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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto nacional de medicina Genómica(INmEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(Gm)(mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Encapsulation of Immature Somatic Embryos of Coffea arabica *** in Vitro Preservation

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Phyton-International Journal of Experimental Botany 2021年第6期90卷 1741-1748页

作者： Eliana Arias-Pérez Carlos Alberto Lecona-Guzmán Federico Antonio Gutiérrez-miceli Joaquín Adolfo montes-molina Nancy Ruiz-Lau Laboratorio de Biotecnología Vegetal Instituto Tecnológico de Tuxtla GutiérrezTecnológico Nacional de MéxicoTuxtla GutiérrezChiapas29050México CONACYT-tecnológico nacional de méxico/Instituto tecnológico de Tuxtla Gutiérrez Tuxtla GutiérrezChiapas29050México

The present study aimed to develop a protocol for somatic embryogenesis and encapsulation of coffee embryos(Coffea arabica L.),for the conservation of genotypes with characteristics of commercial *** embryos were induced from leaf explants in murashige and Skoog medium(mS)supplemented with 1 mg·L^(−1) of 2,4-dichlorophenoxiacetic acid(2,4-D)combined with 2 mg·L^(−1) of benzyladenine(BA).Somatic embryos(SE)at the globular stage were encapsulated in a sodium alginate matrix;two treatments were tested:mS+5 mg·L^(−1) BA+1 mg·L^(−1) NAA+3%(w/v)alginate,and mS+7 mg·L^(−1) BA+5.7 mg·L^(−1) indoleacetic acid(IAA)+3%(w/v)*** was complexed with 100 mm calcium chloride(CaCl_(2)).Viability of the encapsulated SE was determined by staining with 0.01%fluorescein diacetate(FDA)after 0,15,30,and 45 days of storage at 4℃.Embryo viability was 100%in both treatments.

关键词： Coffee explants embryo artificial seeds

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Polygeneration Study of Low-to-medium Enthalpy Geothermal Reservoirs in mexico

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Journal of Thermal Science 2021年第3期30卷 1077-1087页

作者： CHÁVEZ Oscar GODÍNEZ Francisco tecnológico nacional de méxico/I.T.Chihuahua.Av.tecnológico 2909 C.P.31310ChihuahuaChihuahuaMéxico Instituto de Ingeniería Universidad Nacional Autónoma de MéxicoUNAMC.U.Ciudad de MéxicoC.P.04510México Polo Universitario de tecnología Avanzada Universidad Nacional Autónoma de MéxicoVía de la Innovación No.410Autopista Monterrey-Aeropuertokm.10 PIITC.P.66629Apodaca Nuevo LeónMéxico

This study combines the thermodynamic analysis of a polygeneration system along with the numerical modelling of the thermal behavior of geothermal reservoirs in mexico to exploit their *** reservoir was modeled as a porous medium assuming a five-spot well configuration and local thermal *** heat conduction-convection along with the Laplace equations were solved to compute temperature distributions,the useful life and the optimum distance between injection-extraction *** predicted temperature and pressure of the geothermal fluid at the outlet of the reservoir were exploited in the polygeneration system consisting of:(1)a Rankine cycle,(2)an absorption refrigeration cycle,and(3)a heat *** developed approach allows calculating both the optimal distance between injection-extraction wells and the global(utilization)efficiency of six arrangements(each composed by a reservoir connected to a polygeneration system)by assuming that reservoirs have a lifespan of 30 *** also show that:(a)due to the low efficiency of the Rankine cycle,very little thermal energy is converted into electrical one;(b)not only the temperature and the size are important when evaluating the power production performance of reservoirs,but also the permeability plays a fundamental role;(c)the first law efficiency of the polygeneration system ranges from 41.9%to 43.7%;(d)the utilization efficiency of the six arrangements lies in the range between 25.8%and 31%.

