检索结果-南通市图书馆

卵巢组织冻存与移植对宫颈癌患者卵巢内分泌功能的影响

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国临床医生杂志 2019年第7期47卷 759-762页

作者：阮祥燕程姣姣杜娟金凤羽李扬璐 Matthias Korell Thomas Rabe alfred O. Mueck 首都医科大学附属北京妇产医院内分泌科北京100026 Johanna Etienne Krankenhaus Neuss Germany University Women's hospital Heidelberg Germany The University of Tubingen Germany

国际生育力保护保存专家强烈建议所有年轻癌症患者当诊断为癌症时,应立即得到医生关于生育力保护保存的建议。宫颈癌是女性最常见的妇科恶性肿瘤,放化疗会导致卵巢功能不同程度的减退或衰竭,本文主要评述卵巢组织冻存与移植对宫颈癌患... 详细信息

国际生育力保护保存专家强烈建议所有年轻癌症患者当诊断为癌症时,应立即得到医生关于生育力保护保存的建议。宫颈癌是女性最常见的妇科恶性肿瘤,放化疗会导致卵巢功能不同程度的减退或衰竭,本文主要评述卵巢组织冻存与移植对宫颈癌患者卵巢内分泌功能的保护作用。

关键词：卵巢组织冻存卵巢组织移植宫颈癌卵巢内分泌功能

Performance and Trends in Measles Case-Based Surveillance in the North West Region of Cameroon, 2009 to 2015

在线全文

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2022年第6期10卷 37-55页

作者： Wasu Chrispus Nchandone Ginette Claude Mireille Kalla Njamnshi alfred Kongnyu Same Ekobo Albert Assob Nguedia Jules Clement Department of Public Health and Hygiene Faculty of Health Sciences University of Buea Buea Cameroon Regional Technical Group for the Expanded Programme on Immunization RTG-EPI Regional Delegation of Public Health for the North West Region of Cameroon Bamenda Cameroon Department of Paediatrics Faculty of Medicine and Biomedical Science University of Yaounde I Yaounde Cameroon Department of Neurology Central Hospital of Yaounde Yaounde Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Background: Measles is a highly contagious viral disease associated with high morbidity and mortality in developing countries. As an infection with no specific treatment, its control is most importantly through vaccination and adequate disease surveillance. National immunization coverage for the first dose of measles/rubella vaccine in 2019 was 71%. As a result, measles continues to rage with outbreaks not sparing the North West Region (NWR) of Cameroon, hence the need for proper surveillance. Objective: Assess performance of measles case-based surveillance in the NWR of Cameroon. Methods: This was a cross-sectional, descriptive study with retrospective collection of measles surveillance records carried out at the Regional Delegation of Public Health from 2009 to 2015. The data collected using a structured form were: number of persons suspected of measles;number of persons reported to district service;number of persons whose samples were collected and forwarded to the laboratory;number whose results reached the Expanded Programme on Immunization (EPI) Central unit and the time lapse between successive phases. Results: Although not all planned activities were carried out, a constant increase in planned and carried out monitoring activities was found. The average time taken from onset of signs and symptoms in a measles case to consultation at a health facility, from consultation to notification of case to district service, from notification to investigation, from investigation to receipt of biological sample at laboratory, from receipt of sample to provision of results to the EPI Central unit, and from collection of sample to reception of results at the Central EPI unit was 2.59 days, 1.5 days, 1.5 days, 2.6 days, 4 days and 6.6 days respectively. Conclusion: There was an overall rising trend in the performance of measles case-based surveillance, although the high priority site visits witnessed a stagnation during the period, a large scale measles epidemic occurred (2

关键词： Measles Case-Based Surveillance Performance Trends

Breast Cancer Risk Genes-Association Analysis in More than 113,000 Women

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for Cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN Unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are ***:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 *** separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor *** evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast Cancer

多结节融合肝细胞肝癌手术切除治疗——464例患者的观察性研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肝胆外科杂志 2009年第4期17卷 320-320页

作者： R.Andrea P.silvia C Franco C.Iacono V.Alessandro P.Gianluca L.Marta P.Stefano G.alfred 李培坤耿小平赵红川 General Surgery A Department of surgical an gastroenterological sciences Internal Medicine Department of internal medicine Desenzano Hospital

