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^11c-choline PET/MRI for characterization of Primary High-Risk Prostate cancer： correlations between Positron Emission Tomography Imaging Parameters and clinical Features

第15届中国中西医结合学会基础理论专业委员会学术年会暨...

作者：尤良震江爱娟叶树申国明方朝晖 Yin Yundong 安徽中医药大学研究生院安徽省中医药科学院糖尿病防治研究所安徽中医药大学中西医结合学院 graduate Institute Anhui University of Chinese Medicine Department of Endocrinology the First Affiliated Hospital of Anhui University of Chinese Medicine

目的:探讨丹蛭降糖胶囊对Goto-Kakizaki(GK)大鼠糖尿病大血管病变治疗作用机制。方法:采用高脂高糖联合内皮型一氧化氮合酶(NOS)抑制剂N-硝基-L-精氨酸甲酯(L-NAME)(0.1 g·L-1·d-1)喂养复制糖尿病大血管病变大鼠模型。按随机排列表将... 详细信息

目的:探讨丹蛭降糖胶囊对Goto-Kakizaki(GK)大鼠糖尿病大血管病变治疗作用机制。方法:采用高脂高糖联合内皮型一氧化氮合酶(NOS)抑制剂N-硝基-L-精氨酸甲酯(L-NAME)(0.1 g·L-1·d-1)喂养复制糖尿病大血管病变大鼠模型。按随机排列表将模型大鼠随机分为模型组、丹蛭降糖胶囊组(1 260,630,320 mg·kg-1)、阿托伐他汀组(105 mg·kg-1)、二甲双胍组(10 mg·kg-1),每组12只,连续灌胃给药8周。取Wistar大鼠12只作为正常对照组。观测大鼠体质量,饮水量,血糖及血浆Tc,TG,LDL-c,HDL-c,IL-1β,IL-6,TNF-α,NO,ET-1变化;取主动脉组织,HE染色法观察病理改变;RT-PcR法检测大鼠主动脉IL-1β,IL-6,TNF-αmRNA水平,茎环RT-PcR法检测大鼠血浆与主动脉miRNA-126,miRNA-155,miRNA-146a,miRNA-21水平,对miRNAs与炎症因子之间进行典型相关性分析。结果:丹蛭降糖胶囊能增加大鼠体质量,降低饮水量,降低随机血糖,逆转大鼠主动脉组织损伤,降低血浆Tc,TG,LDL-c,LDL-c,ET-1,IL-1β,IL-6,TNF-α,miRNA-155,miRNA-146a,miRNA-21水平,升高血浆HDL-c,NO含量,降低主动脉IL-1β,IL-6,TNF-αmRNA和miRNA-155,miRNA-146a,miRNA-21表达水平,升高主动脉miRNA-126表达;主动脉miRNA-126,miRNA-155,miRNA-146a,miRNA-21与炎症因子表达具有典型相关性,其中miRNA-126为负相关,miRNA-155,miRNA-146a,miRNA-21为正相关。结论:丹蛭降糖胶囊对糖尿病大血管病变具有治疗效果,作用机制可能与调节miRNA-126,miRNA-155,miRNA-146a,miRNA-21水平,减少炎症因子、减轻血管炎症反应有关。

关键词：丹蛭降糖胶囊糖尿病大血管病变 microRNA 炎症 GK大鼠

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Journal of Pharmacy and Pharmacology 2017年第7期5卷 391-400页

作者： Jing-Ren Tseng See-Tong Pang Kang-Hsing Fan Ji-Hong Hong Po-Hung Lin Lan-Yan Yang Hsiu-Ya chang Hou-Ting Yang Kwai-Fong Ng Li-Jen Wang Tzu-chen Yen Department of Nuclear Medicine and center for Advanced Molecular Imaging and Translation Chang Gung Memorial Hospital at Linkou Taoyuan 333 Taiwan Division of Urology Department of Surgery Chang Gung Memorial Hospital at Linkou Taoyuan 333 Taiwan Department of Radiation Oncology Chang Gung Memorial Hospital at Linkou Taoyuan 333 Taiwan Institute for Radiological Research Chang Gung Memorial Hospital/Chang Gung University Taoyuan 333 Taiwan graduate Institute of clinical Medieal Science College of Medicine Chang Gung University Taoyuan 333 Taiwan Biostatistics Unit Clinical Trial Center Chang Gung Memorial Hospital Taoyuan 333 Taiwan Department of Pathology Chang Gung Memorial Hospital at Linkou Taoyuan 333 Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial Hospital at Linkou Taoyuan 333 Taiwan Department of Medical Imaging and Radiological Science College of Medicine Chang Gung University Taoyuan 333 Taiwan

