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Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： XIAO Tian Li YUAN Shu Qian GAO Jing Yu Julien SBaker YANG Yi De WANG Xi Jie ZHENG Chan Juan DONG Yan Hui ZOU Zhi Yong key laboratory of Molecular Epidemiology of hunan province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

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Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

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Bone Research 2024年第2期12卷 421-437页

作者： Hongzhen Chen Xuekun Fu Xiaohao Wu Junyi Zhao Fang Qiu Zhenghong Wang Zhuqian Wang Xinxin Chen Duoli Xie Jie Huang Junyu Fan Xu Yang Yi Song Jie Li Dongyi He Guozhi Xiao Aiping Lu Chao Liang Department of Systems Biology School of Life SciencesSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Institute of Integrated Bioinfomedicine and translational Science(IBTS) School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Division of Immunology and Rheumatology Stanford UniversityStanfordCA 94305USA VA Palo Alto Health Care System Palo AltoCA 94304USA Institute of Plant and Food Science Department of BiologySouthern University of Science and TechnologyShenzhen 518055China Department of Rheumatology Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Computational Biology St.Jude Children’s Research HospitalMemphisTNUSA Department of laboratory medicine Peking University Shenzhen HospitalShenzhenChina Guangdong-Hong Kong-Macao Joint Lab on Chinese medicine and Immune Disease Research Guangzhou 510006China Shanghai University of Traditional Chinese medicine Shanghai 200032China State key laboratory of proteomics National Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics100850 BeijingChina

Rheumatoid arthritis(RA)is an autoimmune *** studies hold an opinion that gut microbiota is environmentally acquired and associated with RA ***,accumulating evidence demonstrates that genetics also shape the gut *** is known that some strains of inbred laboratory mice are highly susceptible to collagen-induced arthritis(CIA),while the others are resistant to ***,we show that transplantation of fecal microbiota of CIA-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice.C57BL/6J mice and healthy human individuals have enriched *** than DBA/1J mice and RA *** of *** prevents CIA in DBA/1J *** identify that *** mainly produces propionate and C57BL/6J mice and healthy human individuals have higher level of ***-like synoviocytes(FLSs)in RA are activated to undergo tumor-like *** disrupts HDAC3-FOXK1 interaction to increase acetylation of FOXK1,resulting in reduced FOXK1 stability,blocked interferon signaling and deactivation of *** treat CIA mice with propionate and show that propionate attenuates ***,a combination of propionate with anti-TNF etanercept synergistically relieves *** results suggest that *** or propionate could be an alternative or complementary approach to the current therapies.

关键词： HDAC3 cytes interferon

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Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of translational medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

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Discrimination of Metastatic from Non-metastatic Mesorectal Lymph Nodes in Rectal cancer Using Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第4期36卷 594-600页

作者：于小平文露侯静王晖卢强 Department of Diagnostic Radiology Hunan Cancer Hospital & Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Department of Radiology the Third Xiangya Hospital Central South University hunan Provincial key laboratory of translational Radiation Oncology Hunan Cancer Hospital

Preoperative detection of lymph nodes（LNs） metastasis is always highly challenging for radiologists nowadays. The utility of quantitative dynamic contrast-enhanced magnetic resonance imaging（QDCE-MRI） in identifying LNs metastasis is not well understood. In the present study, 59 patients with histologically proven rectal carcinoma underwent preoperative QDCE-MRI. The short axis diameter ratio, long axis diameter ratio, short-to-long axis diameter ratio and QDEC-MRI parameters（Ktrans, Kep, fPV and Ve） values were compared between the non-metastatic（n=44） and metastatic（n=35） LNs groups based on pathological examination. Compared with the non-metastatic group, the metastatic group exhibited significantly higher short axis diameter（7.558±0.668 mm vs. 5.427±0.285 mm）, Ktrans（0.483±0.198 min-1 vs. 0.218±0.116 min^-1） and Ve（0.399±0.118 vs. 0.203±0.096） values（all P〈0.05）. The short-to-long axis diameter ratio, long axis diameter ratio, Kep and fPV values did not show significant differences between the two groups. In conclusion, our results showed that for LNs larger than 5 mm in rectal cancer, there are distinctive differences in the Ktrans and Ve values between the metastatic and non-metastatic LNs, suggesting that QDCE-MRI may be potentially helpful in identifying LNs status.

