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Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

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Food Science and Human Wellness 2024年第3期13卷 1258-1270页

作者： Qishan Wang Bin Liu Xianping Li Junying Zhao Zongshen Zhang Weicang Qiao Xinyue Wei Lijun Chen School of Bioengineering Dalian Polytechnic UniversityDalian 116034China National Engineering Research center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research center of Dairy Beijing Sanyuan Foods Co.Ltd.Beijing 100163China

The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are ***,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral *** 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical *** results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid ***,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and ***,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase ***,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.

关键词： Dairy products Calcium Vitamin D Bone turnover markers Gut microbiota Postmenopausal osteoporosis

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Overview of 5G security technology

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Science China(Information Sciences) 2018年第8期61卷 107-131页

作者： Xinsheng JI Kaizhi HUANG Liang JIN Hongbo TANG Caixia LIU Zhou ZHONG Wei YOU Xiaoming XU Hua ZHAO Jiangxing WU Ming YI National Digital Switching System Engineering & technological R&D center Zhengzhou 450002 China National Digital Switching System Engineering & technological R&D center

The 5 th-generation mobile communication system(5 G) has higher security requirements than previous systems. Accordingly, international standard organizations, operators, and equipment manufacturers are focusing extensively on 5 G security technology. This paper analyzes the security requirements of 5 G business applications, network architecture, the air interface, and user privacy. The development trends of5 G security architecture are summarized, with a focus on endogenous defense architecture, which represents a new trend in 5 G security development. Several incremental 5 G security technologies are reviewed, including physical layer security, lightweight encryption, network slice security, user privacy protection, and block chain technology applied to 5 G.

关键词： 5G security endogenous defense mimic defense physical layer security lightweight encryption network slice security user privacy preservation block chain

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Current progress of research on heat -resistant Mg alloys: A review

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1406-1425页

作者： Hong Yang Wenlong Xie Jiangfeng Song Zhihua Dong Yuyang Gao Bin Jiang Fusheng Pan National Engineering Research center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

With the increasing attention received by lightweight metals,numerous essential fields have increased requirements for mag-nesium(Mg)alloys with good room-temperature and high-temperature mechanical ***,the high-temperature mechanic-al properties of commonly used commercial Mg alloys,such as AZ91D,deteriorate considerably with increasing *** the past several decades,extensive efforts have been devoted to developing heat-resistant Mg *** approaches either inhibit the gen-eration of thermally unstable phases or promote the formation of thermally stable precipitates/phases in matrices through solid solution or precipitation *** this review,numerous studies are systematically introduced and *** alloy systems,includ-ing those based on Mg–Al,Mg–Zn,and Mg–rare earth,are carefully classified and compared to reveal their mechanical properties and strengthening *** emphasis,limitations,and future prospects of these heat-resistant Mg alloys are also pointed out and dis-cussed to develop heat-resistant Mg alloys and broaden their potential application areas in the future.

关键词： magnesium alloys mechanical properties heat resistance microstructures high temperatures strengthening mechanisms

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Association of Mosaic Chromosomal Alterations and Genetic Factors with the Risk of Cirrhosis

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Journal of Clinical and Translational Hepatology 2024年第6期12卷 562-570页

作者： Xinyuan Ge Lu Zhang Maojie Liu Xiao Wang Xin Xu Yuqian Yan Chan Tian Juan Yang Yang Ding Chengxiao Yu Jing Lu Longfeng Jiang Qiang Wang Qun Zhang Ci Song Department of Epidemiology China International Cooperation Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina The Dumont-UCLA Transplant center Division of Liver and Pancreas TransplantationDepartment of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCAUSA Department of Health Promotion center Jiangsu Province Hospital and Nanjing Medical University First Affiliated HospitalNanjingJiangsuChina Department of Infectious Disease The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Clinical Science Intervention and Technology(CLINTEC)Karolinska InstitutetStockholmSweden Changzhou Medical center Nanjing Medical UniversityNanjingJiangsuChina Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijingChina Collaborative Innovation center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsuChina

Background and Aims:Age-related mosaic chromosomal alterations(mCAs)detected from genotyping of blood-de-rived DNA are structural somatic variants that indicate clonal *** study aimed to investigate whether mCAs contribute to the risk of cirrhosis and modify the effect of a polygenic risk score(PRS)on cirrhosis risk ***:mCA call sets of individuals with European ancestry were obtained from the UK *** PRS was constructed based on 12 susceptible single-nucleotide poly-morphisms for *** proportional hazard models were applied to evaluate the associations between mCAs and cirrhosis ***:Among 448,645 individuals with a median follow-up of 12.5 years,we identified 2,681 cas-es of cirrhosis,1,775 cases of compensated cirrhosis,and 1,706 cases of decompensated *** to non-carriers,individuals with copy-neutral loss of heterozygosity mCAs had a significantly increased risk of cirrhosis(hazard ratio(HR)1.42,95%confidence interval(CI)1.12-1.81).This risk was higher in patients with expanded cell fractions of mCAs(cell fractions≥10%*** fractions<10%),especially for the risk of decompensated cirrhosis(HR 2.03[95%CI 1.09-3.78]vs.1.14[0.80-1.64]).In comparison to non-carriers of mCAs with low genetic risk,individuals with expanded copy-neutral loss of heterozygosity and high genetic risk showed the highest cirrhosis risk(HR5.39[95%CI 2.41-12.07]).Conclusions:The presence of mCAs is associated with increased susceptibility to cirrhosis risk and could be combined with PRS for personalized cirrhosis risk stratification.