Purpose： The aim of this study was to determine whether PET （positron emission tomography） imaging parameters from simultaneous ^11c-choline PET/MRI （magnetic resonance imaging） could be used to characterize primary prostate cancer. Methods： Forty-six patients with biopsy-proven high-risk prostate cancer （clinical T stage ≥ cT2c, a Gleason score 〉 8, or PSA （prostate-specific antigen） level 〉 20 ng/mL） were prospectively enrolled. A SUV （standardized uptake value） histogram analysis including maximum SUV, mean SUV, SUV variance, SUV entropy, MTV （metabolic tumor volume）, and UVP （uptake volume product） was applied for the calculation of PET imaging parameters. correlations between the PSA level and Gleason score were then evaluated. Results： Maximum SUV, mean SUV, MTV, UVP, and SUV variance were significantly correlated with PSA level, whereas SUV variance was the only parameter negatively correlated with the Gleason score. Multivariate logistic regression analysis demonstrated that MTV and PSA level at diagnosis were independent predictors of positive distant metastasis status. conclusions： PET imaging parameters from simultaneous ^11c-choline PET/MRI were correlated with PSA level. However, ^11c-choline metabolic tumor heterogeneity was not associated with biospecimen-derived Gleason scores in prostate cancer. To apply PET texture quantification analysis to prostate cancer, a more specific PET radiotracer is required.

关键词： ^11c-choline PET/MRI primary high-risk prostate cancer staging.

基于局部因素和全身因素对急性胰腺炎严重程度的新分级——概要与解读

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浙江医学 2014年第5期36卷 831-832,874页

作者：李维勤张璐瑶黎介寿 E.Patchen Dellinger christopher E.Forsmark Peter Layer Philippe L'evy Enrique Maravi-Poma Maxim S.Petrov Tooru Shimosegawa Ajith K.Siriwardena Generoso Uomo David c.Whitcomb John A.Windsor 南京军区南京总医院(南京大学医学院临床学院)普通外科研究所 210002 Department of Surgery University of Washington School of Medicine Division of Gastroenterology Hepatologyand NutritionUniversity of Florida School of Medicine Department of Internal Medicine Israelitic Hospital Poledes Maladies del'Appareil Digestif Service de Gastroent'erologie-Pancr'eatologieHospital Beaujon Servicio de Medicina Internsiva B Complejo Hospitalario de NavarraPamplona Department of Surgery The University of Auckland Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Surgery Manchester Royal InfirmaryUniversity of Manchester Department of Internal Medicine Cardarelli Hospital Division of Gastroenterology Hepatology and NutritionDepartment of MedicineDepartment of Cell Biology and Molecular Physiologyand Department of Human GeneticsUniversity of Pittsburgh

急性胰腺炎严重程度的准确分级对于临床实践和研究十分重要。在临床实践中，准确的分型有助于正确地评估疾病的严重程度，监测疾病的发展，制定治疗策略。而临床研究中，准确的分型对于患者的正确入组、实验结果的有效性都有很大影响。... 详细信息

急性胰腺炎严重程度的准确分级对于临床实践和研究十分重要。在临床实践中，准确的分型有助于正确地评估疾病的严重程度，监测疾病的发展，制定治疗策略。而临床研究中，准确的分型对于患者的正确入组、实验结果的有效性都有很大影响。一个多世纪以来，急性胰腺炎的严重程度被简单地分为轻型和重型，而且对于轻型和重型的定义尚未统一。近年来，研究发现重型胰腺炎又有不同的亚组，而不同亚组患者的预后有很大差异，轻型和重型二分法的局限性慢慢显现。

关键词：急性胰腺炎全身因素局部因素重型胰腺炎解读临床实践临床研究实验结果

Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.c.McKenzie Rungtiwa Phookamsak chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie chen K.W.Thilini chethana chonticha Singtripop Dong Qin Dai Yu cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini c.Jayasiri Ruvishika S.Jayawardena Samantha c.Karunarathna Wen Jing Li Ausana Mapook chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil cSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe callac Putarak chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting chi Wen Jian chu Xu Ji Ye Yan Rui Lin Zhao Erio camporesi Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–J Azad Housing SocietyCurcaGoa VelhaIndia Muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of Microbiology&Beijing Key Laboratory for Forest Pest control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The Key Laboratory for Silviculture and conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083China Mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(capnodiales genera incertae cedis),chaetocapnodium(capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,camarosporium aborescentis,***,***,chaetocapnodium siamensis,chaetothyrium agathis,colletotrichum sedi,conicomyces pseudotransvaalensis,cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,***,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

challenges and opportunities for third-generation ethanol production:A critical review