关键词： polygeneration system geothermal reservoir local thermal equilibrium low-to-medium enthalpy

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Selection and Analysis of Polymorphisms in Somaclonal Variants of Agave americana Resistant to Fusarium oxysporum via an Ethyl methanesulphonate Treatment

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Phyton-International Journal of Experimental Botany 2021年第6期90卷 1727-1739页

作者： Sheila Jazmín Reyes-Zambrano Carlos Alberto Lecona-Guzmán Federico Antonio Gutiérrez-miceli Víctor manuel Ruiz-Valdiviezo Arely Anayansi Vargas-Díaz Laboratorio de Biotecnología Vegetal Instituto Tecnológico de Tuxtla GutiérrezTecnológico Nacional de MéxicoTuxtla GutiérrezChiapas29050México CONACYT-Colegio de Postgraduados Campus Campeche ChampotónCampeche24450México

Agave americana *** were exposed to different concentrations of ethyl methanesulphonate(EmS)0,15,30,45 and 60 mm and to different times of exposure(2 and 4 h).The viability and capacity of shoot formation were shown to be affected when the callus were exposed to high concentrations(30–60 mm).Only the callus exposed to 15 mm EmS presented shoot formation;the exposure time of two hours produced the largest quantity of shoots regenerated per callus(21 shoots/callus).In order to generate somaclonal variants resistant to Fusarium oxysporum,a selection pressure was applied through of a culture filtrate(CF)of 100 ppm of the *** was made in callus obtained in the treatment with 15 mm EmS during 2 h of *** CF caused oxidation and necrosis in 71.25%of the callus;however,they were capable of generating shoots(3.5 shoots/callus).molecular markers type RAPD,ISSR and DAmD were used to evaluate the genetic variation arising from the mutations caused by EmS on control plants and 16-month-old somaclonal *** polymorphic information content(PIC)for each one of the initiating groups was:0.28(DAmD),0.09(ISSR)and 0.14(RAPD).DAmD revealed a greater percentage of polymorphism than RAPD and *** bands were detected in the somaclonal *** indicated that the EmS caused genetic variation in the regenerated plants conferring resistance to them against Fusarium oxysporum.

关键词： mutagenesis polymorphisms genetic variation molecular markers

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Atmospheric-pressure dielectric barrier discharge generation by a full-bridge flying capacitor multilevel inverter

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Plasma Science and Technology 2017年第7期19卷 40-49页

作者： Rosendo PE?A-EGUILUZ José A LóPEZ-FERNáNdeZ Antonio mERCADO-CABRERA Bethsabet JARAmILLO-SIERRA Régulo LóPEZ-CALLEJAS Benjamín RODRíGUEZ-méNdeZ Raúl VALENCIA-ALVARADO Allan A FLORES-FUENTES Arturo E mU?OZ-CASTRO Plasma Physics Laboratory Instituto Nacional de Investigaciones Nucleares tecnológico de Estudios Superiores de Tianguistenco Universidad Autónoma del Estado de méxico

A new configuration of a resonant full-bridge flying capacitor multicell inverter has been designed and constructed with the aim of achieving an extended output voltage frequency range with low harmonic distortion and reduced semiconductor commutation losses. This configuration was tested as a power supply for two different coaxial dielectric barrier discharge reactors, one of them employed for electric characterization and the other one for inorganic compound elimination in an aqueous solution. Two different gas mixtures, 90% Ar-10% 02 and 80% Ar-20% 02, were individually supplied during the experiments; the results showed a high- efficiency removal of meta-cresol （m-cresol） to the order of 98%, which was obtained by adding more oxygen to the plasma gas mixture.

