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Consensus on the application of negative pressure wound therapy of diabetic foot wounds

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Burns & Trauma 2021年第1期9卷 421-432页

作者： Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia Burn Institute of PLA Department of BurnsThe First Affiliated Hospital of Naval Medical UniversityNo.168 Changhai RoadYangpu DistrictShanghai200433China Fujian Burn Institute Fujian Medical University Union HospitalNo.29 Xinquan RoadGulou DistrictFuzhou350001China Department of Burns&Wound Care center Second Affiliated Hospital of Zhejiang UniversityCollege of MedicineNo.88 Jiefang RoadShangcheng DistrictHangzhou310009China No.3 Department of Burns and Plastic Surgery and Wound Healing center The Fourth Medical Center of Chinese PLA General HospitalNo 51 Fucheng RoadHaidian DistrictBeijing100048China Foot and Ankle Surgery Department Guangzhou Zhenggu Orthopedic HospitalNo.449 Dongfeng Middle RoadYuexiu DistrictGuangzhou510031China Department of Burns and Cutaneous Surgery The First Affiliated Hospital of Air Force Medical UniversityNo.127 West Changle RoadXincheng DistrictXi’an710032China Wound Healing Department PLA Strategic Support Force Characteristic Medical CenterNo.9 Anxiang North LaneChaoyang DistrictBeijing100101China Department of Peripheral Vascular Beijing University of Chinese MedicineDongzhimen HospitalHai Yun Cang on the 5thDongcheng DistrictBeijing100700China Department of Orthopedics Zhejiang University School of MedicineSir Run Run Shaw HospitalNo.3 East Qinchun RoadShangcheng DistrictHangzhou310016China Department of Burns The Fifth Hospital of HarbinNo.27 Jiankang RoadXiangfang District150030HarbinChina Institute of Burn Research State Key Laboratory of TraumaBurn and Combined InjurySouthwest HospitalThird Military Medical UniversityGaotanyan Street no.29Shapingba DistrictChongqing400038China Department of Burn Shanghai Jiaotong UniversitySchool of Medicine Affiliated Ruijin HospitalNo.197 Ruijin Road(No.2)Huangpu DistrictShanghai200025China Department of Burn Surgery the Third People’s Hospital of WuxiNo.585 North Xingyuan RoadWuxi214043China innovation center for Wound Rpair Diabetic Foot Care CenterDepartment of Endoc

Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been *** foot has become one of the main health-related killers due to its high disability and mortality *** pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its ***,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment *** 2020,under the leadership of Burns,Trauma and tissue repair Committee of the Cross-Straits medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound *** on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic *** consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot.

关键词： Vacuum sealing drainage Vacuum-assisted closure Vacuum-assisted therapy Negative pressure wound therapy Topical negative pressure therapy Suction wound closure therapy Diabetic foot Diabetic ulcer Diabetic wound

Cross-talk between biometal ions and immune cells for bone repair

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Engineered Regeneration

Engineered regeneration 2024年第3期5卷 375-408页

作者： Shubo Liu Zhengjie Lin Wei Qiao Bin Chen Jie Shen Division of Orthopaedics and Traumatology Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouPR China D Printing Clinical Translational and Regenerative medicine center Department of StomatologyShenzhen Qianhai Shekou Free Trade Zone HospitalShenzhenPR China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhenPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryThe University of Hong KongHong Kong S.A.R.PR China

Biometal ions are crucial in the structure and function of living organisms and have extensively been employed to promote bone tissue ***,the biological functions of biometal ions and the underlying mechanisms responsible for their pro-regenerative effects remain incompletely understood,since bone repair is an intricate physiological process involving multiple cell types and *** accomplishments in the osteoim-munological field have revealed the momentous involvement of the immune system in mediating the therapeutic effects of biometal *** inflammatory factors secreted by immune cells contribute to bone cell migration,activation,and *** review summarizes the immune system and its constituent cells,followed by the current perspective on immunomodulation during bone ***,the physicochemical and physiological properties of various biometal ions,including lithium,sodium,potassium,magnesium,calcium,strontium,vana-dium,iron,cobalt,copper,and zinc,are thoroughly *** addition,the interactions between biometal ions,immune cells,and bone tissue are discussed,aiming to provide insights into the prospective development of novel approaches to bone tissue regeneration by harnessing the therapeutic potential of these biometal ions.