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Engineering Microbiology 2023年第1期3卷 22-36页

作者： caroline Müller Thamarys Scapini Alan Rempel Ederson Rossi Abaide Aline Frumi camargo Mateus Torres Nazari Viviani Tadioto charline Bonatto Marcus Vinícius Tres Giovani Leone Zabot Luciane Maria colla Helen Treichel Sérgio Luiz Alves Jr Laboratory of Yeast Biochemistry Federal University of Fronteira SulCampus ChapecóSC 484Km 2ChapecóSCBrazil Laboratory of Microbiology and Bioprocess Environmental Science and TechnologyFederal University of Fronteira SulCampus ErechimRS 135200ErechimRSBrazil graduate Program in civil and Environmental Engineering University of Passo FundoBR 285Passo FundoRSBrazil Department of chemical Engineering Federal University of Santa Maria1000Roraima AvenueSanta MariaRS 97105-900Brazil Laboratory of Agroindustrial Processes Engineering Federal University of Santa Maria1040Sete de Setembro st.Cachoeira do SulRSBrazil

In recent decades,third-generation(3G)biofuels have become a more attractive method of fuel production,as algae cultivation does not infringe on resources needed for food ***,algae can adapt to different environments,has high photosynthetic efficiency(cO_(2)fixation),and has a high potential for carbohydrate *** prevalence of algae worldwide demonstrates its ability to adapt to different environments and climates,proving its biodiversity and *** can be grown in wastewater,seawater,and even sewage,thus ensuring a lower water footprint and greater energy efficiency during algal biomass *** of this,the optimization of 3G ethanol production appears to be an excellent alternative to mitigate environmental impacts and increase energy and food *** critical review presents(i)the stages of cultivation and processing of micro and macroalgae;(ii)the selection of yeasts(through engineering and/or bioprospecting)to produce ethanol from these biomasses;(iii)the potential of seawater-based facilities to reduce water footprint;and(iv)the mass and energy balances of 3G ethanol production in the world energy *** article is,above all,a brainstorm on the environmental viability of algae bioethanol.

关键词： Algae ethanol Biomass Energy balance Seawater Water footprint Yeasts

Simulation of Fusion Plasmas:current Status and Future Direction

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Plasma Science and Technology 2007年第3期9卷 312-387页

作者： D.A.Batchelor M.Beck A.Becoulet R.V.Budny c.S.chang P.H.Diamond J.Q.Dong G.Y.FU A.Fukuyama T.S.Hahm D.E.Keyes Y.Kishimoto S.Klasky L.L.Lao K.Li Z.Lin B.Ludaescher J.Manickam N.Nakajima T.Ozeki N.Podhorszki W.M.Tang M.A.Vouk R.E.Waltz S.J.Wang H.R.Wilson X.Q.Xu M.Yagi F.Zonca Oak Ridge National Laboratory Oak RidgeTN 37831USA 1122 Volunteer Blvd Suite 203KnoxvilleTN 37996-3450USA AssociationEURATOM-cEA sur la Fusio n contr■lée CEA Cadarache13108 Saint Paul lez Durance CedexFrance Princeton Plasma Physics Laboratory Princeton UniversityPrincetonNJ 08543USA courant Institute of Mathematical Sciences New York University251 Mercer StreetNew YorkNY 10012USA University of california at San Diego Dept.of Physics and Center for Astrophysics and Space SciencesLa JollaCA 92093USA Southwestern Institute of Physics Chengdu 610041China Department of Nuclear Engineering Kyoto UniversityKyoto 606-8501Japan columbia University Department of Applied Physics and Applied MathematicsMC 4701New YorkNY 10027USA Department of Fundamental Energy Science Graduate School of Energy ScienceKyoto UniversityGokashoUjiKyoto 611-0011Japan General Atomics P.O.Box 85608San DiegoCA 92186USA Department of computer Science Princeton University PrincetonNJ 08544USA Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Department of computer Science University of california DavisCA95616USA National Institute for Fusion Science TokiGifu 509-5292Japan Japan Atomic Energy Agency Naka Fusion Research EstablishmentNaka-machiIbaraki-kenJapan Department of computer Science North Carolina State UniversityRaleighNC 27695USA Department of Physics Fudan University200433 ShanghaiChina Department of Physics University of YorkHeslingtonYork YO10 5DD UK Lawrence Livermore National Laboratory LivermoreCA 94550USA Research Institute for Applied Mechanics Kyushu UniversityKasuga 816-8580Japan Associazione Euratom-ENEA sulla fusione CR FrascatiCasella Postale 65-00044FrascatiItaly

