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Effect of Varicocelectomy on Gonadal Function among Patients Reporting with Sexual Dysfunction in Ghana

Open Journal of Urology 2022年第6期12卷 305-330页

作者： Yussif Adams Akisibadek Alekz Afoko Nafiu Amidu Lawrence Quaye Simon Bannison Bani Peter Paul M. Dapare Vivian Afoko department of Biomedical Laboratory Science School of Allied Health Sciences University for Development Studies Tamale Ghana department of surgery School of Medicine University for Development Studies Tamale Ghana Urology Unit Tamale Teaching Hospital Tamale Ghana department of paediatric Nursing School of Nursing and Midwifery University for Development Studies Tamale Ghana

Background: Long-standing varicocele is often associated with testicular hypoxia and that might worsen Leydig cell function, a significant risk factor for hypogonadism. This may affect both the secretory and endocrine functions of the testis. This study aims to determine the effect of microsurgical sub-inguinal varicocelectomy on gonadal function among men reporting sexual dysfunction in Ghana. Methods: This was an intervention study conducted at the Tamale Teaching Hospital from September 2017 to August 2021. A total of 103 participants were randomized into two groups;the surgery group (n = 52) and the observed group (n = 51). Venous blood samples were collected at baseline, varicocelectomy was performed for the surgery group, and no intervention was given to the other. Blood samples were subsequently collected at 12-, 24-, 36-, and 48-month intervals for assay of serum total testosterone, FSH, and LH. The data were analyzed in GraphPad Prism (v8.0) at an alpha value of 0.05. Results: All the participants had varicocele and were aged between 55.0 to 69.0 years old. At the baseline of the study, all participants presented with sexual dysfunction but a significant improvement (p Conclusions: Microsurgical sub-inguinal varicocelectomy improved gonadal function among varicocele patients reporting sexual dysfunction. It is recommended to use this choice for similar patients;however, these findings should be verified by a multi-institutional study to provide more evidence for this choice.

关键词： Varicocele Sub-Inguinal Varicocelectomy Gonadal Function Sexual Dysfunction

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Congenital Cystic Adenomatoid Malformation: A Case Report with Clinical, Radiological, Histological, and Surgical Features

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Open Journal of Pediatrics 2023年第4期13卷 465-472页

作者： Karim Lahrache Samia Malki Soulaimane M’harzi Anas Ayyad Sahar Messouadi Houssain Benhaddou Amal Bennani Rim Amrani Faculty of Medicine and Pharmacy of Oujda Mohammed I University of Oujda Oujda Morocco department of Neonatology and Neonatal Reanimation Mohammed VI University Hospital of Oujda Oujda Morocco Anatomopathology department Mohammed VI University Hospital of Oujda Oujda Morocco paediatric surgery department Mohammed VI University Hospital of Oujda Oujda Morocco

Background: Congenital cystic adenomatoid malformation (CCAM) is a congenital anomaly of lung development, accounting for approximately 25% of congenital lung lesions. Respiratory distress often occurs during the neonatal period, and in 80% to 85% of cases, the diagnosis is made before the age of 2 years following respiratory infections. Case Report: We report a case of MAKC diagnosed in the neonatal period. The diagnosis was based on clinical, radiological and histological elements. Our patient underwent surgical resection. Histological examination confirmed the diagnosis of MAKC without any sign of malignancy. The postoperative evolution was good. Conclusion: Clinicians and pathologists should recognize the early discovery of MAKC in neonatal age. The clinical diagnosis strongly guided by the radiological approach is confirmed by the pathological anatomy insofar as the therapeutic sanction is surgical in the majority of the cases.

关键词： Congenital Cystic Adenomatoid Malformation Congenital Disorder Lung Respiratory Distress Newborn

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Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology department Velkey LászlóPaediatric Health CentreMiskolcHungary department of paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology department Heim Pál Children’s HospitalBudapestHungary department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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Use of endolumenal functional lumen imaging probe in investigating paediatric gastrointestinal motility disorders

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世界临床儿科杂志 2023年第4期12卷 162-170页

作者： Emily White Mohamed Mutalib department of paediatric Gastroenterology Evelina London Children’s HospitalLondon SE17EHUnited Kingdom Faculty of Life Sciences and Medicine King’s College LondonLondon SE17EHUnited Kingdom