关键词： Metal ion Bone regeneration Bone repair Immune cell Osteo-immunomodulation

Co-administration of platelet-rich plasma and small intestinal submucosa is more beneficial than their individual use in promoting acute skin wound healing

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Burns & Trauma 2021年第1期9卷 72-82页

作者： Xiaoxuan Lei Liuhanghang Cheng Yu Yang Mengru Pang Yunqing Dong Xuanru Zhu Caihong Chen Zexin Yao Gang Wu Biao Cheng Tymour Forouzanfar Department of Oral and Maxillofacial Surgery/Pathology Amsterdam UMC and Academic Center for Dentistry Amsterdam(ACTA)Vrije Universiteit AmsterdamAmsterdam Movement ScienceAmsterdam1081HVThe Netherlands Department of Burn and Plastic Surgery General Hospital of Southern Theater CommandGuangzhou510030China Department of Oral Implantology and Prosthetic Dentistry Academic Center for Dentistry Amsterdam(ACTA)University of Amsterdam(UvA)and Vrije Universiteit Amsterdam(VU)Amsterdam1081LAThe Netherlands

Background:Acute skin wounds may compromise the skin barrier,posing a risk of *** intestinal submucosa(SIS)is widely used to treat acute and chronic ***,the efficacy of SIS to accelerate wound healing still needs to be improved to meet clinical *** tackle this problem,platelet-rich plasma(PRP)is used due to its potency to promote proliferation,migration and adhesion of target *** this study,we applied PRP and SIS to skin wounds to explore their effects on wound healing by evaluating re-epithelialization,collagen production,angiogenesis and the inflammatory ***:A1×1-cm full-thickness skin defectwas established in *** mice were divided into four treatment groups:PRP+SIS,PRP,SIS and *** days 3,5,7,10 and 14 post-surgery,tissue specimens were *** and eosin,Masson’s trichrome,immunohistochemical and immunofluorescence double staining were used to visualize epidermal thickness,collagen and vascular regeneration and ***:Wound contraction in the PRP and PRP+SIS groups was significantly greater,compared with the other groups,on days 3 and 5 post-surgery.A histological analysis showed higher collagen expression in the PRP and PRP+SIS groups on day 7,whichwas associated with a thicker epidermal layer on day *** addition,immunohistochemical staining showed that CD31-positive blood vessels and vascular endothelial growth factor expression in the PRP+SIS and PRP groups were significantly higher,compared with the control ***,immunofluorescence double staining showed that the number of M1 and M2 macrophages in the PRP+SIS and PRP groups was higher,compared with the control and SIS groups alone,on day ***,on day 7,the number of M1 macrophages dramatically decreased in the PRP+SIS and PRP *** ratio of M2 to M1 macrophages in the PRP+SIS and PRP groups was 3.97 and 2.93 times that of the control group and 4.56 and 3.37 times that of the SIS group,respectively.