关键词： rectal cancer lymph node dynamic contrast-enhanced magnetic resonance imaging quantitative analysis sensitivity and specificity

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Prognostic prediction and expression validation of NSD3 in pan-cancer analyses

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BIOCELL 2023年第5期47卷 1003-1019页

作者： SHA LI YAQIONG LIU CHAOLING YAO ANJI XU XIAOLING ZENG YUXIN GE XIAOWU SHENG HAILIN ZHANG XIAO ZHOU YING LONG translational medicine Centre Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineCentral South UniversityChangshaChina hunan Provincial Clinical Research Centre for Oncoplastic Surgery Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineCentral South UniversityChangshaChina School of medicine College of MedicineNursing and Health ScienceNational University of IrelandGalwayIreland Central laboratory Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineChangshaChina

Background:Nuclear receptor binding SET domain protein-3(NSD3)is a histone lysine methyltransferase and a crucial regulator of carcinogenesis in several *** aimed to investigate the prognostic value and potential function of NSD3 in 33 types of human ***:The data were obtained from The cancer Genome ***-Meier analysis,CIBERSORT,gene set enrichment analysis,and gene set variation analysis were *** expression of NSD3 was measured using quantitative real-time polymerase chain reaction and western ***:The expression of NSD3 was altered in pan-cancer *** with higher levels of NDS3 generally had shorter overall survival and disease-specific *** of NSD3 were positively correlated with DNA copy number variation(CNV)in ***3 expression was also associated with tumor mutation burden and microsatellite *** levels of immune-cell infiltration differed significantly between high and low NSD3 ***3 negatively correlated with levels of CD8+T *** enrichment analysis showed that while NSD3 expression was positively associated with several immune cell-related and histone methylation-related pathways,it was negatively correlated with cell metabolism-related,drug transport-related,and drug metabolismrelated ***3 levels in the cell lines tested were significantly *** U251 and NCI-H23 cells,silencing NSD3 inhibited cell proliferation and promoted ***:NSD3 expression was changed in pan-cancer samples that was also verified in cell ***3 was associated with CNV and immune-cell infiltration.A poor prognosis was predicted in patients with high expression of ***3 might hence be a potential marker for predicting tumor prognosis.

关键词： NSD3 Pan-cancer Prognosis Immune cell infiltration TMB MSI

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Establishment of a pattern recognition metabolomics model for the diagnosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第31期26卷 4607-4623页

作者： Peng-Cheng Zhou Lun-Quan Sun Li Shao Lun-Zhao Yi Ning Li Xue-Gong Fan hunan key laboratory of Viral Hepatitis and Department of Infectious Diseases Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Infectious Diseases and Infection Control Center The third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Infection Control Center Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Center for Molecular medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Institute of translational medicine The Affiliated HospitalHangzhou Normal UniversityHangzhou 311121Zhejiang ProvinceChina Yunnan Food Safety Research Institute Kunming University of Science and TechnologyKunming 650500Yunnan ProvinceChina Department of Blood Transfusion Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND Early diagnosis of hepatocellular carcinoma may help to ensure that patients have a chance for long-term survival;however,currently available biomarkers lack sensitivity and *** To characterize the serum metabolome of hepatocellular carcinoma in order to develop a new metabolomics diagnostic model and identifying novel biomarkers for screening hepatocellular carcinoma based on the pattern recognition *** Ultra-performance liquid chromatography-mass spectroscopy was used to characterize the serum metabolome of hepatocellular carcinoma(n=30)and cirrhosis(n=29)patients,followed by sequential feature selection combined with linear discriminant analysis to process the multivariate *** The concentrations of most metabolites,including proline,were lower in patients with hepatocellular carcinoma,whereas the hydroxypurine levels were higher in these *** ordinary analysis models failed to discriminate hepatocellular carcinoma from cirrhosis,pattern recognition analysis was used to establish a pattern recognition model that included hydroxypurine and *** leaveone-out cross-validation accuracy and area under the receiver operating characteristic curve analysis were 95.00%and 0.90[95%Confidence Interval(CI):0.81-0.99]for the training set,respectively,and 78.95%and 0.84(95%CI:0.67-1.00)for the validation set,*** contrast,forα-fetoprotein,the accuracy and area under the receiver operating characteristic curve were 65.00%and 0.69(95%CI:0.52-0.86)for the training set,respectively,and 68.42%and 0.68(95%CI:0.41-0.94)for the validation set,*** Z test revealed that the area under the curve of the linear discriminant analysis model was significantly higher than the area under the curve ofα-fetoprotein(P<0.05)in both the training and validation *** Hydroxypurine and proline might be novel biomarkers for hepatocellular carcinoma,and this disease could be diagnosed by the metabolomics model based

