAfibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similarconditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain morecrystallinity and higher T_g than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate ofdegradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretchingstages was released in the post-annealing stage for a1l PGA and PGA-co-PLA samples. During earlier stages of in vitrodegradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. Theheat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLAsamples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, mostlikely due to relaxation of the cleaved chains.

关键词： Polyglycolide Poly(glycolide-co-lactide) Bioabsorbable Fiber processing in vitro Degradation

The Faddeev knots as stable solitons: Existence theorems

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Science China Mathematics 2004年第2期47卷 187-197页

作者： LIN Fanghua & YANG YisongCourant Institute of Mathematical Sciences, new york University, new york, new york 10012, U. S. A.School of Mathematics, Institute for Advanced Study, Princeton, new jersey 08540, U. S. A. Department of Mathematics, Polytechnic University, Brooklyn, new york 11201, U. S. A. Courant Institute of Mathematical Sciences New York University New York U S A School of Mathematics Institute for Advanced Study Princeton U S A Department of Mathematics Polytechnic University Brooklyn U S A

The problem of existence of knot-like solitons as the energy-minimizing configurations in the Faddeev model, topologically characterized by an Hopf invariant, Q, is considered. It is proved that, in the full space situation, there exists an infinite set S of integers so that for any m ∈ S, the Faddeev energy, E, has a minimizer among the class Q = m; in the bounded domain situation, the same existence theorem holds when S is the set of all integers. One of the important technical results is that E and Q satisfy the sublinear inequality E ≤ C|Q|3/4, where C > 0 is a universal constant, which explains why knotted (clustered soliton) configurations are preferred over widely separated unknotted (multisoliton) configurations when |Q| is sufficiently large.

关键词： knots, Hopf invariant, minimization, solitons.

ASimplified Neuronal Model for the Instigation and Propagation of Cortical Spreading Depression

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Advances in Applied Mathematics and Mechanics 2011年第6期3卷 759-773页

作者： Huaxiong Huang Robert M.Miura Wei Yao Department of Mathematics and Statistics York UniversityTorontoOntario M3J1P3Canada Center for Applied Mathematics and Statistics New Jersey Institute of TechnologyNewarkNJ 07102USA Department of Mathematical Sciences New Jersey Institute of TechnologyNewarkNJ 07102USA Department of Mechanics and Engineering Science Fudan UniversityShanghai 200433China

In this paper,we construct a simplified neuronal model that is capable of simulating the instigation of cortical spreading depression(CSD)and propagation of a CSD *** model is a simplification and extension of a single neuron model proposed in the literature for studying the instigation of *** the simplified neuronal model,we construct a network of these simplified *** network model shows that the propagation of a CSD wave occurs naturally after it is instigated electrically or *** the model is simple,the speed of the CSD wave predicted by our model is consistent with experimentally observed ***,our model allows us to investigate the effects of specific ion channels on the spread of a CSD wave.

关键词： Cortical spreading depression neuronal model network numerical simulation

Correlation of subway turnstile entries and COVID-19 incidence and deaths in new york City

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Infectious Disease Modelling 2021年第1期6卷 183-194页

作者： Sina Fathi-Kazerooni Roberto Rojas-Cessa Ziqian Dong Vatcharapan Umpaichitra Department of Electrical and Computer Engineering Newark College of EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA Department of Electrical and Computer Engineering College of Engineering and Computing SciencesNew York Institute of TechnologyNew YorkNY10023USA Department of Pediatrics SUNY Downstate Health Sciences UniversityBrooklynNY11203USA

In this paper,we show a strong correlation between turnstile entries data of the new york City(NYC)subway provided by NYC Metropolitan Transport authority and COVID-19 deaths and cases reported by the NYC Department of Health from March to May *** correlation is obtained through linear regression and confirmed by the prediction of the number of deaths by a Long Short-Term Memory neural *** correlation is more significant after considering incubation and symptomatic phases of this disease as experienced by people who died from *** extend the analysis to each individual NYC *** also estimate the dates when the number of COVID-19 deaths and cases would approach zero by using the Auto-Regressive Integrated Moving Average model on the reported deaths and *** also backward forecast the dates when the first cases and deaths might have occurred.

