A light-regulated synthetic ion channel constructed by an azobenzene modified hydraphile

作     者：Rong-Yan Yang Chun-Yan Bao Qiu-Ning Lin Lin-Yong Zhu 

作者机构：Shanghai Key Laboratory for Functional Materials Chemistry Institute of Fine Chemicals East China University of Science and Technology 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2015年第26卷第7期

页      面：851-856,920页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by NNSFC (Nos. 51273064, 21472044) Innovation Program of Shanghai Municipal Education Commission and Fundamental Research Funds for the Central University 

主　　题：Synthetic ion channelLight regulated ion transportHydraphilesAzobenzene photoisomerizationSelf assembly 

摘      要：Biological ion channels are key molecules for cellular regulation and communication. To mimic the structure and functions of nature ion channels, a new class of light-regulated transmembrane ion channels was reported based on tri（macrocycle） hydraphile and azobenzene photoswitch （hydraphile 1 ）. The liposome-based proton transport assays showed that hydraphile 1 exhibited excellent transmem- brane activity （Y）, and Ymax arrived 0.7 at 40 μmol/L. The successful isomerization of azohenzene moiety was confirmed and qualified by UV and NMR spectra. Upon alternative irradiation of 365 nm UV light and 450 nm visible light, the transmembrane activity of hydraphile I was regulated between 0.35 and 0.5, reversibly. All the obtained results have demonstrated the promise of developing excellent synthetic ion channels with ion gating properties based on simple molecular design.