血浆置换和糖皮质激素治疗抗中性粒细胞胞质抗体相关性血管炎:临床实践指南

在线全文

学校读者我要写书评

暂无评论

英国医学杂志中文版 2022年第12期25卷 703-711页

作者：曾力楠 Michael Walsh Gordon H Guyatt Reed A C Siemieniuk David Collister Michelle Booth Paul Brown Lesha Farrar Mark Farrar Tracy Firth Lynn A Fussner Karin Kilian Mark A Little Thomas A Mavrakanas Reem A Mustafa Maryam Piram Lisa K Stamp 肖瑛琪 Lyubov Lytyn Thomas Agoritsas Per O Vandvik alfred Mahr 刘峥(译) 徐佩佩(译) 张伶俐(校) 四川大学华西第二医院药学部/循证药学中心成都中国 Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Population Health Research Institute McMaster UniversityHamiltonOntarioCanada Department of Medicine McMaster UniversityHamiltonOntarioCanada St.Joseph′s Healthcare HamiltonOntarioCanada USA UK Division of Pulmonary Critical Careand Sleep MedicineDepartment of Internal MedicineThe Ohio State University Wexner Medical CenterColumbusOhioUSA Department of Rheumatology Oslo University HospitalOsloNorway Institute of Clinical Medicine University of OsloOsloNorway Trinity Translational Medicine Institute Trinity College DublinIreland Irish Centre for Vascular Biology Tallaght University HospitalDublinIreland Department of Medicine McGill University Health CentreMontrealQuebecCanada Department of Internal Medicine Division of Nephrology and HypertensionUniversity of Kansas Medical CenterKansasUSA CHU Sainte Justine Research Center Department of PediatricsUniversity of MontrealMontrealQuebecCanada CEREMAIA Centre d′épidémiologie et de santédes populations(CESP)University Paris-SaclayLe Kremlin BicêtreFrance University of Otago Christchurch ChristchurchNew Zealand 四川大学华西护理学院/华西医院护理部成都中国 Division of General Internal Medicine&Division of Clinical Epidemiology University Hospitals of GenevaGenevaSwitzerland Department of Medicine Lovisenberg Hospital TrustOsloNorway Rheumatology Clinic Department of Internal MedicineKantonsspital St GallenSt GallenSwitzerland 四川大学华西第二医院药学部四川大学华西第二医院循证药学中心国家药品监督管理局药物制剂体内外相关性技术研究重点实验室出生缺陷与相关妇儿疾病教育部重点实验室四川大学华西临床医学院四川大学华西医院中国循证医学中心

对于抗中性粒细胞胞质抗体(antineutrophil cytoplasmic antibody,ANCA)相关性血管炎(ANCA-associated vasculitis,AAV)患者,血浆置换的作用是什么?接受治疗前6个月糖皮质激素的最佳剂量是多少?一项新发表的随机对照试验(randomised con... 详细信息

关键词：血浆置换抗中性粒细胞胞质抗体临床实践指南最佳剂量糖皮质激素 ANCA 随机对照试验 AAV

Stigma and epilepsy in onchocerciasisendemic regions in Africa:a review and recommendations from the onchocerciasisassociated epilepsy working group

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2019年第3期8卷 21-31页

作者： Sarah O'Neill Julia Irani Joseph Nelson Siewe Fodjo Denis Nono Catherine Abbo Yasuaki Sato Augustine Mugarura Housseini Dolo Maya Ronse alfred K.Njamnshi Robert Colebunders CRISS-School of Public Health Universite Libre de Bruxelles and LAMC Faculte de Philosophie et de Sciences Sociales Universite Libre de BruxellesBrusselsBelgium Department of Public health Institute o f Tropical MedicineAntwerpBelgium Global Health Institute University of AntwerpAntwerpBelgium Department of Mental Health Austrian Partnership Programme in Higher Education and Research for Developm ent(APPEAR)Project&AVSI FoundationGulu UniversityGuluUganda Department of Psychiatry Makerere UniversityKampalaUganda Department of Environmental Science and Technology Osaka Sangyo UniversityOsakaJapan Epilepsy Support Association of Uganda WakisoUganda Department of Neurology Yaounde Central Hospital/FMBSThe University of Yaounde IBrain Research Africa Initiative(BRAIN)YaoundeCameroon

Background:In onchocerciasis-endemic areas,particularly in those with a sub-optimal onchocerciasis control programme,a high prevalence of epilepsy is *** onchocerciasis and epilepsy are stigmatizing *** first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,Belgium(12-14 October 2017)and during this meeting,an OAE alliance was *** this paper,we review what is known about epilepsy-associated stigma in onchocerciasis-endemic regions,and present the recommendations of the OAE alliance working group on *** body:For this scoping review,literature searches were performed on the electronic databases PubMed,Scopus and Science Direct using the search terms"epilepsy AND onchocerciasis AND stigma".Hand searches were also undertaken using Google Scholar,and in total seven papers were identified that addressed epilepsy-related stigma in an onchocercisasis-endemic *** to the limited number of published research papers on epilepsyassociated stigma in onchocerciasis-endemic areas,other relevant literature that describes important aspects related to stigma is *** thematic presentation of this scoping review follows key insights on the barriers to alleviating the social consequences of stigma in highly affected onchocerciasis-endemic areas,which were established by experts during the working group on stigma and discrimination at the first international workshop on *** themes are:knowledge gaps,perceived disease aetiology,access to education,marriage restrictions,psycho-social well-being,burden on the care-giver and treatment seeking *** on the literature and expert discussions during the OAE working group on stigma,this paper describes important issues regarding epilepsy-related stigma in onchocerciasis-endemic regions and recommends interventions that are needed to reduce stigma and discrimination for the improvement of the psycho-social well-being of persons with ***

