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Activation of cerebral Ras-related C3 botulinum toxin substrate(Rac) 1 promotes post-ischemic stroke functional recovery in aged mice

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Neural Regeneration Research 2024年第4期19卷 881-886页

作者： Fan Bu Jia-Wei min md Abdur Razzaque Ahmad El Hamamy Anthony Patrizz Li Qi Akihiko Urayama Jun Li Department of Neurology University of Texas Health Science Center Department of Neurology&Psychology The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine

Brain functional impairment after stroke is common;however,the molecular mechanisms of post-stroke recovery remain *** is well-recognized that age is the most important independent predictor of poor outcomes after stroke as older patients show poorer functional outcomes following *** evidence suggests that axonal regeneration and angiogenesis,the major forms of brain plasticity responsible for post-stroke recovery,diminished with advanced *** studies suggest that Ras-related C3 botulinum toxin substrate(Rac)1 enhances stroke recovery as activation of Rac1 improved behavior recovery in a young mice stroke ***,we investigated the role of Rac1 signaling in long-term functional recovery and brain plasticity in an aged(male,18 to 22 months old C57BL/6J)brain after ischemic *** found that as mice aged,Rac1 expression declined in the *** overexpression of Rac1,using lentivirus encoding Rac1 injected day 1 after ischemic stroke,promoted cognitive(assessed using novel object recognition test)and sensorimotor(assessed using adhesive removal tests)recovery on days 14–*** was accompanied by the increase of neurite and proliferative endothelial cells in the periinfarct zone assessed by *** a reverse approach,pharmacological inhibition of Rac1 by intraperitoneal injection of Rac1 inhibitor NSC23766 for 14 successive days after ischemic stroke worsened the outcome with the reduction of neurite and proliferative endothelial ***,Rac1 inhibition reduced the activation of p21-activated kinase 1,the protein level of brain-derived neurotrophic factor,and increased the protein level of glial fibrillary acidic protein in the ischemic brain on day 28 after *** work provided insight into the mechanisms behind the diminished plasticity after cerebral ischemia in aged brains and identified Rac1 as a potential therapeutic target for improving functional recovery in the older adults after stroke.

关键词： aging angiogenesis brain-derived neurotrophic factor(BDNF) cerebral ischemia cognitive recovery neurite Pak1 Rac1 sensorimotor recovery

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On optimal streaming kernelization algorithms

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science China(Information sciences) 2024年第8期67卷 337-338页

作者： Hao FENG Wei YANG Jianer CHEN School of Computer science Guangzhou University Department of Computer science and Engineering Texas A&M University

The streaming model has been a popular model in big data computation. Streaming kernelization algorithms can be regarded as data compression processes on streaming data. In this study, we give a general method for developing computational lower bounds for streaming kernelization algorithms that is applicable to a large class of computational problems. As an example, we use the method to prove computational lower bounds for the well-known problem d-Hi TTin GSET.

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TDP-43 is a key molecule accelerating development of Alzheimer’s disease following traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 955-956页

作者： Chu Chen Department of Cellular and Integrative Physiology Long School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in ***,no effective therapies are currently available for the prevention and treatment of *** is largely due to our limited understanding of the mechanisms underlying the neuropathogenesis of *** has widely been recognized that AD is heterogeneous and that multi-factors are contributing to the pathogenesis of *** evidence suggests that traumatic brain injury(TBI)is an important risk factor for the development of AD and dementia later in life(Guo et al.,2000;Johnson et al.,2010).However,the precise mechanism by which TBI contributes to developing AD has yet to be elucidated.