Investigating gastrointestinal(GI)motility disorders relies on diagnostic tools to assess muscular contractions,peristalsis propagation and the integrity and coordination of various *** are the gold standard to study the GI motor function but it is increasingly acknowledged that manometries do not provide a complete picture in relation to sphincters competencies and muscle *** functional lumen imaging probe(EndoFLIP)an emerging technology,uses impedance planimetry to measure hollow organs cross sectional area,distensibility and *** has been successfully used as a complementary tool in the assessment of the upper and lower oesophageal sphincters,oesophageal body,the pylorus and the anal *** this article,we aim to review the uses of EndoFLIP as a tool to investigate GI motility disorders with a special focus on paediatric *** majority of EndoFLIP studies were conducted in adult patients but the uptake of the technology in paediatrics is *** can provide a useful complementary data to the existing GI motility investigation in both children and adults.

关键词： Endolumenal functional lumen imaging probe paediatric Gastrointestinal motility

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Learning from parental experience in a neonatal surgical unit:a qualitative service evaluation

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World Journal of Pediatric surgery 2023年第3期6卷 147-153页

作者： Anna Littlejohns Emile Crouzen Rebecca Mernenko Fiona Metcalfe Waaka Moni-Nwinia Hemma Chauhan Bethan Johnson Douglas McConachie Elizabeth Lawson Victoria Tricklebank John G McElwaine Gurdeep S Sagoo Liz McKechnie Gary Latchford Jonathan Sutcliffe Anaesthesia and Critical Care Leeds Teaching Hospitals NHS TrustLeedsUK paediatric surgery Leeds Children's HospitalLeedsUK Leeds Centre for Newborn Care Leeds Children's HospitalLeedsUK Faculty of Medicine and Health University of LeedsLeedsUK Academic Unit of Health Economics University of LeedsLeedsUK Institute of Health Sciences University of Leeds LeedsLeedsUK St James's University Hospital department of Clinical and Health Psychology LeedsUK

Objectives Patient experience is directly related to health outcomes,and parental experience can be used as a proxy for this in neonatal *** project was designed to assess parental experience of neonatal surgical care to inform future service developments and improve the care we *** This was a qualitative study using rapid qualitative *** study was carried out in a large neonatal surgical intensive care unit in the *** of infants treated by the neonatal surgical team between March 2020 and February 2021,during the COVID-19 pandemic were *** sampling was used to ensure that a representative range of parents were interviewed.A semistructured interview was created and tested in a previous phase of *** questionnaire was used to ask parents open questions about different aspects of their infants’healthcare journey from the antenatal phase through to discharge from the neonatal unit(NUU).Results Rapid qualitative analysis was employed,and parental experiences were grouped into five main categories:before admission to the NNU,initial admission to NNU,information and support,COVID-19 and *** these five groups,we highlighted positive experiences to be fed back to the healthcare teams to reinforce good practice,areas that warranted improvement and suggestions for service *** The wealth of data generated from the interviews has been summarized and shared with healthcare teams who are putting the service improvement suggestions into *** tool is available for services that wish to measure parental experience.

关键词： qualitative service interview

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Advances in minimally invasive neonatal colorectal surgery

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World Journal of Gastrointestinal surgery 2016年第10期8卷 670-678页

作者： Ashwath S Bandi Catherine J Bradshaw Stefano Giuliani department of paediatric surgery St George’s University Hospitals NHS Foundation Trust

Over the last two decades,advances in laparoscopicsurgery and minimally invasive techniques have transformed the operative management of neonatal colorectal surgery for conditions such as anorectal malformations(ARMs) and Hirschsprung's *** of surgical care has mainly occurred due to the use of laparoscopy,as opposed to a laparotomy,for intraabdominal procedures and the development of trans-anal *** review describes these advances and outlines the main minimally invasive techniques currently used for management of ARMs and Hirschsprung's *** does still remain significant variation in the procedures used and this review aims to report the current literature comparing techniques with an emphasis on the short- and long-term clinical outcomes.

关键词： Neonatal surgery Laparoscopy Anorectal malformation Colorectal surgery Hirschsprung’s disease

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Pediatric food allergy clinic:a way to improve the quality of service

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World Journal of Pediatrics 2021年第2期17卷 109-110页

作者： Zakaria Barsoum South West Acute Hospital-paediatric department 124 Irvinestown RdEnniskillen BT746DNNorthern Ireland

paediatric food allergy is a common problem with a preva-lence of 5%across the UK[1].There are increasing demands of developing allergy services across the health care system in the *** new allergy services among district hospitals,run by paediatricians with a special interest in allergy is *** clinics are multi-discipli-nary in their design with emphasis on the role of dieticians and asthma nurses in the management of *** should always think about tools to improve the quality of allergy *** propose an allergy pro forma to be used in food allergy clinics to improve the quality of the service(Supplementary material 1).

