Effect of Varicocelectomy on Gonadal Function among Patients Reporting with Sexual Dysfunction in Ghana

作     者：Yussif Adams Akisibadek Alekz Afoko Nafiu Amidu Lawrence Quaye Simon Bannison Bani Peter Paul M. Dapare Vivian Afoko Yussif Adams;Akisibadek Alekz Afoko;Nafiu Amidu;Lawrence Quaye;Simon Bannison Bani;Peter Paul M. Dapare;Vivian Afoko

作者机构：Department of Biomedical Laboratory Science School of Allied Health Sciences University for Development Studies Tamale Ghana Department of Surgery School of Medicine University for Development Studies Tamale Ghana Urology Unit Tamale Teaching Hospital Tamale Ghana Department of Paediatric Nursing School of Nursing and Midwifery University for Development Studies Tamale Ghana 

出 版 物：《Open Journal of Urology》 (泌尿学期刊（英文）)

年 卷 期：2022年第12卷第6期

页      面：305-330页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Varicocele Sub-Inguinal Varicocelectomy Gonadal Function Sexual Dysfunction 

摘      要：Background: Long-standing varicocele is often associated with testicular hypoxia and that might worsen Leydig cell function, a significant risk factor for hypogonadism. This may affect both the secretory and endocrine functions of the testis. This study aims to determine the effect of microsurgical sub-inguinal varicocelectomy on gonadal function among men reporting sexual dysfunction in Ghana. Methods: This was an intervention study conducted at the Tamale Teaching Hospital from September 2017 to August 2021. A total of 103 participants were randomized into two groups;the surgery group (n = 52) and the observed group (n = 51). Venous blood samples were collected at baseline, varicocelectomy was performed for the surgery group, and no intervention was given to the other. Blood samples were subsequently collected at 12-, 24-, 36-, and 48-month intervals for assay of serum total testosterone, FSH, and LH. The data were analyzed in GraphPad Prism (v8.0) at an alpha value of 0.05. Results: All the participants had varicocele and were aged between 55.0 to 69.0 years old. At the baseline of the study, all participants presented with sexual dysfunction but a significant improvement (p Conclusions: Microsurgical sub-inguinal varicocelectomy improved gonadal function among varicocele patients reporting sexual dysfunction. It is recommended to use this choice for similar patients;however, these findings should be verified by a multi-institutional study to provide more evidence for this choice.