关键词： Alzheimer traumatic

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Dietary glycine supplementation enhances syntheses of creatine and glutathione by tissues of hybrid striped bass(morone saxatilis ♀ × morone chrysops ♂) fed soybean meal-based diets

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Journal of Animal science and Biotechnology 2024年第5期15卷 1996-2011页

作者： Wenliang He Xinyu Li Guoyao Wu Department of Animal science Texas A&M UniversityCollege StationTX 77843USA

Background We recently reported that supplementing glycine to soybean meal-based diets is necessary for the optimum growth of 5-to 40-g(Phase-I)and 110-to 240-g(Phase-II)hybrid striped bass(HSB),as well as their intestinal *** glycine serves as an essential substrate for syntheses of creatine and glutathione(GSH)in mammals(e.g.,pigs),little is known about these metabolic pathways or their nutritional regulation in *** study tested the hypothesis that glycine supplementation enhances the activities of creatine-and GSH-forming enzymes as well as creatine and GSH availabilities in tissues of hybrid striped bass(HSB;morone saxatilis♀×morone chrysops♂).methods Phase-I and Phase-II HSB were fed a soybean meal-based diet supplemented with 0%,1%,or 2%glycine for 8 *** the end of the 56-d feeding,tissues(liver,intestine,skeletal muscle,kidneys,and pancreas)were collected for biochemical *** In contrast to terrestrial mammals and birds,creatine synthesis occurred primarily in skeletal muscle from all *** liver was most active in GSH synthesis among the HSB tissues *** Phase-I HSB,supplementation with 1%or 2%glycine increased(Pmuscular creatine(15%–19%)and hepatic GSH(8%–11%),while reducing(Pmpared with the 0-glycine group;there were no differences(P>0.05)in these variables between the 1%and 2%glycine *** Phase-II HSB,supplementation with 1%and 2%glycine increased(Pmuscle(15%–27%)and liver(11%–20%)in a dose-dependent manner,with reduced ratios of hepatic GSSG/GSH in the 1%or 2%glycine *** all HSB,supplementation with 1%and 2%glycine dose-dependently increased(Pmuscular arginine:glycine amidinotransferase(22%–41%)and hepaticγ-glutamylcysteine synthetase(17%–37%),with elevated activities of intramuscular guanidinoacetate methyltransferase and hepatic GSH synthetase a

关键词： Amino acids Creatine Fish Glutathione Glycine Nutrition

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Discovering genetic biomarkers for targeted cancer therapeutics with eXplainable Artificial Intelligence

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Cancer Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakraborty Elizabeth Gutierrez-Chakraborty Cristian Rodriguez-Aguayo Hakan Başağaoğlu Gabriel Lopez-Berestein Paola Amero School of Civil and Environmental Engineering and Construction management The University of Texas at San AntonioSan AntonioTexasUSA Department of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwards Aquifer Authority San AntonioTexasUSA

High-Grade Serous Ovarian Cancer(HGSC)is the most prevalent and lethal form of gynecologic malignancies[1],accounting for 70%-80%of ovarian cancer *** decades of research,the overall survival rate for HGSC has remained largely unchanged[2],and patients with advanced stages of the disease have only a 41%chance of surviving beyond five years[3].

关键词： cancer Cancer targeted

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Revealing high-dimensional dynamical symmetry in alignment magnetic resonance

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science China(Physics,mechanics & Astronomy) 2024年第10期67卷 162-163页

作者： m.Suhail Zubairy Institute for Quantum science and Engineering(IQSE)and Department of Physics and Astronomy Texas A&M UniversityCollege StationTexas 77843-4242USA

Symmetry permeates throughout science,underlying people's understanding on intriguing physical *** include conserved quantities,critical phenomena and selection *** symmetry,the counterpart of geometrical symmetry or static symmetry referring to the geometrical shape or structure of a physical system,is present in the motion behavior.

关键词： properties symmetry alignment

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OAAFormer:Robust and Efficient Point Cloud Registration Through Overlapping-Aware Attention in Transformer

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Journal of Computer science & Technology 2024年第4期39卷 755-770页

作者： Jun-Jie Gao Qiu-Jie Dong Rui-An Wang Shuang-min Chen Shi-Qing Xin Chang-He Tu Wenping Wang School of Computer science and Technology Shandong UniversityQingdao 266237China School of Information and Technology Qingdao University of Science and TechnologyQingdao 266061China College of Engineering Texas A&M UniversityTexasTX 77843U.S.A.

