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On-line determination of selenium compounds in tea infusion by extractive electrospray ionization mass spectrometry combined with a heating reaction device

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Chinese Chemical Letters 2025年第1期36卷 496-500页

作者： Lu Huang Jiang Wang Hong Jiang Lanfang Chen Huanwen Chen Academician Workstation Jiangxi University of Chinese MedicineNanchang 330004China Suzhou Jingcheng Precision Instrument Technology Co. Ltd.Suzhou 215228China the first affiliated hospital of nanchang university Nanchang 330006China

Selenium is one of the important trace elements in the human *** deficiency will directly affect human *** people's attention to health,the content of selenium in food has gradually attracted ***,detecting selenium compounds in complex samples remains a *** this work,we built an online heating-reaction *** device combines the electrospray extraction ionization mass spectrometry(EESI-MS)with the heating reaction device,which can simultaneously detect various selenium compounds in complex liquid *** acidic conditions,the sample was heated and catalyzed by a heating reaction device,so that the SeO~(2-)_(3)and O-phenylenediamine(OPD)could generate 1,3-dihydro-2,1,*** on the above reactions,we can detect organic selenium,inorganic selenium and other compounds in liquid samples by organic mass *** this experiment,we determined the content of three forms of selenium:selenomethionine(SeMet),l-selenocystine(SeCys(2)),and sodium *** calibration curves for SeMet,SeCys(2),and sodium selenite showed strong linearity within a range of 0.50-50.00μg/*** limits of detection(LOD)for the three compounds were 0.22,0.27,and 0.41μg/L,*** limits of quantification(LOQ)were 0.68,0.81,and 1.23μg/L,*** recoveries at three levels ranged from 98.8%to 106.1%.In addition,this method can simultaneously detect three selenium compounds and three other specific chemical components in tea infusion samples,providing a rapid and efficient method for identifying tea quality.

关键词： Heating reaction device Extractive electrospray ionization mass spectrometry Inorganic selenium Selenium compounds Tea infusion

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The first affiliated hospital of Chongqing Medical university ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Evidence-based control of stress response on intraoperative physiological indexes and recovery of patients undergoing gastrointestinal surgery

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World Journal of Gastroenterology 2025年第8期31卷 72-81页

作者： Chen-Dong Yuan Bao-Zhu Zhou Ning-Yan Wang Qing-Qing Wan Zhen-Zhen Hu Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress ***,stress responses are more severe in older adult ***,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal *** demonstrate nursing benefits through clinical *** This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress ***,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,*** physiological parameters during surgery and postoperative recovery indicators were compared between the *** Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and *** appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation *** with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of po

关键词： Older adult patients Gastrointestinal surgery Stress response Evidence-based nursing Enhanced recovery after surgery

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Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING ZHENG JIANFENG CAI JIE GAO LIE DONG XIANGBIN ZHANG YINGHUI HUANG Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)

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Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai Huang Yi Hu Xiao-Dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes

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World Journal of Diabetes 2025年第2期16卷 114-122页

作者： Ke Chen Ge Wang Jing-Cheng Hu Ying-Yi Zhou Hai-Tao Ma Department of Thoracic Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Endocrine The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND The increasing number of type 2 diabetes mellitus(T2DM)patients leads to higher rates of morbidity and mortality related to lung *** To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ(AIS)complicated by *** One hundred patients with AIS and T2DM(group A),100 patients with AIS alone(group B),and 60 patients with benign lung lesions(group C)admitted to the Department of Thoracic Surgery and Endocrinology of the first affiliated hospital of Soochow university from November 2021 to December 2022 were ***-67 expression was compared among the *** Group A had significantly higher levels of fasting plasma glucose(FPG),total cholesterol(TC),total triglyceride,low-density lipoprotein cholesterol,glycosylated hemoglobin(HbA1c),and insulin than groups B and C(P<0.01).Meanwhile,group B had higher insulin levels than group C(P<0.01).Group A exhibited a significantly higher average Ki-67 positivity rate than group B(P<0.01).The Ki-67 positivity rate in group A was 86.87%,while the positivity rate in group B was 77%.Ki-67 was positively correlated with FPG(P<0.01)and HbA1c levels(P<0.01).Ki-67,FBG,insulin,HbA1c,high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by *** K et ***67 in patients with AIS complicated by T2DM WJD https://*** 2 February 15,2025 Volume 16 Issue 2 CONCLUSION Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS ***,detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.

