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CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions

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Science China Chemistry 2015年第8期58卷 1334-1339页

作者： Yu-Feng Liang Kai Wu Zhiqing Liu Xiaoyang Wang Yujie Liang Chenjiang Liu Ning Jiao State Key Laboratory of Natural and Biomimetic drugs School of Pharmaceutical Sciences Peking University The Key Laboratory of Oil and Gas fine chemicals Ministry of Education & Xinjiang Uygur Autonomous Region Xinjiang University

p-Quinols are ubiquitous structural motifs of various natural products and pharmaceutical compounds,and versatile building blocks in synthetic *** reported methods for the synthesis of p-quinol require stoichiometric amounts of *** oxygen is considered as an ideal oxidant due to its natural,inexpensive,and environmentally friendly *** the ongoing research of C–H bond hydroxylation,we found that multi-alkyl phenols could react with molecular oxygen under mild ***,we describe an efficient oxidative de-aromatization of multi-alkyl phenols to p-quinols.1 atm of molecular oxygen was used as the *** multi-alkyl phenols could react smoothly at room *** labeling experiment was also performed,and the result proved that the oxygen atom in the produced hydroxyl group is from molecular oxygen.

关键词： p-quinol molecular oxygen de-aromatization carbanion cesium hydroxide

A light-regulated synthetic ion channel constructed by an azobenzene modified hydraphile

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Chinese Chemical Letters 2015年第7期26卷 851-856,920页

作者： Rong-Yan Yang Chun-Yan Bao Qiu-Ning Lin Lin-Yong Zhu Shanghai Key Laboratory for Functional Materials Chemistry Institute of Fine Chemicals East China University of Science and Technology

Biological ion channels are key molecules for cellular regulation and communication. To mimic the structure and functions of nature ion channels, a new class of light-regulated transmembrane ion channels was reported based on tri（macrocycle） hydraphile and azobenzene photoswitch （hydraphile 1 ）. The liposome-based proton transport assays showed that hydraphile 1 exhibited excellent transmem- brane activity （Y）, and Ymax arrived 0.7 at 40 μmol/L. The successful isomerization of azohenzene moiety was confirmed and qualified by UV and NMR spectra. Upon alternative irradiation of 365 nm UV light and 450 nm visible light, the transmembrane activity of hydraphile I was regulated between 0.35 and 0.5, reversibly. All the obtained results have demonstrated the promise of developing excellent synthetic ion channels with ion gating properties based on simple molecular design.

关键词： synthetic ion channelLight-regulated ion transportHydraphilesAzobenzene photoisomerizationSelf-assembly

Artificial molecular machines that can perform work

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Science China Chemistry 2018年第10期61卷 1261-1273页

作者： Qiaochun Wang Dizhi Chen He Tian Key Laboratory for Advanced Materials and institute of fine chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology

An artificial molecular machine consists of molecule or substituent components jointed together in a specific way so that their mutual displacements could be initiated using appropriate outside stimuli. Such an ability of performing mechanical motions by consuming external energy has endowed these tiny machines with vast fascinating potential applications in areas such as actuators, manipulating atoms/molecules, drug delivery, molecular electronic devices, etc. To date, although vast kinds of molecular machine archetypes have been synthesized in facile ways, they are inclined to be defined as switches but not true machines in most cases because no useful work has been done during a working cycle. More efforts need to be devoted on the utilization and amplification of the nanoscale mechanical motions among synthetic molecular machines to accomplish useful tasks. Here we highlight some of the recent advances relating to molecular machines that can perform work on different length scales, ranging from microscopic levels to macroscopic ones.

关键词： molecular machines molecular motors rotaxanes catenanes switches

A sulfur-substituted hemicyanine for cancer photothermal therapy without influence of intracellular viscosity

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Science China Chemistry 2022年第4期65卷 821-828页

作者： Xiang Xia Ran Wang Yingqi Hu Qichao Yao Saran Long Wen Sun Jiangli Fan Xiaojun Peng State Key Laboratory of fine chemicals Dalian University of TechnologyDalian 116024China Ningbo institute of Dalian University of Technology Ningbo 315016China

Although photothermal therapy(PTT) has emerged as an appealing strategy for cancer treatment, the development of photothermal agents capable of precisely controlling temperature remains a challenge. In this paper, we present a novel synthetic photosensitizer based on a sulfur-substituted hemicyanine. It was discovered that replacing an oxygen atom in a hemicyanine derivative with a sulfur atom significantly enhances photothermal efficiency and enables lysosome targeting in cancer *** importantly, because of the rigid planer structure of the sulfur-substituted hemicyanine, which differs from traditional photothermal agents(PTAs) based on twisted intramolecular charge transfer(TICT) or group rotation mechanisms, the efficiency of photothermal conversion is not affected by intracellular viscosity, allowing precise temperature control during *** modifying the agent with a glutathione-responsive moiety allows the PTAs to be activated only in cancer cells. The newly proposed PTA achieves efficient PTT in a tumor-bearing mouse model while having negligible toxic side effects on healthy tissues.