关键词： allergy nurse clinic

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Transphyseal separation of the distal humerus in newborns

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Chinese Journal of Traumatology 2017年第3期20卷 183-186页

作者： Cosimo Gigante Sunil Gurpur Kini Carlo Origo Andrea Volpin Unit of paediatric Orthopaedics Azienda Ospedaliera di Pndova. 35128. Padova. Italy department of Orthopaedics Manipal Hospitals Bangalore India department of paediatric Orthopaedics Hospital C Arrigo Alessandria Italy

Obstetric traumatic separation of the distal humeral epiphysis is a very uncommon injury, which presents a diagnostic challenge. These case serials reviewed the functional outcomes of 5 patients who had sustained a fracture-separation of the distal humeral epiphysis at birth. The diagnosis was made at a mean time of 40.8 h after delivery. All the patients were treated with gentle close manipulation, reduction under fluoroscopy and above-elbow cast application. After discharge, the patients were followed up for a mean of 30 months. Clinico-radiological results were excellent in four patients. One case necessitated closed reduction and percutaneous K-wire fixation at one week follow-up due to failed reduction. Cubitusvarus deformity was the only complication noted in 1 case. Good functional outcome can be expected in newborns with fracture-separation of the distal humeral epiphysis wherein the physis is anatomically reduced.

关键词：新生儿远端肱骨分离平均时间挑战性分娩后复位

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Treatment of rectal prolapse in children with cow milk injection sclerotherapy:30-year experience

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World Journal of Gastroenterology 2008年第5期14卷 737-740页

作者： Mirko Zganjer Ante Cizmic Irenej Cigit Bozidar Zupancic Igor Bumci Ljiljana Popovic Antun Kljenak department of paediatric surgery Children's Hospital Zagreb Klai eva 16 Zagreb 10000Croatia

AIM:To evaluate the role and our experience of injecti-on sclerotherapy with cow milk in the treatment of rectal prolapse in children. METHODS:In the last 30 years (1976-2006) we made 100 injections of sclerotherapy with cow milk in 86 chil-dren. In this study we included children who failed to respond to conservative treatment and we perform ope-rative treatment. RESULTS:In our study we included 86 children and in all of the patients we perform cow milk injection sclerot-herapy. In 95.3% (82 children) of patients sclerotherapy was successful. In 4 (4.7%) patients we had recurrent rectal prolapse where we performed operative treatment. Below 4 years we had 62 children (72%) and 24 older children (28%). In children who needed operative trea-tment we performed Thiersch operation and without any complications. CONCLUSION:Injection sclerotherapy with cow milk for treatment rectal prolapse in children is a simple and effective treatment for rectal prolapse with minimal com-plications.

关键词：直肠脱垂儿童硬化疗法症状

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ChatGPT in action:Harnessing artificial intelligence potential and addressing ethical challenges in medicine,education,and scientific research

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World Journal of Methodology 2023年第4期13卷 170-178页

作者： Madhan Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Naveen Jeyaraman Arulkumar Nallakumarasamy Shilpa Sharma department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia department of General Medicine Government Medical CollegeOmandurar Government EstateChennai 600018Tamil NaduIndia department of paediatric surgery All India Institute of Medical SciencesDelhi 110029New DelhiIndia

Artificial intelligence(AI)tools,like OpenAI's Chat Generative Pre-trained Transformer(ChatGPT),hold considerable potential in healthcare,academia,and diverse *** demonstrates its capability at a medical student level in standardized tests,suggesting utility in medical education,radiology reporting,genetics research,data optimization,and drafting repetitive texts such as discharge ***,these tools should augment,not supplant,human *** promising applications,ChatGPT confronts limitations,including critical thinking tasks and generating false references,necessitating stringent *** concerns,such as potential misuse,bias,blind trust,and privacy,underscore the need for transparency,accountability,and clear *** of AI-generated content and preservation of academic integrity are *** responsible use,AI can significantly improve healthcare,academia,and industry without compromising integrity and research *** effective and ethical AI deployment,collaboration amongst AI developers,researchers,educators,and policymakers is *** development of domain-specific tools,guidelines,regulations,and the facilitation of public dialogue must underpin these endeavors to responsibly harness AI's potential.

关键词： Artificial intelligence ChatGPT Open artificial intelligence Education Research

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