关键词： plasma applications water pollution plasma sources power supply circuits electricdischarges

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A New Phasor Estimator for PmU Applications:P Class and m Class

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Journal of modern Power Systems and Clean Energy 2020年第1期8卷 55-66页

作者： Jose R.Razo-Hernandez Arturo mejia-Barron David Granados-Lieberman martin Valtierra-Rodriguez Jose F.Gomez-Aguilar ENAP-Research Group Facultad de IngenieríaUniversidad Autónoma de Querétaro(UAQ)San CayetanoC.P.76807México ENAP-Research Group Departamento de Ingeniería ElectromecánicaInstituto Tecnológico Superior de Irapuato(ITESI)Colonia El CopalC.P.36821México CONACyT-Centro nacional de Investigación y desarrollo tecnológico(CENIdeT) Tecnológico Nacional de MéxicoInterior Internado Palmira S/NCol.PalmiraC.P.62490México

Phasor measurement units(PmUs)are fundamental tools in the applications of modern power systems,where synchronized phasor estimations are *** accuracy and dynamic performance requirements for phasor,frequency,and rate of change of frequency(ROCOF)estimations are established in the IEEE Std.C37.118.1-2011 along with the IEEE Std.C37.118.1 a-2014,where two PmU performances are suggested:P class filters for applications requiring fast response and m class filters for applications requiring high rejection to aliased *** this paper,a methodology to design new phasor estimators that satisfy the P class and m class requirements in PmUs is *** proposed methodology is based on finite impulse response filters,brick-wall filters,and complex filter design concepts,where frequency range,time performance,harmonic rejection and out-of-band interference requirements are considered in its design.A comparative analysis using the reference model given by the IEEE Std.C37.118.1 is *** results show the effectiveness of the phasor estimators under steady-state and dynamic conditions according to the PmU standard,making them suitable tools for applications in power systems.

关键词： Brick-wall filter complex filter IEEE Std.C37.118.1 m class P class phasor measurement unit(PmU) phasor estimator

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Antifungal Potential of Beauveria bassiana on Solanum lycopersicum L. Infected with Fusarium oxysporum f. sp. lycopersici

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1235-1255页

作者： Henry López-López Nancy Ruiz-Lau Rocío meza-Gordillo Víctor manuel Ruiz-Valdiviezo Joseph Galthier Robledo-Luchetti Carlos Alberto Lecona-Guzmán Juan JoséVillalobos-maldonado Luc dendooven Joaquín Adolfo montes-molina Laboratorio de Biotecnología vegetal Tecnológico Nacional de Mexico/Campus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico CONACYT-tecnológico nacional de mexico/Campus Tuxtla Gutiérrez Tuxtla Gutiérrez29050México ABACUS CinvestavCiudad de México07360México

The objective of this work was to evaluate the effect of Beauveria bassiana(Bb 1205)on controlling Fusarium oxysporum ***(Fol 17108)in tomato plants in greenhouse *** of Bb 1205 was the most promising among the agronomic variables and expression of the activity of the enzymesβ-1,3-glucanases and *** of Bb 1205 occurred at a concentration of 1×108 conidia·mL−1,which was administered onto the leaves,directly into the soil and via *** with Fol 17108 occurred with 1×106 spores·mL−1,which were added directly to the *** was used for measuring agronomic parameters,namely activity of chitinases andβ-1,3-glucanases in foliage and *** Bb 1205 was added to the soil,the chlorophyll index and aerial part length showed significant *** addition,it was determined that root length,fresh weight of foliage,flower,and fruit count increased 82 days after inoculation(dai).Chitinase activity induced by Bb 1205 in leaves and roots of tomato plants infected with Fol 17108 was observed when injected into the stem at 32 dai(41.8 and 11.6-fold,respectively).Inoculation on the foliage showed a 10-fold increase ofβ-1,3-glucanases in the roots after 82 *** for leaves,a 3.8-fold increase was found when the stem was *** the different in vivo applications,Bb 1205 activated its defenses by expressing the chitinase enzymes andβ-1,3-glucanase,thus reducing the damage caused by Fol 17108,demonstrating increase plant growth thereafter.