关键词： sulfur-substituted hemicyanine photothermal therapy precise temperature control lysosome targeting glutathione-responsive

Study on a green synthesis of μ-oxo-bis [tetraarylphenylporphyrinatoiron]

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Frontiers of Chemical Science and Engineering 2009年第2期3卷 219-221页

作者： Aixin WANG Yuanbin SHE Jing FAN institute of Green Chemistry and fine chemicals Beijing University of TechnologyBeijing 100124China

A novel method for the synthesis ofμ-oxo-bis[tetraarylporphyrinatoiron]([TRPPFe]_(2)O)based on the reaction between tetraarylporphyrinironchloride(TRPPFeCl)and H_(2)O in toluene was investigated in this *** kinds of[TRPPFe]_(2)O were synthesized by this novel synthetic method,and their structures were characterized by elemental analysis,IR spectra and UV-Vis spectroscopy.

关键词： μ-oxo-bis[tetraarylphenylporphinatoiron] green synthesis water

Study on a green synthetic method of TRPPMCl(M=Fe,Mn,Co)

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Frontiers of Chemical Science and Engineering 2009年第2期3卷 222-223页

作者： Jing FAN Yuanbin SHE Aixin WANG institute of Green Chemistry and fine chemicals Beijing University of TechnologyBeijing 100124China

A green synthetic method using mixted solvents of di-methyl formamide(DMF)and acids instead of single DMF to synthesize metalloporphyrins(TRPPMCl)from TRPPH_(2) and MCl_(2) metallization was proposed in this paper.A series of TRPPMCl(M=Fe,Mn,Co)were synthesized through this innovative synthetic method,and these complexes were characterized with various spectroscopic techniques,includingIR and UV-Vis *** results showed that the metallization time was markedly reduced from about 10h to 0.5h in contrast with the conventional synthetic methods.

关键词： TRPPMCl metalloporphyrins green synth-esis acid

A living foundry for synthetic Biological Materials:A synthetic biology roadmap to new advanced materials

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synthetic and Systems Biotechnology 2018年第2期3卷 105-112页

作者： Rosalind A.Le Feuvre Nigel S.Scrutton BBSRC/EPSRC Manchester Centre for synthetic Biology of fine and Speciality chemicals(SYNBIOCHEM) Manchester Institute of BiotechnologyThe University of ManchesterManchester M17DNUnited Kingdom School of Chemistry The University of ManchesterManchester M17DNUnited Kingdom

Society is on the cusp of harnessing recent advances in synthetic biology to discover new bio-based products and routes to their affordable and sustainable *** is no more evident than in the discovery and manufacture of synthetic Biological Materials,where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological *** will encompass novel,smart,functionalised and hybrid materials for diverse applications whose discovery and routes to bio-production will be stimulated by the fusion of new technologies positioned across physical,digital and biological *** article,which developed from an international workshop held in Manchester,United Kingdom,in 2017[1],sets out to identify opportunities in the new materials from biology *** considers requirements,early understanding and foresight of the challenges faced in delivering a Discovery to Manufacturing Pipeline for synthetic biological materials using synthetic biology *** challenge spans the complete production cycle from intelligent and predictive design,fabrication,evaluation and production of synthetic biological materials to new ways of bringing these products to *** opportunities are identified that will help foster expertise sharing and infrastructure development to accelerate the delivery of a new generation of synthetic biological materials and the leveraging of existing investments in synthetic biology and advanced materials research to achieve this goal.

关键词： synthetic biology Materials Biological materials Biomaterials Advanced materials

A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy

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Chinese Chemical Letters 2022年第10期33卷 4583-4586页

作者： Yanjun Yang Yifeng Zhang Ran Wang Xiang Rong Ting Liu Xiang Xia Jiangli Fan Wen Sun Xiaojun Peng State Key Laboratory of fine chemicals Dalian University of TechnologyDalian 116024China Ningbo institute of Dalian University of Technology Ningbo 315016China

During cancer treatment,chemotherapeutic drugs always result in severe side-effects and drug ***,combining cheomtherapy with other therapeutic modalities,such as photodynamic therapy(PDT)and designing an activable platform is promising for precise and efficient anticancer ***,we report a“pro-drug-photosensitizer”agent,LMB-S-CPT,bearing a disulfide bond as the glutathione(GSH)-activatable ***-S-CPT can be selectively activated by GSH to release activated drug,camptothecin(CPT),for chemotherapy and activated photosensitizer,methylene blue(MB),for ***-S-CPT exhibits excellent tumor-activatable performance when injected into tumor-bearing mice,as well as specific cancer therapy with negligible toxic side *** activatable pro-drug-photosensitizer offers a new strategy for chemo-photodynamic therapy and displays precise,selective and excellent antitumor effect.

关键词： Pro-drug-photosensitizer Chemotherapy Photodynamic therapy GSH activation

Synthesis of tetraphenylene derivatives and their recent advances

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National Science Review 2017年第6期4卷 892-916页

作者： Jian-Wei Han Xiao-Shui Peng Henry N.C.Wong Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic ChemistryChinese Academy of Sciences Key Laboratory for Advanced Materials Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science and Technology Department of Chemistry Center of Novel Functional Molecules Institute of Molecular Functional Materials and State Key Laboratory of Synthetic ChemistryThe Chinese University of Hong Kong

The synthetic strategies towards tetraphenylene derivatives are comprehensively summarized in this *** advances in the functionalized tetraphenylene skeleton for research into their structurally unique properties are ... 详细信息

关键词： tetraphenylene aromatic chiral carbocycles eight-membered rings