关键词： COVID-19 Time-series analysis new york city subway SARS-CoV-2 Long short-term memory ARIMA

Fair Valuation Issues and the Subprime Mortgage Debacle： Could Generally Accepted Accounting Principles Underlying the Historical Cost Method Have Prevented the Crisis？

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Journal of Modern Accounting and Auditing 2011年第11期7卷 1223-1228页

作者： Constance Crawford Corinne Crawford Raymond Rigoli Ramapo College of new jersey N J USA City University of new york NY USA

There are three primary methodologies employed to determine real estate value in the appraisal industry： the cost approach, the sales approach and the income approach. The definition of market value is defined as：＂a type of value, stated as an opinion that includes a set of assumptions concerning the market＂. Unfortunately, untrained and unlicensed appraisers provided opinions using primarily the sales approach or market data approach and virtually ignored the other two methodologies. The ensuing game of ＂Can You Top This＂ resulted in creating an out-of-control real estate market driven by unregulated fiduciaries as appraisers.

关键词： subprime mortgage fair valuation accounting mark-to-market accounting

Consistency of Perfect Fluidity and Jet Quenching in Semi-Quark-Gluon Monopole Plasmas

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Chinese Physics Letters 2015年第9期32卷 25-30页

作者：徐杰谌廖劲峰 Miklos Gyulassy Department of Physics Columbia University New York 10027 USA Physics Department and CEEM Indiana University Bloomington 47408 USA RIKEN BNL Research Center Bldg. 510A Brookhaven National Laboratory New York 11973 USA

We utilize a new framework, CUJET3.0, to deduce the energy and temperature dependence of the jet trans- port parameter, q （E 〉 10 GeV, T）, from a combined analysis of available data on nudear modification factor and azimuthal asymmetries from high energy nuclear collisions at RHIC/BNL and LHC/CERN. Extending a previous perturbative-QCD based jet energy loss model （known as CUJET2.0） with （2＋1）D viscous hydrody- namic bulk evolution, this new framework includes three novel features of nonperturbative physics origin; （i） the Polyakov loop suppression of color-electric scattering （aka ＇semi-QGP＇ of Pisarski et al.）, （ii） the enhancement of jet scattering due to emergent magnetic monopoles near Tc （aka ＇magnetic scenario＇ of Liao and Shuryak）, and Oii） thermodynamic properties constrained by lattice QCD data. CUJET3.0 reduces to v2.0 at high tem- peratures T 〉400 MeV, while greatly enhances ~ near the QCD deconfinement transition temperature range. This enhancement accounts well for the observed elliptic harmonics of jets with pT 〉10 GeV. Extrapolating our data-constrained q down to thermal energy scales, E-2 GeV, we find for the first time a remarkable consistency between high energy jet quenching and bulk perfect fluidity with η/s^T3/q^0.1 near To.

关键词： QGP QCD LHC

Another Look at Skeletal Maturation Using Hand Wrist and Cervical Vertebrae Evaluation

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Open Journal of Orthopedics 2018年第1期8卷 1-10页

作者： Thomas J. Cangialosi V. Jason Vives School of Dental Medicine Department of Orthodontics Rutgers University Newark New Jersey USA College of Dental Medicine Division of Orthodontics Columbia University New York City New York USA Private Practice of Orthodontics Old Bridge New Jersey USA

Introduction and Aims—The Growth stage of a patient can have considerable influence on diagnosis, treatment goals, timing and planning and the eventual outcome of orthodontic/orthopedic treatment. The purpose of this study was to analyze associations between the cervical vertebrae maturation score (CVMS) and skeletal maturation index (SMI). The second objective was to determine the reproducibility of the measurements on lateral cephalograms and hand-wrist radiographs. Materials and Methods—Lateral cephalometric and left hand-wrist radiographs of 92 untreated subjects (44 females and 48 males) aged from 8 to 17 years were obtained from the files of the Columbia University, Division of Orthodontics and measured for growth stage using cervical vertebrae and hand-wrist methods. Results—A high correlation was revealed between the hand-wrist and cervical vertebrae measurements. The Spearman’s rho correlation coefficient was 0.925 and significant at the 0.01 level. The correlation between hand-wrist and age (0.665, p < 0.01) was slightly greater than that of the CVMS (0.611, p < 0.01). Intra rater reliability was high. When the three categorically modified methods of the Fishman’s 11 skeletal maturation stages in hand and wrist analysis were used to compare with CVMS, methods 2 and 3 were both statistically significantly different according to the Wilcoxon signed ranks test and the Sign test at a significance level of less than 0.05. However, for method 1, the tests showed probability scores of 0.028 and 0.151, respectively, showing no significant difference at the 0.01 level in the Wilcoxon Signed Ranks Test, and no significant difference in the 0.01 and 0.05 level in the Signed Test. Conclusions—The Fishman’s hand and wrist skeletal maturation index and Bacetti’s cervical vertebrae maturation stages are both useful tools in evaluating growth stages. Fishman’s hand-wrist method is slightly more accurate.

关键词： Skeletal Maturation Cervical Vertebrae Hand-Wrist