关键词： UK Biobank Cirrhosis Mosaic chromosomal alterations Polygenic risk score Genetic susceptibility Interaction effect

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Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

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Science Bulletin 2024年第13期69卷 2099-2113页

作者： Jianfei Liang Jing Wang Bingdong Sui Yibo Tong Jihua Chai Qin Zhou Chenxi Zheng Hao Wang Liang Kong Haojian Zhang Yi Bai State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhan 430079China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710004China Department of Implant Dentistry College of StomatologyXi’an Jiaotong UniversityXi’an 710004China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hematology Zhongnan HospitalWuhan UniversityWuhan 430079China Frontier Science center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430079China Taikang center for Life and Medical Sciences Wuhan UniversityWuhan 430079China

Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory *** this study,we identified the epigenetic landscape along the developmental trajectory of skeletal stem cells(SSCs)in skeletogenesis governed by a key regulator,Ptip(also known as Paxip1,Pax interaction with transcription-activation domain protein-1).Our results showed that Ptip is required for maintaining the quiescence and potency of SSCs,and loss of Ptip in type II collagen(Col2)^(+)progenitors causes abnormal activation and differentiation of SSCs,impaired growth plate morphogenesis,and long bone *** also found that Ptip suppressed the glycolysis of SSCs through downregulation of phosphoglycerate kinase 1(Pgk1)by repressing histone H3 lysine 27 acetylation(H3K27ac)at the promoter ***,inhibition of glycolysis improved the function of SSCs despite Ptip *** the best of our knowledge,this is the first study to establish an epigenetic framework based on Ptip,which safeguards skeletal stem cell quiescence and potency through metabolic *** framework is expected to improve SSC-based treatments of bone developmental disorders.

关键词： Skeletal stem cells Bone development Epigenetics Ptip Glycolysis

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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng Yiming Deng Xingquan Zhao Liping Liu Ning Ma Feng Gao Dapeng Mo Wengui Yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National center for Neurological Diseases BeijingChina Advanced Innovation center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

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Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

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Journal of Materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng Zou Lifeng Ma Yanchun Zhu Ling Qin Yuan Yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy Machinery Engineering Research center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering Research center for Magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy Magnesium alloy Strengthening mechanism

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Dual-Threshold Based Secure On-Off Transmission Scheme for Dense HCNs with Imperfect CSI

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China Communications 2019年第3期16卷 132-142页

作者： Yunjia Xu Kaizhi Huang Yi Zou Xin Hu National Digital Switching System Engineering & technological Research center

In this paper, we propose a dual-threshold based secure On-Off transmission scheme, where signals are transmitted only if the channel condition can guarantee secure and reliable communication. First, we present a dynamic access strategy to increase access efficiency, which provides an access region for the intended user. Then, we propose an emission control policy to transmit signals according to the current channel condition, which declines the influence of channel estimation errors and guarantees qualities of communication links. Furthermore, we give a comprehensive performance analysis for the proposed scheme in terms of connection outage probability(COP) and secrecy outage probability(SOP), and present a dual-threshold optimization model to further support the performance. Numerical results verify that the secure On-Off transmission scheme can increase the system secure energy efficiency and guarantee reliable and secure communication.

关键词： physical layer security imperfect CSI dense heterogeneous cellular networks On-Off transmission secure energy efficiency

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Physical Layer Security of Multi-hop Aided Downlink MIMO heterogeneous Cellular Networks

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China Communications 2016年第S2期13卷 120-130页

作者： Xiaohui Qi Kaizhi Huang Zhihao Zhong Xiaolei Kang Zhou Zhong National Digital Switching System Engineering & technological Research center

This study investigates physical layer security in downlink multipleinput multiple-output(MIMO) multi-hop heterogeneous cellular networks(MHCNs),in which communication between mobile users and base stations(BSs) is established by a single or multiple hops,to address the problem of insufficient security performance of MIMO heterogeneous cellular ***,two-dimensional homogeneous Poisson point processes(HPPPs) are utilized to model the locations of K-tier BSs in MIMO MHCNs and receivers,including those of legitimate users and ***,based on the channel gain distribution and the statistics property of HPPP,the achievable ergodic rates of the main and eavesdropper channels in direct and ad hoc links are derived,***,the secrecy coverage probability and the achievable ergodic secrecy throughput of downlink MIMO MHCNs are explored,and their expressions are ***,the correctness of the theoretical derivation is verified through Monte Carlo simulations.

关键词： multi-hop heterogeneous cellular networks secrecy coverage probability stochastic geometry secrecy throughput

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Circular polarization-selective optical,photothermal,and optofluidic effects in chiral metasurfaces

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Photonics Research 2024年第2期12卷 331-340页

作者： CUIPING MA PENG YU ZHIMIN JING YISONG ZHU PEIHANG LI WENHAO WANG HONGXING XU YANNING ZHANG LIANG PAN TAE-YOUL CHOI ARUP NEOGI ALEXANDER OGOVOROV ZHIMING WANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China Department of Mechanical Engineering University of North TexasDentonTexas 76207USA Department of Physics and Astronomy and Nanoscale and Quantum Phenomena Institute Ohio UniversityAthensOhio 45701USA

Circular dichroism (CD) is extensively used in various material systems for applications including biological detection,enantioselective catalysis,and chiral *** paper introduces a chiral absorptive metasurface that exhibits a circular polarization-selective effect in dual bands-positive and negative CD peaks at short wavelengths and long wavelengths,***,we uncover that this phenomenon extends beyond the far-field optical response,as it is also observed in the photothermal effect and the dynamics of thermally induced fluid *** carefully engineering the metasurface design,we achieve two distinct CD signals with high g factors (1) at the wavelengths of 877 nm and 1045 nm,*** findings presented in this study advance our comprehension of CD and offer promising prospects for enhancing chiral light–matter interactions in the domains of nanophotonics and optofluidics.

关键词： chiral catalysis circular

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