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A Brief Review of a Common Clinical Question: Intravenous Diltiazem or Metoprolol for Atrial Fibrillation with Rapid Ventricular Response?

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World Journal of Cardiovascular Diseases 2023年第9期13卷 550-555页

作者： Zachary Visinoni Neeladri Misra Daniel Jurewitz Department of Graduate Medical Education Internal Medicine Residency Sutter Roseville Medical Center Roseville USA Sutter Medical group Roseville USA Sutter Medical group Cardiology Roseville USA

Two classes of rate controlling medications—beta blockers (BBs) and non- dihydropyridine calcium channel blockers (CCBs)—are given to patients who present with atrial fibrillation (AF) with rapid ventricular response (RVR). Both are Class I recommendations from the American Heart Association (AHA), American College of Cardiology (ACC), and Heart Rhythm Society (HRS) for the management of AF with RVR. Multiple studies support the view that diltiazem is more effective than metoprolol, even though data from the AFFIRM trial suggests BBs are more frequently used. CCBs are generally avoided in AF with RVR patients who have concomitant heart failure with reduced ejection fraction (HFrEF) for concern of triggering decompensation. However, some recent studies indicate this idea may be unfounded. The aim of this article is to compare the efficacy of diltiazem and metoprolol for rate control in AF with RVR and examine the use of diltiazem in patients with both AF with RVR and HFrEF.

关键词： Atrial Fibrillation Rapid Ventricular Response Diltiazem Metoprolol Heart Failure with Reduced Ejection Fraction

Consideration of Blood Serum Biochemical Parameters of Yellow Fin Sea Bream (<i>Acantopagrus latus</i>Houttuyn, 1782) and Orange-Spotted grouper (<i>Epinephelus coioides</i>Hamilton, 1822)

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Advances in Biological Chemistry 2014年第6期4卷 407-413页

作者： Paria Akbary Fisheries group Department of Marine Sciences Chabahar Maritime University Chabahar Iran

Serum biochemical parameters are important aspects in the management of endangered species. The values of these parameters can be used for confirming the maturity and for monitoring any changes in the quality of waters and related soils. The aim of this research was to determine the reference values of biochemical factors in Acantopagrus latus and Epinephelus coioides. Blood samples were collected from captured fish from coastal waters of Chabahar (Ramin waterfront). Serum levels of glucose, Blood Urea Nitrogen (BUN), cholesterol (CHO), triglyceride, total protein, albumin, calcium (Ca2+), phosphorus (P), sodium (Na+), bilirubin and potassium (K+) were measured. The results showed that the levels of albumin and bilirubin in E. coioides were significantly higher than A. latus and there were significant differences in all of the serum values (except P and glucose) between A. latus and E. coioides (P < 0.05). It can be concluded that the values of blood biochemical parameters may be affected by physiological factors such as the species of fish.

关键词： Serum Acantopagrus latus Epinephelus coioides Electrolyte Non Electrolyte

The compartmented alginate fibres optimisation for bitumen rejuvenator encapsulation

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第4期4卷 347-359页

作者： Amir Tabakouic Dirk Braak Mark van Gerwen Oguzhan Copuroglu Wouter Post Santiago J. Oarcia Erik Schlangen Materials & Environment Faculty of Civil Engineering and Geosciences Delft University of Technology DelftThe Netherlands Novel Aerospace Materials group Faculty of Aerospace Engineering Delft University of Technology DelftThe Netherlands

This article presents development of a novel self-healing technology for asphalt pave- ments, where asphalt binder rejuvenator is encapsulated within the compartmented alginate fibres. The key objective of the study was to optimise the compartmented alginate fibre design, i.e., maximising amount of rejuvenator encapsulated within the fibre. The results demonstrate that optimum rejuvenator content in the alginate fibre is of 70：B0 rejuvenator/alginate ratio. The fibres are of sufficient thermal and mechanical strength to survive harsh asphalt mixing and compaction processes. Furthermore, results illustrate that zeer open asfalt beton （ZOAB） asphalt mix containing 5% of 70：30 rejuvenator/alginate ratio compartmented alginate fibres has higher strength, stiffness and better healing properties in comparison to the control asphalt mix, i.e., mix without fibres, and mix containing fibres with lower rejuvenator content. These results show that compartmented alginate fibres encapsulating bitumen rejuvenator present a promising new approach for the development of self-healing asphalt pavement systems.

关键词： Self-healing Asphalt pavements Compartmented fibres calcium alginate Rejuvenation

Prediction of sorption enhanced steam methane reforming products from machine learning based soft-sensor models

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能源与人工智能(英文) 2020年第2期2卷 157-166页

作者： Paula Nkulikiyinka Yongliang Yan Fatih Gülec Vasilije Manovic Peter T.Clough Energy and Power Theme School of WaterEnergy and EnvironmentCranfield UniversityCranfieldBedfordshireMK430ALUK Advanced Materials Research group Faculty of EngineeringUniversity of NottinghamNottinghamNG72RDUK

Carbon dioxide-abated hydrogen can be synthesised via various processes,one of which is sorption enhanced steam methane reforming(SE-SMR),which produces separated streams of high purity H_(2) and CO_(2).Properties of hydrogen and the sorbent material hinder the ability to rapidly upscale SE-SMR,therefore the use of artificial intelligence models is useful in order to assist scale *** of a data driven soft-sensor model over ther-modynamic simulations,is the ability to obtain real time information dependent on actual process *** this study,two soft sensor models have been developed and used to predict and estimate variables that would otherwise be difficult direct *** artificial neural networks and the random forest models were devel-oped as soft sensor prediction *** were shown to provide good predictions for gas concentrations in the reformer and regenerator reactors of the SE-SMR process using temperature,pressure,steam to carbon ratio and sorbent to carbon ratio as input process *** models were very accurate with high R^(2) values,all above 98%.However,the random forest model was more precise in the predictions,with consistently higher R^(2) values and lower mean absolute error(0.002-0.014)compared to the neural network model(0.005-0.024).

关键词： Machine learning Artificial neural network Soft sensor Sorption enhanced steam methane reforming calcium looping

Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice

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Food Science and Human Wellness 2023年第2期12卷 634-646页

作者： Qi Zhang Sijing Hu Jianjun Wu Peng Sun Quanlong Zhang Yang Wang Qiming Zhao Ting Han Luping Qin Qiaoyan Zhang School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Zhejiang Traditional Chinese Medicine&Health Industry group Co. Ltd.Hangzhou 310016China School of Pharmacy Second Military Medical UniversityShanghai 200433China

Increasing the osteogenic differentiation ability and decreasing the adipogenic differentiation ability of bone marrow mesenchymal stem cells(BMSCs)is a potential strategy for the treatment of osteoporosis(OP).Naturally derived oligosaccharides have shown significant anti-osteoporotic ***(NST),an oligosaccharide,was isolated from the roots of Morinda officinalis How.(MO).The aim of the present study was to investigate the effects of NST on bone loss in ovariectomized mice,and explore the underlying mechanism of NST in promoting differentiation of BMSCs to *** of NST(40,80 and 160 mg/kg)and the positive control of estradiol valerate(0.2 mg/kg)for 8 weeks significantly prevented bone loss induced by ovariectomy(OVX),increased the bone mass density(BMD),improved the bone microarchitecture and reduced urine calcium and deoxypyridinoline(DPD)in ovariectomized mice,while inhibited the increase of body weight without significantly affecting the uterus ***,we found that NST increased osteogenic differentiation,inhibited adipogenic differentiation of BMSCs in vitro,and upregulated the expression of the key proteins of BMP and Wnt/β-catenin *** addition,Noggin and Dickkopf-related protein-1(DKK-1)reversed the effect of NST on osteogenic differentiation and expression of the key proteins in BMP and Wnt/β-catenin *** luciferase activities and the molecular docking analysis further supported the mechanism of *** conclusion,these results indicating that NST can be clinically used as a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis.

关键词： Nystose Bone marrow mesenchymal stem cell Osteoblast Adipocyte BMP pathway Wnt/β-catenin pathway

Exploration of amino trimethylene phosphonic acid to eliminate the adverse effect of seawater in molybdenite flotation

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International Journal of Mining Science and Technology 2021年第6期31卷 1129-1134页

作者： Guanghua Ai Kaihua Huang Cheng Liu Siyuan Yang University of Science and Technology Ganzhou 34100China South China Institute of Environmental science Ministry of Ecology and EnvironmentGuangzhou 510530China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Mineral Processing BGRIMM Technology GroupBeijing 102600China

In this investigation,a chelating agent of amino trimethylene phosphonic acid(ATMP) was introduced to eliminate the adverse effect of seawater in molybdenite *** results presented that high flotation recovery of molybdenite was achieved in freshwater using kerosene as the collector,but it was significantly decreased in the presence of seawater when pH> *** the main ions in seawater,magnesium and calcium ions played a more detrimental role than *** the addition of ATMP,molybdenite floatability can restore in *** potential distribution and solution chemistry calculation results illustrated that the decreased molybdenite floatability was attributed to the interaction of positive Mg(OH)_(2)(s)(major) and CaOH^(+)(minor) components with the molybdenite *** magnesium/calcium ions of positive components of Mg(OH)_(2)(s) and CaOH^(+) interacted with the ionized species of ATMP and then produced ATMP-calcium/magnesium complex,leading to the electrostatic repulsion between molybdenite and ATMP-calcium/magnesium complex that was restoring the molybdenite ***,the ATMP can be utilized as an appropriate reagent to improve molybdenite flotation in seawater.

关键词： Molybdenite Seawater calcium/magnesium ions ATMP Flotation

Mesenchymal stem cell therapy for retinal ganglion cell neuroprotection and axon regeneration

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Neural Regeneration Research 2015年第3期10卷 371-373页

作者： Ben Mead Ben A.Scheven Neurotrauma Research group Neurobiology SectionSchool of Clinical and Experimental MedicineUniversity of Birmingham School of Dentistry University of Birmingham

Retinal ganglion cells （RGCs） are responsible for propagat- ing signals derived from visual stimuli in the eye to the brain, along their axons within the optic nerve to the superior colliculus, lateral geniculate nucleus and visu- al cortex of the brain. Damage to the optic nerve either through trauma, such as head injury, or degenerative dis- ease, such as glaucoma causes irreversible loss of function through degeneration of non-regenerating RGC axons and death of irreplaceable RGCs, ultimately leading to blindness （Berry et al., 2008）. The degeneration of RGCs and their axons is due to the loss of the necessary source of retrogradely transported neurotrophic factors （NTFs） being hindered by axonal injury. NTFs are survival factors for neurons and play a pivotal part in axon regeneration. Stem cells particularly mesenchymal stem cells （MSCs） have been shown to possess a natural intrinsic capacity for paracrine support, releasing multiple signalling mol- ecules including NTFs. By transplanting MSCs into the vitreous, they are positioned adjacent to the injured reti- na to provide paracrine-mediated therapy for the retinal neuronal cells （Johnson et al., 2010a; Mead et al., 2013）. Additionally, MSCs may be pre-differentiated into sup- portive glial-like cells, such as Schwann cells, which could further increase their potential for paracrine support of injured neurons （Martens et al., 2013）. Thus, MSCs have received considerable attention as a new cellular therapy for both traumatic and degenerative eye disease, acting as an alternative source of NTFs, protecting injured RGCs and promoting regeneration of their axons （Figure 1）.

关键词： DPSCs RGCs BMSCs stem Mesenchymal stem cell therapy for retinal ganglion cell neuroprotection and axon regeneration cell

Inclusion Control and Long Sequence Casting

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Inclusion Control and Long Sequence Casting

Glutamate receptors and glutamatergic signalling in the peripheral nerves

技术创新与循环经济——第二届宝钢学术年会

作者： Marc BURTY Leo PEETERS Fabien RUBY Sidmar Arcelor groupBelgium Arcelor Research France

＜正＞The clogging of CC nozzle means higher production cost,increased safety risk,higher internal downgrading and finally customer *** has detrimental consequences on ***,the problem occurs variably on one given strand,one sequence,a specific period,on some *** development has evidenced critical process parameters influencing *** many parameters act on clogging, details of the steelmaking process matter;injection of argon,refractory quality and the inclusion population. We have developed and used some powerful new techniques to better understand the clogging *** content and type can be quickly characterized with SEM and PDA *** have thus specifically tracked the harmful inclusion *** - oxidation with Mg - bearing aluminum leads to the formation of spinel *** are smaller than alumina and form looser *** negative impact is found concerning castability.

关键词： clogging inclusions calcium magnesium oxides spinel

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Neural Regeneration Research 2020年第3期15卷 438-447页

作者： Ting-Jiun Chen Maria Kukley Center for Neuroscience Research Children’s Research InstituteChildren’s National Medical CentreWashingtonDCUSA group of Neuron Glia Interaction University of TübingenTübingenGermany Research Institute of Ophthalmology Tübingen University HospitalTübingenGermany

In the peripheral nervous system,the vast majority of axons are accommodated within the fibre bundles that constitute the peripheral *** within the nerves are in close contact with myelinating glia,the Schwann cells that are ideally placed to respond to,and possibly shape,axonal *** mechanisms of intercellular communication in the peripheral nerves may involve direct contact between the cells,as well as signalling via diffusible *** glutamate has been proposed as a candidate extracellular molecule mediating the cross-talk between cells in the peripheral *** types of experimental findings support this idea:first,glutamate has been detected in the nerves and can be released upon electrical or chemical stimulation of the nerves;second,axons and Schwann cells in the peripheral nerves express glutamate ***,the studies providing direct experimental evidence that intercellular glutamatergic signalling takes place in the peripheral nerves during physiological or pathological conditions are largely ***,in the central nervous system,axons and myelinating glia are involved in glutamatergic *** signalling occurs via different mechanisms,the most intriguing of which is fast synaptic communication between axons and oligodendrocyte precursor *** receptors and/or synaptic axon-glia signalling are involved in regulation of proliferation,migration,and differentiation of oligodendrocyte precursor cells,survival of oligodendrocytes,and re-myelination of axons after *** synaptic signalling exist between axons and Schwann cells in the peripheral nerves?What is the functional role of glutamate receptors in the peripheral nerves?Is activation of glutamate receptors in the nerves beneficial or harmful during diseases?In this review,we summarise the limited information regarding glutamate release and glutamate receptors in the peripheral nerves and speculate about possible mechanisms of

关键词： AMPA receptors axons glutamate metabotropic glutamate receptors myelination nerve injury NMDA receptors peripheral nervous system PNS Schwann cells synaptic signalling