Cross-talk between biometal ions and immune cells for bone repair
作者机构：Division of Orthopaedics and TraumatologyDepartment of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouPR China D Printing Clinical Translational and Regenerative Medicine CenterDepartment of StomatologyShenzhen Qianhai Shekou Free Trade Zone HospitalShenzhenPR China Shenzhen Key Laboratory of Spine SurgeryDepartment of Spine SurgeryPeking University Shenzhen HospitalShenzhenPR China Applied Oral Sciences and Community Dental CareFaculty of DentistryThe University of Hong KongHong Kong S.A.R.PR China
出 版 物：《Engineered Regeneration》 (再生工程（英文）)
年 卷 期：2024年第5卷第3期
页 面：375-408页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by National Natural Science Foundation of China(82002303,12272164,82201124) Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515011536,2021A1515220093,2022A1515011815,2023A1515011963) Shenzhen Science and Technology Innovation Committee Projects(Nos.SGDX20220530111405038,JCYJ20220530151608019) Scientific Research Foundation of Peking University Shenzhen hospital(Nos.KYQD2021064,and KYQD2022215) Health and Medical Research Fund(09201466) Collaborative Research Fund(C7003-22Y)
主 题：Metal ion Bone regeneration Bone repair Immune cell Osteo-immunomodulation
摘 要：Biometal ions are crucial in the structure and function of living organisms and have extensively been employed to promote bone tissue ***,the biological functions of biometal ions and the underlying mechanisms responsible for their pro-regenerative effects remain incompletely understood,since bone repair is an intricate physiological process involving multiple cell types and *** accomplishments in the osteoim-munological field have revealed the momentous involvement of the immune system in mediating the therapeutic effects of biometal *** inflammatory factors secreted by immune cells contribute to bone cell migration,activation,and *** review summarizes the immune system and its constituent cells,followed by the current perspective on immunomodulation during bone ***,the physicochemical and physiological properties of various biometal ions,including lithium,sodium,potassium,magnesium,calcium,strontium,vana-dium,iron,cobalt,copper,and zinc,are thoroughly *** addition,the interactions between biometal ions,immune cells,and bone tissue are discussed,aiming to provide insights into the prospective development of novel approaches to bone tissue regeneration by harnessing the therapeutic potential of these biometal ions.
维普期刊数据库