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Exosomes in viral infection:Effects for pathogenesis and treatment strategies

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BIOCELL 2023年第12期47卷 2597-2608页

作者： FATEMEH HEIDARI REIHANEH SEYEDEBRAHIMI PIAO YANG MOHSEN ESLAMI FARSANI SHIMA ABABZADEH NASER KALHOR HAMED MANOOCHEHRI MOHSEN SHEYKHHASAN MARYAM AZIMZADEH Anatomy Department Faculty of MedicineQom University of Medical SciencesQomIran Cellular and Molecular research center Qom University of Medical SciencesQomIran Department of Molecular Genetics College of Arts and SciencesThe Ohio State UniversityColumbusOH43210USA Tissue Engineering Department Faculty of MedicineQom University of Medical SciencesQomIran Department of Mesenchymal Stem Cells Academic Center for EducationCultureand Research(ACECR)Qom BranchQomIran The persian gulf Marine Biotechnology research center The Persian Gulf Biomedical Sciences Research InstituteBushehr University of Medical SciencesBushehrIran Department of Molecular medicine and Genetics Research Center for Molecular MedicineHamadan University of Medical SciencesHamadanIran Department of Medical Laboratory Sciences Khomein University of Medical SciencesKhomeinIran Molecular and medicine research center Khomein University of Medical SciencesKhomeinIran

Exosomes are small vesicles that carry molecules from one cell to *** have many features that make them interesting for research,such as their stability,low immunogenicity,size of the nanoscale,toxicity,and selective *** can also interact with viruses in diverse *** research highlights the significant role of exosomes in viral infections,particularly in the context of diseases like COVID-19,HIV,HBV and *** the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral *** important aspect is gaining clarity on how exosomes influence the immune system and enhance viral infectivity through their inherent *** leveraging the innate properties of exosomes,viruses exploit the machinery involved in exosome biogenesis to set replication,facilitate the spread of infection,and eliminate immune *** can either help or hinder viral infection by modulating the immune *** review summarizes the recent findings on how exosomes mediate viral infection and how they can be used for diagnosis or *** could lead to new clinical applications of exosomes in disease management.

关键词： Exosomes Viral infection COVID-19 HIV HBV HCV

Lurking epidemic of hepatitis C virus infection in Iran: A call to action

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World Journal of Hepatology 2017年第24期9卷 1040-1042页

作者： Reza Taherkhani Fatemeh Farshadpour the persian gulf Biomedical research center Bushehr University of Medical Sciences the persian gulf Tropical medicine research center Bushehr University of Medical Sciences

Despite having a relatively low prevalence in the Iranian general population, the burden of hepatitis C virus(HCV) infection is on the rise, and hepatitis C is predicted to be the most important leading cause of viral hepatitis-related mortality in the near future in Iran. The recent population-based epidemiological studies have revealed the predominant role of injecting drug use in increasing prevalence of HCV infection. Undoubtedly, new management paradigm is required to drive down the rising wave of hepatitis C in Iran. Priority should be given to young injecting drug users as the cornerstone of the lurking epidemic of HCV infection in Iran.

关键词：一般人口注射药用户传染病学丙肝病毒伊朗

Epidemiological evidence of mosquito-borne viruses among persons and vectors in Iran:A study from North to South

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Virologica Sinica 2022年第1期37卷 149-152页

作者： Abbas Ahmadi Vasmehjani Farhad Rezaei Mohammad Farahmand Talat Mokhtari-Azad Mohammad Reza Yaghoobi-Ershadi Mohsen Keshavarz Hamid Reza Baseri Morteza Zaim Mahmood Iranpour Habibollah Turki Mohammad Esmaeilpour-Bandboni Department of Virology School of Public HealthTehran University of Medical SciencesTehran14156446Iran Department of Medical Entomology and Vector Control School of Public HealthTehran University of Medical SciencesTehran14156446Iran The persian gulf Tropical medicine research center The Persian Gulf Biomedical Sciences Research InstituteBushehr University of Medical SciencesBushehr***Iran Department of Entomology University of ManitobaR3T 2N2Canada Infectious and Tropical Diseases research center Hormozgan Health InstituteHormozgan University of Medical SciencesBandar Abbas***Iran School of Nursing Midwifery and ParamedicineGuilan University of Medical SciencesRasht***Iran