关键词： Epilepsy Onchocerciasis Stigma,Anti-epileptic treatment Nodding syndrome Discrimination Misconception,Africa

Report of the first international workshop on onchocerciasis-associated epilepsy

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2018年第1期7卷 238-242页

作者： Robert Colebunders Michel Mandro alfred K.Njamnshi Michel Boussinesq An Hotterbeekx Joseph Kamgno Sarah O’Neill Adrian Hopkins Patrick Suykerbuyk Maria-Gloria Basanez Rory J.Post Belen Pedrique Pierre-Marie Preux Wilma A.Stolk Thomas B.Nutman Richard Idro Global Health Institute University of AntwerpAntwerpBelgium Provincial Health Division of Ituri BuniaDemocratic Republic of the Congo Department of Neurology Yaounde Central Hospital/University of Yaounde 1Brain Research Africa Initiative(BRAIN)YaoundeCameroon Institut de Recherche pour le Developpement(IRD) MontpellierFrance Centre for Research on Filariasis and other Tropical Diseases(CRFilMT) and Faculty of Medicine and Biomedical SciencesUniversity of Yaounde 1YaoundeCameroon Department of Public Health Institute of Tropical MedicineAntwerpBelgium Neglected and Disabling Diseases of Poverty Consultant KentUK London Centre for Neglected Tropical Disease Research Imperial College LondonLondonUK London School of Hygiene&Tropical Medicine and Liverpool John Moores University LondonUK Drugs for Neglected Diseases initiative GenevaSwitzerland Preux Pierre-Marie INSERMUniversity LimogesCHU LimogesUMR_S 1094Tropical NeuroepidemiologyInstitute of Neuroepidemiology and Tropical NeurologyCNRS FR 3503 GEIST87000 LimogesFrance Department of Public Health Erasmus MCUniversity Medical Centre RotterdamRotterdamThe Netherlands Laboratory of Parasitic Diseases National Institutes of HealthBethesdaMarylandUSA Makerere University College of Health SciencesKampalaUganda

Background:Recently,several epidemiological studies performed in Onchocerca volvulus-endemic regions have suggested that onchocerciasis-associated epilepsy(OAE)may constitute an important but neglected public health problem in many countries where onchocerciasis is still *** text:On October 12-14th 2017,the first international workshop on onchocerciasis-associated epilepsy(OAE)was held in Antwerp,*** workshop was attended by 79 participants from 20 different *** research findings strongly suggest that *** is an important contributor to epilepsy,particularly in meso-and hyperendemic areas for *** with *** is associated with a spectrum of epileptic seizures,mainly generalised tonic-clonic seizures but also atonic neck seizures(nodding),and stunted *** is characterised by an onset of seizures between the ages of 3-18 *** working groups discussed topics such as how to 1)strengthen the evidence for an association between onchocerciasis and epilepsy,2)determine the burden of disease caused by OAE,3)prevent OAE,4)improve the treatment/care for persons with OAE and affected families,5)identify the pathophysiological mechanism of OAE,and 6)deal with misconceptions,stigma,discrimination and gender violence associated with *** OAE Alliance was created to increase awareness about OAE and its public health importance,stimulate research and disseminate research findings,and create partnerships between OAE researchers,communities,advocacy groups,ministries of health,non-governmental organisations,the pharmaceutical industry and funding ***:Although the exact pathophysiological mechanism underlying OAE remains unknown,there is increasing evidence that by controlling and eliminating onchocerciasis,OAE will also ***,OAE constitutes an additional argument for strengthening onchocerciasis elimination *** the high numbers of people with epilepsy

关键词： Onchocerciasis Epilepsy Nodding syndrome Nakalanga syndrome Prevalence Burden of disease Africa

同方期刊数据库

Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

Cell:新分子或可有效清除肝脏和血液中的脂肪

在线全文

学校读者我要写书评

暂无评论

现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Department of Chemistry Indiana University Bloomington IN 47405 USA Institut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Molecular EXposomics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany German Mouse Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Division of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Institute of Comparative Molecular Endocrinology University of Ulm 89081 Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Institute of Virology Technische Universität München 81675 Munich Germany Institute of Experimental Pediatric Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich Germany Comprehensive Diabetes Center and Department of Medicine-Endocrinology Diabetes & Metabolism University of Alabama at Birmingham Birmingham AL 35294 USA Institute for Diabetes and Regeneration Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany Calibrium LLC Carmel IN 46032 USA Institute for Experimental Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany German Center for Diabetes Research (DZD) 85764 Neuherberg Germany

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病