In the domain of point cloud registration,the coarse-to-fine feature matching paradigm has received significant attention due to its impressive *** paradigm involves a two-step process:first,the extraction of multilevel features,and subsequently,the propagation of correspondences from coarse to fine ***,this approach faces two notable ***,the use of the Dual Softmax operation may promote one-to-one correspondences between superpoints,inadvertently excluding valuable ***,it is crucial to closely examine the overlapping areas between point clouds,as only correspondences within these regions decisively determine the actual *** these issues,we propose OAAFormer to enhance correspondence *** the one hand,we introduce a soft matching mechanism to facilitate the propagation of potentially valuable correspondences from coarse to fine *** the other hand,we integrate an overlapping region detection module to minimize mismatches to the greatest extent ***,we introduce a region-wise attention module with linear complexity during the fine-level matching phase,designed to enhance the discriminative capabilities of the extracted *** on the challenging 3DLomatch benchmark demonstrate that our approach leads to a substantial increase of about 7%in the inlier ratio,as well as an enhancement of 2%-4%in registration ***,to accelerate the prediction process,we replace the Conventional Random Sample Consensus(RANSAC)algorithm with the selection of a limited yet representative set of high-confidence correspondences,resulting in a 100 times speedup while still maintaining comparable registration performance.

关键词： point cloud registration coarse-to-fine overlapping region feature matching Transformer

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mAP4K inhibition as a potential therapy for amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第8期19卷 1639-1640页

作者： Shuaipeng ma Chun-Li Zhang Department of molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon center for Regenerative science and medicine University of Texas Southwestern Medical CenterDallasTXUSA

Amyotrophic lateral sclerosis(ALS)is a rare neurological disease,featuring gradual loss of muscle controls due to degeneration of motor ***,there is currently no cure for *** available therapies only offer a limited e... 详细信息

关键词： degeneration sclerosis mAP4

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Chimeric monkey Born Alive with a High Contribution of Donor Cells

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Neuroscience Bulletin 2024年第6期40卷 849-851页

作者： Jia Huang Jun Wu Department of molecular Biology University of Texas Southwestern Medical CenterDallasTX75390USA Hamon center for Regenerative science and medicine University of Texas Southwestern Medical CenterDallasTX75390USA Cecil H.and Ida Green center for Reproductive Biology sciences University of Texas Southwestern Medical CenterDallasTX75390USA

Chimeras,which consist of cells from different individuals or different species,represent an important tool in biological *** in the early twentieth century,studies on chimeras have been focusing on understanding fundamental genetic and cellular developmental *** the advances in genetic engineering and embryonic stem cell(ESC)technology,chimeras have become an important tool for the generation of transgenic animals.

关键词： mechanisms advances developmental

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Ultrafast magneto-optical dynamics in nickel(111)single crystal studied by the integration of ultrafast reflectivity and polarimetry probes

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Chinese Physics B 2024年第3期33卷 65-69页

作者：匡皓余军潇陈洁 H.E.Elsayed-Ali 李润泽 Peter m.Rentzepis School of Physical science and Technology ShanghaiTech UniversityShanghai 201210China center for Transformative science ShanghaiTech UniversityShanghai 201210China center for Ultrafast science and Technology Key Laboratory for Laser Plasmas (Ministry of Education)Collaborative Innovation Center of IFSA (CICIFSA)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Department of Electrical and Computer Engineering Old Dominion UniversityNorfolkVirginia 23529USA Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTexas 77843USA

With the integration of ultrafast reflectivity and polarimetry probes,we observed carrier relaxation and spin dynamics induced by ultrafast laser excitation of Ni(111)single *** carrier relaxation time within the linear excitation range reveals that electron-phonon coupling and dissipation of photon energy into the bulk of the crystal take tens of *** the other hand,the observed spin dynamics indicate a longer time of about 120 *** further understand how the lattice degree of freedom is coupled with these dynamics may require the integration of an ultrafast diffraction probe.

关键词： ultrafast spin dynamics non-equilibrium dynamics multi-probe

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