Dear Editor,Arthropod-borne viruses are a group of the most important emerging *** cause a range of diseases in vertebrate hosts and threaten human health(Gan and Leo,2014).The global distribution of arboviruses is as... 详细信息

关键词： conditions. diseases viruses

Two-dimensional Langevin modeling of fission dynamics of the excited compound nuclei ^(188)Pt,^(227)Pa and ^(251)Es

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Chinese Physics C 2016年第2期40卷 33-39页

作者： H.Eslamizadeh Department of Physics Persian Gulf University

A stochastic approach based on one-and two-dimensional Langevin equations is applied to calculate the pre-scission neutron multiplicity,fission probability,anisotropy of fission fragment angular distribution,fission cross section and the evaporation cross section for the compound nuclei ^188Pt,^227Pa and ^251Es in an intermediate range of excitation *** chaos weighted wall and window friction formula are used in the Langevin *** elongation parameter,c,is used as the first dimension and projection of the total spin of the compound nucleus onto the symmetry axis,K,considered as the second dimension in Langevin dynamical calculations.A constant dissipation coefficient of K,γk=0.077（MeV zs）^-1/2）,is used in two-dimensional calculations to reproduce the above mentioned experimental *** of the theoretical results of the pre-scission neutron multiplicity,fission probability,fission cross section and the evaporation cross section with the experimental data shows that the results of two-dimensional calculations are in better agreement with the experimental ***,it is shown that the two-dimensional Langevin equations together with a dissipation coefficient of K,γk=0.077（MeV zs）^-1/2,can satisfactorily reproduce the anisotropy of fission fragment angular distribution for the heavy compound nucleus^***,a larger value of γk=0.250（MeV zs）^-1/2is needed to reproduce the anisotropy of fission fragment angular distribution for the lighter compound nucleus^227Pa.

关键词： Langevin fission dynamics mean neutron multiplicity nuclear viscosity

Global elimination of hepatitis C virus infection:Progresses and the remaining challenges

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World Journal of Hepatology 2017年第33期9卷 1239-1252页

作者： Reza Taherkhani Fatemeh Farshadpour the persian gulf Tropical medicine research center Bushehr University of Medical SciencesBushehr ***Iran

Today, with the introduction of interferon-free direct-acting antivirals and outstanding progresses in the prevention, diagnosis and treatment of hepatitis C virus(HCV) infection, the elimination of HCV infection seems more achievable. A further challenge is continued transmission of HCV infection in high-risk population specially injecting drug users(IDUs) as the major reservoir of HCV infection. Considering the fact that most of these infections remain undiagnosed, unidentified HCVinfected IDUs are potential sources for the rapid spread of HCV in the community. The continuous increase in the number of IDUs along with the rising prevalence of HCV infection among young IDUs is harbinger of a forthcoming public health dilemma, presenting a serious challenge to control transmission of HCV infection. Even the changes in HCV genotype distribution attributed to injecting drug use confirm this issue. These circumstances create a strong demand for timely diagnosis and proper treatment of HCV-infected patients through risk-based screening to mitigate the risk of HCV transmission in the IDUs community and, consequently, in the society. Meanwhile, raising general awareness of HCV infection, diagnosis and treatment through public education should be the core activity of any harm reduction intervention, as the root cause of failure in control of HCV infection has been lack of awareness among young drug takers. In addition, effective prevention, comprehensive screening programs with a specific focus on high-risk population, accessibility to the new anti-HCV treatment regimens and public education should be considered as the top priorities of any health policy decision to eliminate HCV infection.