关键词： Hepatocellular carcinoma Pattern recognition Metabolomics Biomarkers

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Immunological Evaluation of a Novel Mycobacterium tuberculosis Antigen Rv0674

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Biomedical and Environmental Sciences 2019年第6期32卷 427-437页

作者： XIAO Tong Yang LIU Hai Can LI Xiao Qin HUANG Ming Xiang LI Gui Lian LI Na YAN Yu Han LUO Qiao WANG Xue Zhi LI Ma Chao WAN Kang Lin State key laboratory for Infectious Diseases Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China key laboratory of laboratory medicine Ministry of Education College of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou 325035 Zhejiang China Clinical laboratory Fuzhou Pulmonary Hospital Fuzhou 350008 Fujian China The first hospital of Changsha Changsha 410005 Hunan China key laboratory of translational medicine of Guangdong Center for Tuberculosis Control of Guangdong Province Guangzhou 510630 Guangdong China

Objective This study aimed to characterize the diagnostic and vaccine potential of a novel Mycobacterium tuberculosisantigen Rv0674. Methods To evaluate thediagnostic potential and antigenicity of Rv0674, IgG was evaluated using ELISA and interferon (IFN)-γ was done by using ELISpot assay among TB patients and healthy donors. For immunogenicity evaluation, BALB/c mice were immunized with Rv0674. Cytokine production was determined by cytokine release assay using an ELISA kit, and the antibodies were tested using ELISA. Results The results of serum Elisa tests showed that Rv0674 specific immunoglobulin G (IgG) response was higher in TB patients than negative controls. And Rv0674 had good performance in serological test with sensitivity and specificity of 77.1% and 81.1%, respectively. While it shows poor sensitivity and specificity of 26.23% and 79.69% for IFN-γ tests. In BALB/c mice, Rv0674 adjuvant by DDA/PolyI:C could also induce a high level of IFN-γ, interleukin-2 and interleukin-6 as well as a high IgG titer in both high-and low-dose groups indicating that Rv0674 is essential in humoral and cellular immunity. Moreover, the cytokine profile and IgG isotypecharacterized Rv0674 as a Th1/Th2-mixed-type protective immunity with the predominance of Th1 cytokines. Conclusion Rv0674 may be a good potential candidate for the development of TB serological diagnosis and a new TB vaccine.

关键词： Antigen Immunologic diagnosis Mycobacterium tuberculosis Rv0674 Vaccine

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Ser-897 phosphorylation of EphA2 promotes metastasis and CSCs-like properties by AKT/Stat3/Sox-2 and c-Myc signaling in nasopharyngeal carcinoma

Ser-897 phosphorylation of EphA2 promotes metastasis and CSC...

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Jiao-Yang Li Yuan-Yuan Wang Hong-Mei Yi Hong Yi Ta Xiao Juan Feng Jin-Feng Zhu Wei Huang Shan-Shan Lu Yan-Hong Zhou Zhi-Qiang Xiao Research Center of Carcinogenesis and Targeted Therapy Xiangya HospitalCentral South University the higher educational key laboratory for cancer proteomics and translational medicine of hunan province Xiangya HospitalCentral South University Department of Dermatology Xiangya HospitalCentral South University cancer Research Institute Xiangya Medical SchoolCentral South University

Our quantitative plasma membrane phosphoproteomics identified that phosphorylation of EphA2 at serine 897(p-EphA2-S897) was significantly upregulated in the high metastatic nasopharyngeal carcinoma(NPC) cells relative to non-metastatic NPC cells. P-EphA2-S897 has been proposed as a key reaction in the ligandindependent tumor promotion of EphA2. However, the role and underlying mechanism of p-EphA2-S897 in tumor metastasis and cancer stem cells(CSCs) properties maintenance remains poorly understood. In this study, with a combination of loss-of-function(EphA2-S897 A, phosphorylation-inactivation) and gain-offunction(EphA2-S897 D, phosphomimetic) approaches, we observed that p-EphA2-S897 in NPC cells promoted tumor cells in vitro invasion and in vivo metastasis in a mouse lung metastasis model, and maintained CSCs-like properties, i.e. increasing side-population cell fraction, tumorsphere formation, the three known NPC stem markers expression, EMT-like alterations and the tumor initiating capacity of NPC cells in vivo. Using phospho-kinase antibody array to identify signaling downstream of p-S897-EphA2, we found that AKT/Stat3 signaling mediated p-EphA2-S897-dependent NPC cells invasion and CSCs-like properties maintenance, and Sox-2 and c-Myc were the effectors of p-EphA2-S897. Moreover, p-EphA2-S897 was significantly increased in the NPCs with metastasis relative to NPCs without metastasis and correlated with poor patient survival, and there were positive correlations among p-EphA2-S897, p-AKT, pStat3, Sox-2 and c-Myc expressions in the NPC tissues. Collectively, our data establish the role and mechanistic basis for p-EphA2-S897-dependent NPC invasion and metastasis and CSCs-like function maintenance, suggesting p-EphA2-S897 as an attractive therapeutic target in NPC and perhaps in other cancers.