关键词： Ki-67 Type 2 diabetes mellitus Lung adenocarcinoma in situ Immunohistochemistry Prognostic marker

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Research on equity analysis and forecasting of nursing human resource allocation in Jiangxi Province,China

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International Journal of Nursing Sciences 2025年第1期12卷 19-26,I0001页

作者： Yunyu Du Zhiqin Xie Zhen Yang Wanyin Xiong Li Zhou Min Zhang Suhua Zeng Min Wang Department of Thoracic Surgery The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangJiangxiChina Department of Nursing The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangJiangxiChina Jiangxi Medical Center for Critical Public Health Events The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangJiangxiChina

Objectives:This study aimed to assess the equity of nursing human resource allocation in Jiangxi Province,China,and forecast future trends in the next five ***:We used the related data from the China Statistical Yearbook,China Health Statistics Yearbook,and Jiangxi Statistical Yearbook(2003-2022).The equity of nursing human resource allocation was evaluated using Lorenz curves,Gini coefficients,and Theil index,from the perspective of population and geographical *** for nursing human resource in Jiangxi Province from 2023 to 2027 were forecasted using the Autoregressive Integrated Moving Average(ARIMA)and Grey(1,1)***:From 2003 to 2022,all the key nursing human resource indicators continuously increased;the number of registered nurses in Jiangxi Province increased by 109,786,with an average annual growth rate of 7.80%.Registered nurses per 1,000 population rose by 2.21,while nurses per square kilometer increased by *** Province has surpassed the national level in several nursing resource indicators,including registered nurses as a percentage of health technicians,registered nurses per square kilometer,and doctor-to-nurse *** the province,all indicators in cities are higher than those in county-level *** the cities in Jiangxi Province,Ganzhou City had the highest number of registered nurses,Xinyu City led in the doctor-to-nurse ratio,and nanchang City had the highest bed-tonurse *** 2022,the Gini coefficients for registered nurses in Jiangxi Province were 0.09 by population and 0.34 by geographical area,reflecting the allocation of registered nurses in Jiangxi Province is highly equitable by population but relatively equitable by geographical *** results suggested that the number of registered nurses in Jiangxi Province will reach 170,100 by 2027,indicating continued growth and improvement in nursing resource ***:Over the past two decades,the human nursing resources in Jiang

关键词： Forecasting Equity Nursing administration Nursing human resource

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Purple red rice bran anthocyanins ameliorate inflammatory response induced by LPS from Porphyromonas gingivalis in RAW264.7 cells via suppressing NF- κB and AP-1 signaling pathways

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Food Science and Human Wellness 2025年

作者： Jilan Jiao Junwei Zhao Ting Chen Liwei Zeng Xiangke Ci Jianhua Xie Xiaoyan Ou affiliated Stomatological hospital of nanchang university State Key Laboratory of Food Science and Resources， nanchang university

Periodontitis， a persistent inflammatory condition， targets the gums and periodontal structures， negatively impacting health. Systemic and local antimicrobials are often used to treat periodontitis， but they may lead to adverse effects such as drug resistance and ecological imbalance. As natural water-soluble pigment， anthocyanins has been reported to be an effective antiinflammatory， antiobesity， anticancer， antimicrobial and so on. The purpose of the study was to elucidate the anti-inflammatory effects and potential molecular mechanisms of purple rice bran anthocyanins (PRBA) on RAW264.7 cells induced by lipopolysaccharide from Porphyromonas gingivalis (Pg-LPS). The results indicated that PRBA inhibited the expression of iNOS and COX-2 in RAW264.7 cells， reduced the level of NO， TNF-α， and IL-6， while increasing the expression of Arg-1 and the production of IL-10 in RAW264.7 cells. Among them， cyanidin-3-glucoside and peonidin-3-glucoside， the two main anthocyanin glycosides in PRBA， also had the same effect. RNA-seq results revealed that there were 1，840 differentially expressed genes (DEGs) after PRBA treatment， with 1263 upregulated and 577 downregulated. Western blot also confirmed that PRBA significantly inhibited the activation of NF-κB and AP-1 in RAW264.7 cells. In summary， these findings suggested that PRBA inhibited the expression of proinflammatory cytokines in RAW264.7 cells induced by Pg-LPS through the NF-κB and AP-1 pathways， which providing its potential application in the treatment of periodontitis for anti-inflammatory effects.

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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