Signaling pathways governing the behaviors of leukemia stem cells

作     者：Shirin Azizidoost Ava Nasrolahi Mohadeseh Sheykhi-Sabzehpoush Amir Anbiyaiee Seyed Esmaeil Khoshnam Maryam Farzaneh Shahab Uddin Shirin Azizidoost;Ava Nasrolahi;Mohadeseh Sheykhi-Sabzehpoush;Amir Anbiyaiee;Seyed Esmaeil Khoshnam;Maryam Farzaneh;Shahab Uddin

作者机构：Atherosclerosis Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Infectious Ophthalmologic Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Department of LaboratoryImam Khomeini Hospital ComplexTehran University of Medical SciencesTehran ***Iran Department of SurgerySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Persian Gulf Physiology Research CenterMedical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran FertilityInfertility and Perinatology Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Translational Research Institute and Dermatology InstituteAcademic Health SystemHamad Medical CorporationDoha 3050Qatar 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第2期

页      面：830-846页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Leukemia Leukemia stem cells Pathogenesis Signaling pathways Stem cells 

摘      要：Leukemia is a malignancy in the blood that develops from the lymphatic system and bone *** various treatment options have been used for different types of leukemia,understanding the molecular pathways involved in the development and progression of leukemia is *** studies showed that leukemia stem cells(LSCs)play essential roles in the pathogenesis of leukemia by targeting several signaling pathways,including Notch,Wnt,Hedgehog,and *** are highly proliferative cells that stimulate tumor initiation,migration,EMT,and drug *** review summarizes cellular pathways that stimulate and prevent LSCs self-renewal,metastasis,and tumorigenesis.