关键词： nasopharyngeal carcinoma metastasis cancer stem cells phospho-EphA2(S897) AKT Stat3

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EphA2 promotes tumor cell invasion, metastasis and CSCslike properties in nasopharyngeal carcinoma through Stat3/Sox2 and c-Myc signaling pathway

EphA2 promotes tumor cell invasion, metastasis and CSCslike ...

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Yuan-Yuan Wang Jiao-Yang Li Hong-Mei Yi Hong Yi Ta Xiao Juan Feng Jin-Feng Zhu Wei Huang Shan-Shan Lu Yan-Hong Zhou Zhi-Qiang Xiao Research Center of Carcinogenesis and Targeted Therapy Xiangya HospitalCentral South University the higher educational key laboratory for cancer proteomics and translational medicine of hunan province Xiangya HospitalCentral South University Department of Dermatology Xiangya HospitalCentral South University cancer Research Institute Xiangya Medical SchoolCentral South University

Our quantitative plasma membrane proteome analysis identified EphA2 as one of upregulated proteins in high metastatic nasopharyngeal carcinoma(NPC) cells relative to non-metastatic NPC cells. However, the role and mechanism of EphA2 in NPC are poorly understood. In this study, we showed that EphA2 expression was significantly increased in the NPCs with metastasis relative to NPCs without metastasis and correlated with poor patient survival;high EphA2 expression in NPC cells promoted tumor cell in vitro invasion and in vivo metastasis, and enhanced cancer stem cells(CSCs)-like properties, i.e. increasing side-population cell fraction, tumorsphere formation, the expression of the four known NPC stem markers and tumor initiating capacity of NPC cells in vivo. Mechanistically, Stat3 signaling mediated EphA2-dependent NPC cell invasion and CSCs-like properties maintenance, and Sox-2 and c-Myc were the effectors of EphA2-dependent NPC invasion and CSCs-like properties maintenance. Moreover, there was a positive correlation among EphA2, p-Stat3, Sox-2 and c-Myc expression in the NPC tissues. We further showed that EphA2 activated Stat3 by increasing IL-6 secretion in NPC cells. Our data reveal that EphA2 functions as a driver in the NPC invasion and metastasis and CSCs-like properties promotion, and provide evidences for EphA2 as an attractive therapeutic target for NPC.

关键词： Nasopharyngeal carcinoma EphA2 cancer stem cells Metastasis Stat3 Sox-2 c-Myc

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Intelligent nanotherapeutic strategies for the delivery of CRISPR system

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药学学报:英文版 2023年第6期13卷 2510-2543页

作者： Chao Chen Wu Zhong Shiyu Du Yayao Li Yunfei Zeng Kunguo Liu Jingjing Yang Xiaoxiang Guan Xin Han Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjing 210023China key laboratory of Study and Discovery of Small Targeted Molecules of hunan province School of MedicineHunan Normal UniversityChangsha 410013China Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

CRISPR, as an emerging gene editing technology, has been widely used in multiple fields due to its convenient operation, less cost, high efficiency and precision. This robust and effective device has revolutionized the development of biomedical research at an unexpected speed in recent years. The development of intelligent and precise CRISPR delivery strategies in a controllable and safe manner is the prerequisite for translational clinical medicine in gene therapy field. In this review, the therapeutic application of CRISPR delivery and the translational potential of gene editing was firstly discussed. Critical obstacles for the delivery of CRISPR system in vivo and shortcomings of CRISPR system itself were also analyzed. Given that intelligent nanoparticles have demonstrated great potential on the delivery of CRISPR system, here we mainly focused on stimuli-responsive nanocarriers. We also summarized various strategies for CIRSPR-Cas9 system delivered by intelligent nanocarriers which would respond to different endogenous and exogenous signal stimulus. Moreover, new genome editors mediated by nanotherapeutic vectors for gene therapy were also discussed. Finally, we discussed future prospects of genome editing for existing nanocarriers in clinical settings.

关键词： CRISPR system Intelligent delivery Gene editing Endogenous responsive Exogenous control Nanotherapeutic platforms Gene therapy Diseases correction

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