关键词： Small intestinal submucosa Platelet-rich plasma Full-thickness skin defect M1macrophages M2macrophages Animal model wound healing skin

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang Hongqi Chen Yaozhong Zhang Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

Hybrid Bioelastomer Reinforced by Ultrathin Nanowires of Lanthanide Hydroxycarbonates for Promising Biomedical Applications

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CCS Chemistry 2022年第3期4卷 926-937页

作者： Xinyu Zhang Yannan Li Juan Ge Lei Qin Yanzhen Zheng Bo Lei Zhiping Zheng Yaping Du Frontier Institute of Science and Technology Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyXi’an Jiaotong UniversityXi’anShaanxi 710054 Department of Chemistry and Shenzhen Grubbs Institute Southern University of Science and TechnologyShenzhen 518000 School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021 Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsSchool of Materials Science and EngineeringNational Institute for Advanced MaterialsNankai UniversityTianjin 300350

Hybrids composed of biocompatible polymers reinforced with inorganic nanomaterials are useful for many biomedical applications including implantation and tissue regeneration and *** this work,we report a new type of hybrid prepared by doping ultrathin nanowires of lanthanide hydroxycarbonates into classical biocompatible poly(citrates-siloxane).The doping of the inorganic nanowires imparts the hybrids with excellent miscibility with the polymeric matrix,producing hybrids with high elasticity and high tensile *** hybrids containing Eu(III)and Gd(III)display their respective luminescence and magnetic properties and thus,offer opportunities to monitor the fate of such hybrids when used in *** degradation and excellent biocompatibility of these hybrids have also been ***,these favorable traits portend useful applications of the newly developed hybrid elastomers.

关键词： lanthanides hybrid elastomer ultrathin nanowires biomedical application

生物材料介观结构组装及工程化的最新进展、挑战和前景

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Science China Materials 2024年第8期67卷 2462-2468页

作者：焦芸可雷淼唱荣航屈雪 Key Laboratory for Ultrafine Materials of Ministry of Education School of Material Science and EngineeringFrontiers Science Center for Materiobiology and Dynamic ChemistryEast China University of Science and TechnologyShanghai 200237China Wenzhou Institute of Shanghai University Wenzhou 325000China Shanghai Frontier Science center of Optogenetic Techniques for Cell Metabolism Shanghai 200237China

尽管天然生物组织的组分性能有限,但其跨越多尺度的复杂有序结构赋予了其出色的功能,这一点在介观尺度尤为显著.介观结构在调控材料的物理性质和生物活性方面发挥着至关重要的作用.本文深入探讨了对组织再生修复材料进行介观结构控制的... 详细信息

尽管天然生物组织的组分性能有限,但其跨越多尺度的复杂有序结构赋予了其出色的功能,这一点在介观尺度尤为显著.介观结构在调控材料的物理性质和生物活性方面发挥着至关重要的作用.本文深入探讨了对组织再生修复材料进行介观结构控制的挑战,并提出了一种新型的场调控动态自组装技术.该技术以电化学沉积技术为基础,通过调控电化学参数或与其他物理场进行耦合,能够更精准地控制生物大分子组装体的介观结构,从而实现材料的高性能化.此外,本文还讨论了该技术在工程化应用上的优势.最后强调了跨学科和跨部门合作的重要性,这对于推动生物材料制造技术的产业化和商业化至关重要.总之,该技术在组织再生领域展现出了广阔的发展前景.

关键词：电化学参数组织再生介观结构跨部门合作介观尺度电化学沉积物理场工程化

A shape-persistent plasticine-like conductive hydrogel with self-healing properties for peripheral nerve regeneration

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Journal of Materials Science & Technology 2023年第11期142卷 134-143页

作者： Xinchang Kang Xiaojun Li Can Liu Min Cai Pengfei Guan Yian Luo Youjun Guan Yu Tian Kunyu Ren Chengyun Ning Lei Fan Guoxin Tan Lei Zhou School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Department of Spine Surgery Guangzhou Key Laboratory of Spine Disease Prevention and Treatmentthe Third Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510150China Department of Orthopedic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Orthopedic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou 510055China Department of Pediatric Orthopedic Center for Orthopedic Surgerythe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China