关键词： mycoparasitism agronomic parameters chitinases β-1,3-glucanases

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A Numerical Study Comparing the Effect on Residual Stresses of Two Different Types of Projectiles During Shot Peening

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Computers, materials & Continua 2016年第3期51卷 203-215页

作者： J.Solórzano-López F.A.García-Pastor Angélica Flores-Luna UNAm Facultad de QuímicaCiudad de MéxicoMéxico Cinvestav Unidad Saltillo CoahuilaMéxico TecNm Instituto Tecnológico de Tláhuac IIICiudad de MéxicoMéxico

Shot peening is a widely used technique to improve fatigue life in metallic *** processing technique introduces a subsurface compressive residual stress field through a plastic deformation of the surface caused by the impact of a large number of high-speed *** are a number of parameters that affect the residual stress field depth and *** effects of the impact angle,shot speed and shot geometry are currently being *** particular,substituting spherical cast shots by cylindrical cut wire shots is an attractive option,especially in terms of *** effect of shot geometry on residual stresses,however,needs to be further *** industrial-scale experimentation is costly and cumbersome,mathematical modeling offers a convenient alternative to carry out this type of *** present work shows a comparison between the residual stresses generated by the impact of spherical and cylindrical projectiles on a steel *** threedimensional model was developed using ABAQUS finite element commercial software(Release 6.12,Dassault Systémes,France).The results show that cylindrical shots generate residual stress fields t hat a re higher in magnitude than t hose generated by a spherical ***,the residual stress field of cylindrical shots impacting the surface at an oblique angle shows an important degree of *** effect is not found when spherical shots impact the surface at the same oblique angle.

关键词： Shot Peening Finite element method Residual Stresses

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Effect of Water Stress Induced by Polyethylene Glycol on Growth, Proline Accumulation in Agave americana L.

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 629-643页

作者： Alfaro-Corres Arnoldo Enrique Lecona-Guzman Carlos Alberto Gutiérrez-miceli Federico Antonio martínez-Esteves manuel Silverio-Gómez maría del Carmen medina-Lara maría de Fátima Ruiz-Lau Nancy Laboratorio de Biotecnología vegetal Instituto Tecnológico de Tuxtla GutiérrezTuxtla Gutiérrez29050México Centro de Investigación Científica de Yucatán Unidad de Bioquímica y Biología Molecular de PlantasMérida97205México Insituto nacional de Investigaciones Forestales Agrícolas y PecuariasHuimanguilloTabasco86400México CONACYT-tecnológico nacional de méxico/Instituto tecnológico de Tuxtla Gutiérrez Tuxtla Gutiérrez29050México

The effect of water deficit was determined on both in vitro and soil seedling as well as in cells in suspension of Agave americana *** order to do the establishment of cells,the formation of callus was induced;for it two auxins were evaluated:2,4-dichlorophenoxyacetic acid(2,4-D)and 4-mino-3,5,6-trichloropicolinic acid(picloram)at three concentrations(0.25,0.5 and 0.75 mg L−1)in three explants(leaf,root and meristems)cultured in mS semisolid *** callogenesis response was related to the type and section of the explant,as well as the regulator used,and a cell suspension was established using 0.5 mg L−1 naphthaleneacetic acid(NAA)+0.5 mg L−1 Benzylaminopurine(BAP).Seedlings were exposed to polyethyleneglycol(15%and 30%w/v)with a water potential of−0.87 and−2.67 mPa,respectively,under soil *** stress was applied through restricted *** weight,root system growth,and chlorophyll concentration were some of the parameters that were affected by the effect of water deficit on *** *** concentration values were significantly decreased by 15 at 30%PEG(19.6 SPAD units)compared to the control *** in vitro plants,the highest concentration of proline was found in the roots,being the treatment with 30%polyethylene glycol where the highest concentration of this osmoregulator was obtained(62.5 mg g−1 DW).Under restricted irrigation conditions,an increase in proline concentration was observed both in the aerial part(2.2μg 100 g−1 DW)and in the root system(1.8μg 100 g−1 DW).However,the concentrations found were approximately ten times greater,less than those found under in vitro ***,the accumulation of proline can be considered an indicator of stress in Agave Americana *** in vitro.

关键词： Agave americana water deficit proline

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