关键词： Hepatitis C virus Epidemiology Elimination Injecting drug user Prevention Vaccine Diagnosis Treatment

Study of shape isomer yields of ^(240)Am in the framework of a dynamical-statistical model

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Chinese Physics C 2010年第11期34卷 1714-1716页

作者： Hadi Eslamizadeh Department of Physics Persian Gulf University

A dynamical statistical model is used to analyze the experimental shape isomer yields data in the reaction d＋240Pu at E=20–29 *** possibility of determining the nuclear dissipation is *** of the experimental data wi... 详细信息

关键词： fission fission barrier reduced dissipation coeffcient

硅胶键合N-丙基哌嗪n-丙酸钠作为可循环使用催化剂催化4H-吡喃衍生物合成(英文)

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催化学报 2013年第12期34卷 2245-2254页

作者： Khodabakhsh Niknam Nassim Borazjani Reza Rashidian Abbas Jamali Department of Chemistry Faculty of Sciences Persian Gulf University Presian Gulf Reaserch and Studies Center Persian Gulf University

Silica‐bonded N‐propylpiperazine sodium n‐propionate(SBPPSP) was found to act as an efficient solid base for the preparation of a series of 4H‐benzo[b]pyran derivatives. SBPPSP was used as a recyclable heterogeneous solid base catalyst for the synthesis of 3,4‐dihydropyrano[c]chromenes, 2‐amino‐4H‐pyrans, 1,4‐dihydropyrano[2,3‐c]pyrazoles, and 2‐amino‐4H‐benzo[e]‐chromenes via the condensation reaction of dimedone, ethyl acetoacetate, 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐ one, and α‐naphthol, respectively, with aromatic aldehydes and malononitrile in refluxing aqueous ethanol. The heterogeneous solid base showed similar efficiency when reused in consecutive reactions.

关键词： Silica‐bonded n‐propylpiperazine sodium n‐propionate Heterogeneous solid base catalyst Aldehyde 4H‐Pyran derivative Malononitrile

Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第1期25卷 42-58页

作者： Shahab Mahmoudvand Somayeh Shokri Reza Taherkhani Fatemeh Farshadpour Department of Virology School of Medicine Ahvaz Jundishapur University of Medical Sciences Department of Medical Virology School of MedicineHamadan University of Medical Sciences The persian gulf Tropical medicine research center Bushehr University of Medical Sciences

Hepatocellular carcinoma(HCC) is the fifth most common cancer, and hepatitis C virus(HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β(TGF-β), vascular endothelial growth factor(VEGF), Wnt/β-catenin(WNT), cyclooxygenase-2(COX-2) and peroxisome proliferator-activated receptor α(PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC.

关键词： Hepatitis C virus Core protein Transforming growth factorβ Vascular endothelial growth factor Wnt/β-catenin Cyclooxygenase-2 Peroxisome proliferatoractivated receptorα Hepatocellular carcinoma

Epidemiology of Hepatitis E in Pregnant Women and Children in Iran: A General Overview

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Journal of Clinical and Translational Hepatology 2016年第3期4卷 269-276页

作者： Reza Taherkhani Fatemeh Farshadpour Department of Microbiology and Parasitology School of Medicine Bushehr University of Medical Sciences Bushehr Iran persian gulf Biomedical research center Bushehr University of Medical Sciences Bushehr Iran Department of Microbiology and Parasitology School of Medicine Bushehr University of Medical Sciences Bushehr Iran persian gulf Tropical medicine research center Bushehr University of Medical Sciences Bushehr Iran

From an epidemiological point of view,hepatitis E is an old infection in Iran,but only recently has its importance as a public health concern been considered from research and public health *** such,there is still a long road ahead to clarify the real burden of hepatitis E virus (HEV) infection in *** to the available epidemiological studies,the seroprevalence of HEV infection among pregnant women is between 3.6% and 7.4%,and among Iranian children is between 0.9% to 8.5%,varying by geographic regions within the country and directly dependent upon the sanitary status of *** addition to evaluating the sanitation level of a society,community-based seroprevalence studies of HEV infection demonstrate the most prevalent risk factors,the major routes of transmission,and the epidemiological patterns of HEV among that country's *** this review,the current knowledge about the pathogenesis and epidemiology of HEV infection in pregnant women and children in Iran,as well as the recent advances in diagnosis,prevention and treatment of HEV infection have been summarized.

关键词： Hepatitis E virus Pregnant women Children Epidemiology Iran