In recent years,electrically conductive hydrogel-based nerve guidance conduits(NGCs)have yielded promising results for treating peripheral nerve injuries(PNIs).However,developed ones are generally pre-manufactured and exhibit a limited ability to achieve good contact with nerve tissue with irregu-lar ***,we developed a plasticine-like electrically conductive hydrogel consisting of gelatin,conducting polypyrrole,and tannic acid(named GPT)and assessed its ability to promote peripheral nerve *** shape-persistent GPT hydrogel exhibited good self-healing properties and could easily be molded to form a conduit that could match any injured nerve *** electrical properties could be tuned by changing the PPy *** vitro,the improved conductivity of the hydrogel pro-moted dorsal root ganglion(DRG)axonal *** importantly,we found that the GPT hydrogel enhanced axonal regeneration and remyelination in vivo,preventing denervation atrophy and enhancing functional recovery in a mice model of sciatic nerve *** results suggest that our plasticine-like NGC has huge prospects for clinical application in the repair of PNI.

关键词： Plasticine-like Conductive hydrogel Self-healing Moldability Peripheral nerve conduit

Preparation and Osteogenic Efficacy of Emodin-loaded Hydroxyapatite Electrospun Fibers

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Journal of Bionic Engineering 2023年第3期20卷 1060-1071页

作者： Yiwen Pan Mu He Shaoqing Chen Yanyan Meng Cheli Wang Xinye Ni School of Pharmacy Changzhou UniversityChangzhou213000China Department of Radiotherapy Changzhou Second People’s HospitalNanjing Medical UniversityChangzhou213000China Laboratory of Medical Physics center Nanjing Medical UniversityNanjing210000China Changzhou Key Laboratory of Medical Physics Changzhou213000China

Biological scaffolds have been the focus of bone tissue engineering research in recent years. In this paper, emodin (EM), macromolecular compound polycaprolactone (PCL), and hydroxyapatite (HA) were used as raw materials to prepare EM/PCL/HA fibers containing different EM ratios by electrospinning, and the properties and osteogenic efficacy of EM/PCL/HA were studied. Scanning electron microscopy, transmission electron microscopy, and atomic force microscopy were used to characterize the structures of HA and the electrospun fibers. Results showed that HA has high crystallinity and loose porous structure, and the electrospun fibers have a smooth and flat surface. In vitro release results showed that EM was slowly released from EM/PCL/HA within 216 h. Cell proliferation assay in mouse embryonic osteoblast precursor cells (MC3T3-E1) exhibited that 5% EM/PCL/HA had the best effect on promoting cell proliferation. Alkaline phosphatase (ALP) and mineralized nodules staining results also showed that 5% EM/PCL/HA had the best effect on promoting osteogenic differentiation. qRT-PCR results showed that the mRNA expression level of osteoblast differentiation markers, namely, bone morphogenetic protein (BMP)-2, BMP-9, and osteocalcin were significantly upregulated by 5% EM/PCL/HA treatment. These results indicate that EM/PCL/HA is a potential osteogenic material, which can provide a reference for the development of bone injury repair materials.

关键词： Emodin Hydroxyapatite Electrospinning Bone regeneration

Manganese silicate nanospheres-incorporated hydrogels:starvation therapy and tissue regeneration

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Bioactive Materials 2021年第12期6卷 4558-4567页

作者： Hongshi Ma Qingqing Yu Yu Qu Yufang Zhu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai200050China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesNo19(A)Yuquan RoadBeijing100049China

To prevent postoperative skin tumor recurrence and repair skin wound,a glucose oxidase(GOx)-loaded manganese silicate hollow nanospheres(MS HNSs)-incorporated alginate hydrogel(G/MS-SA)was constructed for starvation-photothermal therapy and skin tissue *** MS HNSs showed a photothermal conversion efficiency of 38.5%,and endowed composite hydrogels with satisfactory photothermal *** advantage of the catalytic activity of Mn ions,the composite hydrogels could decompose hydrogen peroxide(H2O2)into oxygen(O2),which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor ***,hyperthermia triggered by near infrared(NIR)irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx,but also ablate tumor *** anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups,and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation ***,the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS *** is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.

关键词： Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy tissue regeneration