I. Introduction (Z. Lin, G. Y. Fu, J. Q. Dong) II. Role of theory and simulation in fusion sciences 1. The Impact of theory and simulation on tokomak experiments (H. R. Wilson, T.S. Hahm and F. Zonca) 2. Tokomak Transport Physics for the Era of ITER: Issues for Simulations (P.H. Diamond and T.S. Hahm) III. Status of fusion simulation and modeling 1. Nonlinear Governing Equations for Plasma Simulations (T. S. Hahm) 2. Equilibrium and stability (L.L. Lao, J. Manickam) 3. Transport modeling (R.E. Waltz) 4. Nonlinear MHD (G.Y. Fu) 5. Turbulence (Z. Lin and R.E. Waltz) 6. RF heating and current drive (D.A. Batchelor) 7. Edge physics Simulations (X.Q. Xu and c.S. chang) 8. Energetic particle physics (F. Zonca, G.Y. Fu and S.J. Wang) 9. Time-dependent Integrated Modeling (R.V. Budny) 10. Validation and verification (J. Manickam) IV. Major initiatives on fusion simulation 1. US Scientific Discovery through Advanced computing (SciDAc) Program & Fusion Energy Science (W. Tang) 2. EU Integrated Tokamak Modelling (ITM) Task Force (A. Becoulet) 3. Fusion Simulations Activities in Japan (A. Fukuyama, N. Nakajima, Y. Kishimoto, T. Ozeki, and M. Yagi) V. cross-disciplinary research in fusion simulation 1. Applied mathematics: Models, Discretizations, and Solvers (D.E. Keyes) 2. computational Science (K. Li) 3. Scientific Data and Workflow Management (S. Klasky, M. Beck, B. Ludaescher, N. Podhorszki, M.A. Vouk) 4. collaborative tools (J. Manickam)

关键词： mode ITER

Phyllotaxis-inspired nanosieves with multiplexed orbital angular momentum

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eLight 2021年第1期1卷 46-56页

作者： Zhongwei Jin David Janoschka Junhong Deng Lin Ge Pascal Dreher Bettina Frank Guangwei Hu Jincheng Ni Yuanjie Yang Jing Li changyuan Yu Dangyuan Lei Guixin Li Shumin Xiao Shengtao Mei Harald Giessen Frank Meyer zu Heringdorf cheng-Wei Qiu Department of Electrical and computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Singapore college of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Faculty of Physics and center for Nanointegration Duisburg-Essen(cENIDE) University of Duisburg-EssenLotharstrasse 1-2147057 DuisburgGermany Department of Materials Science and Engineering Shenzhen Institute for Quantum Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Beijing Qianjunyide Technology co.Ltd Beijing 100031China. Physics Institute and Stuttgart center of Photonics Engineering(ScoPE) University of Stuttgart70569 Stutt-gartGermany. School of Physics University of ElectronicScience and Technology of ChinaChengdu 611731China. Key Laboratory of Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China. Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina. Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina. State Key Laboratory On Tunable Laser Technology Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information SystemShenzhen Graduate SchoolHarbin Institute of TechnologyShenzhen 518055China.

Nanophotonic platforms such as metasurfaces,achieving arbitrary phase profiles within ultrathin thickness,emerge as miniaturized,ultracompact and kaleidoscopic optical vortex ***,it is often required to segment or interleave independent sub-array metasurfaces to multiplex optical vortices in a single nano-device,which in turn affects the device’s compactness and channel ***,inspired by phyllotaxis patterns in pine cones and sunflowers,we theoretically prove and experimentally report that multiple optical vortices can be produced in a single compact phyllotaxis nanosieve,both in free space and on a chip,where one meta-atom may contribute to many vortices *** time-resolved dynamics of on-chip interference wavefronts between multiple plasmonic vortices was revealed by ultrafast time-resolved photoemission electron *** nature-inspired optical vortex generator would facilitate various vortex-related optical applications,including structured wavefront shaping,free-space and plasmonic vortices,and high-capacity information metaphotonics.

关键词： Phyllotaxis vortex nanosieve Free-space Plasmonic vortices Ultrafast time-resolved

Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin Lee Young Uk cho Jung Woo Lee Woon-Hong Yeo Young Min Song Youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and computer Science(EEcS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST graduate School of converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN center for Human-centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin Kim Young Uk cho Jaejin Park Jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee Jung Huanyu cheng Il-Joo cho Ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST graduate School of converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous