Glutamate receptors and glutamatergic signalling in the peripheral nerves

作     者：Ting-Jiun Chen Maria Kukley Ting-Jiun Chen;Maria Kukley

作者机构：Center for Neuroscience ResearchChildren’s Research InstituteChildren’s National Medical CentreWashingtonDCUSA Group of Neuron Glia InteractionUniversity of TübingenTübingenGermany Research Institute of OphthalmologyTübingen University HospitalTübingenGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第3期

页      面：438-447页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：the laboratory of Maria Kukley was supported by the Excellence Strategy Program of the University of Tübingen(Deutsche Forschungsgemeinschaft ZUK63) 

主　　题：AMPA receptors axons glutamate metabotropic glutamate receptors myelination nerve injury NMDA receptors peripheral nervous system PNS Schwann cells synaptic signalling 

摘      要：In the peripheral nervous system,the vast majority of axons are accommodated within the fibre bundles that constitute the peripheral *** within the nerves are in close contact with myelinating glia,the Schwann cells that are ideally placed to respond to,and possibly shape,axonal *** mechanisms of intercellular communication in the peripheral nerves may involve direct contact between the cells,as well as signalling via diffusible *** glutamate has been proposed as a candidate extracellular molecule mediating the cross-talk between cells in the peripheral *** types of experimental findings support this idea:first,glutamate has been detected in the nerves and can be released upon electrical or chemical stimulation of the nerves;second,axons and Schwann cells in the peripheral nerves express glutamate ***,the studies providing direct experimental evidence that intercellular glutamatergic signalling takes place in the peripheral nerves during physiological or pathological conditions are largely ***,in the central nervous system,axons and myelinating glia are involved in glutamatergic *** signalling occurs via different mechanisms,the most intriguing of which is fast synaptic communication between axons and oligodendrocyte precursor *** receptors and/or synaptic axon-glia signalling are involved in regulation of proliferation,migration,and differentiation of oligodendrocyte precursor cells,survival of oligodendrocytes,and re-myelination of axons after *** synaptic signalling exist between axons and Schwann cells in the peripheral nerves?What is the functional role of glutamate receptors in the peripheral nerves?Is activation of glutamate receptors in the nerves beneficial or harmful during diseases?In this review,we summarise the limited information regarding glutamate release and glutamate receptors in the peripheral nerves and speculate about possible mechanisms of